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Питание и сон ребенка первого года жизни: это нужно знать детскому врачу
Питание и сон ребенка первого года жизни: это нужно знать детскому врачу
Захарова И.Н., Бережная И.В., Оробинская Я.В., Пупыкина В.В., Чурилова В.Д. Питание и сон ребенка первого года жизни: это нужно знать детскому врачу. Педиатрия. Consilium Medicum. 2025;(4):318–326. DOI: 10.26442/26586630.2025.4.203503
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Аннотация
Сон регулируется циркадными ритмами, гомеостатическими процессами и имеет колоссальное значение для здоровья и развития ребенка. Недостаток сна коррелирует с поведенческими проблемами, трудностями в обучении и повышенным риском развития различных заболеваний. Функциональные нарушения, в частности младенческие колики, часто сопровождают нарушения сна у грудных детей, что требует комплексного подхода к коррекции. Онтогенез сна тесно связан с морфофункциональными изменениями головного мозга, при этом сон играет критическую роль в формировании нейронных сетей, консолидации памяти и регуляции синаптической плотности. Формирование циркадных ритмов представляет собой сложный процесс, начинающийся во внутриутробный период. Экзогенные факторы, такие как нарушения сна у беременной и особенности питания, могут десинхронизировать циркадные ритмы ребенка, что имеет неблагоприятные последствия для его здоровья. Факторами, влияющими на становление циркадных ритмов после рождения, являются свет, хрононутриенты грудного молока (ГМ) и микробиота кишечника. ГМ – «золотой стандарт» питания, обеспечивающий иммунную защиту и нормальный нейрогенез. В статье рассматривается роль триптофана, нуклеотидов, жирных кислот и мелатонина, содержащихся в ГМ, в формировании здорового сна. Анализируется роль адаптированных молочных смесей в случаях, когда грудное вскармливание невозможно, а также подчеркивается важность выбора смесей, содержащих пребиотики для улучшения пищеварения и сна младенцев.
Ключевые слова: сон, младенческие колики, хрононутриент, хронопитание, циркадный ритм, нарушение сна, мелатонин, микробиота кишечника
Keywords: sleep, infantile colic, chrononutrient, chrononutrition, circadian rhythm, sleep disturbance, melatonin, intestinal microbiota
Ключевые слова: сон, младенческие колики, хрононутриент, хронопитание, циркадный ритм, нарушение сна, мелатонин, микробиота кишечника
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Keywords: sleep, infantile colic, chrononutrient, chrononutrition, circadian rhythm, sleep disturbance, melatonin, intestinal microbiota
Полный текст
Список литературы
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4. Pulido-Arjona L, Correa-Bautista JE, Agostinis-Sobrinho C, et al. Role of sleep duration and sleep-related problems in the metabolic syndrome among children and adolescents. Ital J Pediatr. 2018;44(1):9. DOI:10.1186/s13052-018-0451-7
5. Hysing M, Harvey AG, Torgersen L, et al. Trajectories and predictors of nocturnal awakenings and sleep duration in infants. J Dev Behav Pediatr. 2014;35(5):309-16. DOI:10.1097/DBP.0000000000000064
6. Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended Amount of Sleep for Pediatric Populations: A Consensus Statement of the American Academy of Sleep Medicine. J Clin Sleep Med. 2016;12(6):785-6. DOI:10.5664/jcsm.5866
7. Mindell J, Owens J. A clinical guide to pediatric sleep. Diagnosis and management of sleep problems. Philadelphia: Lippincott Williams & Wilkins, 2005. 232 p.
8. Goodlin-Jones BL, Burnham MM, Gaylor EE, Anders TF. Night waking, sleep-wake organization, and self-soothing in the first year of life. J Dev Behav Pediatr. 2001;22(4):226-33. DOI:10.1097/00004703-200108000-00003
9. St James-Roberts I, Peachey E. Distinguishing infant prolonged crying from sleep-waking problems. Arch Dis Child. 2011;96(4):340-4. DOI:10.1136/adc.2010.200204
10. Wolke D, Bilgin A, Samara M. Systematic Review and Meta-Analysis: Fussing and Crying Durations and Prevalence of Colic in Infants. J Pediatr. 2017;185:55-61.e4. DOI:10.1016/j.jpeds.2017.02.020
11. Hemmi MH, Wolke D, Schneider S. Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a meta-analysis. Arch Dis Child. 2011;96(7):622-9. DOI:10.1136/adc.2010.191312
12. Chaput JP, Gray CE, Poitras VJ, et al. Systematic review of the relationships between sleep duration and health indicators in the early years (0-4 years). BMC Public Health. 2017;17(Suppl. 5):855. DOI:10.1186/s12889-017-4850-2
13. Hysing M, Sivertsen B, Garthus-Niegel S, Eberhard-Gran M. Pediatric sleep problems and social-emotional problems. A population-based study. Infant Behav Dev. 2016;42:111-8. DOI:10.1016/j.infbeh.2015.12.005
14. Sivertsen B, Harvey AG, Reichborn-Kjennerud T, et al. Later emotional and behavioral problems associated with sleep problems in toddlers: a longitudinal study. JAMA Pediatr. 2015;169(6):575-82. DOI:10.1001/jamapediatrics.2015.0187
15. Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. JPGN. 2015;61(5):531-7. DOI:10.1097/MPG.0000000000000949
16. Vandenplas Y, Hauser B, Salvatore S. Functional gastrointestinal disorders in infancy: impact on infants and family health. Pediatrics. Consilium Medicum. 2020;1:36-41 (in Russian). DOI:10.26442/26586630.2020.1.190721
17. Weissbluth M. Sleep and the colicky infant. In: Guilleminault C. Sleep and its disorders in children. New York: Raven Press, 1987.
18. Kirjavainen J, Kirjavainen T, Huhtala V, et al. Infants with colic have a normal sleep structure at 2 and 7 months of age. J Pediatr. 2001;138(2):218-23. DOI:10.1067/mpd.2001.110326
19. Orr WC, Fass R, Sundaram SS, Scheimann AO. The effect of sleep on gastrointestinal functioning in common digestive diseases. Lancet Gastroenterol Hepatol. 2020;5(6):616-24. DOI:10.1016/S2468-1253(19)30412-1
20. Mutti C, Misirocchi F, Zilioli A, et al. Sleep and brain evolution across the human lifespan: A mutual embrace. Front Netw Physiol. 2022;2:938012. DOI:10.3389/fnetp.2022.938012
21. Frank MG. The Ontogenesis of Mammalian Sleep: Form and Function. Curr Sleep Med Rep. 2020;6(4):267-79. DOI:10.1007/s40675-020-00190-y
22. Kelmanson IA. Child sleep ontogeny and application of the standardized questionnaire for the evaluation of child behaviour during sleep. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(3):37-52 (in Russian). DOI:10.21508/1027-4065-2017-62-3-37-52
23. Serón-Ferré M, Mendez N, Abarzua-Catalan L, et al. Circadian rhythms in the fetus. Mol Cell Endocrinol. 2012;349(1):68-75. DOI:10.1016/j.mce.2011.07.039
24. Bates K, Herzog ED. Maternal-Fetal Circadian Communication During Pregnancy. Front Endocrinol (Lausanne). 2020;11:198. DOI:10.3389/fendo.2020.00198
25. Loy SL, Loo RSX, Godfrey KM, et al. Chrononutrition during Pregnancy: A Review on Maternal Night-Time Eating. Nutrients. 2020;12(9):2783. DOI:10.3390/nu12092783
26. Varcoe TJ, Boden MJ, Voultsios A, et al. Characterisation of the maternal response to chronic phase shifts during gestation in the rat: implications for fetal metabolic programming. PLoS One. 2013;8(1):e53800. DOI:10.1371/journal.pone.0053800
27. Korte J, Wulff K, Oppe C, Siegmund R. Ultradian and circadian activity-rest rhythms of preterm neonates compared to full-term neonates using actigraphic monitoring. Chronobiol Int. 2001;18(4):697-708. DOI:10.1081/cbi-100106082
28. Hirshkowitz M, Whiton K, Albert SM, et al. National Sleep Foundation's updated sleep duration recommendations: final report. Sleep Health. 2015;1(4):233-43. DOI:10.1016/j.sleh.2015.10.004
29. Miike T. Appropriate Lifelong Circadian Rhythms Are Established During Infancy: A Narrative Review. Clocks Sleep. 2025;7(3):41. DOI:10.3390/clockssleep7030041
30. Miike T, Toyoura M, Tonooka S, et al. Neonatal irritable sleep-wake rhythm as a predictor of autism spectrum disorders. Neurobiol Sleep Circadian Rhythms. 2020;9:100053. DOI:10.1016/j.nbscr.2020.100053
31. Ohta H, Mitchell AC, McMahon DG. Constant light disrupts the developing mouse biological clock. Pediatr Res. 2006;60(3):304-8. DOI:10.1203/01.pdr.0000233114.18403.66
32. Ohta H, Yamazaki S, McMahon DG. Constant light desynchronizes mammalian clock neurons. Nat Neurosci. 2005;8(3):267-9. DOI:10.1038/nn1395
33. Rivkees SA, Mayes L, Jacobs H, Gross I. Rest-activity patterns of premature infants are regulated by cycled lighting. Pediatrics. 2004;113(4):833-9. DOI:10.1542/peds.113.4.833
34. Vásquez-Ruiz S, Maya-Barrios JA, Torres-Narváez P, et al. A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants. Early Hum Dev. 2014;90(9):535-40. DOI:10.1016/j.earlhumdev.2014.04.015
35. Guerrero-Vargas NN, Espitia-Bautista E, Buijs RM, Escobar C. Shift-work: is time of eating determining metabolic health? Evidence from animal models. Proc Nutr Soc. 2018;77(3):199-215. DOI:10.1017/S0029665117004128
36. Reiter RJ, Tan DX, Korkmaz A, Rosales-Corral SA. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum Reprod Update. 2014;20(2):293-307. DOI:10.1093/humupd/dmt054
37. Cubero J, Narciso D, Terrón P, et al. Chrononutrition applied to formula milks to consolidate infants' sleep/wake cycle. Neuro Endocrinol Lett. 2007;28(4):360-6.
38. Pundir S, Wall CR, Mitchell CJ, et al. Variation of Human Milk Glucocorticoids over 24 hour Period. J Mammary Gland Biol Neoplasia. 2017;22(1):85-92. DOI:10.1007/s10911-017-9375-x
39. Sánchez CL, Cubero J, Sánchez J, et al. Evolution of the circadian profile of human milk amino acids during breastfeeding. J Appl Biomed. 2013;11(2):59-70. DOI:10.2478/v10136-012-0020-0
40. França EL, Nicomedes TdR, Calderon IdMP, França ACH. Time-dependent alterations of soluble and cellular components in human milk. Biological Rhythm Research. 2010;41(5):333-47. DOI:10.1080/09291010903407441
41. Cannon AM, Kakulas F, Hepworth AR, et al. The Effects of Leptin on Breastfeeding Behaviour. Int J Environ Res Public Health. 2015;12(10):12340-55. DOI:10.3390/ijerph121012340
42. Illnerová H, Buresová M, Presl J. Melatonin rhythm in human milk. J Clin Endocrinol Metab. 1993;77(3):838-41. DOI:10.1210/jcem.77.3.8370707
43. Lodemore MR, Petersen SA, Wailoo MP. Factors affecting the development of night time temperature rhythms. Arch Dis Child. 1992;67(10):1259-61. DOI:10.1136/adc.67.10.1259
44. Lee H, Park H, Ha E, et al. Effect of Breastfeeding Duration on Cognitive Development in Infants: 3-Year Follow-up Study. J Korean Med Sci. 2016;31(4):579-84. DOI:10.3346/jkms.2016.31.4.579
45. Fitri SYR, Lusmilasari L, Juffrie M, Rakhmawati W. Pain in Neonates: A Concept Analysis. Anesth Pain Med. 2019;9(4):e92455. DOI:10.5812/aapm.92455
46. Moberg KU, Handlin L, Petersson M. Neuroendocrine mechanisms involved in the physiological effects caused by skin-to-skin contact – With a particular focus on the oxytocinergic system. Infant Behav Dev. 2020;61:101482. DOI:10.1016/j.infbeh.2020.101482
47. Schneider N, Mutungi G, Cubero J. Diet and nutrients in the modulation of infant sleep: A review of the literature. Nutr Neurosci. 2018;21(3):151-61. DOI:10.1080/1028415X.2016.1258446
48. Häusler S, Lanzinger E, Sams E, et al. Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition? Nutrients. 2024;16(10):1422. DOI:10.3390/nu16101422
49. Booker LA, Spong J, Deacon-Crouch M, Skinner TC. Preliminary Exploration into the Impact of Mistimed Expressed Breast Milk Feeding on Infant Sleep Outcomes, Compared to Other Feeding Patterns. Breastfeed Med. 2022;17(10):853-8. DOI:10.1089/bfm.2022.0125
50. Cubero J, Valero V, Sánchez J, et al. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett. 2005;26(6):657-61.
51. Abdul Jafar NK, Tham EKH, Pang WW, et al. Association between breastfeeding and sleep patterns in infants and preschool children. Am J Clin Nutr. 2021;114(6):1986-96. DOI:10.1093/ajcn/nqab297
52. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020;53:101340. DOI:10.1016/j.smrv.2020.101340
53. Xu D, Wan F. Breastfeeding and infant gut microbiota: influence of bioactive components. Gut Microbes. 2025;17(1):2446403. DOI:10.1080/19490976.2024.2446403
54. Lawson MAE, O'Neill IJ, Kujawska M, et al. Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem. ISME J. 2020;14(2):635-48. DOI:10.1038/s41396-019-0553-2
55. Le Doare K, Holder B, Bassett A, Pannaraj PS. Mother's Milk: A Purposeful Contribution to the Development of the Infant Microbiota and Immunity. Front Immunol. 2018;9:361. DOI:10.3389/fimmu.2018.00361
56. Savino F, Palumeri E, Castagno E, et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr. 2006;60(11):1304-10. DOI:10.1038/sj.ejcn.1602457
57. Carosella M. Nutritional management of functional gastrointestinal disorders in infants: Quality of life evaluation. Poster presented at the 57th annual meeting of the ESPGHAN. Helsinki, Finland. 2025
58. Mihatsch WA, Franz AR, Kuhnt B, et al. Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats. Biol Neonate. 2005;87(3):160-3. DOI:10.1159/000082367
59. Yao M, Lien EL, Capeding MR, et al. Effects of term infant formulas containing high sn-2 palmitate with and without oligofructose on stool composition, stool characteristics, and bifidogenicity. J Pediatr Gastroenterol Nutr. 2014;59(4):440-8. DOI:10.1097/MPG.0000000000000443
60. Yaron S, Shachar D, Abramas L, et al. Effect of high β-palmitate content in infant formula on the intestinal microbiota of term infants. J Pediatr Gastroenterol Nutr. 2013;56(4):376-81. DOI:10.1097/MPG.0b013e31827e1ee
61. Haiden N, Savino F, Hill S, et al. Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee. J Pediatr Gastroenterol Nutr. 2024; 79(1):168-80. DOI:10.1002/jpn3.12240
62. Bronsky J, Campoy С, Embleton N, et al. Palm oil and beta-palmitate in infant formula - A position paper by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2019;68(5):742-60. DOI:10.1097/MPG.0000000000002307
63. Knol J, Scholtens P, Kafka C, et al. Colon Microflora in Infants Fed Formula with Galacto- and Fructo-Oligosaccharides: More Like Breast-Fed Infants. J Pediatr Gastroenterol Nutr. 2005;40(1):36-42. DOI:10.1097/00005176-200501000-00007
64. Moro G, Minoli I, Mosca M, et al. Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants. J Pediatr Gastroenterol Nutr. 2002;34(3):291-5. DOI:10.1097/00005176-200203000-00014
65. Scholtens P, Alliet P, Raes M, et al. Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides. J Nutr. 2008;138:1141-7. DOI:10.1093/jn/138.6.1141
2. Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, et al. Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol. 2017;45(2):337-44. DOI:10.1007/s10802-016-0166-4
3. Staples AD, Bates JE, Petersen IT, et al. Measuring sleep in young children and their mothers: Identifying actigraphic sleep composites. Int J Behav Dev. 2019;43(3):278-85. DOI:10.1177/0165025419830236
4. Pulido-Arjona L, Correa-Bautista JE, Agostinis-Sobrinho C, et al. Role of sleep duration and sleep-related problems in the metabolic syndrome among children and adolescents. Ital J Pediatr. 2018;44(1):9. DOI:10.1186/s13052-018-0451-7
5. Hysing M, Harvey AG, Torgersen L, et al. Trajectories and predictors of nocturnal awakenings and sleep duration in infants. J Dev Behav Pediatr. 2014;35(5):309-16. DOI:10.1097/DBP.0000000000000064
6. Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended Amount of Sleep for Pediatric Populations: A Consensus Statement of the American Academy of Sleep Medicine. J Clin Sleep Med. 2016;12(6):785-6. DOI:10.5664/jcsm.5866
7. Mindell J, Owens J. A clinical guide to pediatric sleep. Diagnosis and management of sleep problems. Philadelphia: Lippincott Williams & Wilkins, 2005. 232 p.
8. Goodlin-Jones BL, Burnham MM, Gaylor EE, Anders TF. Night waking, sleep-wake organization, and self-soothing in the first year of life. J Dev Behav Pediatr. 2001;22(4):226-33. DOI:10.1097/00004703-200108000-00003
9. St James-Roberts I, Peachey E. Distinguishing infant prolonged crying from sleep-waking problems. Arch Dis Child. 2011;96(4):340-4. DOI:10.1136/adc.2010.200204
10. Wolke D, Bilgin A, Samara M. Systematic Review and Meta-Analysis: Fussing and Crying Durations and Prevalence of Colic in Infants. J Pediatr. 2017;185:55-61.e4. DOI:10.1016/j.jpeds.2017.02.020
11. Hemmi MH, Wolke D, Schneider S. Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a meta-analysis. Arch Dis Child. 2011;96(7):622-9. DOI:10.1136/adc.2010.191312
12. Chaput JP, Gray CE, Poitras VJ, et al. Systematic review of the relationships between sleep duration and health indicators in the early years (0-4 years). BMC Public Health. 2017;17(Suppl. 5):855. DOI:10.1186/s12889-017-4850-2
13. Hysing M, Sivertsen B, Garthus-Niegel S, Eberhard-Gran M. Pediatric sleep problems and social-emotional problems. A population-based study. Infant Behav Dev. 2016;42:111-8. DOI:10.1016/j.infbeh.2015.12.005
14. Sivertsen B, Harvey AG, Reichborn-Kjennerud T, et al. Later emotional and behavioral problems associated with sleep problems in toddlers: a longitudinal study. JAMA Pediatr. 2015;169(6):575-82. DOI:10.1001/jamapediatrics.2015.0187
15. Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. JPGN. 2015;61(5):531-7. DOI:10.1097/MPG.0000000000000949
16. Vandenplas Y, Hauser B, Salvatore S. Функциональные гастроинтестинальные расстройства: влияние на здоровье ребенка и семьи. Педиатрия. Consilium Medicum. 2020;1:36-41 [Vandenplas Y, Hauser B, Salvatore S. Functional gastrointestinal disorders in infancy: impact on infants and family health. Pediatrics. Consilium Medicum. 2020;1:36-41 (in Russian)]. DOI:10.26442/26586630.2020.1.190721
17. Weissbluth M. Sleep and the colicky infant. In: Guilleminault C. Sleep and its disorders in children. New York: Raven Press, 1987.
18. Kirjavainen J, Kirjavainen T, Huhtala V, et al. Infants with colic have a normal sleep structure at 2 and 7 months of age. J Pediatr. 2001;138(2):218-23. DOI:10.1067/mpd.2001.110326
19. Orr WC, Fass R, Sundaram SS, Scheimann AO. The effect of sleep on gastrointestinal functioning in common digestive diseases. Lancet Gastroenterol Hepatol. 2020;5(6):616-24. DOI:10.1016/S2468-1253(19)30412-1
20. Mutti C, Misirocchi F, Zilioli A, et al. Sleep and brain evolution across the human lifespan: A mutual embrace. Front Netw Physiol. 2022;2:938012. DOI:10.3389/fnetp.2022.938012
21. Frank MG. The Ontogenesis of Mammalian Sleep: Form and Function. Curr Sleep Med Rep. 2020;6(4):267-79. DOI:10.1007/s40675-020-00190-y
22. Кельмансон И.А. Сон ребенка в онтогенезе и использование стандартизованного опросника для оценки поведения детей во время сна. Российский вестник перинатологии и педиатрии. 2017;62(3):37-52 [Kelmanson IA. Child sleep ontogeny and application of the standardized questionnaire for the evaluation of child behaviour during sleep. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2017;62(3):37-52 (in Russian)]. DOI:10.21508/1027-4065-2017-62-3-37-52
23. Serón-Ferré M, Mendez N, Abarzua-Catalan L, et al. Circadian rhythms in the fetus. Mol Cell Endocrinol. 2012;349(1):68-75. DOI:10.1016/j.mce.2011.07.039
24. Bates K, Herzog ED. Maternal-Fetal Circadian Communication During Pregnancy. Front Endocrinol (Lausanne). 2020;11:198. DOI:10.3389/fendo.2020.00198
25. Loy SL, Loo RSX, Godfrey KM, et al. Chrononutrition during Pregnancy: A Review on Maternal Night-Time Eating. Nutrients. 2020;12(9):2783. DOI:10.3390/nu12092783
26. Varcoe TJ, Boden MJ, Voultsios A, et al. Characterisation of the maternal response to chronic phase shifts during gestation in the rat: implications for fetal metabolic programming. PLoS One. 2013;8(1):e53800. DOI:10.1371/journal.pone.0053800
27. Korte J, Wulff K, Oppe C, Siegmund R. Ultradian and circadian activity-rest rhythms of preterm neonates compared to full-term neonates using actigraphic monitoring. Chronobiol Int. 2001;18(4):697-708. DOI:10.1081/cbi-100106082
28. Hirshkowitz M, Whiton K, Albert SM, et al. National Sleep Foundation's updated sleep duration recommendations: final report. Sleep Health. 2015;1(4):233-43. DOI:10.1016/j.sleh.2015.10.004
29. Miike T. Appropriate Lifelong Circadian Rhythms Are Established During Infancy: A Narrative Review. Clocks Sleep. 2025;7(3):41. DOI:10.3390/clockssleep7030041
30. Miike T, Toyoura M, Tonooka S, et al. Neonatal irritable sleep-wake rhythm as a predictor of autism spectrum disorders. Neurobiol Sleep Circadian Rhythms. 2020;9:100053. DOI:10.1016/j.nbscr.2020.100053
31. Ohta H, Mitchell AC, McMahon DG. Constant light disrupts the developing mouse biological clock. Pediatr Res. 2006;60(3):304-8. DOI:10.1203/01.pdr.0000233114.18403.66
32. Ohta H, Yamazaki S, McMahon DG. Constant light desynchronizes mammalian clock neurons. Nat Neurosci. 2005;8(3):267-9. DOI:10.1038/nn1395
33. Rivkees SA, Mayes L, Jacobs H, Gross I. Rest-activity patterns of premature infants are regulated by cycled lighting. Pediatrics. 2004;113(4):833-9. DOI:10.1542/peds.113.4.833
34. Vásquez-Ruiz S, Maya-Barrios JA, Torres-Narváez P, et al. A light/dark cycle in the NICU accelerates body weight gain and shortens time to discharge in preterm infants. Early Hum Dev. 2014;90(9):535-40. DOI:10.1016/j.earlhumdev.2014.04.015
35. Guerrero-Vargas NN, Espitia-Bautista E, Buijs RM, Escobar C. Shift-work: is time of eating determining metabolic health? Evidence from animal models. Proc Nutr Soc. 2018;77(3):199-215. DOI:10.1017/S0029665117004128
36. Reiter RJ, Tan DX, Korkmaz A, Rosales-Corral SA. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum Reprod Update. 2014;20(2):293-307. DOI:10.1093/humupd/dmt054
37. Cubero J, Narciso D, Terrón P, et al. Chrononutrition applied to formula milks to consolidate infants' sleep/wake cycle. Neuro Endocrinol Lett. 2007;28(4):360-6.
38. Pundir S, Wall CR, Mitchell CJ, et al. Variation of Human Milk Glucocorticoids over 24 hour Period. J Mammary Gland Biol Neoplasia. 2017;22(1):85-92. DOI:10.1007/s10911-017-9375-x
39. Sánchez CL, Cubero J, Sánchez J, et al. Evolution of the circadian profile of human milk amino acids during breastfeeding. J Appl Biomed. 2013;11(2):59-70. DOI:10.2478/v10136-012-0020-0
40. França EL, Nicomedes TdR, Calderon IdMP, França ACH. Time-dependent alterations of soluble and cellular components in human milk. Biological Rhythm Research. 2010;41(5):333-47. DOI:10.1080/09291010903407441
41. Cannon AM, Kakulas F, Hepworth AR, et al. The Effects of Leptin on Breastfeeding Behaviour. Int J Environ Res Public Health. 2015;12(10):12340-55. DOI:10.3390/ijerph121012340
42. Illnerová H, Buresová M, Presl J. Melatonin rhythm in human milk. J Clin Endocrinol Metab. 1993;77(3):838-41. DOI:10.1210/jcem.77.3.8370707
43. Lodemore MR, Petersen SA, Wailoo MP. Factors affecting the development of night time temperature rhythms. Arch Dis Child. 1992;67(10):1259-61. DOI:10.1136/adc.67.10.1259
44. Lee H, Park H, Ha E, et al. Effect of Breastfeeding Duration on Cognitive Development in Infants: 3-Year Follow-up Study. J Korean Med Sci. 2016;31(4):579-84. DOI:10.3346/jkms.2016.31.4.579
45. Fitri SYR, Lusmilasari L, Juffrie M, Rakhmawati W. Pain in Neonates: A Concept Analysis. Anesth Pain Med. 2019;9(4):e92455. DOI:10.5812/aapm.92455
46. Moberg KU, Handlin L, Petersson M. Neuroendocrine mechanisms involved in the physiological effects caused by skin-to-skin contact – With a particular focus on the oxytocinergic system. Infant Behav Dev. 2020;61:101482. DOI:10.1016/j.infbeh.2020.101482
47. Schneider N, Mutungi G, Cubero J. Diet and nutrients in the modulation of infant sleep: A review of the literature. Nutr Neurosci. 2018;21(3):151-61. DOI:10.1080/1028415X.2016.1258446
48. Häusler S, Lanzinger E, Sams E, et al. Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition? Nutrients. 2024;16(10):1422. DOI:10.3390/nu16101422
49. Booker LA, Spong J, Deacon-Crouch M, Skinner TC. Preliminary Exploration into the Impact of Mistimed Expressed Breast Milk Feeding on Infant Sleep Outcomes, Compared to Other Feeding Patterns. Breastfeed Med. 2022;17(10):853-8. DOI:10.1089/bfm.2022.0125
50. Cubero J, Valero V, Sánchez J, et al. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett. 2005;26(6):657-61.
51. Abdul Jafar NK, Tham EKH, Pang WW, et al. Association between breastfeeding and sleep patterns in infants and preschool children. Am J Clin Nutr. 2021;114(6):1986-96. DOI:10.1093/ajcn/nqab297
52. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020;53:101340. DOI:10.1016/j.smrv.2020.101340
53. Xu D, Wan F. Breastfeeding and infant gut microbiota: influence of bioactive components. Gut Microbes. 2025;17(1):2446403. DOI:10.1080/19490976.2024.2446403
54. Lawson MAE, O'Neill IJ, Kujawska M, et al. Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem. ISME J. 2020;14(2):635-48. DOI:10.1038/s41396-019-0553-2
55. Le Doare K, Holder B, Bassett A, Pannaraj PS. Mother's Milk: A Purposeful Contribution to the Development of the Infant Microbiota and Immunity. Front Immunol. 2018;9:361. DOI:10.3389/fimmu.2018.00361
56. Savino F, Palumeri E, Castagno E, et al. Reduction of crying episodes owing to infantile colic: A randomized controlled study on the efficacy of a new infant formula. Eur J Clin Nutr. 2006;60(11):1304-10. DOI:10.1038/sj.ejcn.1602457
57. Carosella M. Nutritional management of functional gastrointestinal disorders in infants: Quality of life evaluation. Poster presented at the 57th annual meeting of the ESPGHAN. Helsinki, Finland. 2025
58. Mihatsch WA, Franz AR, Kuhnt B, et al. Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats. Biol Neonate. 2005;87(3):160-3. DOI:10.1159/000082367
59. Yao M, Lien EL, Capeding MR, et al. Effects of term infant formulas containing high sn-2 palmitate with and without oligofructose on stool composition, stool characteristics, and bifidogenicity. J Pediatr Gastroenterol Nutr. 2014;59(4):440-8. DOI:10.1097/MPG.0000000000000443
60. Yaron S, Shachar D, Abramas L, et al. Effect of high β-palmitate content in infant formula on the intestinal microbiota of term infants. J Pediatr Gastroenterol Nutr. 2013;56(4):376-81. DOI:10.1097/MPG.0b013e31827e1ee
61. Haiden N, Savino F, Hill S, et al. Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee. J Pediatr Gastroenterol Nutr. 2024; 79(1):168-80. DOI:10.1002/jpn3.12240
62. Bronsky J, Campoy С, Embleton N, et al. Palm oil and beta-palmitate in infant formula - A position paper by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2019;68(5):742-60. DOI:10.1097/MPG.0000000000002307
63. Knol J, Scholtens P, Kafka C, et al. Colon Microflora in Infants Fed Formula with Galacto- and Fructo-Oligosaccharides: More Like Breast-Fed Infants. J Pediatr Gastroenterol Nutr. 2005;40(1):36-42. DOI:10.1097/00005176-200501000-00007
64. Moro G, Minoli I, Mosca M, et al. Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants. J Pediatr Gastroenterol Nutr. 2002;34(3):291-5. DOI:10.1097/00005176-200203000-00014
65. Scholtens P, Alliet P, Raes M, et al. Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides. J Nutr. 2008;138:1141-7. DOI:10.1093/jn/138.6.1141
________________________________________________
2. Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, et al. Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol. 2017;45(2):337-44. DOI:10.1007/s10802-016-0166-4
3. Staples AD, Bates JE, Petersen IT, et al. Measuring sleep in young children and their mothers: Identifying actigraphic sleep composites. Int J Behav Dev. 2019;43(3):278-85. DOI:10.1177/0165025419830236
4. Pulido-Arjona L, Correa-Bautista JE, Agostinis-Sobrinho C, et al. Role of sleep duration and sleep-related problems in the metabolic syndrome among children and adolescents. Ital J Pediatr. 2018;44(1):9. DOI:10.1186/s13052-018-0451-7
5. Hysing M, Harvey AG, Torgersen L, et al. Trajectories and predictors of nocturnal awakenings and sleep duration in infants. J Dev Behav Pediatr. 2014;35(5):309-16. DOI:10.1097/DBP.0000000000000064
6. Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended Amount of Sleep for Pediatric Populations: A Consensus Statement of the American Academy of Sleep Medicine. J Clin Sleep Med. 2016;12(6):785-6. DOI:10.5664/jcsm.5866
7. Mindell J, Owens J. A clinical guide to pediatric sleep. Diagnosis and management of sleep problems. Philadelphia: Lippincott Williams & Wilkins, 2005. 232 p.
8. Goodlin-Jones BL, Burnham MM, Gaylor EE, Anders TF. Night waking, sleep-wake organization, and self-soothing in the first year of life. J Dev Behav Pediatr. 2001;22(4):226-33. DOI:10.1097/00004703-200108000-00003
9. St James-Roberts I, Peachey E. Distinguishing infant prolonged crying from sleep-waking problems. Arch Dis Child. 2011;96(4):340-4. DOI:10.1136/adc.2010.200204
10. Wolke D, Bilgin A, Samara M. Systematic Review and Meta-Analysis: Fussing and Crying Durations and Prevalence of Colic in Infants. J Pediatr. 2017;185:55-61.e4. DOI:10.1016/j.jpeds.2017.02.020
11. Hemmi MH, Wolke D, Schneider S. Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a meta-analysis. Arch Dis Child. 2011;96(7):622-9. DOI:10.1136/adc.2010.191312
12. Chaput JP, Gray CE, Poitras VJ, et al. Systematic review of the relationships between sleep duration and health indicators in the early years (0-4 years). BMC Public Health. 2017;17(Suppl. 5):855. DOI:10.1186/s12889-017-4850-2
13. Hysing M, Sivertsen B, Garthus-Niegel S, Eberhard-Gran M. Pediatric sleep problems and social-emotional problems. A population-based study. Infant Behav Dev. 2016;42:111-8. DOI:10.1016/j.infbeh.2015.12.005
14. Sivertsen B, Harvey AG, Reichborn-Kjennerud T, et al. Later emotional and behavioral problems associated with sleep problems in toddlers: a longitudinal study. JAMA Pediatr. 2015;169(6):575-82. DOI:10.1001/jamapediatrics.2015.0187
15. Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. JPGN. 2015;61(5):531-7. DOI:10.1097/MPG.0000000000000949
16. Vandenplas Y, Hauser B, Salvatore S. Functional gastrointestinal disorders in infancy: impact on infants and family health. Pediatrics. Consilium Medicum. 2020;1:36-41 (in Russian). DOI:10.26442/26586630.2020.1.190721
17. Weissbluth M. Sleep and the colicky infant. In: Guilleminault C. Sleep and its disorders in children. New York: Raven Press, 1987.
18. Kirjavainen J, Kirjavainen T, Huhtala V, et al. Infants with colic have a normal sleep structure at 2 and 7 months of age. J Pediatr. 2001;138(2):218-23. DOI:10.1067/mpd.2001.110326
19. Orr WC, Fass R, Sundaram SS, Scheimann AO. The effect of sleep on gastrointestinal functioning in common digestive diseases. Lancet Gastroenterol Hepatol. 2020;5(6):616-24. DOI:10.1016/S2468-1253(19)30412-1
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Авторы
И.Н. Захарова*1, И.В. Бережная1,2, Я.В. Оробинская1, В.В. Пупыкина1, В.Д. Чурилова1
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Российская Федерация
2ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы, Москва, Российская Федерация
*zakharova-rmapo@yandex.ru
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2Bashlyaeva Children's City Clinical Hospital, Moscow, Russian Federation
*zakharova-rmapo@yandex.ru
1ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Российская Федерация
2ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» Департамента здравоохранения г. Москвы, Москва, Российская Федерация
*zakharova-rmapo@yandex.ru
________________________________________________
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2Bashlyaeva Children's City Clinical Hospital, Moscow, Russian Federation
*zakharova-rmapo@yandex.ru
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