Целиакия: история и современность

Дмитриева Ю.А., Захарова И.Н., Османов И.М., Майкова И.Д., Гостюхина А.Д., Радченко Е.Р., Дубовец Н.Ф., Абдурахманова Л.С. Целиакия: история и современность. Педиатрия. Consilium Medicum. 2022;4:361–365. DOI: 10.26442/26586630.2022.4.202010

© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.

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Dmitrieva YuA, Zakharova IN, Osmanov IM, Maikova ID, Gostyukhina AD, Radchenko ER, Dubovets NF., Abdurakhmanova LS. Celiac disease: history and modern era. Pediatrics. Consilium Medicum. 2022;4:361–365. DOI: 10.26442/26586630.2022.4.202010

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Аннотация

Целиакия является одним из древнейших заболеваний человека, зародившимся в эпоху неолита, с приходом в жизнь человека культуры земледелия. Более чем за 10 тыс. лет целиакия прошла путь от неизвестной и пугающей «чревной болезни» до одной из наиболее распространенных генетически детерминированных патологий с детально изученным патогенезом и эффективным способом лечения. Согласно современным эпидемиологическим данным частота целиакии в мире в среднем составляет 1%, при этом большинство случаев заболевания остаются нераспознанными. С учетом полиморфизма клинических проявлений программа выборочного скрининга на целиакию среди пациентов, имеющих определенные настораживающие симптомы, оправдала себя лишь частично. Большинство экспертов указывают на необходимость проведения универсального массового скрининга для эффективного выявления малосимптомных форм целиакии и своевременного начала диетотерапии во избежание грозных осложнений заболевания.

Ключевые слова: целиакия, история, антитела, эндоскопия, эпидемиология, скрининг

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Celiac disease is one of the oldest human diseases, dating back to the Neolithic Era with the advent of the farming culture. In over 10,000 years, celiac disease has evolved from an unknown and frightening "sickness of the coeliac" to one of the most common genetically determined conditions with a thoroughly understood pathogenesis and effective treatment. Current epidemiological data suggest that the global prevalence of celiac disease averages 1%, with most cases unrecognized. Given the diversity of clinical manifestations, a selective screening program for celiac disease among patients with some suspicious symptoms proved its value only partially. Most experts point to the need for universal screening to effectively detect asymptomatic forms of celiac disease and early initiation of nutritional therapy to avoid serious complications.

Keywords: celiac disease, history, antibodies, endoscopy, epidemiology, screening

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Список литературы

1. Catassi C. Editorial: Celiac disease in Turkey: lessons from the fertile crescent. Am J Gastroenterol. 2011;106(8):1518-20. DOI:10.1038/ajg.2011.188
2. Dowd B, Walker-Smith J. Samuel Gee, Aretaeus, and the coeliac affection. Br Med J. 1974;2(5909):45-7. DOI:10.1136/bmj.2.5909.45
3. Cluysenaer OJJ, van Tongeren JHM. Malabsorption in coeliac sprue. The Hague; Martinus Nijhoff Medical Division, 1977; p. 1-4. DOI:10.1007/978-94-010-1093-1
4. Gee S. On the coeliac affection. St Bartholomew’s Hospital Report. 1888;24:17-20.
5. Gibbons RA. The Celiac Affection in Children. Edinburgh Med J. 1889;XXXV.-NO.IV:321-30.
6. Cheadle WB. A Clinical Lecture ON ACHOLIA. The Lancet. 1903;161(4161):1497‑500. DOI:10.1016/S0140-6736(01)70414-X
7. Herter CA. Infantilism from chronic intestinal infection. New York: Macmillan 1908; p. 119.
8. Haas SV. The value of the banana in the treatment of celiac disease. Am J Dis Child. 1924;28(4):421-37. DOI:10.1001/archpedi.1924.0412022001700
9. Dicke WK. Coeliakie. Een onderzoek naar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. MD Thesis. Utrecht, 1950.
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11. Paulley JW. Observation on the aetiology of idiopathic steatorrhoea; jejunal and lymph-node biopsies. Br Med J. 1954;2(4900):1318-21. DOI:10.1136/bmj.2.4900.1318
12. Crosby WH, Kugler HW. Intraluminal biopsy of the small intestine; the intestinal biopsy capsule. Am J Dig Dis. 1957;2(5):236-41. DOI:10.1007/BF02231100
13. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3(7):797-801.
DOI:10.1038/nm0797-797
14. Davidson LS, Fountain JR. Incidence of the sprue syndrome; with some observations on the natural history. Br Med J. 1950;1(4663):1157-61. DOI:10.1136/bmj.1.4663.1157
15. Logan RF, Rifkind EA, Busuttil A, et al. Prevalence and "incidence" of celiac disease in Edinburgh and the Lothian region of Scotland. Gastroenterology. 1986;90(2):334-42. DOI:10.1016/0016-5085(86)90929-7
16. Mylotte M, Egan-Mitchell B, McCarthy CF, et al. Incidence of coeliac disease in the West of Ireland. Br Med J. 1973;1(5855):703-5. DOI:10.1136/bmj.1.5855.703
17. van Stirum J, Baerlocher K, Fanconi A, et al. The incidence of coeliac disease in children in Switzerland. Helv Paediatr Acta. 1982;37(5):421-30.
18. Greco L, Maki M, Di Donato F, et al. Epidemiology of Coeliac Disease in Europe and the Mediterranean Area. A Summary Report on the Multicentre Study by the European Society of Pediatric Gastroenterology and Nutrition. In: Auricchio S, Visakorpi JK (eds.) Common Food Intolerances. 1. Epidemiology of Coeliac Disease. Dynamic Nutrition Research, Karger, Basel, Switzerland, 1992; pp. 25-44.
19. Mustalahti K, Catassi C, Reunanen A, et al; Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med. 2010;42(8):587-95. DOI:10.3109/07853890.2010.505931
20. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42(7):530-8. DOI:10.3109/07853890.2010.514285
21. Burger JP, Roovers EA, Drenth JP, et al. Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010. Scand J Gastroenterol. 2014;49(8):933-41. DOI:10.3109/00365521.2014.915054
22. White LE, Merrick VM, Bannerman E, et al. The rising incidence of celiac disease in Scotland. Pediatrics. 2013;132(4):e924-31. DOI:10.1542/peds.2013-0932
23. Catassi C, Gatti S, Fasano A. The new epidemiology of celiac disease. J Pediatr Gastroenterol Nutr. 2014;59(Suppl. 1):S7-9. DOI:10.1097/01.mpg.0000450393.23156.59
24. Burger JP, Roovers EA, Drenth JP, et al. Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010. Scand J Gastroenterol. 2014;49(8):933-41. DOI:10.3109/00365521.2014.915054
25. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018;16(6):823-36.e2. DOI:10.1016/j.cgh.2017.06.037
26. Logan RF A. Problems and pitfalls in epidemiological studies of coeliac disease. In: Auricchio S, Visakorpi JK (eds.) Common Food Intolerances 1: Epidemiology of Coeliac Disease (Dynamic Nutrition Research) (Pt. 1). Karger, Basel, Swizerland, 1992; pp. 14-24.
27. Catassi C, Rätsch IM, Fabiani E, et al. Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994;343(8891):200-3. DOI:10.1016/s0140-6736(94)90989-x
28. Захарова И.Н., Дмитриева Ю.А., Дзебисова Ф.С. Целиакия и ассоциированные заболевания. Российский вестник перинатологии и педиатрии. 2014;59(3):44-9 [Zakharova IN, Dmitrieva IuA, Dzebisova FS. Tseliakiia i assotsiirovannye zabolevaniia. Rossiiskii vestnik perinatologii i pediatrii. 2014;59(3):44-9 (in Russian)].
29. Fasano A. Should we screen for coeliac disease? Yes. BMJ. 2009;339:b3592. DOI:10.1136/bmj.b3592
30. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102(7):1454-60. DOI:10.1111/j.1572-0241.2007.01173.x
31. Berti I, Della Vedova R, Paduano R, et al. Coeliac disease in primary care: evaluation of a case-finding strategy. Dig Liver Dis. 2006;38(7):461-7. DOI:10.1016/j.dld.2005.12.007
32. Rosén A, Sandström O, Carlsson A, et al. Usefulness of symptoms to screen for celiac disease. Pediatrics. 2014;133(2):211-8. DOI:10.1542/peds.2012-3765
33. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137(1):88-93. DOI:10.1053/j.gastro.2009.03.059
34. Kondrashova A, Mustalahti K, Kaukinen K, et al. Lower economic status and inferior hygienic environment may protect against celiac disease. Ann Med. 2008;40(3):223-31. DOI:10.1080/07853890701678689
35. Savvateeva LV, Erdes SI, Antishin AS, et al. Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence. J Immunol Res. 2017;2017:2314813. DOI:10.1155/2017/2314813

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1. Catassi C. Editorial: Celiac disease in Turkey: lessons from the fertile crescent. Am J Gastroenterol. 2011;106(8):1518-20. DOI:10.1038/ajg.2011.188
2. Dowd B, Walker-Smith J. Samuel Gee, Aretaeus, and the coeliac affection. Br Med J. 1974;2(5909):45-7. DOI:10.1136/bmj.2.5909.45
3. Cluysenaer OJJ, van Tongeren JHM. Malabsorption in coeliac sprue. The Hague; Martinus Nijhoff Medical Division, 1977; p. 1-4. DOI:10.1007/978-94-010-1093-1
4. Gee S. On the coeliac affection. St Bartholomew’s Hospital Report. 1888;24:17-20.
5. Gibbons RA. The Celiac Affection in Children. Edinburgh Med J. 1889;XXXV.-NO.IV:321-30.
6. Cheadle WB. A Clinical Lecture ON ACHOLIA. The Lancet. 1903;161(4161):1497‑500. DOI:10.1016/S0140-6736(01)70414-X
7. Herter CA. Infantilism from chronic intestinal infection. New York: Macmillan 1908; p. 119.
8. Haas SV. The value of the banana in the treatment of celiac disease. Am J Dis Child. 1924;28(4):421-37. DOI:10.1001/archpedi.1924.0412022001700
9. Dicke WK. Coeliakie. Een onderzoek naar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. MD Thesis. Utrecht, 1950.
10. Van de Kamer JH, Weijers HA, Dicke WK. Coeliac disease. IV. An investigation into the injurious constituents of wheat in connection with their action on patients with coeliac disease. Acta Paediatr (Stockh). 1953;42(3):223-31. DOI:10.1111/j.1651-2227.1953.tb05586.x
11. Paulley JW. Observation on the aetiology of idiopathic steatorrhoea; jejunal and lymph-node biopsies. Br Med J. 1954;2(4900):1318-21. DOI:10.1136/bmj.2.4900.1318
12. Crosby WH, Kugler HW. Intraluminal biopsy of the small intestine; the intestinal biopsy capsule. Am J Dig Dis. 1957;2(5):236-41. DOI:10.1007/BF02231100
13. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997;3(7):797-801.
DOI:10.1038/nm0797-797
14. Davidson LS, Fountain JR. Incidence of the sprue syndrome; with some observations on the natural history. Br Med J. 1950;1(4663):1157-61. DOI:10.1136/bmj.1.4663.1157
15. Logan RF, Rifkind EA, Busuttil A, et al. Prevalence and "incidence" of celiac disease in Edinburgh and the Lothian region of Scotland. Gastroenterology. 1986;90(2):334-42. DOI:10.1016/0016-5085(86)90929-7
16. Mylotte M, Egan-Mitchell B, McCarthy CF, et al. Incidence of coeliac disease in the West of Ireland. Br Med J. 1973;1(5855):703-5. DOI:10.1136/bmj.1.5855.703
17. van Stirum J, Baerlocher K, Fanconi A, et al. The incidence of coeliac disease in children in Switzerland. Helv Paediatr Acta. 1982;37(5):421-30.
18. Greco L, Maki M, Di Donato F, et al. Epidemiology of Coeliac Disease in Europe and the Mediterranean Area. A Summary Report on the Multicentre Study by the European Society of Pediatric Gastroenterology and Nutrition. In: Auricchio S, Visakorpi JK (eds.) Common Food Intolerances. 1. Epidemiology of Coeliac Disease. Dynamic Nutrition Research, Karger, Basel, Switzerland, 1992; pp. 25-44.
19. Mustalahti K, Catassi C, Reunanen A, et al; Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med. 2010;42(8):587-95. DOI:10.3109/07853890.2010.505931
20. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010;42(7):530-8. DOI:10.3109/07853890.2010.514285
21. Burger JP, Roovers EA, Drenth JP, et al. Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010. Scand J Gastroenterol. 2014;49(8):933-41. DOI:10.3109/00365521.2014.915054
22. White LE, Merrick VM, Bannerman E, et al. The rising incidence of celiac disease in Scotland. Pediatrics. 2013;132(4):e924-31. DOI:10.1542/peds.2013-0932
23. Catassi C, Gatti S, Fasano A. The new epidemiology of celiac disease. J Pediatr Gastroenterol Nutr. 2014;59(Suppl. 1):S7-9. DOI:10.1097/01.mpg.0000450393.23156.59
24. Burger JP, Roovers EA, Drenth JP, et al. Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010. Scand J Gastroenterol. 2014;49(8):933-41. DOI:10.3109/00365521.2014.915054
25. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018;16(6):823-36.e2. DOI:10.1016/j.cgh.2017.06.037
26. Logan RF A. Problems and pitfalls in epidemiological studies of coeliac disease. In: Auricchio S, Visakorpi JK (eds.) Common Food Intolerances 1: Epidemiology of Coeliac Disease (Dynamic Nutrition Research) (Pt. 1). Karger, Basel, Swizerland, 1992; pp. 14-24.
27. Catassi C, Rätsch IM, Fabiani E, et al. Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994;343(8891):200-3. DOI:10.1016/s0140-6736(94)90989-x
28. Zakharova IN, Dmitrieva IuA, Dzebisova FS. Tseliakiia i assotsiirovannye zabolevaniia. Rossiiskii vestnik perinatologii i pediatrii. 2014;59(3):44-9 (in Russian).
29. Fasano A. Should we screen for coeliac disease? Yes. BMJ. 2009;339:b3592. DOI:10.1136/bmj.b3592
30. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 2007;102(7):1454-60. DOI:10.1111/j.1572-0241.2007.01173.x
31. Berti I, Della Vedova R, Paduano R, et al. Coeliac disease in primary care: evaluation of a case-finding strategy. Dig Liver Dis. 2006;38(7):461-7. DOI:10.1016/j.dld.2005.12.007
32. Rosén A, Sandström O, Carlsson A, et al. Usefulness of symptoms to screen for celiac disease. Pediatrics. 2014;133(2):211-8. DOI:10.1542/peds.2012-3765
33. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137(1):88-93. DOI:10.1053/j.gastro.2009.03.059
34. Kondrashova A, Mustalahti K, Kaukinen K, et al. Lower economic status and inferior hygienic environment may protect against celiac disease. Ann Med. 2008;40(3):223-31. DOI:10.1080/07853890701678689
35. Savvateeva LV, Erdes SI, Antishin AS, et al. Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence. J Immunol Res. 2017;2017:2314813. DOI:10.1155/2017/2314813

Авторы

Ю.А. Дмитриева*1,2, И.Н. Захарова1, И.М. Османов2, И.Д. Майкова2, А.Д. Гостюхина1, Е.Р. Радченко2, Н.Ф. Дубовец2, Л.С. Абдурахманова3

1 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования», Москва, Россия;
2 ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы, Москва, Россия;
3 ФГБУ «Детский медицинский центр» Управления делами Президента РФ, Москва, Россия
*jadmitrieva@mail.ru

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Yulia A. Dmitrieva*1,2, Irina N. Zakharova1, Ismail M. Osmanov2, Irina D. Maikova2, Anastasia D. Gostyukhina1, Elena R. Radchenko2, Nataliia F. Dubovets2, Lala S. Abdurakhmanova3

1 Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
2 Bashlyaeva Children's City Clinical Hospital, Moscow, Russia;
3 Children's Medical Center, Moscow, Russia
*jadmitrieva@mail.ru

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