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Антибиотик-ассоциированный дисбиоз: современная стратегия восстановления микробиоты
Антибиотик-ассоциированный дисбиоз: современная стратегия восстановления микробиоты
Дзотцоева Э.С., Горелов А.В., Хабибулина Л.Р. Антибиотик-ассоциированный дисбиоз: современная стратегия восстановления микробиоты. Педиатрия. Consilium Medicum. 2024;4:386–395. DOI: 10.26442/26586630.2024.4.203021
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
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Аннотация
Антибиотик-ассоциированный дисбиоз – это нарушение кишечной микробиоты, вызванное применением антибиотиков, что может способствовать развитию антибиотик-ассоциированной диареи и других осложнений. Нарушение ранее стабильной, функционально полноценной микробиоты может привести к неблагоприятным последствиям для здоровья как в краткосрочной, так и в долгосрочной перспективе с потенциальным увеличением риска возникновения различных неинфекционных заболеваний, а также неврологических, поведенческих и психологических расстройств. Современные стратегии восстановления микробиоты включают применение специфических пробиотиков, таких как Saccharomyces boulardii CNCM I-745 и Lactobacillus rhamnosus GG. Систематические обзоры и метаанализы клинических исследований подтверждают штамм-специфическую эффективность данных пробиотиков при лечении и профилактике антибиотик-ассоциированной диареи как у детей, так и у взрослых, а также демонстрируют, что своевременное назначение пробиотика в адекватной дозе (с 1-го дня антибактериальной терапии) может помочь предотвратить или устранить последствия антибиотик-ассоциированного дисбиоза и способствовать сохранению устойчивости кишечной микробиоты, возвращая ее в состояние, предшествовавшее применению антибиотиков.
Ключевые слова: антибиотик-ассоциированный дисбиоз, антибиотик-ассоциированная диарея, микробиота, восстановление микробиоты, пробиотики, Saccharomyces boulardii CNCM I-745
Keywords: antibiotic-associated dysbiosis, antibiotic-associated diarrhea, microbiota, restoring of microbiota, probiotics, Saccharomyces boulardii CNCM I-745
Ключевые слова: антибиотик-ассоциированный дисбиоз, антибиотик-ассоциированная диарея, микробиота, восстановление микробиоты, пробиотики, Saccharomyces boulardii CNCM I-745
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Keywords: antibiotic-associated dysbiosis, antibiotic-associated diarrhea, microbiota, restoring of microbiota, probiotics, Saccharomyces boulardii CNCM I-745
Полный текст
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3. Waitzberg D, Guarner F, Hojsak I, et al. Сan the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis? Adv Ther. 2024;41(3):901-14. DOI:10.1007/s12325-024-02783-3
4. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480-4. DOI:10.1038/nature07540
5. Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-80. DOI:10.1038/nature09944
6. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207-14. DOI:10.1038/nature11234
7. Ottman N, Smidt H, de Vos WM, Belzer C. The function of our microbiota: who is out there and what do they do? Front Cell Infect Microbiol. 2012;2:104. DOI:10.3389/fcimb.2012.00104
8. Damiani F, Cornuti S, Tognini P. The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders. Neuropharmacology. 2023;231:109491. DOI:10.1016/j.neuropharm.2023.109491
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10. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9(5):313-23. DOI:10.1038/nri2515
11. Weber C, Dilthey A, Finzer P. The role of microbiome-host interactions in the development of Alzheimer´s disease. Front Cell Infect Microbiol. 2023;13:1151021. DOI:10.3389/fcimb.2023.1151021
12. Zhao M, Chu J, Feng S, et al. Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review. Biomed Pharmacother. 2023;164:114985. DOI:10.1016/j.biopha.2023.114985
13. Feng Y, Huang Y, Wang Y, et al. Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy. PLoS One. 2019;14(6):e0218384. DOI:10.1371/journal.pone.0218384
14. Scott NA, Andrusaite A, Andersen P, et al. Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Sci Transl Med. 2018;10(464). DOI:10.1126/scitranslmed.aao4755
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Авторы
Э.С. Дзотцоева*1,2, А.В. Горелов1,3,4, Л.Р. Хабибулина5
1ФБУН «Центральный научно-исследовательский институт эпидемиологии» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, Москва, Россия;
2ГБУЗ МО «Химкинская клиническая больница», Химки, Россия;
3ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
4ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
5Biocodex Россия, Москва, Россия
*sidelnikovaes@gmail.com
1Central Research Institute of Epidemiology, Moscow, Russia;
2Khimki Clinical Hospital, Khimki, Russia;
3Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
4Russian University of Medicine, Moscow, Russia;
5Biocodex Russia, Moscow, Russia
*sidelnikovaes@gmail.com
1ФБУН «Центральный научно-исследовательский институт эпидемиологии» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, Москва, Россия;
2ГБУЗ МО «Химкинская клиническая больница», Химки, Россия;
3ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
4ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
5Biocodex Россия, Москва, Россия
*sidelnikovaes@gmail.com
________________________________________________
1Central Research Institute of Epidemiology, Moscow, Russia;
2Khimki Clinical Hospital, Khimki, Russia;
3Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
4Russian University of Medicine, Moscow, Russia;
5Biocodex Russia, Moscow, Russia
*sidelnikovaes@gmail.com
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