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Витамин D как эссенциальный иммунонутриент – обновление доказательной базы
Витамин D как эссенциальный иммунонутриент – обновление доказательной базы
Макарова С.Г., Емельяшенков Е.Е., Ясаков Д.С., Пронина И.Ю., Ерешко О.А., Гордеева И.Г., Галимова А.А., Чумбадзе Т.Р., Лебедева А.М. Витамин D как эссенциальный иммунонутриент – обновление доказательной базы. Педиатрия. Consilium Medicum. 2022;2. DOI: 10.26442/26586630.2022.2.201682
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Аннотация
Роль микронутриентного статуса является ключевой для формирования адекватного иммунного ответа, в том числе при заболеваниях, вызванных респираторными вирусами. Многочисленные исследования, проведенные с начала пандемии COVID-19, изучающие влияние обеспеченности микронутриентами, показали их значение в профилактике этого заболевания. Наибольшее количество публикаций посвящено витамину D, в результате менее чем за 2 года опубликовано 17 метаанализов и аналитических обзоров, посвященных роли витамина D и обеспеченности данным микронутриентом различных групп населения в снижении заболеваемости, частоты развития тяжелых форм COVID-19 и смертности. В обзоре в ходе анализа данных литературы подтверждается, что витамин D обладает наибольшей доказательной базой как микронутриент, снижающий риск заболевания тяжелыми формами COVID-19, а также приводятся рекомендации по дотации витамина D пациентам взрослого и детского возраста.
Ключевые слова: микронутриенты, вирусные инфекции, новая коронавирусная инфекция, витамин D, COVID-19, SARS-CoV-2, пандемия, иммунный ответ
Keywords: micronutrients, viral infections, coronavirus disease, vitamin D, COVID-19, SARS-CoV-2, pandemic, immune response
Ключевые слова: микронутриенты, вирусные инфекции, новая коронавирусная инфекция, витамин D, COVID-19, SARS-CoV-2, пандемия, иммунный ответ
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Keywords: micronutrients, viral infections, coronavirus disease, vitamin D, COVID-19, SARS-CoV-2, pandemic, immune response
Полный текст
Список литературы
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2. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020;12(4):1181. DOI:10.3390/nu12041181
3. Фисенко А.П., Макарова С.Г. Обеспеченность микронутриентами, иммунный ответ, COVID-19. Российский педиатрический журнал. 2020;23(3):183-90 [Fisenko AP, Makarova SG. Micronutrients availability, immune response, and COVID-19. Russian Pediatric Journal. 2020;23(3):183-90 (in Russian)]. DOI:10.18821/1560-9561-2020-23-3-183-190
4. Calder P. Conferenceon ‘Transforming the nutrition landscape in Africa’. Plenary Session 1: Feeding the immune system. Proc Nutr Soc. 2013;72:299-309.
5. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12:236. DOI:10.3390/nu12010236
6. Wishart K. Increased micronutrient requirements during physiologically demanding situations: Review of the current evidence. Vitamin Miner. 2017;6:1‑16.
7. Carr AC, Shaw GM, Fowler AA., Natarajan R. Ascorbate-dependent vasopressor synthesis: а rationale for vitamin C administration in severe sepsis and septic shock? Crit Care. 2015;19:418.
8. Gröber U, Holick MF. The coronavirus disease (COVID-19) – а supportive approach with selected micronutrients. Int J Vitam Nutr Res. 2022;92(1):13-34.
DOI:10.1024/0300-9831/a000693
9. Kumar P, Kumar M, Bedi O, et al. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology. 2021;29(4):1001-16.
DOI:10.1007/s10787-021-00826-7
10. Singh V. Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? Curr Nutr Rep. 2020;9(3):202-9.
DOI:10.1007/s13668-020-00330-4
11. Pedrosa LFC, Barros ANAB, Leite-Lais L. Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review. Clin Nutr ESPEN. 2022;47:9-27. DOI:10.1016/j.clnesp.2021.11.003
12. Torshin IY, Gromova OA, Chuchalin AG. Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19. medRxiv. 2021. DOI:10.1101/2021.09.10.21263398
13. Khajavi A, Amirhakimi GH. The rachitic lung. Pulmonary findings in 30 infants and children with malnutritional rickets. Clin Pediatr (Phila). 1977;16(1):36-8. DOI:10.1177/000992287701600106
14. Grant WB, Lahore H, McDonnell ShL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. DOI:10.3390/nu12040988
15. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384-90. DOI:10.1001/archinternmed.2008.560
16. Laaksi I, Ruohola JP, Tuohimaa P, et al. An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr. 2007;86:714-7.
17. Sabetta JR, DePetrillo P, Cipriani RJ, et al. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS ONE. 2010;5:e11088. DOI:10.1371/journal.pone.0011088
18. Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis. 2013;57:392-7. DOI:10.1093/cid/cit289
19. Autier P, Mullie P, Macacu A, et al. Effect of vitamin D supplementation on non-skeletal disorders: A systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5:986-1004.
20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
21. Rejnmark L, Bislev LS, Cashman KD, et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE. 2017;12:e0180512.
22. Bergman P, Lindh Å, Björkhem-Bergman L, Lindh J. Vitamin D and respiratory tract infections: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE. 2013;8:e65835.
23. Charan J, Goyal J, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3:300-3.
24. Vuichard Gysin D, Dao D, Gysin CM, et al. Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2016;11:e0162996. DOI:10.1371/journal.pone.0162996
25. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015;70:617-24.
26. Han JE, Jones JL, Tangpricha V, et al. High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol. 2016;4:59-65.
27. Xiao L, Xing C, Yang Z, et al. Vitamin D supplementation for the prevention of childhood acute respiratory infections: A systematic review of randomised controlled trials. Br J Nutr. 2015;114:1026-34.
28. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11:CD008824.
29. Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia. Cochrane Database Syst Rev. 2018;7:CD011597.
30. Yamshchikov AV, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of infectious diseases: A systematic review of randomized controlled trials. Endocr Pract. 2009;15:438-49.
31. Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276-92. DOI:10.1016/S2213-8587(21)00051-6
32. Slominski AT, Slominski RM, Goepfert PA, et al. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab. 2020;319(2):E455-7. DOI:10.1152/ajpendo.00348.2020
33. Wimalawansa SJ. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology (Basel). 2019;8(2):30. DOI:10.3390/biology8020030
34. Ahmed A, Siman-Tov G, Hall G, et al. Human Antimicrobial Peptides as Therapeutics for Viral Infections. Viruses. 2019;11(8):704. DOI:10.3390/v11080704
35. Slominski RM, Stefan J, Athar M, et al. COVID-19 and Vitamin D: A lesson from the skin. Exp Dermatol. 2020;29(2):885-90. DOI:10.1111/exd.14170
36. Rhodes JM, Subramanian S, Laird E, Kenny RA. Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity. Aliment Pharmacol Ther. 2020;51(12):1434-7. DOI:10.1111/apt.15777
37. Rao Z, Chen X, Wu J, et al. Vitamin D receptor inhibits NLRP3 activation by impeding Its BRCC3-mediated deubiquitination. Front Immunol. 2019;10:2783. DOI:10.3389/fimmu.2019.02783
38. Xu J, Yang J, Chen J, et al. Vitamin D alleviates lipopolysaccharide‑induced acute lung injury via regulation of the renin‑angiotensin system. Mol Med Rep. 2017;16(5):7432-8. DOI:10.3892/mmr.2017.7546
39. Kaharan S, Katkat F. Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging. 2020;5:1-8.
DOI:10.1007/s12603-020-1479-0
40. Chiu S-K, Tsai K-W, Wu C-C, et al. Putative Role of Vitamin D for COVID-19 Vaccination. Int J Mol Sci. 2021;22:8988. DOI:10.3390/ijms22168988
41. Maghbooli Z, Ali Sahraian M, Ebrahimi M, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS ONE. 2020;15(9):e0239799.
42. Kaufman HW, Niles JK, Kroll MH, et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One. 2020;15(9):e0239252.
43. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373-80. DOI:10.1016/j.jiph.2020.06.021
44. Panfili FM, Roversi M, D'Argenio P, et al. Possible role of vitamin D in Covid-19 infection in pediatric population. J Endocrinol Invest. 2021;44(1):27-35.
DOI:10.1007/s40618-020-01327-0
45. Bassatne A, Basbous M, Chakhtoura M, et al. The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis. Metabolism. 2021;119:154753. DOI:10.1016/j.metabol.2021.154753
46. Teshome A, Adane A, Girma B, Mekonnen ZA. The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Front Public Health. 2021;9:624559. DOI:10.3389/fpubh.2021.624559
47. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM. 2021;114(3):175-81. DOI:10.1093/qjmed/hcab009
48. Borsche L, Glauner B, von Mendel J. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero
Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients. 2021;13(10):3596. DOI:10.3390/nu13103596
49. Szarpak L, Rafique Z, Gasecka A, et al. A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19. Cardiol J. 2021;28(5):647-54. DOI:10.5603/CJ.a2021.0072
50. Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. Int J Clin Pract. 2021;75(11):e14675. DOI:10.1111/ijcp.14675
51. Petrelli F, Luciani A, Perego G, et al. Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies. J Steroid Biochem Mol Biol. 2021;211:105883. DOI:10.1016/j.jsbmb.2021.105883
52. Kaya MO, Pamukçu E, Yakar B. The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis of observational studies. Epidemiol Health. 2021;43:e2021074. DOI:10.4178/epih.e2021074
53. Crafa A, Cannarella R, Condorelli RA, et al. Influence of 25-hydroxy-cholecalciferol levels on SARS-CoV-2 infection and COVID-19 severity: A systematic review and meta-analysis. EClinicalMedicine. 2021;37:100967. DOI:10.1016/j.eclinm.2021.100967
54. Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis. Front Nutr. 2021;8:660420. DOI:10.3389/fnut.2021.660420
55. Corrao S, Mallaci Bocchio R, Lo Monaco M, et al. Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. Nutrients. 2021;13(4):1261. DOI:10.3390/nu13041261
56. Liu N, Sun J, Wang X, et al. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis. 2021;104:58-64. DOI:10.1016/j.ijid.2020.12.077
57. Ebrahimzadeh A, Mohseni S, Narimani B, et al. Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr. 2021;9:1-11. DOI:10.1080/10408398.2021.2012419
58. Pereira M, Dantas Damascena A, Galvão Azevedo LM, et al. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62(5):1308-16. DOI:10.1080/10408398.2020.1841090
59. Wang Z, Joshi A, Leopold K, et al. Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis. Clin Endocrinol (Oxf). 2022;96(3):281-7. DOI:10.1111/cen.14540
60. Pal R, Banerjee M, Bhadada SK, et al. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest. 2022;45(1):53-68. DOI:10.1007/s40618-021-01614-4
61. Varikasuvu SR, Thangappazham B, Vykunta A, et al. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022;3:1-7. DOI:10.1080/14787210.2022.2035217
62. Feketea G, Vlacha V, Bocsan IC, et al. Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C). Front Immunol. 2021;12:648546. DOI:10.3389/fimmu.2021.648546
63. Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. Soiuz pediatrov Rossii. Moscow: Pediatr, 2021 (in Russian).
2. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020;12(4):1181. DOI:10.3390/nu12041181
3. Фисенко А.П., Макарова С.Г. Обеспеченность микронутриентами, иммунный ответ, COVID-19. Российский педиатрический журнал. 2020;23(3):183-90 [Fisenko AP, Makarova SG. Micronutrients availability, immune response, and COVID-19. Russian Pediatric Journal. 2020;23(3):183-90 (in Russian)]. DOI:10.18821/1560-9561-2020-23-3-183-190
4. Calder P. Conferenceon ‘Transforming the nutrition landscape in Africa’. Plenary Session 1: Feeding the immune system. Proc Nutr Soc. 2013;72:299-309.
5. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12:236. DOI:10.3390/nu12010236
6. Wishart K. Increased micronutrient requirements during physiologically demanding situations: Review of the current evidence. Vitamin Miner. 2017;6:1‑16.
7. Carr AC, Shaw GM, Fowler AA., Natarajan R. Ascorbate-dependent vasopressor synthesis: а rationale for vitamin C administration in severe sepsis and septic shock? Crit Care. 2015;19:418.
8. Gröber U, Holick MF. The coronavirus disease (COVID-19) – а supportive approach with selected micronutrients. Int J Vitam Nutr Res. 2022;92(1):13-34.
DOI:10.1024/0300-9831/a000693
9. Kumar P, Kumar M, Bedi O, et al. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology. 2021;29(4):1001-16.
DOI:10.1007/s10787-021-00826-7
10. Singh V. Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? Curr Nutr Rep. 2020;9(3):202-9.
DOI:10.1007/s13668-020-00330-4
11. Pedrosa LFC, Barros ANAB, Leite-Lais L. Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review. Clin Nutr ESPEN. 2022;47:9-27. DOI:10.1016/j.clnesp.2021.11.003
12. Torshin IY, Gromova OA, Chuchalin AG. Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19. medRxiv. 2021. DOI:10.1101/2021.09.10.21263398
13. Khajavi A, Amirhakimi GH. The rachitic lung. Pulmonary findings in 30 infants and children with malnutritional rickets. Clin Pediatr (Phila). 1977;16(1):36-8. DOI:10.1177/000992287701600106
14. Grant WB, Lahore H, McDonnell ShL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. DOI:10.3390/nu12040988
15. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384-90. DOI:10.1001/archinternmed.2008.560
16. Laaksi I, Ruohola JP, Tuohimaa P, et al. An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr. 2007;86:714-7.
17. Sabetta JR, DePetrillo P, Cipriani RJ, et al. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS ONE. 2010;5:e11088. DOI:10.1371/journal.pone.0011088
18. Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis. 2013;57:392-7. DOI:10.1093/cid/cit289
19. Autier P, Mullie P, Macacu A, et al. Effect of vitamin D supplementation on non-skeletal disorders: A systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5:986-1004.
20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
21. Rejnmark L, Bislev LS, Cashman KD, et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE. 2017;12:e0180512.
22. Bergman P, Lindh Å, Björkhem-Bergman L, Lindh J. Vitamin D and respiratory tract infections: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE. 2013;8:e65835.
23. Charan J, Goyal J, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3:300-3.
24. Vuichard Gysin D, Dao D, Gysin CM, et al. Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2016;11:e0162996. DOI:10.1371/journal.pone.0162996
25. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015;70:617-24.
26. Han JE, Jones JL, Tangpricha V, et al. High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol. 2016;4:59-65.
27. Xiao L, Xing C, Yang Z, et al. Vitamin D supplementation for the prevention of childhood acute respiratory infections: A systematic review of randomised controlled trials. Br J Nutr. 2015;114:1026-34.
28. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11:CD008824.
29. Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia. Cochrane Database Syst Rev. 2018;7:CD011597.
30. Yamshchikov AV, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of infectious diseases: A systematic review of randomized controlled trials. Endocr Pract. 2009;15:438-49.
31. Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276-92. DOI:10.1016/S2213-8587(21)00051-6
32. Slominski AT, Slominski RM, Goepfert PA, et al. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab. 2020;319(2):E455-7. DOI:10.1152/ajpendo.00348.2020
33. Wimalawansa SJ. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology (Basel). 2019;8(2):30. DOI:10.3390/biology8020030
34. Ahmed A, Siman-Tov G, Hall G, et al. Human Antimicrobial Peptides as Therapeutics for Viral Infections. Viruses. 2019;11(8):704. DOI:10.3390/v11080704
35. Slominski RM, Stefan J, Athar M, et al. COVID-19 and Vitamin D: A lesson from the skin. Exp Dermatol. 2020;29(2):885-90. DOI:10.1111/exd.14170
36. Rhodes JM, Subramanian S, Laird E, Kenny RA. Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity. Aliment Pharmacol Ther. 2020;51(12):1434-7. DOI:10.1111/apt.15777
37. Rao Z, Chen X, Wu J, et al. Vitamin D receptor inhibits NLRP3 activation by impeding Its BRCC3-mediated deubiquitination. Front Immunol. 2019;10:2783. DOI:10.3389/fimmu.2019.02783
38. Xu J, Yang J, Chen J, et al. Vitamin D alleviates lipopolysaccharide‑induced acute lung injury via regulation of the renin‑angiotensin system. Mol Med Rep. 2017;16(5):7432-8. DOI:10.3892/mmr.2017.7546
39. Kaharan S, Katkat F. Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging. 2020;5:1-8.
DOI:10.1007/s12603-020-1479-0
40. Chiu S-K, Tsai K-W, Wu C-C, et al. Putative Role of Vitamin D for COVID-19 Vaccination. Int J Mol Sci. 2021;22:8988. DOI:10.3390/ijms22168988
41. Maghbooli Z, Ali Sahraian M, Ebrahimi M, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS ONE. 2020;15(9):e0239799.
42. Kaufman HW, Niles JK, Kroll MH, et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS One. 2020;15(9):e0239252.
43. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373-80. DOI:10.1016/j.jiph.2020.06.021
44. Panfili FM, Roversi M, D'Argenio P, et al. Possible role of vitamin D in Covid-19 infection in pediatric population. J Endocrinol Invest. 2021;44(1):27-35.
DOI:10.1007/s40618-020-01327-0
45. Bassatne A, Basbous M, Chakhtoura M, et al. The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis. Metabolism. 2021;119:154753. DOI:10.1016/j.metabol.2021.154753
46. Teshome A, Adane A, Girma B, Mekonnen ZA. The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Front Public Health. 2021;9:624559. DOI:10.3389/fpubh.2021.624559
47. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM. 2021;114(3):175-81. DOI:10.1093/qjmed/hcab009
48. Borsche L, Glauner B, von Mendel J. COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero
Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis. Nutrients. 2021;13(10):3596. DOI:10.3390/nu13103596
49. Szarpak L, Rafique Z, Gasecka A, et al. A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19. Cardiol J. 2021;28(5):647-54. DOI:10.5603/CJ.a2021.0072
50. Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. Int J Clin Pract. 2021;75(11):e14675. DOI:10.1111/ijcp.14675
51. Petrelli F, Luciani A, Perego G, et al. Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies. J Steroid Biochem Mol Biol. 2021;211:105883. DOI:10.1016/j.jsbmb.2021.105883
52. Kaya MO, Pamukçu E, Yakar B. The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis of observational studies. Epidemiol Health. 2021;43:e2021074. DOI:10.4178/epih.e2021074
53. Crafa A, Cannarella R, Condorelli RA, et al. Influence of 25-hydroxy-cholecalciferol levels on SARS-CoV-2 infection and COVID-19 severity: A systematic review and meta-analysis. EClinicalMedicine. 2021;37:100967. DOI:10.1016/j.eclinm.2021.100967
54. Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis. Front Nutr. 2021;8:660420. DOI:10.3389/fnut.2021.660420
55. Corrao S, Mallaci Bocchio R, Lo Monaco M, et al. Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. Nutrients. 2021;13(4):1261. DOI:10.3390/nu13041261
56. Liu N, Sun J, Wang X, et al. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis. 2021;104:58-64. DOI:10.1016/j.ijid.2020.12.077
57. Ebrahimzadeh A, Mohseni S, Narimani B, et al. Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr. 2021;9:1-11. DOI:10.1080/10408398.2021.2012419
58. Pereira M, Dantas Damascena A, Galvão Azevedo LM, et al. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62(5):1308-16. DOI:10.1080/10408398.2020.1841090
59. Wang Z, Joshi A, Leopold K, et al. Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis. Clin Endocrinol (Oxf). 2022;96(3):281-7. DOI:10.1111/cen.14540
60. Pal R, Banerjee M, Bhadada SK, et al. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest. 2022;45(1):53-68. DOI:10.1007/s40618-021-01614-4
61. Varikasuvu SR, Thangappazham B, Vykunta A, et al. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022;3:1-7. DOI:10.1080/14787210.2022.2035217
62. Feketea G, Vlacha V, Bocsan IC, et al. Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C). Front Immunol. 2021;12:648546. DOI:10.3389/fimmu.2021.648546
63. Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции». Союз педиатров России. М.: ПедиатрЪ, 2021 [Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. Soiuz pediatrov Rossii. Moscow: Pediatr, 2021 (in Russian)].
________________________________________________
2. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020;12(4):1181. DOI:10.3390/nu12041181
3. Фисенко А.П., Макарова С.Г. Обеспеченность микронутриентами, иммунный ответ, COVID-19. Российский педиатрический журнал. 2020;23(3):183-90 [Fisenko AP, Makarova SG. Micronutrients availability, immune response, and COVID-19. Russian Pediatric Journal. 2020;23(3):183-90 (in Russian)]. DOI:10.18821/1560-9561-2020-23-3-183-190
4. Calder P. Conferenceon ‘Transforming the nutrition landscape in Africa’. Plenary Session 1: Feeding the immune system. Proc Nutr Soc. 2013;72:299-309.
5. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12:236. DOI:10.3390/nu12010236
6. Wishart K. Increased micronutrient requirements during physiologically demanding situations: Review of the current evidence. Vitamin Miner. 2017;6:1‑16.
7. Carr AC, Shaw GM, Fowler AA., Natarajan R. Ascorbate-dependent vasopressor synthesis: а rationale for vitamin C administration in severe sepsis and septic shock? Crit Care. 2015;19:418.
8. Gröber U, Holick MF. The coronavirus disease (COVID-19) – а supportive approach with selected micronutrients. Int J Vitam Nutr Res. 2022;92(1):13-34.
DOI:10.1024/0300-9831/a000693
9. Kumar P, Kumar M, Bedi O, et al. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology. 2021;29(4):1001-16.
DOI:10.1007/s10787-021-00826-7
10. Singh V. Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? Curr Nutr Rep. 2020;9(3):202-9.
DOI:10.1007/s13668-020-00330-4
11. Pedrosa LFC, Barros ANAB, Leite-Lais L. Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review. Clin Nutr ESPEN. 2022;47:9-27. DOI:10.1016/j.clnesp.2021.11.003
12. Torshin IY, Gromova OA, Chuchalin AG. Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19. medRxiv. 2021. DOI:10.1101/2021.09.10.21263398
13. Khajavi A, Amirhakimi GH. The rachitic lung. Pulmonary findings in 30 infants and children with malnutritional rickets. Clin Pediatr (Phila). 1977;16(1):36-8. DOI:10.1177/000992287701600106
14. Grant WB, Lahore H, McDonnell ShL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. DOI:10.3390/nu12040988
15. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169:384-90. DOI:10.1001/archinternmed.2008.560
16. Laaksi I, Ruohola JP, Tuohimaa P, et al. An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr. 2007;86:714-7.
17. Sabetta JR, DePetrillo P, Cipriani RJ, et al. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS ONE. 2010;5:e11088. DOI:10.1371/journal.pone.0011088
18. Science M, Maguire JL, Russell ML, et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis. 2013;57:392-7. DOI:10.1093/cid/cit289
19. Autier P, Mullie P, Macacu A, et al. Effect of vitamin D supplementation on non-skeletal disorders: A systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5:986-1004.
20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
21. Rejnmark L, Bislev LS, Cashman KD, et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS ONE. 2017;12:e0180512.
22. Bergman P, Lindh Å, Björkhem-Bergman L, Lindh J. Vitamin D and respiratory tract infections: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE. 2013;8:e65835.
23. Charan J, Goyal J, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3:300-3.
24. Vuichard Gysin D, Dao D, Gysin CM, et al. Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2016;11:e0162996. DOI:10.1371/journal.pone.0162996
25. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015;70:617-24.
26. Han JE, Jones JL, Tangpricha V, et al. High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol. 2016;4:59-65.
27. Xiao L, Xing C, Yang Z, et al. Vitamin D supplementation for the prevention of childhood acute respiratory infections: A systematic review of randomised controlled trials. Br J Nutr. 2015;114:1026-34.
28. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11:CD008824.
29. Das RR, Singh M, Naik SS. Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia. Cochrane Database Syst Rev. 2018;7:CD011597.
30. Yamshchikov AV, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of infectious diseases: A systematic review of randomized controlled trials. Endocr Pract. 2009;15:438-49.
31. Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276-92. DOI:10.1016/S2213-8587(21)00051-6
32. Slominski AT, Slominski RM, Goepfert PA, et al. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab. 2020;319(2):E455-7. DOI:10.1152/ajpendo.00348.2020
33. Wimalawansa SJ. Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology (Basel). 2019;8(2):30. DOI:10.3390/biology8020030
34. Ahmed A, Siman-Tov G, Hall G, et al. Human Antimicrobial Peptides as Therapeutics for Viral Infections. Viruses. 2019;11(8):704. DOI:10.3390/v11080704
35. Slominski RM, Stefan J, Athar M, et al. COVID-19 and Vitamin D: A lesson from the skin. Exp Dermatol. 2020;29(2):885-90. DOI:10.1111/exd.14170
36. Rhodes JM, Subramanian S, Laird E, Kenny RA. Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity. Aliment Pharmacol Ther. 2020;51(12):1434-7. DOI:10.1111/apt.15777
37. Rao Z, Chen X, Wu J, et al. Vitamin D receptor inhibits NLRP3 activation by impeding Its BRCC3-mediated deubiquitination. Front Immunol. 2019;10:2783. DOI:10.3389/fimmu.2019.02783
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Авторы
С.Г. Макарова*1,2, Е.Е. Емельяшенков1, Д.С. Ясаков1, И.Ю. Пронина1,3, О.А. Ерешко1, И.Г. Гордеева1, А.А. Галимова1, Т.Р. Чумбадзе1, А.М. Лебедева1,4
1 ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России, Москва, Россия;
2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
3 ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия;
4 ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи», Москва, Россия
*sm27@yandex.ru
1 National Medical Research Center for Children's Health, Moscow, Russia;
2 Lomonosov Moscow State University, Moscow, Russia;
3 Endocrinology Research Centre, Moscow, Russia;
4 Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia
*sm27@yandex.ru
1 ФГАУ «Национальный медицинский исследовательский центр здоровья детей» Минздрава России, Москва, Россия;
2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
3 ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России, Москва, Россия;
4 ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи», Москва, Россия
*sm27@yandex.ru
________________________________________________
1 National Medical Research Center for Children's Health, Moscow, Russia;
2 Lomonosov Moscow State University, Moscow, Russia;
3 Endocrinology Research Centre, Moscow, Russia;
4 Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia
*sm27@yandex.ru
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