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Возможности применения блокатора рецепторов к ангиотензину лозартана при комбинированной терапии артериальной гипертензии - Журнал Системные Гипертензии №4 (2009)
Возможности применения блокатора рецепторов к ангиотензину лозартана при комбинированной терапии артериальной гипертензии
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Аннотация
Блокада ренин-ангиотензиновой системы является одним из краеугольных камней в тактике лечения артериальной гипертензии. Нередко встречающаяся резистентная гипертензия и пациенты с высоким кардиоваскулярным риском требуют зачастую использования комбинированных антигипертензивных препаратов. В нескольких крупных клинических многоцентровых рандомизированных исследованиях изучалась возможность использования блокатора рецепторов к ангиотензину лозартана в комбинации с гидрохлоротиазидом в терапии артериальной гипертензии. Показана высокая антигипертензивная эффективность и безопасность данного сочетания препаратов.
Ключевые слова: лозартан, Лориста, высокие дозы, артериальная гипертензия, гидрохлоротиазид.
Keywords: losartan, Lorista, high doses, arterial hypertension, hydrochlorothiazide.
Ключевые слова: лозартан, Лориста, высокие дозы, артериальная гипертензия, гидрохлоротиазид.
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Keywords: losartan, Lorista, high doses, arterial hypertension, hydrochlorothiazide.
Полный текст
Список литературы
1. Беленков Ю.Н. и рабочая группа исследователей ЭПИГРАФ-2. Эналаприл плюс Индапамид в лечение АГ: оценка эффективности и безопасности Рациональной Фармакотерапии. Применение нефиксированной комбинации Эналаприла и Индапамида (Энзикс). Дизайн и основные результаты исследования ЭПИГРАФ-2. Сердце. 2005; 4 (5): 277–86.
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3. Фомин И.В. Артериальная гипертония в Российской Федерации – последние десять лет. Что дальше? Сердце. 2007; 6 (3): 120–3.
4. Brenner BM, Cooper ME, de Zeeuw D et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861–9.
5. Christensen DB, Williams B, Goldberg HI et al. Assessing compliance to antihypertensive medications using computer-based pharmacy records. Med Care 1999; 35 (11): 1164–70.
6. Coca A, Sobrino J, Soler J et al. Trough-to-peak ratio, smoothness index, and circadian blood pressure profile after treatment with once-daily fixed combination of losartan 100 and hydrochlorothiazide 25 in essential hypertension. J Cardiovasc Pharmacol 2002; 39: 824–33.
7. Collins R, Peto R, MacMahon S et al. Blood pressure, stroke, and coronary heart disease. Part2: short-term reductions in blood pressure: Overview of randomized drug trials in their epidemiological context. Lancet 1990; 335: 827–8.
8. Dahlof B, Devereux RB, Kjeldsen SE et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002; 359: 995–1003.
9. Flack JM, Saunders E, Gradman A et al. Antihypertensive efficacy and safety of losartan alone and in combination with hydrochlorothiazide in adult African Americans with mild to moderate hypertension. Clin Ther 2001; 23: 1193–208.
10. F?rster A, Smolka W, Jung C et al. Fixed-dose combination of losartan/hydrochlorothiazide 100mg/25mg: safety and efficacyon office and 24-h blood pressure. MMW Fortschr Med 2007; 149: 111–8.
11. Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003; 362: 782–8.
12. Gradman AH, Brady WE, Gazdick LP et al. A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and losartan 50 mg/hydrochlorothiazide 12,5 mg in the treatment of moderate-to-severe essential hypertension. Clin Ther 2002; 24: 1049–61.
13. Lakshman MR, Reda DJ, Materson BJ et al. Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Arch Intern Med 1999; 159: 551–8.
14. Longobardi G, Corbi G, Cacciatore F et al. Effect of Losartan in Treatment of Exercise-Induced Myocardial Ischemia Am J Cardiol 2007; 100: 1517–21.
15. Lubsen J, Wagener G, Kirwan B et al. ACTION (A Coronary disease Trial Investigating Outcome with Niefedipine GITS) investigators. Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension: the ACTION trial. J Hypertens 2005; 23: 642–8.
16. Moen MD, Wagstaff AJ. Losartan: a review of its use in stroke risk reduction in patients with hypertension and left ventricular hypertrophy. Drugs 2005; 65: 2657–74.
17. Naidoo DP, Sareli P, Marin F et al. Increased efficacy and tolerability with losartan plus hydrochlorothiazide in patients with uncontrolled hypertension and therapy-related symptoms receiving two monotherapies. Adv Ther 1999; 16: 187–99.
18. Nissen SE, Tuzcu EM, Libby P et al. Effect of antihypertensiveagents on cardiovascular events in patients with coronary diseaseand normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217–25.
19. Okano Y, Tamura K, Kuji T et al. Effects of Angiotensin II Receptor Blockers on Relationships Between 24-Hour Blood Pressure, Autonomic Function, and Health-Related QOL. Clinical and Experimental Hypertension 2009; 31: 250–8.
20. Oparil S, Aurup P, Snavely D et al. Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension. Am J Cardiol 2001; 87: 721–6.
21. Pitt B, Poole-Wilson PA, Segal R et al. Effect of losartan compared with captopril on mortality in patinets with symptomatic heart failure randomized trial – the Losartan Heart Failure Survival Study ELITE II. Lancet 2000; 355: 1582–7.
22. Soffer BA, Wright JrJT, Pratt JH et al. Effects of losartan on a background of hydrochlorothiazide in patients with hypertension. Hypertension 1995; 26: 112–7.
23. Weir MR, Moser M. Diuretics and beta-blockers: is there a risk for dyslipidemia? Am Heart J 2000; 139: 174–83.
2. Лопатин Ю.М. Фиксированные низкодозовые комбинации антигипертензивных средств с позиции препаратов первого выбора для лечения артериальной гипертонии. Сердце. 2006; 4 (3): 113–55.
3. Фомин И.В. Артериальная гипертония в Российской Федерации – последние десять лет. Что дальше? Сердце. 2007; 6 (3): 120–3.
4. Brenner BM, Cooper ME, de Zeeuw D et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861–9.
5. Christensen DB, Williams B, Goldberg HI et al. Assessing compliance to antihypertensive medications using computer-based pharmacy records. Med Care 1999; 35 (11): 1164–70.
6. Coca A, Sobrino J, Soler J et al. Trough-to-peak ratio, smoothness index, and circadian blood pressure profile after treatment with once-daily fixed combination of losartan 100 and hydrochlorothiazide 25 in essential hypertension. J Cardiovasc Pharmacol 2002; 39: 824–33.
7. Collins R, Peto R, MacMahon S et al. Blood pressure, stroke, and coronary heart disease. Part2: short-term reductions in blood pressure: Overview of randomized drug trials in their epidemiological context. Lancet 1990; 335: 827–8.
8. Dahlof B, Devereux RB, Kjeldsen SE et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet 2002; 359: 995–1003.
9. Flack JM, Saunders E, Gradman A et al. Antihypertensive efficacy and safety of losartan alone and in combination with hydrochlorothiazide in adult African Americans with mild to moderate hypertension. Clin Ther 2001; 23: 1193–208.
10. F?rster A, Smolka W, Jung C et al. Fixed-dose combination of losartan/hydrochlorothiazide 100mg/25mg: safety and efficacyon office and 24-h blood pressure. MMW Fortschr Med 2007; 149: 111–8.
11. Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003; 362: 782–8.
12. Gradman AH, Brady WE, Gazdick LP et al. A multicenter, randomized, double-blind, placebo-controlled, 8-week trial of the efficacy and tolerability of once-daily losartan 100 mg/hydrochlorothiazide 25 mg and losartan 50 mg/hydrochlorothiazide 12,5 mg in the treatment of moderate-to-severe essential hypertension. Clin Ther 2002; 24: 1049–61.
13. Lakshman MR, Reda DJ, Materson BJ et al. Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Arch Intern Med 1999; 159: 551–8.
14. Longobardi G, Corbi G, Cacciatore F et al. Effect of Losartan in Treatment of Exercise-Induced Myocardial Ischemia Am J Cardiol 2007; 100: 1517–21.
15. Lubsen J, Wagener G, Kirwan B et al. ACTION (A Coronary disease Trial Investigating Outcome with Niefedipine GITS) investigators. Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension: the ACTION trial. J Hypertens 2005; 23: 642–8.
16. Moen MD, Wagstaff AJ. Losartan: a review of its use in stroke risk reduction in patients with hypertension and left ventricular hypertrophy. Drugs 2005; 65: 2657–74.
17. Naidoo DP, Sareli P, Marin F et al. Increased efficacy and tolerability with losartan plus hydrochlorothiazide in patients with uncontrolled hypertension and therapy-related symptoms receiving two monotherapies. Adv Ther 1999; 16: 187–99.
18. Nissen SE, Tuzcu EM, Libby P et al. Effect of antihypertensiveagents on cardiovascular events in patients with coronary diseaseand normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217–25.
19. Okano Y, Tamura K, Kuji T et al. Effects of Angiotensin II Receptor Blockers on Relationships Between 24-Hour Blood Pressure, Autonomic Function, and Health-Related QOL. Clinical and Experimental Hypertension 2009; 31: 250–8.
20. Oparil S, Aurup P, Snavely D et al. Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension. Am J Cardiol 2001; 87: 721–6.
21. Pitt B, Poole-Wilson PA, Segal R et al. Effect of losartan compared with captopril on mortality in patinets with symptomatic heart failure randomized trial – the Losartan Heart Failure Survival Study ELITE II. Lancet 2000; 355: 1582–7.
22. Soffer BA, Wright JrJT, Pratt JH et al. Effects of losartan on a background of hydrochlorothiazide in patients with hypertension. Hypertension 1995; 26: 112–7.
23. Weir MR, Moser M. Diuretics and beta-blockers: is there a risk for dyslipidemia? Am Heart J 2000; 139: 174–83.
Авторы
Н.Ш.Загидуллин*, Ш.З.Загидуллин
ГОУ ВПО Башкирский государственный медицинский университет Росздрава
*nau36@ufanet.ru
Bashkir State Medical University
*nau36@ufanet.ru
ГОУ ВПО Башкирский государственный медицинский университет Росздрава
*nau36@ufanet.ru
________________________________________________
Bashkir State Medical University
*nau36@ufanet.ru
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