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Взаимоотношение отдельных популяций лейкоцитов и деятельность сердечно-сосудистой системы у женщин, страдающих гипертонической болезнью - Журнал Системные Гипертензии Том 14, №4
Взаимоотношение отдельных популяций лейкоцитов и деятельность сердечно-сосудистой системы у женщин, страдающих гипертонической болезнью
Кузник Б.И., Давыдов С.О., Гусева Е.С. и др. Взаимоотношение отдельных популяций лейкоцитов и деятельность сердечно-сосудистой системы у женщин, страдающих гипертонической болезнью. Системные гипертензии. 2017; 14 (4): 32–37. DOI: 10.26442/2075-082X_14.4.32-37
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Аннотация
Цель – исследовать влияние количественных соотношений различных видов лейкоцитов на деятельность сердечно-сосудистой системы у здоровых людей и страдающих гипертонической болезнью (ГБ).
Материалы и методы. Исследования проведены с участием 102 женщин, страдающих ГБ. Контрольную группу составили 30 здоровых пациенток.
Результаты. У женщин, больных ГБ, как не занимающихся (ГБ-1), так и занимающихся регулярно кинезитерапией (ГБ-2), по сравнению с контролем повышено общее содержание лейкоцитов, а также соотношение НЕЙТР/ЭОЗ, ЛИМ/ЭОЗ, ЛИМ/БАЗ и ЭОЗ/БАЗ. У больных ГБ увеличены ударный объем и конечный диастолический объем левого желудочка, минутный объем сердца, повышены масса и индекс массы миокарда левого желудочка. У больных ГБ-1 баланс распределения скоростей в микроциркуляторном русле изменяется в сторону быстрых межслоевых процессов. У больных ГБ-2 эти изменения выражены в значительно меньшей степени. У здоровых женщин и больных ГБ обнаружены существенные взаимосвязи между лейкоцитарными соотношениями и уровнем систолического, диастолического, среднего, пульсового давления, показателями кардиогемодинамики и гемодинамическими индексами.
Заключение. Регулярные занятия кинезитерапией приближают тесты, характеризующие состояние гемокардиодинамики, гемодинамические индексы, а также исследуемые корреляционные отношения к показателям, характерным для здоровых женщин. Представленные данные свидетельствуют о важной роли взаимоотношения различных популяций лейкоцитов в патогенезе ГБ.
Ключевые слова: гипертоническая болезнь, лейкоцитарные отношения, кинезитерапия.
Materials and methods. The study was performed on 102 women suffering EH. The control group consisted of 30 healthy patients.
Results. In women with EH, both non-engaged (EH-1) and regularly engaged in kinesitherapy (EH-2), compared with the control group, the total content of leukocytes was increased, as well as the ratios of NEUTR/EOS, LYM/EOS, LYM/BAS and EOS/BAS. In hypertensive patients increased stroke volume and end-diastolic left ventricular volume, cardiac output, increased mass and the index of left ventricular mass. In EH-1 patients group, the balance of velocity distribution in the microcirculatory bed changes to fast interlayer processes. In patients with EH-2, these changes are much less pronounced. In healthy women and patients with EH, significant relationships between leukocyte ratios and the level of systolic diastolic, mean, pulse pressure, cardiohemodynamics, hemodynamic indices were found.
Conclusion. Regular practice of kinesitherapy brings the condition of cardiohemodynamics, hemodynamic indices, as well as the investigated correlations to the characteristic of healthy women. These data suggest an important role of the relationship of various leukocyte populations in the pathogenesis of EH.
Key words: essential hypertension, leukocyte relationships, kinesitherapy.
Материалы и методы. Исследования проведены с участием 102 женщин, страдающих ГБ. Контрольную группу составили 30 здоровых пациенток.
Результаты. У женщин, больных ГБ, как не занимающихся (ГБ-1), так и занимающихся регулярно кинезитерапией (ГБ-2), по сравнению с контролем повышено общее содержание лейкоцитов, а также соотношение НЕЙТР/ЭОЗ, ЛИМ/ЭОЗ, ЛИМ/БАЗ и ЭОЗ/БАЗ. У больных ГБ увеличены ударный объем и конечный диастолический объем левого желудочка, минутный объем сердца, повышены масса и индекс массы миокарда левого желудочка. У больных ГБ-1 баланс распределения скоростей в микроциркуляторном русле изменяется в сторону быстрых межслоевых процессов. У больных ГБ-2 эти изменения выражены в значительно меньшей степени. У здоровых женщин и больных ГБ обнаружены существенные взаимосвязи между лейкоцитарными соотношениями и уровнем систолического, диастолического, среднего, пульсового давления, показателями кардиогемодинамики и гемодинамическими индексами.
Заключение. Регулярные занятия кинезитерапией приближают тесты, характеризующие состояние гемокардиодинамики, гемодинамические индексы, а также исследуемые корреляционные отношения к показателям, характерным для здоровых женщин. Представленные данные свидетельствуют о важной роли взаимоотношения различных популяций лейкоцитов в патогенезе ГБ.
Ключевые слова: гипертоническая болезнь, лейкоцитарные отношения, кинезитерапия.
________________________________________________
Materials and methods. The study was performed on 102 women suffering EH. The control group consisted of 30 healthy patients.
Results. In women with EH, both non-engaged (EH-1) and regularly engaged in kinesitherapy (EH-2), compared with the control group, the total content of leukocytes was increased, as well as the ratios of NEUTR/EOS, LYM/EOS, LYM/BAS and EOS/BAS. In hypertensive patients increased stroke volume and end-diastolic left ventricular volume, cardiac output, increased mass and the index of left ventricular mass. In EH-1 patients group, the balance of velocity distribution in the microcirculatory bed changes to fast interlayer processes. In patients with EH-2, these changes are much less pronounced. In healthy women and patients with EH, significant relationships between leukocyte ratios and the level of systolic diastolic, mean, pulse pressure, cardiohemodynamics, hemodynamic indices were found.
Conclusion. Regular practice of kinesitherapy brings the condition of cardiohemodynamics, hemodynamic indices, as well as the investigated correlations to the characteristic of healthy women. These data suggest an important role of the relationship of various leukocyte populations in the pathogenesis of EH.
Key words: essential hypertension, leukocyte relationships, kinesitherapy.
Полный текст
Список литературы
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2. Azab B, Chainani V, Shah N, McGinn JT. Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study. Angiology 2013; 64: 456–65.
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10. Toyama K, Sugiyama S, Oka H et al. Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease. PLoS One 2012; 7 (7): e41369.
11. Tani S, Nagao K, Anazawa T et al. Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment. Am J Cardiol 2009; 104 (4): 464–9.
12. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант, 2008. / Ketlinskij S.A., Simbircev A.S. Citokiny. SPb.: Foliant, 2008. [in Russian]
13. Marchesi C, Ebrahimian T, Angulo O et al. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 2009; 54: 1384–92.
14. Shenkman B, Brill I, Solpov A et al. CD4+ lymphocytes require platelet for adhesion to immobilized fibronectin in flow: Role of b1 (CD29)-, b2 (CD18) related integrins and non-integrin receptors. Cell Immunol 2006; 242 (1): 52–9.
15. Okamura K, Okuda T, Shirai K, Urata H. Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA. Clin Exp Hypertens 2017: 1–6. DOI: 10.1080/10641963.2017.1339071
2. Azab B, Chainani V, Shah N, McGinn JT. Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study. Angiology 2013; 64: 456–65.
3. Sabatine MS, Morrow DA, Cannon CP et al. Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICSTIMI 18 (treat angina with aggrastat and determine cost of therapy with an invasive or conservative strategy-trombolysis myocardial infarction 18) substudy. J Am Coll Cardiol 2002; 40: 1761–8.
4. Tatsukawa Y, Hsu WL, Yamada M et al. White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res 2008; 31: 1391–7.
5. Yayla Ç, Canpolat U, Akyel A et al. Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients. Blood Press Monit 2015; 20 (3): 127–31.
6. Laurent S, Cockcroft J, Van Bortel L et al. Expert consensus document on arterial stiffness: methodological issues, clinical applications. Eur Heart J 2006; 27: 2588–605.
7. Wang H, Hu Y, Geng Y et al. The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension. J Clin Hypertens (Greenwich) 2017. DOI: 10.1111/jch.13002
8. Fine I, Kuznik B, Kaminsky A, Shenkman L. A non-invasive method for the assessment of hemostasis in vivo by using dynamic light scattering. Laser Physics 2012; 22 (2): 1–7.
9. Kocaman SA, Sahinarslan A, Kunak T et al. The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study. Anadolu Kardiyol Derg 2011; 11 (7): 573–81.
10. Toyama K, Sugiyama S, Oka H et al. Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease. PLoS One 2012; 7 (7): e41369.
11. Tani S, Nagao K, Anazawa T et al. Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment. Am J Cardiol 2009; 104 (4): 464–9.
12. Ketlinskij S.A., Simbircev A.S. Citokiny. SPb.: Foliant, 2008. [in Russian]
13. Marchesi C, Ebrahimian T, Angulo O et al. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 2009; 54: 1384–92.
14. Shenkman B, Brill I, Solpov A et al. CD4+ lymphocytes require platelet for adhesion to immobilized fibronectin in flow: Role of b1 (CD29)-, b2 (CD18) related integrins and non-integrin receptors. Cell Immunol 2006; 242 (1): 52–9.
15. Okamura K, Okuda T, Shirai K, Urata H. Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA. Clin Exp Hypertens 2017: 1–6. DOI: 10.1080/10641963.2017.1339071
2. Azab B, Chainani V, Shah N, McGinn JT. Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study. Angiology 2013; 64: 456–65.
3. Sabatine MS, Morrow DA, Cannon CP et al. Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICSTIMI 18 (treat angina with aggrastat and determine cost of therapy with an invasive or conservative strategy-trombolysis myocardial infarction 18) substudy. J Am Coll Cardiol 2002; 40: 1761–8.
4. Tatsukawa Y, Hsu WL, Yamada M et al. White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res 2008; 31: 1391–7.
5. Yayla Ç, Canpolat U, Akyel A et al. Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients. Blood Press Monit 2015; 20 (3): 127–31.
6. Laurent S, Cockcroft J, Van Bortel L et al. Expert consensus document on arterial stiffness: methodological issues, clinical applications. Eur Heart J 2006; 27: 2588–605.
7. Wang H, Hu Y, Geng Y et al. The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension. J Clin Hypertens (Greenwich) 2017. DOI: 10.1111/jch.13002
8. Fine I, Kuznik B, Kaminsky A, Shenkman L. A non-invasive method for the assessment of hemostasis in vivo by using dynamic light scattering. Laser Physics 2012; 22 (2): 1–7.
9. Kocaman SA, Sahinarslan A, Kunak T et al. The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study. Anadolu Kardiyol Derg 2011; 11 (7): 573–81.
10. Toyama K, Sugiyama S, Oka H et al. Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease. PLoS One 2012; 7 (7): e41369.
11. Tani S, Nagao K, Anazawa T et al. Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment. Am J Cardiol 2009; 104 (4): 464–9.
12. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант, 2008. / Ketlinskij S.A., Simbircev A.S. Citokiny. SPb.: Foliant, 2008. [in Russian]
13. Marchesi C, Ebrahimian T, Angulo O et al. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 2009; 54: 1384–92.
14. Shenkman B, Brill I, Solpov A et al. CD4+ lymphocytes require platelet for adhesion to immobilized fibronectin in flow: Role of b1 (CD29)-, b2 (CD18) related integrins and non-integrin receptors. Cell Immunol 2006; 242 (1): 52–9.
15. Okamura K, Okuda T, Shirai K, Urata H. Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA. Clin Exp Hypertens 2017: 1–6. DOI: 10.1080/10641963.2017.1339071
________________________________________________
2. Azab B, Chainani V, Shah N, McGinn JT. Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study. Angiology 2013; 64: 456–65.
3. Sabatine MS, Morrow DA, Cannon CP et al. Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICSTIMI 18 (treat angina with aggrastat and determine cost of therapy with an invasive or conservative strategy-trombolysis myocardial infarction 18) substudy. J Am Coll Cardiol 2002; 40: 1761–8.
4. Tatsukawa Y, Hsu WL, Yamada M et al. White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res 2008; 31: 1391–7.
5. Yayla Ç, Canpolat U, Akyel A et al. Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients. Blood Press Monit 2015; 20 (3): 127–31.
6. Laurent S, Cockcroft J, Van Bortel L et al. Expert consensus document on arterial stiffness: methodological issues, clinical applications. Eur Heart J 2006; 27: 2588–605.
7. Wang H, Hu Y, Geng Y et al. The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension. J Clin Hypertens (Greenwich) 2017. DOI: 10.1111/jch.13002
8. Fine I, Kuznik B, Kaminsky A, Shenkman L. A non-invasive method for the assessment of hemostasis in vivo by using dynamic light scattering. Laser Physics 2012; 22 (2): 1–7.
9. Kocaman SA, Sahinarslan A, Kunak T et al. The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study. Anadolu Kardiyol Derg 2011; 11 (7): 573–81.
10. Toyama K, Sugiyama S, Oka H et al. Combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease. PLoS One 2012; 7 (7): e41369.
11. Tani S, Nagao K, Anazawa T et al. Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment. Am J Cardiol 2009; 104 (4): 464–9.
12. Ketlinskij S.A., Simbircev A.S. Citokiny. SPb.: Foliant, 2008. [in Russian]
13. Marchesi C, Ebrahimian T, Angulo O et al. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 2009; 54: 1384–92.
14. Shenkman B, Brill I, Solpov A et al. CD4+ lymphocytes require platelet for adhesion to immobilized fibronectin in flow: Role of b1 (CD29)-, b2 (CD18) related integrins and non-integrin receptors. Cell Immunol 2006; 242 (1): 52–9.
15. Okamura K, Okuda T, Shirai K, Urata H. Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA. Clin Exp Hypertens 2017: 1–6. DOI: 10.1080/10641963.2017.1339071
Авторы
Б.И.Кузник*1,2, С.О.Давыдов1,2, Е.С.Гусева1,2, А.В.Степанов1,2, Ю.Н.Смоляков1, Н.Н.Цыбиков1, И.В.Файн3, Э.Маген4
1 ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России. 672000, Россия, Чита, ул. Горького, д. 39а;
2 Иновационная клиника «Академия здоровья». 672038, Россия, Чита, ул. Коханского, д. 13;
3 Elfi-Tech Ltd., 2 Prof. Bergman St., Science Park, Rehovot, 76705, Israel;
4 Университетский медицинский центр Барзилай, Университет им. Бен-Гуриона, Израиль
*bi_kuznik@mail.ru
1 Chita State Medical Academy. 672090, Russian Federation, Chita, ul. Gorkogo, d. 39a;
2 Innovative Clinic “Health Academy”. 672038, Russian Federation, Chita, ul. Kokhanskogo, d. 13;
3 Elfi-Tech Ltd., 2 Prof. Bergman St., Science Park, Rehovot, 76705, Israel;
4 Medicine C Department, Barzilai Medical Center, Ben-Gurion University of the Negev, Ashkelon, Israel
*bi_kuznik@mail.ru
1 ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России. 672000, Россия, Чита, ул. Горького, д. 39а;
2 Иновационная клиника «Академия здоровья». 672038, Россия, Чита, ул. Коханского, д. 13;
3 Elfi-Tech Ltd., 2 Prof. Bergman St., Science Park, Rehovot, 76705, Israel;
4 Университетский медицинский центр Барзилай, Университет им. Бен-Гуриона, Израиль
*bi_kuznik@mail.ru
________________________________________________
1 Chita State Medical Academy. 672090, Russian Federation, Chita, ul. Gorkogo, d. 39a;
2 Innovative Clinic “Health Academy”. 672038, Russian Federation, Chita, ul. Kokhanskogo, d. 13;
3 Elfi-Tech Ltd., 2 Prof. Bergman St., Science Park, Rehovot, 76705, Israel;
4 Medicine C Department, Barzilai Medical Center, Ben-Gurion University of the Negev, Ashkelon, Israel
*bi_kuznik@mail.ru
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