В обзоре представлены данные, касающиеся связи ожирения и расстройств сна в детском возрасте. Рассматриваются вопросы, связанные с механизмами влияния ожирения на риск расстройств сна у детей. Обсуждается влияние различных вариантов расстройств сна на риск нарушения пищевого поведения и формирования ожирения у ребенка. Приводится обоснование высокой вероятности коморбидности ожирения и расстройств сна, реципрокной связи расстройств сна, нарушений пищевого поведения и формирования ожирения. Делается вывод о необходимости комплексного обследования детей с ожирением на предмет возможных расстройств сна и их коррекции. Нормализация массы тела рассматривается как составной компонент устранения расстройств сна у ребенка, а нарушения сна – как фактор риска отклонений пищевого поведения и формирования ожирения, что должно учитываться при разработке подходов к профилактике ожирения. Ключевые слова: ожирение, расстройства сна, нарушения пищевого поведения, дети.
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The review addresses the findings related to association between obesity and sleep disturbances in children. Mechanisms linking obesity and high risk of sleep disturbances in children are considered. The effects of several forms of sleep disturbances on the risk of abnormal feeding behavior and emergence of obesity are discussed. The arguments on high probability of co morbid co-existence of obesity and sleep disturbances, as well as on reciprocating relationships between sleep disturbances, abnormal feeding patterns and obesity are provided. The conclusion is drawn that children presenting with obesity should be thoroughly scrutinized for potential sleep disturbances that need to be treated. Body weight control is considered as a component of the treatment of sleep disturbances, and sleep disturbances are considered as risk factors of abnormal feeding behavior resulting in obesity, which should be taken into account in offering preventive measures against obesity. Key words: obesity, sleep disturbances, feeding behavior, children.
Список литературы
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38. Agras WS, Hammer LD, McNicholas F, Kraemer HC. Risk factors for childhood overweight: a prospective study from birth to 9.5 years. J Pediatr 2004; 145 (1): 20–5.
39. Reilly JJ, Armstrong J, Dorosty AR et al. Early life risk factors for obesity in childhood: cohort study. BMJ 2005; 330 (7504): 1357.
40. Gupta NK, Mueller WH, Chan W, Meininger JC. Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol (The Official Journal of the Human Biology Council) 2002; 14 (6): 762–8.
41. Cappuccio FP, Taggart FM, Kandala NB et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31 (5): 619–26.
42. Patel SR, Hu FB. Short sleep duration and weight gain: a systematic review. Obesity 2008; 16 (3): 643–53.
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59. Zhao I, Bogossian F, Turner C. Does maintaining or changing shift types affect BMI? A longitudinal study. J Occup Environ Med 2012; 54 (5): 525–31.
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1. Ogden CL, Carroll MD, Fakhouri TH et al. Prevalence of Obesity Among Youths by Household Income and Education Level of Head of Household – United States 2011–2014. MMWR Morbidity and mortality weekly report. 2018; 67 (6): 186–9.
2. Finkelstein EA, Khavjou OA, Thompson H et al. Obesity and severe obesity forecasts through 2030. Am J Prev Med 2012; 42 (6): 563–70.
3. Owens J. Classification and epidemiology of childhood sleep disorders. Prim Care 2008; 35 (3): 533–46.
4. Alonso-Alvarez ML, Cordero-Guevara JA, Teran-Santos J et al. Obstructive sleep apnea in obese community-dwelling children: the NANOS study. Sleep 2014; 37 (5): 943–9.
5. Redline S, Tishler PV, Schluchter M et al. Risk factors for sleep-disordered breathing in children: associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med 1999; 159 (5): 1527–32.
6. Gozal D, Kheirandish‐Gozal L. Childhood obesity and sleep: relatives, partners, or both? – a critical perspective on the evidence. An New York Acad Sci. 2012; 1264 (1): 135–41.
7. Arens R, Sin S, Nandalike K et al. Upper airway structure and body fat composition in obese children with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2011; 183 (6): 782–7.
8. Dayyat E, Kheirandish-Gozal L, Capdevila OS et al. Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy. Chest 2009; 136 (1): 137–44.
9. Bhattacharjee R, Kheirandish-Gozal L, Spruyt K et al. Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study. Am J Respir Crit Care Med 2010; 182 (5): 676–83.
10. Marcus CL, Moore RH, Rosen CL et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. New Eng J Med 2013; 368 (25): 2366–76.
11. Canapari CA, Hoppin AG, Kinane TB et al. Relationship between sleep apnea, fat distribution, and insulin resistance in obese children. J Clin Sleep Med 2011; 7 (3): 268–73.
12. Reid MB, Lannergren J, Westerblad H. Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments. Am
J Respir Crit Care Med 2002; 166 (4): 479–84.
13. Tsaoussoglou M, Bixler EO, Calhoun S et al. Sleep-disordered breathing in obese children is associated with prevalent excessive daytime sleepiness, inflammation, and metabolic abnormalities. J Clin Endocrinol Metab 2010; 95 (1): 143–50.
14. Vgontzas AN, Zoumakis E, Lin HM et al. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist. J Clin Endocrinol Metab 2004; 89 (9): 4409–13.
15. Kheirandish-Gozal L, Gileles-Hillel A, Alonso-Álvarez ML et al. Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: a community-based study. Int J Obesity 2015; 39 (7): 1094.
16. Bhattacharjee R, Kim J, Kheirandish‐Gozal L, Gozal D. Obesity and obstructive sleep apnea syndrome in children: a tale of inflammatory cascades. Pediatr Pulmonol 2011; 46 (4): 313–23.
17. Vgontzas AN, Papanicolaou DA, Bixler EO et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000; 85 (3): 1151–8.
18. Gozal D, Kheirandish-Gozal L. Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea. Pediatrics 2009; 123 (1): 13–8.
19. LaGrotte C, Fernandez-Mendoza J, Calhoun SL et al. The relative association of obstructive sleep apnea, obesity and excessive daytime sleepiness with incident depression: a longitudinal, population-based study. Int J Obes 2016; 40 (9): 1397–404.
20. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 2001; 24 (12): 726–31.
21. Pace-Schott EF, Hobson JA. The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 2002; 3 (8): 591.
22. Saper CB. Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms. Prog Brain Res 2006; 153: 243–52.
23. Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regul Pept 2008; 149 (1–3): 3–10.
24. Knutson KL, Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci 2008; 1129 (1): 287–304.
25. Schoeller D, Cella L, Sinha M, Caro J. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 1997; 100 (7): 1882–7.
26. Simon C, Gronfier C, Schlienger J, Brandenberger G. Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocrinol Metab 1998; 83 (6): 1893–9.
27. Mullington J, Chan J, Van Dongen H et al. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol 2003; 15 (9): 851–4.
28. Dzaja A, Dalal MA, Himmerich H et al. Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Am J Physiol Endocrinol Metabol 2004; 286 (6): E963–7.
29. Weikel JC, Wichniak A, Ising M et al. Ghrelin promotes slow-wave sleep in humans. Am J Physiol Endocrinol Metabol 2003; 284 (2): E407–E15.
30. Taheri S. The link between short sleep duration and obesity: we should recommend more sleep to prevent obesity. Arch Dis Child 2006; 91 (11): 881–4.
31. Taheri S, Lin L, Austin D et al. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 2004; 1 (3): e62.
32. Mullington JM, Chan JL, Van Dongen HP et al. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol 2003; 15 (9): 851–4.
33. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004; 141 (11): 846–50.
34. Nedeltcheva AV, Kilkus JM, Imperial J et al. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr 2009; 89 (1): 126–33.
35. Shechter A, O'Keeffe M, Roberts AL et al. Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance. Am J Phys Reg Integrative Comp Physiol 2012; 303 (9): R883–9.
36. Buxton OM, Cain SW, O'Connor SP et al. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 2012; 4 (129): 129ra43.
37. Taveras EM, Rifas-Shiman SL, Oken E et al. Short sleep duration in infancy and risk of childhood overweight. Arch Pediatr Adolesc Med 2008; 162 (4): 305–11.7. Taveras EM, Rifas-Shiman SL, Oken E et al. Short sleep duration in infancy and risk of childhood overweight. Arch Pediatr Adolesc Med 2008; 162 (4): 305–11.
38. Agras WS, Hammer LD, McNicholas F, Kraemer HC. Risk factors for childhood overweight: a prospective study from birth to 9.5 years. J Pediatr 2004; 145 (1): 20–5.
39. Reilly JJ, Armstrong J, Dorosty AR et al. Early life risk factors for obesity in childhood: cohort study. BMJ 2005; 330 (7504): 1357.
40. Gupta NK, Mueller WH, Chan W, Meininger JC. Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol (The Official Journal of the Human Biology Council) 2002; 14 (6): 762–8.
41. Cappuccio FP, Taggart FM, Kandala NB et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31 (5): 619–26.
42. Patel SR, Hu FB. Short sleep duration and weight gain: a systematic review. Obesity 2008; 16 (3): 643–53.
43. Bell JF, Zimmerman FJ. Shortened nighttime sleep duration in early life and subsequent childhood obesity. Arch Ped Adolesc Med 2010; 164 (9): 840–5.
44. Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 2010; 33 (2): 414–20.
45. Thivel D, Isacco L, Aucouturier J et al. Bedtime and sleep timing but not sleep duration are associated with eating habits in primary school children. J Dev Behav Pediatr 2015; 36 (3): 158–65.
46. Scharf RJ, DeBoer MD. Sleep timing and longitudinal weight gain in 4‐and 5‐year‐old children. Pediatr Obes 2015; 10 (2): 141–8.
47. Berentzen NE, Smit HA, Bekkers MB et al. Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study. J Sleep Res 2014; 23 (1): 3–12.
48. St-Onge MP, Roberts AL, Chen J et al. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr 2011; 94 (2): 410–6.
49. Beebe DW, Miller N, Kirk S et al. The association between obstructive sleep apnea and dietary choices among obese individuals during middle to late childhood. Sleep Med 2011; 12 (8): 797–9.
50. Buxton OM, Quintiliani LM, Yang MH et al. Association of sleep adequacy with more healthful food choices and positive workplace experiences among motor freight workers. Am J Public Health 2009; 99 (Suppl. 3): S636–3.
51. Benedict C, Brooks SJ, O'Daly OG et al. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab 2012; 97 (3): E443–7.
52. St-Onge MP, McReynolds A, Trivedi ZB et al. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr 2012; 95 (4): 818–24.
53. Barber L, Grawitch MJ, Munz DC. Are better sleepers more engaged workers? A self-regulatory approach to sleep hygiene and work engagement. Stress and Health: Journal of the International Society for the Investigation of Stress 2013; 29 (4): 307–16.
54. Huang W, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. J Clin Invest 2011; 121 (6): 2133–41.
55. Leproult R, Van Cauter E. Role of sleep and sleep loss in hormonal release and metabolism. Pediatric Neuroendocrinology. 17: Karger Publishers 2010; p. 11–21.
56. Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people. Occup Environ Med 2001; 58 (11): 747–52.
57. Morikawa Y, Nakagawa H, Miura K et al. Effect of shift work on body mass index and metabolic parameters. Scand J Work Environ Health 2007; 33 (1): 45–50.
58. Suwazono Y, Dochi M, Sakata K et al. A longitudinal study on the effect of shift work on weight gain in male Japanese workers. Obesity 2008; 16 (8): 1887–93.
59. Zhao I, Bogossian F, Turner C. Does maintaining or changing shift types affect BMI? A longitudinal study. J Occup Environ Med 2012; 54 (5): 525–31.
60. Kalsbeek A, Fliers E, Romijn J et al. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 2001; 142 (6): 2677–85.
61. Muccioli G, Tschöp M, Papotti M et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 2002; 440 (2–3): 235–54.
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Авторы
И.А. Кельмансон*
ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, Санкт-Петербург, Россия; СПб ГАОУ ВО «Санкт-Петербургский государственный институт психологии и социальной работы», Санкт-Петербург, Россия
*iakelmanson@hotmail.com
________________________________________________
Igor A. Kelmanson*
Almazov National Medical Research Centre, Saint Petersburg, Russia;
Saint Petersburg State Institute of Psychology and Social Work, Saint Petersburg, Russia
*iakelmanson@hotmail.com