Педиатрические вопросы о новой коронавирусной инфекции – есть ли на них сегодня ответы?
Педиатрические вопросы о новой коронавирусной инфекции – есть ли на них сегодня ответы?
Заплатников А.Л., Горев В.В., Дмитриев А.В. и др. Педиатрические вопросы о новой коронавирусной инфекции – есть ли на них сегодня ответы? Педиатрия. Consilium Medicum. 2020; 1: 16–19. DOI: 10.26442/26586630.2020.1.200122
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Аннотация
Представлен обзор литературы, посвященный основным особенностям новой коронавирусной инфекции у детей. Отмечено, что до настоящего времени нет убедительных данных в пользу вертикального инфицирования, в то время как показана возможность горизонтальной передачи инфекции от матери ее новорожденному ребенку. Приводятся основные положения согласованных рекомендаций международных и национальных профессиональных медицинских сообществ по тактике ведения новорожденных детей от матерей с COVID-19 (Coronavirus disease 2019). Показано, что в структуре пациентов с тяжелым течением COVID-19 на долю детей приходится не более 5%. Установлено, что у детей новая коронавирусная инфекция в подавляющем большинстве случаев протекает бессимптомно или в легкой форме. Представлены основные гипотезы более легкого течения COVID-19 у педиатрических пациентов. При этом особо подчеркивается, что дети с бессимптомным и легким течением заболевания составляют основной трансмиссивный потенциал для продолжения пандемии.
Ключевые слова: дети, новая коронавирусная инфекция, новорожденные дети, COVID-19.
Key words: children, new coronavirus infection, newborns, COVID-19.
Ключевые слова: дети, новая коронавирусная инфекция, новорожденные дети, COVID-19.
________________________________________________
Key words: children, new coronavirus infection, newborns, COVID-19.
Список литературы
1. World Health Organization (WHO) Coronavirus disease (COVID-19) pandemic. https://www.who.int/emergencies/diseases/novel-coronavirus-2019
2. Mascio D, Asma K, Saccone G. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1-19) during pregnancy:a systematic review and meta-analysis.
Am J Obstet Gynecol 2020. https://doi.org/10.1016/j.ajogmf.2020.100107
3. World Health Organization (WHO) Q&A on COVID-19, pregnancy, childbirth and breastfeeding. https://www.who.int/news-room/q-a-detail/q-a-on-covid-19-pregnancy-childbirth-and-breastfeeding
4. COVID-19 and Breastfeeding Position Paper. European Paediatric Association, the Union of National European Paediatric Societies and Associations (EPA/UNEPSA). https://r.epa-unepsa.eu/i/sSSE9qOATiQSgn-7s12OA1kqh62ccuew
5. Chen H, Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809–15.
6. Zeng L, Xia S, Yuan W et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics Published online March 26, 2020. DOI: 10.1001/jamapediatrics.2020.0878
7. Zhu H, Wang L, Fang C et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV. Transl Pediatr 2020; 9 (1): 51–60. http://dx.doi.org/10.21037/tp.2020.02.06
8. Wang L, Shi Y, Xiao T. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Ann Transl Med 2020; 8 (3): 47. http://dx.doi.org/10.21037/atm.2020.02.20
9. Li N, Han L, Peng M et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Med Rxiv 2020. https://doi.org/10.1101/2020.03.10.20033605(2020); https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1.full.pdf+html
10. Liu W, Wang Q, Zhang Q et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints 2020; 2020020373. https://www.preprints.org/manuscript/202002.0373/v1
11. Dashraath P, Jing LJW, Mei XL et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020 Mar 23. DOI: 10.1016/j.ajog.2020.03.021. https://www.ncbi.nlm.nih.gov/pubmed/32217113
12. Chen Y, Peng H, Wang L et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr 2020; 8: 104. DOI: 10.3389/fped.2020.00104
13. Wang J, Wang D, Chen GC et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate. Zhongguo Dang Dai Er Ke Za Zhi 2020; 22 (3): 211–4.
14. Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med 2020 Mar 17. DOI: 10.5858/arpa.2020-0901-SA. https://www.ncbi.nlm.nih.gov/pubmed/32180426
15. AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19. Alyson Sulaski Wyckoff, Associate Editor April 02, 2020. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220
16. Liu W, Zhang Q, Chen J et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020 Mar 12. DOI: 10.1056/NEJMc2003717. https://www.nejm.org/doi/10.1056/NEJMc2003717
17. Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514–23. https://www.scopus.com/record/display.uri?eid=2-s2.0-85078241697&origin=inward&txGid...
18. Zhang YP. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol 2020; 41: 145–51.
19. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (3): 670–3. DOI: 10.1016/j.jfma.2020.02.009. https://www.ncbi.nlm.nih.gov/pubmed/32139299
20. Lu X, Zhang L, Du H et al. SARS-CoV-2 infection in children. N Engl J Med 2020 Mar 18. https://doi.org/10.1056/NEJMc2005073
21. Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr 2020 Mar 23. DOI: 10.1111/apa.15270. https://www.ncbi.nlm.nih.gov/pubmed/32202343
22. Lee PI, Hu YL, Chen PY et al. Are children less susceptible to COVID-19? J Microbiol Immunol Infect 2020 Feb 25. DOI: 10.1016/j.jmii.2020.02.011. https://www.sciencedirect.com/science/journal/16841182
23. Gu H, Xie Z, Li T et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840.
24. Dong Y, Mo Х, Hu Y et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020 March. https://doi.org/10.1542/peds.2020-0702
25. Hagmann S. COVID-19 in children: More than meets the eye. Travel Med Infect Dis 2020 March 28. https://www.sciencedirect.com/science/article/pii/
S1477893920301174?via%3Dihub
2. Mascio D, Asma K, Saccone G. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1-19) during pregnancy:a systematic review and meta-analysis.
Am J Obstet Gynecol 2020. https://doi.org/10.1016/j.ajogmf.2020.100107
3. World Health Organization (WHO) Q&A on COVID-19, pregnancy, childbirth and breastfeeding. https://www.who.int/news-room/q-a-detail/q-a-on-covid-19-pregnancy-childbirth-and-breastfeeding
4. COVID-19 and Breastfeeding Position Paper. European Paediatric Association, the Union of National European Paediatric Societies and Associations (EPA/UNEPSA). https://r.epa-unepsa.eu/i/sSSE9qOATiQSgn-7s12OA1kqh62ccuew
5. Chen H, Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809–15.
6. Zeng L, Xia S, Yuan W et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics Published online March 26, 2020. DOI: 10.1001/jamapediatrics.2020.0878
7. Zhu H, Wang L, Fang C et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV. Transl Pediatr 2020; 9 (1): 51–60. http://dx.doi.org/10.21037/tp.2020.02.06
8. Wang L, Shi Y, Xiao T. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Ann Transl Med 2020; 8 (3): 47. http://dx.doi.org/10.21037/atm.2020.02.20
9. Li N, Han L, Peng M et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Med Rxiv 2020. https://doi.org/10.1101/2020.03.10.20033605(2020); https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1.full.pdf+html
10. Liu W, Wang Q, Zhang Q et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints 2020; 2020020373. https://www.preprints.org/manuscript/202002.0373/v1
11. Dashraath P, Jing LJW, Mei XL et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020 Mar 23. DOI: 10.1016/j.ajog.2020.03.021. https://www.ncbi.nlm.nih.gov/pubmed/32217113
12. Chen Y, Peng H, Wang L et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr 2020; 8: 104. DOI: 10.3389/fped.2020.00104
13. Wang J, Wang D, Chen GC et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate. Zhongguo Dang Dai Er Ke Za Zhi 2020; 22 (3): 211–4.
14. Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med 2020 Mar 17. DOI: 10.5858/arpa.2020-0901-SA. https://www.ncbi.nlm.nih.gov/pubmed/32180426
15. AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19. Alyson Sulaski Wyckoff, Associate Editor April 02, 2020. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220
16. Liu W, Zhang Q, Chen J et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020 Mar 12. DOI: 10.1056/NEJMc2003717. https://www.nejm.org/doi/10.1056/NEJMc2003717
17. Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514–23. https://www.scopus.com/record/display.uri?eid=2-s2.0-85078241697&origin=inward&txGid...
18. Zhang YP. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol 2020; 41: 145–51.
19. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (3): 670–3. DOI: 10.1016/j.jfma.2020.02.009. https://www.ncbi.nlm.nih.gov/pubmed/32139299
20. Lu X, Zhang L, Du H et al. SARS-CoV-2 infection in children. N Engl J Med 2020 Mar 18. https://doi.org/10.1056/NEJMc2005073
21. Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr 2020 Mar 23. DOI: 10.1111/apa.15270. https://www.ncbi.nlm.nih.gov/pubmed/32202343
22. Lee PI, Hu YL, Chen PY et al. Are children less susceptible to COVID-19? J Microbiol Immunol Infect 2020 Feb 25. DOI: 10.1016/j.jmii.2020.02.011. https://www.sciencedirect.com/science/journal/16841182
23. Gu H, Xie Z, Li T et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840.
24. Dong Y, Mo Х, Hu Y et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020 March. https://doi.org/10.1542/peds.2020-0702
25. Hagmann S. COVID-19 in children: More than meets the eye. Travel Med Infect Dis 2020 March 28. https://www.sciencedirect.com/science/article/pii/
S1477893920301174?via%3Dihub
2. Mascio D, Asma K, Saccone G. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1-19) during pregnancy:a systematic review and meta-analysis.
Am J Obstet Gynecol 2020. https://doi.org/10.1016/j.ajogmf.2020.100107
3. World Health Organization (WHO) Q&A on COVID-19, pregnancy, childbirth and breastfeeding. https://www.who.int/news-room/q-a-detail/q-a-on-covid-19-pregnancy-childbirth-and-breastfeeding
4. COVID-19 and Breastfeeding Position Paper. European Paediatric Association, the Union of National European Paediatric Societies and Associations (EPA/UNEPSA). https://r.epa-unepsa.eu/i/sSSE9qOATiQSgn-7s12OA1kqh62ccuew
5. Chen H, Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809–15.
6. Zeng L, Xia S, Yuan W et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics Published online March 26, 2020. DOI: 10.1001/jamapediatrics.2020.0878
7. Zhu H, Wang L, Fang C et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV. Transl Pediatr 2020; 9 (1): 51–60. http://dx.doi.org/10.21037/tp.2020.02.06
8. Wang L, Shi Y, Xiao T. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Ann Transl Med 2020; 8 (3): 47. http://dx.doi.org/10.21037/atm.2020.02.20
9. Li N, Han L, Peng M et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Med Rxiv 2020. https://doi.org/10.1101/2020.03.10.20033605(2020); https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1.full.pdf+html
10. Liu W, Wang Q, Zhang Q et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints 2020; 2020020373. https://www.preprints.org/manuscript/202002.0373/v1
11. Dashraath P, Jing LJW, Mei XL et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020 Mar 23. DOI: 10.1016/j.ajog.2020.03.021. https://www.ncbi.nlm.nih.gov/pubmed/32217113
12. Chen Y, Peng H, Wang L et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr 2020; 8: 104. DOI: 10.3389/fped.2020.00104
13. Wang J, Wang D, Chen GC et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate. Zhongguo Dang Dai Er Ke Za Zhi 2020; 22 (3): 211–4.
14. Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med 2020 Mar 17. DOI: 10.5858/arpa.2020-0901-SA. https://www.ncbi.nlm.nih.gov/pubmed/32180426
15. AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19. Alyson Sulaski Wyckoff, Associate Editor April 02, 2020. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220
16. Liu W, Zhang Q, Chen J et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020 Mar 12. DOI: 10.1056/NEJMc2003717. https://www.nejm.org/doi/10.1056/NEJMc2003717
17. Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514–23. https://www.scopus.com/record/display.uri?eid=2-s2.0-85078241697&origin=inward&txGid...
18. Zhang YP. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol 2020; 41: 145–51.
19. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (3): 670–3. DOI: 10.1016/j.jfma.2020.02.009. https://www.ncbi.nlm.nih.gov/pubmed/32139299
20. Lu X, Zhang L, Du H et al. SARS-CoV-2 infection in children. N Engl J Med 2020 Mar 18. https://doi.org/10.1056/NEJMc2005073
21. Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr 2020 Mar 23. DOI: 10.1111/apa.15270. https://www.ncbi.nlm.nih.gov/pubmed/32202343
22. Lee PI, Hu YL, Chen PY et al. Are children less susceptible to COVID-19? J Microbiol Immunol Infect 2020 Feb 25. DOI: 10.1016/j.jmii.2020.02.011. https://www.sciencedirect.com/science/journal/16841182
23. Gu H, Xie Z, Li T et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840.
24. Dong Y, Mo Х, Hu Y et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020 March. https://doi.org/10.1542/peds.2020-0702
25. Hagmann S. COVID-19 in children: More than meets the eye. Travel Med Infect Dis 2020 March 28. https://www.sciencedirect.com/science/article/pii/
S1477893920301174?via%3Dihub
________________________________________________
2. Mascio D, Asma K, Saccone G. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1-19) during pregnancy:a systematic review and meta-analysis.
Am J Obstet Gynecol 2020. https://doi.org/10.1016/j.ajogmf.2020.100107
3. World Health Organization (WHO) Q&A on COVID-19, pregnancy, childbirth and breastfeeding. https://www.who.int/news-room/q-a-detail/q-a-on-covid-19-pregnancy-childbirth-and-breastfeeding
4. COVID-19 and Breastfeeding Position Paper. European Paediatric Association, the Union of National European Paediatric Societies and Associations (EPA/UNEPSA). https://r.epa-unepsa.eu/i/sSSE9qOATiQSgn-7s12OA1kqh62ccuew
5. Chen H, Guo J, Wang C et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395 (10226): 809–15.
6. Zeng L, Xia S, Yuan W et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics Published online March 26, 2020. DOI: 10.1001/jamapediatrics.2020.0878
7. Zhu H, Wang L, Fang C et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV. Transl Pediatr 2020; 9 (1): 51–60. http://dx.doi.org/10.21037/tp.2020.02.06
8. Wang L, Shi Y, Xiao T. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Ann Transl Med 2020; 8 (3): 47. http://dx.doi.org/10.21037/atm.2020.02.20
9. Li N, Han L, Peng M et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Med Rxiv 2020. https://doi.org/10.1101/2020.03.10.20033605(2020); https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1.full.pdf+html
10. Liu W, Wang Q, Zhang Q et al. Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints 2020; 2020020373. https://www.preprints.org/manuscript/202002.0373/v1
11. Dashraath P, Jing LJW, Mei XL et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol 2020 Mar 23. DOI: 10.1016/j.ajog.2020.03.021. https://www.ncbi.nlm.nih.gov/pubmed/32217113
12. Chen Y, Peng H, Wang L et al. Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr 2020; 8: 104. DOI: 10.3389/fped.2020.00104
13. Wang J, Wang D, Chen GC et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate. Zhongguo Dang Dai Er Ke Za Zhi 2020; 22 (3): 211–4.
14. Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med 2020 Mar 17. DOI: 10.5858/arpa.2020-0901-SA. https://www.ncbi.nlm.nih.gov/pubmed/32180426
15. AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19. Alyson Sulaski Wyckoff, Associate Editor April 02, 2020. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220
16. Liu W, Zhang Q, Chen J et al. Detection of COVID-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020 Mar 12. DOI: 10.1056/NEJMc2003717. https://www.nejm.org/doi/10.1056/NEJMc2003717
17. Chan JF, Yuan S, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395: 514–23. https://www.scopus.com/record/display.uri?eid=2-s2.0-85078241697&origin=inward&txGid...
18. Zhang YP. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol 2020; 41: 145–51.
19. Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formos Med Assoc 2020; 119 (3): 670–3. DOI: 10.1016/j.jfma.2020.02.009. https://www.ncbi.nlm.nih.gov/pubmed/32139299
20. Lu X, Zhang L, Du H et al. SARS-CoV-2 infection in children. N Engl J Med 2020 Mar 18. https://doi.org/10.1056/NEJMc2005073
21. Ludvigsson JF. Systematic review of COVID-19 in children show milder cases and a better prognosis than adults. Acta Paediatr 2020 Mar 23. DOI: 10.1111/apa.15270. https://www.ncbi.nlm.nih.gov/pubmed/32202343
22. Lee PI, Hu YL, Chen PY et al. Are children less susceptible to COVID-19? J Microbiol Immunol Infect 2020 Feb 25. DOI: 10.1016/j.jmii.2020.02.011. https://www.sciencedirect.com/science/journal/16841182
23. Gu H, Xie Z, Li T et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep 2016; 6: 19840.
24. Dong Y, Mo Х, Hu Y et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020 March. https://doi.org/10.1542/peds.2020-0702
25. Hagmann S. COVID-19 in children: More than meets the eye. Travel Med Infect Dis 2020 March 28. https://www.sciencedirect.com/science/article/pii/
S1477893920301174?via%3Dihub
Авторы
А.Л. Заплатников*1, В.В. Горев1,2, А.В. Дмитриев1,3, А.А. Дементьев1, Ж.Л. Чабаидзе1, В.И. Свинцицкая1
1 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2 Департамент здравоохранения г. Москвы, Москва, Россия;
3 ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Рязань, Россия
*zaplatnikov@mail.ru
1 Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2 Department of Health of Moscow, Moscow, Russia;
3 Pavlov Ryazan State Medical University, Ryazan, Russia
*zaplatnikov@mail.ru
1 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
2 Департамент здравоохранения г. Москвы, Москва, Россия;
3 ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Рязань, Россия
*zaplatnikov@mail.ru
________________________________________________
1 Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2 Department of Health of Moscow, Moscow, Russia;
3 Pavlov Ryazan State Medical University, Ryazan, Russia
*zaplatnikov@mail.ru
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