Лихорадка (новые штрихи на древней картине)
Лихорадка (новые штрихи на древней картине)
Делягин В.М. Лихорадка (новые штрихи на древней картине). Педиатрия (Прил. к журн. Consilium Medicum). 2018; 2: 89–93.
DOI: 10.26442/2413-8460_2018.2.89-93
DOI: 10.26442/2413-8460_2018.2.89-93
DOI: 10.26442/2413-8460_2018.2.89-93
________________________________________________
DOI: 10.26442/2413-8460_2018.2.89-93
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Лихорадка, особенно у детей раннего и младшего возраста, – одна из самых частых причин обращений к педиатрам. Несмотря на то что подавляющее большинство случаев лихорадки вызываются самозавершающимися вирусными респираторными инфекциями, причинами могут быть серьезные бактериальные инфекции, иммунные и онкологические заболевания. В статье обсуждаются проблемы диагностики и дифференциальной диагностики. В качестве симптоматического фармакологического средства на первое место выдвигается ибупрофен.
Ключевые слова: дети, лихорадка, диагностика, дифференциальная диагностика, лечение, ибупрофен.
Key words: children, fever, diagnosis, differential diagnosis, treatment, ibuprofen.
Ключевые слова: дети, лихорадка, диагностика, дифференциальная диагностика, лечение, ибупрофен.
________________________________________________
Key words: children, fever, diagnosis, differential diagnosis, treatment, ibuprofen.
Список литературы
1. Green R, Alergo D, Jenna P et al. Management of acute fever in children: Guideline for community healthcare providers and pharmacists. S Afr Med J 2013; 103 (12): 948–54.
2. Roth A, Baselle G. Fever. In: Kellerman R, Bape E (Ed.). Connʹs Current Therapy. Saunders, 2018; p. 12–4.
3. Делягин В.М. Патогенез лихорадки и патогенетически обоснованный выбор антипиретических средств. Врач. 2016; 12: 67–71. / Delyagin V.M. Patogenez lihoradki i patogeneticheski obosnovannyj vybor antipireticheskih sredstv. Vrach. 2016; 12: 67–71. [in Russian]
4. Volpi-Abadie J, Kaye A-M, Kaye AD. Serotonin Syndrome Ochsner J 2013; 13 (4): 533–40.
5. Chien Ya, Huang F, Huang Ch, Chen Po-Yen. Clinical approach to fever of unknown origin in children. J Microbiol, Immunol Infect 2017; 50 (6): 893–8.
6. Wright W, Mackwiak D. Fever of unknown origin. In: Bennet J, Dolin R, Blaser M (Ed.) Mandell, Douglas and Bennetʹs Principles and practice of infection diseases. 8th Ed., 2015; 721–31e1.
7. Mick N. Pediatric Fever. In: Marx J, Hotberger R, Walls R (Ed.). Rosenʹs Emergency Medicine. 8th Ed. 2014; 2096–105.e2.
8. Wong R, Dor M, McQuilkin P. Fever in pediatric patient. Emerg Med Clin N Am 2013; 31: 1073–96.
9. Chusid M. Fever of unknown origin. Pediatr Clin N Am 2017; 64: 205–30.
10. Gould J. Fever in the Infant and Toddler. Updated: Sep 12, 2017. https://emedicine.medscape.com/article/1834870-overview
11. Fever in under 5s: assesment and initiall management. Clinical guideline NICE. Published: 22 May 2013 Last updated: August 2017.
12. Делягин В.М. Педиатр около лихорадящего ребенка. РМЖ. 2007; 15 (21): 1570–7. / Delyagin V.M. Pediatr okolo lihoradyashchego rebenka. RMZh. 2007; 15 (21): 1570–7. [in Russian]
13. Mazer-Amirshahi M, Mattew D. Drug therapy for the pediatric patients. In: Wals R, Hockberger R, Gaushe-Hill M (Ed.). Rosenʹs Emergency medicine: concepts and clinical practice. 9th Ed. 2018; 2218–23.e2.
14. Fever in Infants and Children. Last updated April 1, 2014. https://familydoctor.org/condition/fever-in-infants-and-children/
15. Баранов А.А., Багненко С.Ф., Намазова-Баранова Л.С. и др. Федеральные клинические рекомендации по оказанию скорой неотложной помощи при острой лихорадке у детей. М., 2015. / Baranov A.A., Bagnenko S.F., Namazova-Baranova L.S. i dr. Federal'nye klinicheskie rekomendacii po okazaniyu skoroj neotlozhnoj pomoshchi pri ostroj lihoradke u detej. M., 2015. [in Russian]
16. Зайченко А.В., Мищенко О.Я. Использование ибупрофена и парацетамола в педиатрии: фармакоэкономический анализ. Новости в медицине и фармации. 2016; 4 (567): 8–11. / Zajchenko A.V., Mishchenko O.Ya. Ispol'zovanie ibuprofena i paracetamola v pediatrii: farmakoekonomicheskij analiz. Novosti v medicine i farmacii. 2016; 4 (567): 8–11. [in Russian]
17. Farrel S. Acetaminophen Toxicity Updated: Jan 22, 2018. https://emedicine.medscape.com/article/820200-overview
18. Alhelail M, Hoppe J, Rhyee S, Heard K. Clinical course of repeated supratherapeutic ingestion of acetaminophen. Clin Toxicol (Phila) 2011; 49 (2):108–12.
19. Litovitz T, Klein-Schwartz W, Rodgers G et al. Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2001; 20 (5): 391–452.
20. Hodgman M, Garrard A. A review of acetaminophen poisoning. Crit Care Clin 2012; 28 (4): 499–516.
21. Masarwa R, Levine H, Gorelik E, Reif Sh et al. Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. Am J Epidemiol 2018. DOI: 10.1093/aje/kwy086
22. Eneli I, Sadri K, Camargo C, Barr R. Acetaminophen and the risk of asthma: the epidemiologic and pathophysiologic evidence. Chest 2005; 127 (2): 604–12.
23. Allmers H. Frequent acetaminophen use and allergic diseases: is the association clear? J Allergy Clin Immunol 2005; 116 (4): 859–62.
24. Shaheen S, Newson R, Sherriff A et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002; 57 (11): 958–63.
25. Shaheen S, Newson R, Henderson A et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 2005; 35 (1): 18–25.
26. Lesko S, Louik C, Vezina R, Mitchell A. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
27. Cabalerro N, Welch K, Carpenter P, Mehrota S et al. Association between chronic acetaminophen exposure and allergic rhinitis in a rat model. Allergy Rhinol (Providence) 2015; 6 (3): e162–e167.
28. Amberbir A, Medhin G, Hanlon Ch et al. Frequent Use of Paracetamol and Risk of Allergic Disease Among Women in an Ethiopian Population. Plos One 2011; 6 (7): e22551.
29. Weatheral M, Joannides S, Braithwaite J, Beasley R et al. The association between paracetamol use and asthma: causation ore coincendence? Clin Exp Allergy 2015; 45 (1): 109–13.
30. Pereira G, Dagostini J, Pizzol Tda S. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. J Pediatr (Rio J) 2012; 88 (4): 289–96.
31. Wong T, Stang A, Ganshorn H et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Datebase Syst Rev 2013; 10: CD 009572. DOI: 10.1002/14651858.cd009572.pub.2
32. Yue Zh, Jiang P, Sun H, Wa J. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
33. Баранов А.А., Таточенко В.К., Бакрадзе М.Д. Лихорадящий ребенок. Протоколы диагностики и лечения (сер.: Клинические рекомендации для педиатров). 3-е изд., испр. и доп. М., 2017. / Baranov A.A., Tatochenko V.K., Bakradze M.D. Lihoradyashchij rebenok. Protokoly diagnostiki i lecheniya (ser.: Klinicheskie rekomendacii dlya pediatrov). 3-e izd., ispr. i dop. M., 2017. [in Russian]
34. Игнатов Ю.Д., Кукес В.Г., Мазуров В.И. Клиническая фармакология нестероидных противовоспалительных средств. М.: ГЭОТАР-Медиа, 2010. / Ignatov Yu.D., Kukes V.G., Mazurov V.I. Klinicheskaya farmakologiya nesteroidnyh protivovospalitel'nyh sredstv. M.: GEOTAR-Media, 2010. [in Russian]
35. Юлиш Е.И., Талалаенко А. Лихорадка у детей: тактика педиатра. Childʹs Health. 2014; 1 (52): 88–94. / Yulish E.I., Talalaenko A. Lihoradka u detej: taktika pediatra. Childʹs Health. 2014; 1 (52): 88–94. [in Russian]
36. Делягин В.М. Лихорадка. Многообразие причин и сложность решения. Педиатрия (Прил. к журн. Consilium Medicum). 2011; 4: 49–52. / Delyagin V.M. Lihoradka. Mnogoobrazie prichin i slozhnost' resheniya. Pediatrics (Suppl. Consilium Medicum). 2011; 4: 49–52. [in Russian]
37. Wahba H. The antipyretic effect of ibuprofen and acetominofen in children. Pharmacotherapy 2004; 24 (2): 280–4.
38. Kelley M, Walson Ph, Edge J et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clin Pharmacol Ther 1992; 52 (2): 181–9.
39. Chiappini E, Principi N, Longhi R et al. Management of fever in children: summary of the Italian Pediatric Society guidelines. Clin Ther 2009; 31 (8): 1826–43.
40. Kannabar D. A clinical and safety review of paracetamol and ibuprofen in children. Inflammopharmacol 2017; 25 (1): 1–9.
2. Roth A, Baselle G. Fever. In: Kellerman R, Bape E (Ed.). Connʹs Current Therapy. Saunders, 2018; p. 12–4.
3. Delyagin V.M. Patogenez lihoradki i patogeneticheski obosnovannyj vybor antipireticheskih sredstv. Vrach. 2016; 12: 67–71. [in Russian]
4. Volpi-Abadie J, Kaye A-M, Kaye AD. Serotonin Syndrome Ochsner J 2013; 13 (4): 533–40.
5. Chien Ya, Huang F, Huang Ch, Chen Po-Yen. Clinical approach to fever of unknown origin in children. J Microbiol, Immunol Infect 2017; 50 (6): 893–8.
6. Wright W, Mackwiak D. Fever of unknown origin. In: Bennet J, Dolin R, Blaser M (Ed.) Mandell, Douglas and Bennetʹs Principles and practice of infection diseases. 8th Ed., 2015; 721–31e1.
7. Mick N. Pediatric Fever. In: Marx J, Hotberger R, Walls R (Ed.). Rosenʹs Emergency Medicine. 8th Ed. 2014; 2096–105.e2.
8. Wong R, Dor M, McQuilkin P. Fever in pediatric patient. Emerg Med Clin N Am 2013; 31: 1073–96.
9. Chusid M. Fever of unknown origin. Pediatr Clin N Am 2017; 64: 205–30.
10. Gould J. Fever in the Infant and Toddler. Updated: Sep 12, 2017. https://emedicine.medscape.com/article/1834870-overview
11. Fever in under 5s: assesment and initiall management. Clinical guideline NICE. Published: 22 May 2013 Last updated: August 2017.
12. Delyagin V.M. Pediatr okolo lihoradyashchego rebenka. RMZh. 2007; 15 (21): 1570–7. [in Russian]
13. Mazer-Amirshahi M, Mattew D. Drug therapy for the pediatric patients. In: Wals R, Hockberger R, Gaushe-Hill M (Ed.). Rosenʹs Emergency medicine: concepts and clinical practice. 9th Ed. 2018; 2218–23.e2.
14. Fever in Infants and Children. Last updated April 1, 2014. https://familydoctor.org/condition/fever-in-infants-and-children/
15. Baranov A.A., Bagnenko S.F., Namazova-Baranova L.S. i dr. Federal'nye klinicheskie rekomendacii po okazaniyu skoroj neotlozhnoj pomoshchi pri ostroj lihoradke u detej. M., 2015. [in Russian]
16. Zajchenko A.V., Mishchenko O.Ya. Ispol'zovanie ibuprofena i paracetamola v pediatrii: farmakoekonomicheskij analiz. Novosti v medicine i farmacii. 2016; 4 (567): 8–11. [in Russian]
17. Farrel S. Acetaminophen Toxicity Updated: Jan 22, 2018. https://emedicine.medscape.com/article/820200-overview
18. Alhelail M, Hoppe J, Rhyee S, Heard K. Clinical course of repeated supratherapeutic ingestion of acetaminophen. Clin Toxicol (Phila) 2011; 49 (2):108–12.
19. Litovitz T, Klein-Schwartz W, Rodgers G et al. Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2001; 20 (5): 391–452.
20. Hodgman M, Garrard A. A review of acetaminophen poisoning. Crit Care Clin 2012; 28 (4): 499–516.
21. Masarwa R, Levine H, Gorelik E, Reif Sh et al. Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. Am J Epidemiol 2018. DOI: 10.1093/aje/kwy086
22. Eneli I, Sadri K, Camargo C, Barr R. Acetaminophen and the risk of asthma: the epidemiologic and pathophysiologic evidence. Chest 2005; 127 (2): 604–12.
23. Allmers H. Frequent acetaminophen use and allergic diseases: is the association clear? J Allergy Clin Immunol 2005; 116 (4): 859–62.
24. Shaheen S, Newson R, Sherriff A et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002; 57 (11): 958–63.
25. Shaheen S, Newson R, Henderson A et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 2005; 35 (1): 18–25.
26. Lesko S, Louik C, Vezina R, Mitchell A. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
27. Cabalerro N, Welch K, Carpenter P, Mehrota S et al. Association between chronic acetaminophen exposure and allergic rhinitis in a rat model. Allergy Rhinol (Providence) 2015; 6 (3): e162–e167.
28. Amberbir A, Medhin G, Hanlon Ch et al. Frequent Use of Paracetamol and Risk of Allergic Disease Among Women in an Ethiopian Population. Plos One 2011; 6 (7): e22551.
29. Weatheral M, Joannides S, Braithwaite J, Beasley R et al. The association between paracetamol use and asthma: causation ore coincendence? Clin Exp Allergy 2015; 45 (1): 109–13.
30. Pereira G, Dagostini J, Pizzol Tda S. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. J Pediatr (Rio J) 2012; 88 (4): 289–96.
31. Wong T, Stang A, Ganshorn H et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Datebase Syst Rev 2013; 10: CD 009572. DOI: 10.1002/14651858.cd009572.pub.2
32. Yue Zh, Jiang P, Sun H, Wa J. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
33. Baranov A.A., Tatochenko V.K., Bakradze M.D. Lihoradyashchij rebenok. Protokoly diagnostiki i lecheniya (ser.: Klinicheskie rekomendacii dlya pediatrov). 3-e izd., ispr. i dop. M., 2017. [in Russian]
34. Ignatov Yu.D., Kukes V.G., Mazurov V.I. Klinicheskaya farmakologiya nesteroidnyh protivovospalitel'nyh sredstv. M.: GEOTAR-Media, 2010. [in Russian]
35. Yulish E.I., Talalaenko A. Lihoradka u detej: taktika pediatra. Childʹs Health. 2014; 1 (52): 88–94. [in Russian]
36. Delyagin V.M. Lihoradka. Mnogoobrazie prichin i slozhnost' resheniya. Pediatrics (Suppl. Consilium Medicum). 2011; 4: 49–52. [in Russian]
37. Wahba H. The antipyretic effect of ibuprofen and acetominofen in children. Pharmacotherapy 2004; 24 (2): 280–4.
38. Kelley M, Walson Ph, Edge J et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clin Pharmacol Ther 1992; 52 (2): 181–9.
39. Chiappini E, Principi N, Longhi R et al. Management of fever in children: summary of the Italian Pediatric Society guidelines. Clin Ther 2009; 31 (8): 1826–43.
40. Kannabar D. A clinical and safety review of paracetamol and ibuprofen in children. Inflammopharmacol 2017; 25 (1): 1–9.
2. Roth A, Baselle G. Fever. In: Kellerman R, Bape E (Ed.). Connʹs Current Therapy. Saunders, 2018; p. 12–4.
3. Делягин В.М. Патогенез лихорадки и патогенетически обоснованный выбор антипиретических средств. Врач. 2016; 12: 67–71. / Delyagin V.M. Patogenez lihoradki i patogeneticheski obosnovannyj vybor antipireticheskih sredstv. Vrach. 2016; 12: 67–71. [in Russian]
4. Volpi-Abadie J, Kaye A-M, Kaye AD. Serotonin Syndrome Ochsner J 2013; 13 (4): 533–40.
5. Chien Ya, Huang F, Huang Ch, Chen Po-Yen. Clinical approach to fever of unknown origin in children. J Microbiol, Immunol Infect 2017; 50 (6): 893–8.
6. Wright W, Mackwiak D. Fever of unknown origin. In: Bennet J, Dolin R, Blaser M (Ed.) Mandell, Douglas and Bennetʹs Principles and practice of infection diseases. 8th Ed., 2015; 721–31e1.
7. Mick N. Pediatric Fever. In: Marx J, Hotberger R, Walls R (Ed.). Rosenʹs Emergency Medicine. 8th Ed. 2014; 2096–105.e2.
8. Wong R, Dor M, McQuilkin P. Fever in pediatric patient. Emerg Med Clin N Am 2013; 31: 1073–96.
9. Chusid M. Fever of unknown origin. Pediatr Clin N Am 2017; 64: 205–30.
10. Gould J. Fever in the Infant and Toddler. Updated: Sep 12, 2017. https://emedicine.medscape.com/article/1834870-overview
11. Fever in under 5s: assesment and initiall management. Clinical guideline NICE. Published: 22 May 2013 Last updated: August 2017.
12. Делягин В.М. Педиатр около лихорадящего ребенка. РМЖ. 2007; 15 (21): 1570–7. / Delyagin V.M. Pediatr okolo lihoradyashchego rebenka. RMZh. 2007; 15 (21): 1570–7. [in Russian]
13. Mazer-Amirshahi M, Mattew D. Drug therapy for the pediatric patients. In: Wals R, Hockberger R, Gaushe-Hill M (Ed.). Rosenʹs Emergency medicine: concepts and clinical practice. 9th Ed. 2018; 2218–23.e2.
14. Fever in Infants and Children. Last updated April 1, 2014. https://familydoctor.org/condition/fever-in-infants-and-children/
15. Баранов А.А., Багненко С.Ф., Намазова-Баранова Л.С. и др. Федеральные клинические рекомендации по оказанию скорой неотложной помощи при острой лихорадке у детей. М., 2015. / Baranov A.A., Bagnenko S.F., Namazova-Baranova L.S. i dr. Federal'nye klinicheskie rekomendacii po okazaniyu skoroj neotlozhnoj pomoshchi pri ostroj lihoradke u detej. M., 2015. [in Russian]
16. Зайченко А.В., Мищенко О.Я. Использование ибупрофена и парацетамола в педиатрии: фармакоэкономический анализ. Новости в медицине и фармации. 2016; 4 (567): 8–11. / Zajchenko A.V., Mishchenko O.Ya. Ispol'zovanie ibuprofena i paracetamola v pediatrii: farmakoekonomicheskij analiz. Novosti v medicine i farmacii. 2016; 4 (567): 8–11. [in Russian]
17. Farrel S. Acetaminophen Toxicity Updated: Jan 22, 2018. https://emedicine.medscape.com/article/820200-overview
18. Alhelail M, Hoppe J, Rhyee S, Heard K. Clinical course of repeated supratherapeutic ingestion of acetaminophen. Clin Toxicol (Phila) 2011; 49 (2):108–12.
19. Litovitz T, Klein-Schwartz W, Rodgers G et al. Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2001; 20 (5): 391–452.
20. Hodgman M, Garrard A. A review of acetaminophen poisoning. Crit Care Clin 2012; 28 (4): 499–516.
21. Masarwa R, Levine H, Gorelik E, Reif Sh et al. Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. Am J Epidemiol 2018. DOI: 10.1093/aje/kwy086
22. Eneli I, Sadri K, Camargo C, Barr R. Acetaminophen and the risk of asthma: the epidemiologic and pathophysiologic evidence. Chest 2005; 127 (2): 604–12.
23. Allmers H. Frequent acetaminophen use and allergic diseases: is the association clear? J Allergy Clin Immunol 2005; 116 (4): 859–62.
24. Shaheen S, Newson R, Sherriff A et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002; 57 (11): 958–63.
25. Shaheen S, Newson R, Henderson A et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 2005; 35 (1): 18–25.
26. Lesko S, Louik C, Vezina R, Mitchell A. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
27. Cabalerro N, Welch K, Carpenter P, Mehrota S et al. Association between chronic acetaminophen exposure and allergic rhinitis in a rat model. Allergy Rhinol (Providence) 2015; 6 (3): e162–e167.
28. Amberbir A, Medhin G, Hanlon Ch et al. Frequent Use of Paracetamol and Risk of Allergic Disease Among Women in an Ethiopian Population. Plos One 2011; 6 (7): e22551.
29. Weatheral M, Joannides S, Braithwaite J, Beasley R et al. The association between paracetamol use and asthma: causation ore coincendence? Clin Exp Allergy 2015; 45 (1): 109–13.
30. Pereira G, Dagostini J, Pizzol Tda S. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. J Pediatr (Rio J) 2012; 88 (4): 289–96.
31. Wong T, Stang A, Ganshorn H et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Datebase Syst Rev 2013; 10: CD 009572. DOI: 10.1002/14651858.cd009572.pub.2
32. Yue Zh, Jiang P, Sun H, Wa J. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
33. Баранов А.А., Таточенко В.К., Бакрадзе М.Д. Лихорадящий ребенок. Протоколы диагностики и лечения (сер.: Клинические рекомендации для педиатров). 3-е изд., испр. и доп. М., 2017. / Baranov A.A., Tatochenko V.K., Bakradze M.D. Lihoradyashchij rebenok. Protokoly diagnostiki i lecheniya (ser.: Klinicheskie rekomendacii dlya pediatrov). 3-e izd., ispr. i dop. M., 2017. [in Russian]
34. Игнатов Ю.Д., Кукес В.Г., Мазуров В.И. Клиническая фармакология нестероидных противовоспалительных средств. М.: ГЭОТАР-Медиа, 2010. / Ignatov Yu.D., Kukes V.G., Mazurov V.I. Klinicheskaya farmakologiya nesteroidnyh protivovospalitel'nyh sredstv. M.: GEOTAR-Media, 2010. [in Russian]
35. Юлиш Е.И., Талалаенко А. Лихорадка у детей: тактика педиатра. Childʹs Health. 2014; 1 (52): 88–94. / Yulish E.I., Talalaenko A. Lihoradka u detej: taktika pediatra. Childʹs Health. 2014; 1 (52): 88–94. [in Russian]
36. Делягин В.М. Лихорадка. Многообразие причин и сложность решения. Педиатрия (Прил. к журн. Consilium Medicum). 2011; 4: 49–52. / Delyagin V.M. Lihoradka. Mnogoobrazie prichin i slozhnost' resheniya. Pediatrics (Suppl. Consilium Medicum). 2011; 4: 49–52. [in Russian]
37. Wahba H. The antipyretic effect of ibuprofen and acetominofen in children. Pharmacotherapy 2004; 24 (2): 280–4.
38. Kelley M, Walson Ph, Edge J et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clin Pharmacol Ther 1992; 52 (2): 181–9.
39. Chiappini E, Principi N, Longhi R et al. Management of fever in children: summary of the Italian Pediatric Society guidelines. Clin Ther 2009; 31 (8): 1826–43.
40. Kannabar D. A clinical and safety review of paracetamol and ibuprofen in children. Inflammopharmacol 2017; 25 (1): 1–9.
________________________________________________
2. Roth A, Baselle G. Fever. In: Kellerman R, Bape E (Ed.). Connʹs Current Therapy. Saunders, 2018; p. 12–4.
3. Delyagin V.M. Patogenez lihoradki i patogeneticheski obosnovannyj vybor antipireticheskih sredstv. Vrach. 2016; 12: 67–71. [in Russian]
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Авторы
В.М.Делягин*
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России. 117997, Россия, Москва, ул. Саморы Машела, д. 1
*delyagin-doktor@yandex.ru
Dmitry Rogachev National Research Center Hematology, Oncology and Immunology. 117997, Russian Federation, Moscow, ul. Samory Mashela, d. 1
*delyagin-doktor@yandex.ru
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России. 117997, Россия, Москва, ул. Саморы Машела, д. 1
*delyagin-doktor@yandex.ru
________________________________________________
Dmitry Rogachev National Research Center Hematology, Oncology and Immunology. 117997, Russian Federation, Moscow, ul. Samory Mashela, d. 1
*delyagin-doktor@yandex.ru
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