В статье представлено клиническое наблюдение кератоакантомы (КА) кожи левой височной области с атипией у 91-летнего больного, получавшего лазерное лечение с адъювантной лучевой терапией. Также представлен случай КА кожи правой височной области без атипии у больной 77 лет, получавшей лазерное лечение. Сходство КА с плоскоклеточным раком диктует необходимость участия онколога на этапах диагностики и лечения.
We report a 91-year-old male patient with keratoacanthoma (KA) of left temporal skin with atypia, treated with laser vaporization followed by radiation therapy. Also we report a 77-year-old female patient with KA of right temporal skin without atypia, treated with laser vaporization alone. The KA and squamous cell carcinoma similarity demands oncologist assistance for KA management.
1. Chuang T-Y et al. Keratoacanthoma. http://emedicine.medscape.com
2. Молочков В.А., Казанцева И.А., Кунцевич Ж.С., Бочкарева Е.В. Кератоакантома: клиника, диагностика, лечение, трансформация в рак. М.: Бином, 2006.
3. Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol 2014; 53 (2): 131–6.
4. Goudie DR, D'Alessandro M, Merriman B et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet 2011; 43 (4): 365–9.
5. Stedman’s medical dictionary. 28th ed. Philadelphia: Lippincott Williams & Wilkins, 2006.
6. Zargaran M, Baghaei F. A clinical, histopathological and immunohistochemical approach to the bewildering diagnosis of keratoacanthoma. J Dent (Shiraz) 2014; 15 (3): 91–7.
7. Clifford Chao KS, Perez CA, Brady LW. Radiation oncology: management decisions. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2002.
8. Pyne JH, Windrum G, Sapkota D, Wong JC. Keratoacanthoma versus invasive squamous cell carcinoma: a comparison of dermatoscopic vascular features in 510 cases. Dermatol Pract Concept 2014; 4 (3): 37–41.
9. Edge S, Byrd DR, Compton CC et al. AJCC Cancer Staging Manual. 7th ed. 2010; 15. With CD-ROM.
10. Basoglu Y, Metze D, Nashan D, Ständer S. Keratoacanthoma with perineural invasion: an indicator for aggressive behavior? J Dtsch Dermatol Ges 2008; 6 (11): 952–5.
11. Basal cell and squamous cell skin cancers. Version 2.2014 02/20/14. National Comprehensive Cancer Network, Inc. 2014. http://www.nccn.org
12. Клиническая онкология: учебное пособие. Под ред. П.Г.Брюсова, П.Н.Зубарева. СПб: СпецЛит, 2012.
13. Wang T, Zhu X, Liu B et al. A case of nasal keratoacanthoma (a case report and literatures review) [Article in Chinese]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010; 24 (5): 214–6.
14. Weedon DD, Malo J, Brooks D, Williamson R. Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly. Am J Dermatopathol 2010; 32 (5): 423–6.
15. Yang F, Zhao Y, Dan LV. The clinical study of eight cases of nasal solitary keratoacanthoma [Article in Chinese]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013; 27 (23): 1337–8.
Авторы
К.А.Тетерин, Ю.Е.Кижаев, Н.П.Болотова
ГБОУ ДПО РМАПО Минздрава России, Москва
________________________________________________
K.A.Teterin, Yu.E.Kizhaev, N.P.Bolotova
Department of Oncology, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow (125993, Russia, Moscow, Barricadnaya st. 2/1)