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Комбинированная фармакотерапия артериальной гипертонии. Обзор фиксированных комбинаций антигипертензивных препаратов
Комбинированная фармакотерапия артериальной гипертонии. Обзор фиксированных комбинаций антигипертензивных препаратов
Морозова Т.Е., Андрущишина Т.Б., Юдина И.Ю. Комбинированная фармакотерапия артериальной гипертонии. Обзор фиксированных комбинаций антигипертензивных препаратов. Системные гипертензии. 2016; 13 (3): 58–63.
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Аннотация
Артериальная гипертензия остается краеугольным камнем сердечно-сосудистого континуума. Все большее число пациентов получают комбинированную антигипертензивную терапию для достижения целевых цифр артериального давления, расширяются показания для комбинированной терапии в дебюте лечения. Постоянно растет рынок фиксированных комбинаций (ФК) антигипертензивных препаратов. В статье приведен обзор ФК, зарегистрированных в Российской Федерации, рассматриваются клинические ситуации для преимущественного назначения той или иной ФК. Более подробно анализируются ФК, включающие блокатор рецепторов ангиотензина II и диуретики, в частности, обсуждаются преимущества ФК, включающих блокатор рецепторов ангиотензина II кандесартан и гидрохлоротиазид.
Ключевые слова: артериальная гипертензия, антигипертензивная терапия, рациональная фармакотерапия, комбинированная фармакотерапия, фиксированные комбинации, тиазидные диуретики, гидрохлоротиазид, блокатор рецепторов ангиотензина II, кандесартан, обзор.
Key words: hypertension, antihypertensive therapy, rational pharmacotherapy, combined pharmacotherapy, a fixed combination, thiazide diuretics, hydrochlorothiazide, angiotensin II receptor blocker, candesartan, review.
Ключевые слова: артериальная гипертензия, антигипертензивная терапия, рациональная фармакотерапия, комбинированная фармакотерапия, фиксированные комбинации, тиазидные диуретики, гидрохлоротиазид, блокатор рецепторов ангиотензина II, кандесартан, обзор.
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Key words: hypertension, antihypertensive therapy, rational pharmacotherapy, combined pharmacotherapy, a fixed combination, thiazide diuretics, hydrochlorothiazide, angiotensin II receptor blocker, candesartan, review.
Полный текст
Список литературы
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9. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Анализ фармакотерапии артериальной гипертензии по результатам исследования ПИФАГОР III. Фарматека. 2010; 13: 87–95. / Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Analiz farmakoterapii arterial'noi gipertenzii po rezul'tatam issledovaniia PIFAGOR III. Farmateka. 2010; 13: 87–95. [in Russian]
10. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Результаты фармакоэпидемиологического исследования артериальной гипертонии ПИФАГОР IV (опрос пациентов с артериальной гипертонией). Системные гипертензии. 2015; 12 (3): 11–8. / Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Rezul'taty farmakoepidemiologicheskogo issledovaniia arterial'noi gipertonii PIFAGOR IV (opros patsientov s arterial'noi gipertoniei). Systemic Hypertension. 2015; 12 (3): 11–8. [in Russian]
11. Spratt J, Shiels A, Williams B et al on behalf of the LVH study group. Effects of candesartan cilexetil on left ventricular and arterial structure and function in hypertensive patients. J Hypertens 2000; 18 (Suppl. 2): S188.
12. Cuspidi C, Muiesan ML, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the Candesartan Assessment in the Treatment of Cardiac Hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
13. Lindholm LH, Persson M, Alaupovic P et al. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive treatmen and Lipid Profile In a North of Sweden efficacy Evaluation (ALPINE) study. J Hypertens 2003; 21: 1563–74.
14. Lithell H, Hansson L, Elmfeldt D et al. The Study of Cognition and Prognosis in the Elderly (SCOPE). J Hypertens 2003; 21: 875–86.
15. Vauquelin G, Fierens FLP, Verheijen I et al. Distinctions between non-peptide angiotensin II AT1-receptor antagonists. JRAAS 2001; 2 (Suppl. 1): S24–S31.
16. Unger T. Inhibiting renin-angiotensin in the brain: the possible therapeutic implications. Blood Pressure 2001; 10 (Suppl. 1): 12–6.
17. Unger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
18. Van Lier JJ, van Heiningen PNM, Sunzel M. Absorption, metabolism and excretion of 14C-candesartan and 14C-candesartan cilexetil in healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S27–S28.
19. Pfeffer MF, Swedberg K, Granger CB et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: CHARM-overall program. Lancet 2003; 362: 759–66.
20. Yusuf S, Ostergren JB, Gerstein HC et al. Effect of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation 2005; 112: 48–53.
21. Burgess E. Renal effects of angiotensin II receptor antagonists. Blood Pressure 2000; 10 (Suppl. 1): 17–20.
22. Morgensen E, Neldam S, Tikkanen I et al. Randomised controlled trial of dual blockade renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. Brit Med J 2000; 321: 1440–4.
23. Thijs L, Staessen JA, Beleva S et al. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2). Curr Control Trials Cardiovasc Med 2001; 2: 298–306.
24. Dahlof B, Sever PS, Poulter NR et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895–906.
2. 2013 ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
3. Klinicheskie rekomendatsii «Diagnostika i lechenie arterial'noi gipertonii», 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
4. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2016; 37: 2315–81. doi: 10.1093/eurheartj/ehw106
5. Shal'nova S.A., Kukushkin S.K., Manoshkina E.M., Timofeeva T.N. Arterial'naia gipertenziia i priverzhennost' terapii. Vrach. 2009; 12: 39–42. [in Russian]
6. Mazzaglia G, Ambrosioni E, Alacqua M. Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation 2009; 120: 1598–605.
7. Morozova T.E., Iudina I.Iu. Sovremennaia strategiia uluchsheniia priverzhennosti lecheniiu bol'nykh arterial'noi gipertoniei: fiksirovannye kombinatsii lekarstvennykh sredstv. Consilium Medicum. 2010; 12 (1): 22–8. [in Russian]
8. Iudina I.Iu., Morozova T.E. Klinicheskoe primenenie fiksirovannykh kombinatsii antigipertenzivnykh lekarstvennykh sredstv. Lechashchii vrach. 2015; 2: 8–12. [in Russian]
9. Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Analiz farmakoterapii arterial'noi gipertenzii po rezul'tatam issledovaniia PIFAGOR III. Farmateka. 2010; 13: 87–95. [in Russian]
10. Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Rezul'taty farmakoepidemiologicheskogo issledovaniia arterial'noi gipertonii PIFAGOR IV (opros patsientov s arterial'noi gipertoniei). Systemic Hypertension. 2015; 12 (3): 11–8. [in Russian]
11. Spratt J, Shiels A, Williams B et al on behalf of the LVH study group. Effects of candesartan cilexetil on left ventricular and arterial structure and function in hypertensive patients. J Hypertens 2000; 18 (Suppl. 2): S188.
12. Cuspidi C, Muiesan ML, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the Candesartan Assessment in the Treatment of Cardiac Hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
13. Lindholm LH, Persson M, Alaupovic P et al. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive treatmen and Lipid Profile In a North of Sweden efficacy Evaluation (ALPINE) study. J Hypertens 2003; 21: 1563–74.
14. Lithell H, Hansson L, Elmfeldt D et al. The Study of Cognition and Prognosis in the Elderly (SCOPE). J Hypertens 2003; 21: 875–86.
15. Vauquelin G, Fierens FLP, Verheijen I et al. Distinctions between non-peptide angiotensin II AT1-receptor antagonists. JRAAS 2001; 2 (Suppl. 1): S24–S31.
16. Unger T. Inhibiting renin-angiotensin in the brain: the possible therapeutic implications. Blood Pressure 2001; 10 (Suppl. 1): 12–6.
17. Unger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
18. Van Lier JJ, van Heiningen PNM, Sunzel M. Absorption, metabolism and excretion of 14C-candesartan and 14C-candesartan cilexetil in healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S27–S28.
19. Pfeffer MF, Swedberg K, Granger CB et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: CHARM-overall program. Lancet 2003; 362: 759–66.
20. Yusuf S, Ostergren JB, Gerstein HC et al. Effect of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation 2005; 112: 48–53.
21. Burgess E. Renal effects of angiotensin II receptor antagonists. Blood Pressure 2000; 10 (Suppl. 1): 17–20.
22. Morgensen E, Neldam S, Tikkanen I et al. Randomised controlled trial of dual blockade renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. Brit Med J 2000; 321: 1440–4.
23. Thijs L, Staessen JA, Beleva S et al. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2). Curr Control Trials Cardiovasc Med 2001; 2: 298–306.
24. Dahlof B, Sever PS, Poulter NR et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895–906.
2. 2013 ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
3. Клинические рекомендации «Диагностика и лечение артериальной гипертонии», 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii / Klinicheskie rekomendatsii «Diagnostika i lechenie arterial'noi gipertonii», 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
4. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2016; 37: 2315–81. doi: 10.1093/eurheartj/ehw106
5. Шальнова С.А., Кукушкин С.К., Маношкина Е.М., Тимофеева Т.Н. Артериальная гипертензия и приверженность терапии. Врач. 2009; 12: 39–42. / Shal'nova S.A., Kukushkin S.K., Manoshkina E.M., Timofeeva T.N. Arterial'naia gipertenziia i priverzhennost' terapii. Vrach. 2009; 12: 39–42. [in Russian]
6. Mazzaglia G, Ambrosioni E, Alacqua M. Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation 2009; 120: 1598–605.
7. Морозова Т.Е., Юдина И.Ю. Современная стратегия улучшения приверженности лечению больных артериальной гипертонией: фиксированные комбинации лекарственных средств. Consilium Medicum. 2010; 12 (1): 22–8. / Morozova T.E., Iudina I.Iu. Sovremennaia strategiia uluchsheniia priverzhennosti lecheniiu bol'nykh arterial'noi gipertoniei: fiksirovannye kombinatsii lekarstvennykh sredstv. Consilium Medicum. 2010; 12 (1): 22–8. [in Russian]
8. Юдина И.Ю., Морозова Т.Е. Клиническое применение фиксированных комбинаций антигипертензивных лекарственных средств. Лечащий врач. 2015; 2: 8–12. / Iudina I.Iu., Morozova T.E. Klinicheskoe primenenie fiksirovannykh kombinatsii antigipertenzivnykh lekarstvennykh sredstv. Lechashchii vrach. 2015; 2: 8–12. [in Russian]
9. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Анализ фармакотерапии артериальной гипертензии по результатам исследования ПИФАГОР III. Фарматека. 2010; 13: 87–95. / Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Analiz farmakoterapii arterial'noi gipertenzii po rezul'tatam issledovaniia PIFAGOR III. Farmateka. 2010; 13: 87–95. [in Russian]
10. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Результаты фармакоэпидемиологического исследования артериальной гипертонии ПИФАГОР IV (опрос пациентов с артериальной гипертонией). Системные гипертензии. 2015; 12 (3): 11–8. / Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Rezul'taty farmakoepidemiologicheskogo issledovaniia arterial'noi gipertonii PIFAGOR IV (opros patsientov s arterial'noi gipertoniei). Systemic Hypertension. 2015; 12 (3): 11–8. [in Russian]
11. Spratt J, Shiels A, Williams B et al on behalf of the LVH study group. Effects of candesartan cilexetil on left ventricular and arterial structure and function in hypertensive patients. J Hypertens 2000; 18 (Suppl. 2): S188.
12. Cuspidi C, Muiesan ML, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the Candesartan Assessment in the Treatment of Cardiac Hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
13. Lindholm LH, Persson M, Alaupovic P et al. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive treatmen and Lipid Profile In a North of Sweden efficacy Evaluation (ALPINE) study. J Hypertens 2003; 21: 1563–74.
14. Lithell H, Hansson L, Elmfeldt D et al. The Study of Cognition and Prognosis in the Elderly (SCOPE). J Hypertens 2003; 21: 875–86.
15. Vauquelin G, Fierens FLP, Verheijen I et al. Distinctions between non-peptide angiotensin II AT1-receptor antagonists. JRAAS 2001; 2 (Suppl. 1): S24–S31.
16. Unger T. Inhibiting renin-angiotensin in the brain: the possible therapeutic implications. Blood Pressure 2001; 10 (Suppl. 1): 12–6.
17. Unger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
18. Van Lier JJ, van Heiningen PNM, Sunzel M. Absorption, metabolism and excretion of 14C-candesartan and 14C-candesartan cilexetil in healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S27–S28.
19. Pfeffer MF, Swedberg K, Granger CB et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: CHARM-overall program. Lancet 2003; 362: 759–66.
20. Yusuf S, Ostergren JB, Gerstein HC et al. Effect of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation 2005; 112: 48–53.
21. Burgess E. Renal effects of angiotensin II receptor antagonists. Blood Pressure 2000; 10 (Suppl. 1): 17–20.
22. Morgensen E, Neldam S, Tikkanen I et al. Randomised controlled trial of dual blockade renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. Brit Med J 2000; 321: 1440–4.
23. Thijs L, Staessen JA, Beleva S et al. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2). Curr Control Trials Cardiovasc Med 2001; 2: 298–306.
24. Dahlof B, Sever PS, Poulter NR et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895–906.
________________________________________________
2. 2013 ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013; 31 (7): 1281–357.
3. Klinicheskie rekomendatsii «Diagnostika i lechenie arterial'noi gipertonii», 2013. http://www.cardioweb.ru/klinicheskie-rekomendatsii [in Russian]
4. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2016; 37: 2315–81. doi: 10.1093/eurheartj/ehw106
5. Shal'nova S.A., Kukushkin S.K., Manoshkina E.M., Timofeeva T.N. Arterial'naia gipertenziia i priverzhennost' terapii. Vrach. 2009; 12: 39–42. [in Russian]
6. Mazzaglia G, Ambrosioni E, Alacqua M. Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation 2009; 120: 1598–605.
7. Morozova T.E., Iudina I.Iu. Sovremennaia strategiia uluchsheniia priverzhennosti lecheniiu bol'nykh arterial'noi gipertoniei: fiksirovannye kombinatsii lekarstvennykh sredstv. Consilium Medicum. 2010; 12 (1): 22–8. [in Russian]
8. Iudina I.Iu., Morozova T.E. Klinicheskoe primenenie fiksirovannykh kombinatsii antigipertenzivnykh lekarstvennykh sredstv. Lechashchii vrach. 2015; 2: 8–12. [in Russian]
9. Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Analiz farmakoterapii arterial'noi gipertenzii po rezul'tatam issledovaniia PIFAGOR III. Farmateka. 2010; 13: 87–95. [in Russian]
10. Leonova M.V., Belousov Iu.B., Shteinberg L.L. i dr. Rezul'taty farmakoepidemiologicheskogo issledovaniia arterial'noi gipertonii PIFAGOR IV (opros patsientov s arterial'noi gipertoniei). Systemic Hypertension. 2015; 12 (3): 11–8. [in Russian]
11. Spratt J, Shiels A, Williams B et al on behalf of the LVH study group. Effects of candesartan cilexetil on left ventricular and arterial structure and function in hypertensive patients. J Hypertens 2000; 18 (Suppl. 2): S188.
12. Cuspidi C, Muiesan ML, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the Candesartan Assessment in the Treatment of Cardiac Hypertrophy (CATCH) study. J Hypertens 2002; 20: 2293–300.
13. Lindholm LH, Persson M, Alaupovic P et al. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive treatmen and Lipid Profile In a North of Sweden efficacy Evaluation (ALPINE) study. J Hypertens 2003; 21: 1563–74.
14. Lithell H, Hansson L, Elmfeldt D et al. The Study of Cognition and Prognosis in the Elderly (SCOPE). J Hypertens 2003; 21: 875–86.
15. Vauquelin G, Fierens FLP, Verheijen I et al. Distinctions between non-peptide angiotensin II AT1-receptor antagonists. JRAAS 2001; 2 (Suppl. 1): S24–S31.
16. Unger T. Inhibiting renin-angiotensin in the brain: the possible therapeutic implications. Blood Pressure 2001; 10 (Suppl. 1): 12–6.
17. Unger T. Differences among angiotensin II type 1 receptor blockers: characterization of candesartan cilexetil. Blood Pressure 2000; 9 (Suppl. 1): 14–8.
18. Van Lier JJ, van Heiningen PNM, Sunzel M. Absorption, metabolism and excretion of 14C-candesartan and 14C-candesartan cilexetil in healthy volunteers. J Hum Hypertens 1997; 11 (Suppl. 2): S27–S28.
19. Pfeffer MF, Swedberg K, Granger CB et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: CHARM-overall program. Lancet 2003; 362: 759–66.
20. Yusuf S, Ostergren JB, Gerstein HC et al. Effect of candesartan on the development of a new diagnosis of diabetes mellitus in patients with heart failure. Circulation 2005; 112: 48–53.
21. Burgess E. Renal effects of angiotensin II receptor antagonists. Blood Pressure 2000; 10 (Suppl. 1): 17–20.
22. Morgensen E, Neldam S, Tikkanen I et al. Randomised controlled trial of dual blockade renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. Brit Med J 2000; 321: 1440–4.
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Авторы
Т.Е.Морозова*, Т.Б.Андрущишина, И.Ю.Юдина
ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М.Сеченова. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*temorozova@gmail.com
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
*temorozova@gmail.com
ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М.Сеченова. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*temorozova@gmail.com
________________________________________________
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
*temorozova@gmail.com
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