Гастроэзофагеальный рефлюкс у детей: терапевтическая тактика
Гастроэзофагеальный рефлюкс у детей: терапевтическая тактика
Espinheira M., Dias J. Гастроэзофагеальный рефлюкс у детей: терапевтическая тактика. Педиатрия (Прил. к журн. Consilium Medicum). 2018; 3: 16–23.
DOI: 10.26442/2413-8460_2018.3.16-23
DOI: 10.26442/2413-8460_2018.3.16-23
DOI: 10.26442/2413-8460_2018.3.16-23
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DOI: 10.26442/2413-8460_2018.3.16-23
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Аннотация
Гастроэзофагеальный рефлюкс (ГЭР) возникает более чем у 2/3 здоровых младенцев. Регургитация отмечается как минимум один раз в день у 1/2 детей в первые 3 мес жизни. Большинство эпизодов рефлюкса являются асимптоматическими. При возникновении симптомов ГЭР, нарушающих самочувствие ребенка, можно говорить о гастроэзофагеальной рефлюксной болезни. Настоящий обзор сконцентрирован на лечении ГЭР.
Ключевые слова: гастроэзофагеальный рефлюкс, регургитация, гастроэзофагеальная рефлюксная болезнь, терапевтические возможности, дети.
Key words: gastroesophageal reflux, regurgitation, gastro-esophageal reflux disease, therapeutic options, children.
Ключевые слова: гастроэзофагеальный рефлюкс, регургитация, гастроэзофагеальная рефлюксная болезнь, терапевтические возможности, дети.
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Key words: gastroesophageal reflux, regurgitation, gastro-esophageal reflux disease, therapeutic options, children.
Список литературы
1. Vandenplas Y et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2009; 49 (4): 498–547.
2. Van Wijk MP et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr 2007; 151 (6): 585–90: 590.e1-2.
3. Vandenplas Y et al. A preliminary report on the efficacy of the Multicare AR-Bed in 3-week-3-month-old infants on regurgitation, associated symptoms and acid reflux. Arch Dis Child 2010; 95 (1): 26–30.
4. Moon RY. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics 2011; 128 (5): e1341–67.
5. Orenstein SR, Whitington PF, Orenstein DM. The infant seat as treatment for gastroesophageal reflux. N Engl J Med 1983; 309 (13): 760–3.
6. Khoshoo V et al. Smaller volume, thickened formulas in the management of gastroesophageal reflux in thriving infants. J Pediatr Gastroenterol Nutr 2000; 31 (5): 554–6.
7. Orenstein SR, Magill HL, Brooks P. Thickening of infant feedings for therapy of gastroesophageal reflux. J Pediatr 1987; 110 (2): 181–6.
8. Bosscher D et al. Thickening infant formula with digestible and indigestible carbohydrate: availability of calcium, iron, and zinc in vitro. J Pediatr Gastroenterol Nutr 2000; 30 (4): 373–8.
9. Dupont C, Vandenplas Y. Efficacy and Tolerance of a New Anti-Regurgitation Formula. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (2): 104–9.
10. Vandenplas Y. Management of paediatric GERD. Nat Rev Gastroenterol Hepatol 2014; 11 (3): 147–57.
11. D'Agostino JA et al. Use of Gastroesophageal Reflux Medications in Premature Infants After NICU Discharge. Pediatrics 2016; 138 (6). PII: e20161977.
12. Mattos AZ et al. Antisecretory treatment for pediatric gastroesophageal reflux disease. A systematic review. Arq Gastroenterol 2017; 54 (4): 271–80.
13. Williams RM et al. Multicenter trial of sucralfate suspension for the treatment of reflux esophagitis. Am J Med 1987; 83 (3b): 61–6.
14. Herrera JL et al. Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. Am J Gastroenterol 1990; 85 (10): 1335–8.
15. Simon B, Ravelli GP, Goffin H. Sucralfate gel versus placebo in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1996; 10 (3): 441–6.
2. Van Wijk MP et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr 2007; 151 (6): 585–90: 590.e1-2.
3. Vandenplas Y et al. A preliminary report on the efficacy of the Multicare AR-Bed in 3-week-3-month-old infants on regurgitation, associated symptoms and acid reflux. Arch Dis Child 2010; 95 (1): 26–30.
4. Moon RY. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics 2011; 128 (5): e1341–67.
5. Orenstein SR, Whitington PF, Orenstein DM. The infant seat as treatment for gastroesophageal reflux. N Engl J Med 1983; 309 (13): 760–3.
6. Khoshoo V et al. Smaller volume, thickened formulas in the management of gastroesophageal reflux in thriving infants. J Pediatr Gastroenterol Nutr 2000; 31 (5): 554–6.
7. Orenstein SR, Magill HL, Brooks P. Thickening of infant feedings for therapy of gastroesophageal reflux. J Pediatr 1987; 110 (2): 181–6.
8. Bosscher D et al. Thickening infant formula with digestible and indigestible carbohydrate: availability of calcium, iron, and zinc in vitro. J Pediatr Gastroenterol Nutr 2000; 30 (4): 373–8.
9. Dupont C, Vandenplas Y. Efficacy and Tolerance of a New Anti-Regurgitation Formula. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (2): 104–9.
10. Vandenplas Y. Management of paediatric GERD. Nat Rev Gastroenterol Hepatol 2014; 11 (3): 147–57.
11. D'Agostino JA et al. Use of Gastroesophageal Reflux Medications in Premature Infants After NICU Discharge. Pediatrics 2016; 138 (6). PII: e20161977.
12. Mattos AZ et al. Antisecretory treatment for pediatric gastroesophageal reflux disease. A systematic review. Arq Gastroenterol 2017; 54 (4): 271–80.
13. Williams RM et al. Multicenter trial of sucralfate suspension for the treatment of reflux esophagitis. Am J Med 1987; 83 (3b): 61–6.
14. Herrera JL et al. Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. Am J Gastroenterol 1990; 85 (10): 1335–8.
15. Simon B, Ravelli GP, Goffin H. Sucralfate gel versus placebo in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1996; 10 (3): 441–6.
2. Van Wijk MP et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr 2007; 151 (6): 585–90: 590.e1-2.
3. Vandenplas Y et al. A preliminary report on the efficacy of the Multicare AR-Bed in 3-week-3-month-old infants on regurgitation, associated symptoms and acid reflux. Arch Dis Child 2010; 95 (1): 26–30.
4. Moon RY. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics 2011; 128 (5): e1341–67.
5. Orenstein SR, Whitington PF, Orenstein DM. The infant seat as treatment for gastroesophageal reflux. N Engl J Med 1983; 309 (13): 760–3.
6. Khoshoo V et al. Smaller volume, thickened formulas in the management of gastroesophageal reflux in thriving infants. J Pediatr Gastroenterol Nutr 2000; 31 (5): 554–6.
7. Orenstein SR, Magill HL, Brooks P. Thickening of infant feedings for therapy of gastroesophageal reflux. J Pediatr 1987; 110 (2): 181–6.
8. Bosscher D et al. Thickening infant formula with digestible and indigestible carbohydrate: availability of calcium, iron, and zinc in vitro. J Pediatr Gastroenterol Nutr 2000; 30 (4): 373–8.
9. Dupont C, Vandenplas Y. Efficacy and Tolerance of a New Anti-Regurgitation Formula. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (2): 104–9.
10. Vandenplas Y. Management of paediatric GERD. Nat Rev Gastroenterol Hepatol 2014; 11 (3): 147–57.
11. D'Agostino JA et al. Use of Gastroesophageal Reflux Medications in Premature Infants After NICU Discharge. Pediatrics 2016; 138 (6). PII: e20161977.
12. Mattos AZ et al. Antisecretory treatment for pediatric gastroesophageal reflux disease. A systematic review. Arq Gastroenterol 2017; 54 (4): 271–80.
13. Williams RM et al. Multicenter trial of sucralfate suspension for the treatment of reflux esophagitis. Am J Med 1987; 83 (3b): 61–6.
14. Herrera JL et al. Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. Am J Gastroenterol 1990; 85 (10): 1335–8.
15. Simon B, Ravelli GP, Goffin H. Sucralfate gel versus placebo in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1996; 10 (3): 441–6.
________________________________________________
2. Van Wijk MP et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate. J Pediatr 2007; 151 (6): 585–90: 590.e1-2.
3. Vandenplas Y et al. A preliminary report on the efficacy of the Multicare AR-Bed in 3-week-3-month-old infants on regurgitation, associated symptoms and acid reflux. Arch Dis Child 2010; 95 (1): 26–30.
4. Moon RY. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics 2011; 128 (5): e1341–67.
5. Orenstein SR, Whitington PF, Orenstein DM. The infant seat as treatment for gastroesophageal reflux. N Engl J Med 1983; 309 (13): 760–3.
6. Khoshoo V et al. Smaller volume, thickened formulas in the management of gastroesophageal reflux in thriving infants. J Pediatr Gastroenterol Nutr 2000; 31 (5): 554–6.
7. Orenstein SR, Magill HL, Brooks P. Thickening of infant feedings for therapy of gastroesophageal reflux. J Pediatr 1987; 110 (2): 181–6.
8. Bosscher D et al. Thickening infant formula with digestible and indigestible carbohydrate: availability of calcium, iron, and zinc in vitro. J Pediatr Gastroenterol Nutr 2000; 30 (4): 373–8.
9. Dupont C, Vandenplas Y. Efficacy and Tolerance of a New Anti-Regurgitation Formula. Pediatr Gastroenterol Hepatol Nutr 2016; 19 (2): 104–9.
10. Vandenplas Y. Management of paediatric GERD. Nat Rev Gastroenterol Hepatol 2014; 11 (3): 147–57.
11. D'Agostino JA et al. Use of Gastroesophageal Reflux Medications in Premature Infants After NICU Discharge. Pediatrics 2016; 138 (6). PII: e20161977.
12. Mattos AZ et al. Antisecretory treatment for pediatric gastroesophageal reflux disease. A systematic review. Arq Gastroenterol 2017; 54 (4): 271–80.
13. Williams RM et al. Multicenter trial of sucralfate suspension for the treatment of reflux esophagitis. Am J Med 1987; 83 (3b): 61–6.
14. Herrera JL et al. Sucralfate used as adjunctive therapy in patients with severe erosive peptic esophagitis resulting from gastroesophageal reflux. Am J Gastroenterol 1990; 85 (10): 1335–8.
15. Simon B, Ravelli GP, Goffin H. Sucralfate gel versus placebo in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1996; 10 (3): 441–6.
Авторы
Maria do Céu Espinheira, Jorge Amil Dias*
Universidade do Porto. Portugal, Porto, 4099-002;Centro Hospitalar de São João, Serviço de Pediatria, Unidade de Gastroenterologia Pediátrica. Portugal, Porto, 4202-451
*Jorge.amil@outkook.pt
Universidade do Porto. Portugal, Porto, 4099-002;
Centro Hospitalar de São João, Serviço de Pediatria, Unidade de Gastroenterologia Pediátrica. Portugal, Porto, 4202-451
*Jorge.amil@outkook.pt
Universidade do Porto. Portugal, Porto, 4099-002;Centro Hospitalar de São João, Serviço de Pediatria, Unidade de Gastroenterologia Pediátrica. Portugal, Porto, 4202-451
*Jorge.amil@outkook.pt
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Universidade do Porto. Portugal, Porto, 4099-002;
Centro Hospitalar de São João, Serviço de Pediatria, Unidade de Gastroenterologia Pediátrica. Portugal, Porto, 4202-451
*Jorge.amil@outkook.pt
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