Антиангиогенная терапия при раке молочной железы с тройным негативным фенотипом

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Аннотация

Терапия рака молочной железы с тройным негативным фенотипом является трудной клинической задачей. С одной стороны, высокая пролиферативная активность опухоли, характерная для этой когорты больных, обусловливает относительно высокую чувствительность к химиотерапии, с другой стороны – агрессивное течение с быстрой диссеминацией процесса и высокой смертностью. До настоящего времени химиотерапия остается основным методом лечения больных раком молочной железы с тройным негативным фенотипом. Однако результаты ее применения неудовлетворительны и существует острая потребность в поиске новых терапевтических мишеней, воздействие на которые могло бы увеличить эффективность лечения этой прогностически крайне неблагоприятной подгруппы больных. Антиангиогенная терапия позволяет несколько улучшить результаты лечения, однако до сих пор мы не имеем ни одного маркера, позволяющего предсказывать эффективность антиангиогенных препаратов. В связи с этим в настоящее время усилия исследователей должны быть направлены на поиск предсказательных факторов, позволяющих выявлять больных с чувствительными к антиангиогенным препаратам опухолями.

Ключевые слова: рак молочной железы, рак молочной железы с тройным негативным фенотипом, антиангиогенная терапия, бевацизумаб.

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The treatment for triple-negative breast cancer is a difficult clinical task. On the one hand, a high tumor proliferative activity, typical for this cohort, results in a relatively high sensitivity to chemotherapy; on the other hand, there is an aggressive clinical behavior with rapid dissemination and high mortality. To date, chemotherapy remains the principal treatment option for triple-negative breast cancer. However, its results are unsatisfactory and there is a critical need for new therapeutic targets, hitting which might increase the treatment efficacy in this extremely challenging patient subpopulation. Antiangiogenic therapy allows some improvement of treatment results; however, to date, we do not have any markers to predict the efficacy of antiangiogenic drugs. Therefore, the investigators’ efforts should be currently focused on searching for predictors of tumor susceptibility to antiangiogenic drugs, and hence eligible patients.

Key words: breast cancer, triple-negative breast cancer, antiangiogenic therapy, bevacizumab

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Авторы

Л.Г.Жукова

ФГБУ Российский онкологический научный центр им. Н.Н.Блохина РАМН

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L.G.Zhukova

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