Роль витамина D в профилактике и лечении острых респираторных инфекций у детей

1. Намазова Л.С., Ботвиньева В.В., Торшхоева Р.М., и др. Лечение и профилактика острых респираторных инфекций у часто болеющих детей, проживающих в мегаполисах. Детские инфекции. 2007;2:49-52 [Namazova LS, Botvin'eva VV, Torshkhoeva RM, et al. Lechenie i profilaktika ostrykh respiratornykh infektsii u chasto boleiushchikh detei, prozhivaiushchikh v megapolisakh. Detskie infektsii. 2007;2:49-52 (in Russian)].
2. Зайцева С.В., Застрожина А.К., Бельская Е.А. Место ароматерапии в лечении и профилактике острых респираторных заболеваний. Трудный пациент. 2015;13(1-2):48-54. [Zaitseva SV, Zastrozhina AK, Bel'skaia EA. Mesto aromaterapii v lechenii i profilaktike ostrykh respiratornykh zabolevanii. Trudnyi patsient. 2015;13(1-2):48-54 (in Russian)].
3. Заплатников А.Л. Современные возможности иммунопрофилактики и иммунотерапии острых респираторных инфекций у детей. Медицинский совет. 2007;1:74-6 [Zaplatnikov AL. Sovremennye vozmozhnosti immunoprofilaktiki i immunoterapii ostryh respiratornyh infekcij u detej. Medicinskij sovet. 2007;1:74-6 (in Russian)].
4. Chiappini E, Santamaria F, Marseglia GL, et al. Prevention of recurrent respiratory infections. Ital J Pediatr. 2021;47(1):211. DOI:10.1186/s13052-021-01150-0
5. Мельниченко Г.А., Намазова-Баранова Л.С., Громова О.А., и др. Профилактика и лечение дефицита витамина D: выбор оптимального подхода. Вопросы современной педиатрии. 2021;20(4):338-45 [Mel'nichenko GA, Namazova-Baranova LS, Gromova OA, et al. Profilaktika i lechenie defitsita vitamina D: vybor optimal'nogo podkhoda. Voprosy sovremennoi pediatrii. 2021;20(4):338-45 (in Russian)]. DOI:10.15690/vsp.v20i4.2246
6. Castro LC. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 2011;55(8):566-75.
7. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
8. Толстова Е.М., Сорокина Н.В. О дозировках витамина D для детей: национальные рекомендации и мировой опыт. Status praesens. Педиатрия и неонатология. 2019;3(60):73-9 [Tolstova EM, Sorokina NV. O dozirovkakh vitamina D dlia detei: natsional'nye rekomendatsii i mirovoi opyt. Status praesens. Pediatriia i neonatologiia. 2019;3(60):73-9 (in Russian)].
9. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11(11):CD008824. DOI:10.1002/14651858.CD008824
10. Mazzoleni S, Magni G, Toderini D. Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study). Ital J Pediatr. 2019;45(1):18. DOI:10.1186/s13052-018-0590-x
11. Wang S, Shen G, Jiang S, et al. Nutrient status of vitamin D among Chinese children. Nutrients. 2017;9(4):319.
12. Al-Taiar A, Rahman A, Al-Sabah R, et al. Vitamin D status among adolescents in Kuwait: a cross-sectional study. BMJ Open. 2018;8(7):e021401. DOI:10.1136/bmjopen-2017-021401
13. Суплотова Л.А., Авдеева В.А., Пигарова Е.А., и др. Дефицит витамина D в России: первые результаты регистрового неинтервенционного исследования частоты дефицита и недостаточности витамина D в различных географических регионах страны. Проблемы эндокринологии. 2021;67(2):84-92 [Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, noninterventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian)]. DOI:10.14341/probl12736
14. Захарова И.Н., Мальцев С.В., Боровик Т.Э., и др. Результаты многоцентрового когортного исследования «РОДНИЧОК» по изучению недостаточности витамина D у детей раннего возраста в России. Педиатрия. Журнал им. Г.Н. Сперанского. 2015;94(1):62-7 [Zakharova IN, Mal'tsev SV, Borovik TE, et al. Rezul'taty mnogotsentrovogo kogortnogo issledovaniia “RODNIChOK” po izucheniiu nedostatochnosti vitamina D u detei rannego vozrasta v Rossii. Pediatriia. Zhurnal im. G.N. Speranskogo. 2015;94(1):62-7 (in Russian)].
15. Кондратьева Е.И., Лошкова Е.В., Захарова И.Н., и др. Оценка обеспеченности витамином D детей Москвы и Московской области. Российский вестник перинатологии и педиатрии. 2021;66(2):78-84 [Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2021;66(2):78-84 (in Russian)]. DOI:10.21508/1027-4065-2021-66-2-78-84
16. Braegger C, Campoy C, Colomb V, et al. Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013;56:692.
17. Дорофейков В.В., Зазерская И.Е., Кузнецова Л.В., и др. Под ред. И.Е. Зазерской. Витамин D и здоровье женщины. СПб: Эко-Вектор, 2021 [Dorofeikov VV, Zazerskaia IE, Kuznetsova LV, et al. Pod red. IE Zazerskoi. Vitamin D i zdorov'e zhenshchiny. Saint Petersburg: Eko-Vektor, 2021 (in Russian)].
18. Романцова Е.Б., Бабцева А.Ф., Борисенко Е.П., и др. D-дефицитное состояние у часто болеющих детей в Амурской области. Практичеcкая медицина. 2017;5(106):53-5 [Romantsova EB, Babtseva AF, Borisenko EP, et al. D-defitsitnoe sostoianie u chasto boleiushchikh detei v Amurskoi oblasti. Prakticheckaia meditsina. 2017;5(106):53-5 (in Russian)].
19. Дедов И.И., Мельниченко Г.А., Пигарова Е.А., и др. Дефицит витамина D у взрослых: диагностика, лечение и профилактика: учебное пособие. М.–Тверь: Триада, 2020 [Dedov II, Mel'nichenko GA, Pigarova EA, et al. Defitsit vitamina D u vzroslykh: diagnostika, lechenie i profilaktika: uchebnoe posobie. Moscow–Tver: Triada, 2020 (in Russian)]. 
20. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: ГЭОТАР-Медиа, 2021 [Gromova OA, Torshin IIu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2021 (in Russian)]. 
21. Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции». Союз педиатров России. М.: ПедиатрЪ, 2018 [Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. Soiuz pediatrov Rossii. Moscow: Pediatr, 2018 (in Russian)].
22. Neme A, Seuter S. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochim Biophys Acta Gene Regul Mech. 2017;1860(9):952-61.
23. Мальцев С.В., Рылова Н.В. Витамин D и иммунитет. Практическая медицина. 2015:1:114-20 [Mal'tsev SV, Rylova NV. Vitamin D i immunitet. Prakticheskaia meditsina. 2015:1:114-20 (in Russian)].
24. Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med. 2010;235(9):1034-45.
25. Спиричев В.Б. О биологических эффектах витамина Д. Педиатрия. 2011;90(6):113-9 [Spirichev VB. O biologicheskikh effektakh vitamina D. Pediatriia. 2011;90(6):113-9 (in Russian)].
26. Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci. 2004;29(12):664-73. DOI:10.1016/j.tibs.2004.10.005
27. Рылова Н.В., Мальцев С.В., Жолинский А.В. Применение витамина D в клинической практике. Практическая медицина. 2017;5(106):10-4 [Rulova NV, Maltsev SV, Zholinskiy AV. Role of vitamin D in regulation of the immune system. Prakticheskaia meditsina. 2017;5(106):10-4 (in Russian)].
28. Telcian AG, Zdrenghea MT, Edwards MR, et al. Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro. Antiviral Res. 2017;137:93-101. DOI:10.1016/j.antiviral.2016.11.004
29. Olliver M, Spelmink L, Hiew J, et al. Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J Infect Dis. 2013;208:1474-81. DOI:10.1093/infdis/jit355
30. Hansdottir S, Monick MM, Lovan N, et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappaBlinked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010;184:965‑74. DOI:10.4049/jimmunol.0902840
31. Захарова И.Н., Цуцаева А.Н., Климов Л.Я., и др. Витамин D и продукция дефензинов у детей раннего возраста. Медицинский совет. 2020;1:153-64 [Zakharova IN, Tsutsayeva AN, Klimov LYa, et al. Vitamin D and defensins production in infants. Medical Council. 2020;1:153-64 (in Russian)]. DOI:10.21518/2079-701X-2020-1-174-185
32. Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300-3.
33. Bergman P, Lindh AU. Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2013;8(6):e65835.
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46. Carpagnano GE, Di Lecce V, Quaranta VN, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021;44(4):765-71. DOI:10.1007/s40618-020-01370-x
47. Macaya F, Paeres CE, Valls A, et al. Interaction between age and vitamin D deficiency in severe COVID-19 infection. Nutricion Hospitalaria. 2020;37(5):1039‑42. DOI:10.20960/nh.03193
48. Ye K, Tang F, Liao X, et al. Does serum vitamin D level affect COVID-19 infection and its severity? A case-control study. J Am Coll Nutr. 2021;40(8):724-31. DOI:10.1080/07315724.2020.1826005
49. Kaufman HW, Niles JK, Kroll MH, et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS ONE. 2020;15(9):e0239252. DOI:10.1371/journal.pone.0239252
50. Zhou Y-F, Luo B-A, Qin L-L. The association between vitamin D deficiency and community-acquired pneumonia: a meta-analysis of observational studies. Medicine. 2019;98(38):e17252.
51. Каронова Т.Л., Андреева А.Т., Вашукова М.А. Уровень 25(ОН)D в сыворотке крови у больных COVID-19. Журнал инфектологии. 2020;12(3):21-7 [Karonova TL, Andreeva AT, Vashukova MA. Uroven' 25(ON)D v syvorotke krovi u bol'nykh COVID-19. Zhurnal infektologii. 2020;12(3):21-7 (in Russian)]. DOI:10.22625/2072-6732-2020-12-3-21-27
52. Povaliaeva A, Rozhinskaya LYa, Pigarova EA, et al. Vitamin D Metabolism Is Significantly Impaired in COVID-19 Inpatients. Journal of the Endocrine Society. 2021;5(Suppl. 1):A281-2. DOI:10.1210/jendso/bvab048.572
53. Oscanoa TJ, Amado J, Vidal X, et al. The relationship between the severity and mortality of SARS-CoV-2 infection and 25-hydroxyvitamin D concentration – a metaanalysis. Adv Respir Med. 2021;89:145-57.
54. Shoemaker ME, Huynh LM, Smith CM, et al. Immunomodulatory Effects of Vitamin D and Prevention of Respiratory Tract Infections and COVID-19. Top Clin Nutr. 2022;37(3):203-17. DOI:10.1097/TIN.0000000000000284
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1. Namazova LS, Botvin'eva VV, Torshkhoeva RM, et al. Lechenie i profilaktika ostrykh respiratornykh infektsii u chasto boleiushchikh detei, prozhivaiushchikh v megapolisakh. Detskie infektsii. 2007;2:49-52 (in Russian).
2. Zaitseva SV, Zastrozhina AK, Bel'skaia EA. Mesto aromaterapii v lechenii i profilaktike ostrykh respiratornykh zabolevanii. Trudnyi patsient. 2015;13(1-2):48-54 (in Russian).
3. Zaplatnikov AL. Sovremennye vozmozhnosti immunoprofilaktiki i immunoterapii ostryh respiratornyh infekcij u detej. Medicinskij sovet. 2007;1:74-6 (in Russian).
4. Chiappini E, Santamaria F, Marseglia GL, et al. Prevention of recurrent respiratory infections. Ital J Pediatr. 2021;47(1):211. DOI:10.1186/s13052-021-01150-0
5. Mel'nichenko GA, Namazova-Baranova LS, Gromova OA, et al. Profilaktika i lechenie defitsita vitamina D: vybor optimal'nogo podkhoda. Voprosy sovremennoi pediatrii. 2021;20(4):338-45 (in Russian). DOI:10.15690/vsp.v20i4.2246
6. Castro LC. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 2011;55(8):566-75.
7. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
8. Tolstova EM, Sorokina NV. O dozirovkakh vitamina D dlia detei: natsional'nye rekomendatsii i mirovoi opyt. Status praesens. Pediatriia i neonatologiia. 2019;3(60):73-9 (in Russian).
9. Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016;11(11):CD008824. DOI:10.1002/14651858.CD008824
10. Mazzoleni S, Magni G, Toderini D. Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study). Ital J Pediatr. 2019;45(1):18. DOI:10.1186/s13052-018-0590-x
11. Wang S, Shen G, Jiang S, et al. Nutrient status of vitamin D among Chinese children. Nutrients. 2017;9(4):319.
12. Al-Taiar A, Rahman A, Al-Sabah R, et al. Vitamin D status among adolescents in Kuwait: a cross-sectional study. BMJ Open. 2018;8(7):e021401. DOI:10.1136/bmjopen-2017-021401
13. Suplotova LA, Avdeeva VA, Pigarova EA, et al. Vitamin D deficiency in Russia: the first results of a registered, noninterventional study of the frequency of vitamin D deficiency and insufficiency in various geographic regions of the country. Problems of Endocrinology. 2021;67(2):84-92 (in Russian). DOI:10.14341/probl12736
14. Zakharova IN, Mal'tsev SV, Borovik TE, et al. Rezul'taty mnogotsentrovogo kogortnogo issledovaniia “RODNIChOK” po izucheniiu nedostatochnosti vitamina D u detei rannego vozrasta v Rossii. Pediatriia. Zhurnal im. G.N. Speranskogo. 2015;94(1):62-7 (in Russian).
15. Kondratyeva EI, Loshkova EV, Zakharova IN, et al. Assessment of vitamin D supply in children of Moscow and the Moscow Region. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2021;66(2):78-84 (in Russian). DOI:10.21508/1027-4065-2021-66-2-78-84
16. Braegger C, Campoy C, Colomb V, et al. Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013;56:692.
17. Dorofeikov VV, Zazerskaia IE, Kuznetsova LV, et al. Pod red. IE Zazerskoi. Vitamin D i zdorov'e zhenshchiny. Saint Petersburg: Eko-Vektor, 2021 (in Russian).
18. Romantsova EB, Babtseva AF, Borisenko EP, et al. D-defitsitnoe sostoianie u chasto boleiushchikh detei v Amurskoi oblasti. Prakticheckaia meditsina. 2017;5(106):53-5 (in Russian).
19. Dedov II, Mel'nichenko GA, Pigarova EA, et al. Defitsit vitamina D u vzroslykh: diagnostika, lechenie i profilaktika: uchebnoe posobie. Moscow–Tver: Triada, 2020 (in Russian). 
20. Gromova OA, Torshin IIu. Vitamin D – smena paradigmy. Moscow: GEOTAR-Media, 2021 (in Russian). 
21. Natsional'naia programma “Nedostatochnost' vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii”. Soiuz pediatrov Rossii. Moscow: Pediatr, 2018 (in Russian).
22. Neme A, Seuter S. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochim Biophys Acta Gene Regul Mech. 2017;1860(9):952-61.
23. Мальцев С.В., Рылова Н.В. Витамин D и иммунитет. Практическая медицина. 2015:1:114-20 [Mal'tsev SV, Rylova NV. Vitamin D i immunitet. Prakticheskaia meditsina. 2015:1:114-20 (in Russian)].
24. Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med. 2010;235(9):1034-45.
25. Spirichev VB. O biologicheskikh effektakh vitamina D. Pediatriia. 2011;90(6):113-9 (in Russian).
26. Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci. 2004;29(12):664-73. DOI:10.1016/j.tibs.2004.10.005
27. Rulova NV, Maltsev SV, Zholinskiy AV. Role of vitamin D in regulation of the immune system. Prakticheskaia meditsina. 2017;5(106):10-4 (in Russian).
28. Telcian AG, Zdrenghea MT, Edwards MR, et al. Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro. Antiviral Res. 2017;137:93-101. DOI:10.1016/j.antiviral.2016.11.004
29. Olliver M, Spelmink L, Hiew J, et al. Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J Infect Dis. 2013;208:1474-81. DOI:10.1093/infdis/jit355
30. Hansdottir S, Monick MM, Lovan N, et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappaBlinked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010;184:965‑74. DOI:10.4049/jimmunol.0902840
31. Zakharova IN, Tsutsayeva AN, Klimov LYa, et al. Vitamin D and defensins production in infants. Medical Council. 2020;1:153-64 (in Russian).
DOI:10.21518/2079-701X-2020-1-174-185
32. Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300-3.
33. Bergman P, Lindh AU. Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2013;8(6):e65835.
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Э.Э. Локшина*1, О.В. Зайцева1,2

1 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия;
2 ГБУЗ «Детская городская клиническая больница святого Владимира» Департамента здравоохранения г. Москвы, Москва, Россия
*elokshina@yandex.ru

________________________________________________

Evelina E. Lokshina*1, Olga V. Zaytseva1,2

1 Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia;
2 Children’s State Hospital of Saint Vladimir, Moscow, Russia
*elokshina@yandex.ru