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Современные ультразвуковые технологии при мониторинге эффективности химиотерапии рака шейки матки
Современные ультразвуковые технологии при мониторинге эффективности химиотерапии рака шейки матки
Мусаева З.Р.-Б., Чекалова М.А., Мещеряков А.А. Современные ультразвуковые технологии при мониторинге эффективности химиотерапии рака шейки матки. Современная Онкология. 2019; 21 (3): 56–61. DOI: 10.26442/18151434.2019.3.190658
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Аннотация
Рак шейки матки (РШМ) остается одной из важнейших социальных и медицинских проблем во всем мире в связи с ростом заболеваемости и смертности. Усовершенствование существующих и разработка новых вариантов диагностики и лечения распространенных стадий РШМ являются актуальной задачей современной онкологии. В соответствии со стандартами терапии при распространенном РШМ применяют лекарственную, лучевую терапию и оперативное лечение в различных модификациях. Неоадъювантная химиотерапия позволяет уменьшить объем опухоли, что способствует достижению оптимальной ее резектабельности, повышает абластичность операции. Кроме того, она дает возможность за счет подавления микрометастазирования улучшить выживаемость. Точная оценка эффективности лечения является одним из важных факторов успешного лечения. Комплексная ультразвуковая диагностика остается самым доступным и распространенным методом визуализации, обладая рядом важных технологий, позволяющих максимально объективно визуализировать опухолевый очаг шейки матки, распространенность, особенности кровотока и получить своевременную информацию о регрессе опухоли. В связи с внедрением новых технологий сегодня наблюдается значительное расширение возможностей ультразвуковой диагностики в онкологии в целом. Наиболее перспективными из них считаются ультразвуковая эластография и контрастно-усиленное ультразвуковое исследование. Данный обзор посвящен возможностям методик в оценке эффективности неоадъювантной химиотерапии.
Ключевые слова: рак шейки матки, распространенный рак шейки матки, неоадъювантная химиотерапия, химиолучевая терапия, ультразвуковая диагностика, контрастно-усиленное ультразвуковое исследование, эластография.
Key words: cervical cancer, advanced cervical cancer, neoadjuvant chemotherapy, chemoradiotherapy, ultrasound diagnosis, contrast-enhanced ultrasound, elastography.
Ключевые слова: рак шейки матки, распространенный рак шейки матки, неоадъювантная химиотерапия, химиолучевая терапия, ультразвуковая диагностика, контрастно-усиленное ультразвуковое исследование, эластография.
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Key words: cervical cancer, advanced cervical cancer, neoadjuvant chemotherapy, chemoradiotherapy, ultrasound diagnosis, contrast-enhanced ultrasound, elastography.
Полный текст
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17. Lu R, Xiao Y, Liu M et al. Ultrasound elastography in the differential diagnosis of benign and malignant cervical lesions. J Ultrasound Med 2014; 33 (4): 667–71. DOI: 10.7863/ultra.33.4.667
18. Sun LT, Ning CP, Liu YJ et al. Is transvaginal elastography useful in pre-operative diagnosis of cervical cancer? Eur J Radiol 2012; 81 (8): 888–92. DOI: 10.1016/j.ejrad.2012.04.025
19. Ma X, Li Q, Wang JL et al. Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer. Clin Hemorheol Microcirc 2017; 66 (1): 27–35. DOI: 10.3233/CH-16235
20. Mabuchi S, Sasano T, Kuroda H et al. Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results. J Med Ultrason (2001) 2015; 42 (3): 379–85. DOI: 10.1007/s10396-015-0616-6. PMID: 26576790.
21. Kriazheva V.S., Chekalova M.A. Primenenie elastografii v otsenke effektivnosti luchevoi terapii u bol'nykh rakom sheiki matki. Luchevaia diagnostika, luchevaia terapiia. 2018; 1 (4): 60 (in Russian).
22. Xu Y, Zhu L, Liu B et al. Strain elastography imaging for early detection and prediction of tumor response to concurrent chemoradiotherapy in locally advanced cervical cancer: feasibility study. BMC Cancer 2017; 17: 427. DOI: 10.1186/s12885-017-3411-5
23. Davydov A.I., Kuz'mina T.E. Kontrastno-usilennye ul'trazvukovye issledovaniia v ginekologii. Vopr. ginekologii, akusherstva i perinatologii. 2017; 16 (6): 50–8. DOI: 10.20953/1726-1678-2017-6-50-58 (in Russian).
24. Сorreas JM, Burns PN, Lai X et al. Infusion versus bolus of an ultrasound contrast agent: in vivo doseresponse measurements of BRI. Invest Radiol 2000; 35 (1): 72–9.
25. Morel DR, Schwieger I, Hohn L et al. Human pharmacokinetics and safety evaluation of SonoVue, a new contrast agent for ultrasound imaging. Invest Radiol 2000; 35 (1): 80–5. PMID: 10639039 DOI: 10.1097/00004424-200001000-00009
26. Claudon M, Deitrich CF, Choi BI et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver – update 2012 AWFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 2013; 39: 187–210. PMID: 23129518. DOI: 10.1055/s-0032-1325499
27. Piscaglia F, Nolsøe C, Dietrich CF et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications. Ultraschall Med 2012 2012; 33 (1): 33–59. DOI: 10.1055/s-0031-1281676. PMID: 21874631
28. Leoni S, Piscaglia F, Golfieri R et al. The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria. Am J Gastroenterol 2010; 105: 599–609.
29. Dong Y, Wang WP, Cantisani V et al. Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma. World J Gastroenterol 2016; 22 (19): 4741–9.
30. Dietrich CF, Kratzer W, Strobe D et al. Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 2006; 12 (11): 1699–705.
31. D‘Onofrio M, Barbi E, Dietrich CF et al. Pancreatic multicenter ultrasound study (PAMUS). Eur J Radiol 2012; 81 (4): 630–8.
32. Dong X, Sheng Y, Xu L et al. Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma. Chin Med J 2009; 122 (10): 1179–83.
33. Sorelli PG, Cosgrove DO, Svensson WE et al. Can contrast-enhanced sonography distinguish benign from malignant breast masses? J Clin Ultrasound 2010; 38: 177–81.
34. Kotliarov P.M., Sencha A.N., Kashmanova A.V. et al. Ul'trazvukovoe issledovanie s kontrastnym usileniem v diagnostike ochagovoi patologii molochnykh zhelez u zhenshchin i muzhchin. Med. vizualizatsiia. 2015; 2: 120–8 (in Russian).
35. Sencha A.N., Mogutov M.S., Patrunov Iu.N. et al. Vozmozhnosti ul'trazvukovogo issledovaniia s kontrastnym usileniem v diagnostike raka shchitovidnoi zhelezy. Ul'trazvukovaia i funktsional'naia diagnostika. 2015; 6: 10–26 (in Russian).
36. Lieng M, Qvigstad E, Dahl GF et al. Flow differences between endometrial polyps and cancer: a prospective study using intravenous contrast-enhanced transvaginal color flow Doppler and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol 2008; 32 (7): 935–40. DOI: 10.1002/uog.6267. PMID: 19035544
37. Testa AC, Ferrandina G Fruscella E et al. The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases: A preliminary study. J Ultrasound Med 2005; 24 (9): 1267–78. PMID: 16123187. DOI: 10.7863/jum.2005.24.9.1267
38. Shi PL, Song DY, Shi TM. Application of real-time gray scale contrast-enhanced ultrasonography in differentiation of benign and malignant diseases in uterine cavity. Chinese J Med Imag Technol 2009; 25: 150–2.
39. Liu Y, Xu Y, Cheng W, Liu X. Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncol Letters 2016; 12 (5): 3763–70. DOI: 10.3892/ol.2016.5206. PMID: 27895728
40. Fleischer AC, Lyshchik A, Jones HW Jr et al. Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: Preliminary findings. J Ultrasound Med 2008; 27 (7): 1011–8. PMID: 18577664. DOI: 10.7863/jum.2008.27.7.1011
41. Szymanski M, Socha MW, Kowalkowska ME et al. Differentiating between benign and malignant adnexal lesions with contrast-enhanced transvaginal ultrasonography. Int J Gynaecol Obstet 2015; 131 (2): 147–51. DOI: 10.1016/j.ijgo.2015.04.047
42. Wu Y, Peng H, Zhao X. Diagnostic performance of contrast-enhanced ultrasound for ovarian cancer: A meta-analysis. Ultrasound Med Biol 2015; 41 (4): 967–74. PMID: 25701533. DOI: 10.1016/j.ultrasmedbio.2014.11.018
43. Lixia L, Jianhui L, Aimin Z et al. Comparison of application value between CEUS and conventional ultrasound in preoperative and staging diagnosis of cervical cancer. Biomed Res (India) 2016; 27 (2): 553–6.
44. Zheng W, Xiong YH, Han J et al. Contrast-enhanced ultrasonography of cervical carcinoma: perfusion pattern and relationship with tumour angiogenesis. Br J Radiol 2016; 89 (1065): 436–45. DOI: 10.1259/bjr.20150887
45. Pálsdóttir K, Epstein E. A Pilot Study on Diagnostic Performance of Contrast-Enhanced Ultrasonography for Detection of Early Cervical Cancer. Ultrasound Med Biol 2018; 44 (8): 1664–71. DOI: 10.1016/j.ultrasmedbio.2018.04.01846. Zheng W, Chen K, Peng C et al. Contrast-enhanced ultrasonography vs MRI for evaluation of local invasion by cervical cancer. Br J Radiol 2018; 91 (1091). DOI: 10.1259/bjr.20170858. PMID: 30028181
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49. Paul S, Sidhu, Vito Cantisani et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version). Ultraschall Med 2018; 39 (2): 154–80. DOI: 10.1055/ s-0044-101254. PMID: 29510440
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19. Ma X, Li Q, Wang JL et al. Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer. Clin Hemorheol Microcirc 2017; 66 (1): 27–35. DOI: 10.3233/CH-16235
20. Mabuchi S, Sasano T, Kuroda H et al. Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results. J Med Ultrason (2001) 2015; 42 (3): 379–85. DOI: 10.1007/s10396-015-0616-6. PMID: 26576790.
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24. Сorreas JM, Burns PN, Lai X et al. Infusion versus bolus of an ultrasound contrast agent: in vivo doseresponse measurements of BRI. Invest Radiol 2000; 35 (1): 72–9.
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26. Claudon M, Deitrich CF, Choi BI et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver – update 2012 AWFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 2013; 39: 187–210. PMID: 23129518. DOI: 10.1055/s-0032-1325499
27. Piscaglia F, Nolsøe C, Dietrich CF et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications. Ultraschall Med 2012 2012; 33 (1): 33–59. DOI: 10.1055/s-0031-1281676. PMID: 21874631
28. Leoni S, Piscaglia F, Golfieri R et al. The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria. Am J Gastroenterol 2010; 105: 599–609.
29. Dong Y, Wang WP, Cantisani V et al. Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma. World J Gastroenterol 2016; 22 (19): 4741–9.
30. Dietrich CF, Kratzer W, Strobe D et al. Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 2006; 12 (11): 1699–705.
31. D‘Onofrio M, Barbi E, Dietrich CF et al. Pancreatic multicenter ultrasound study (PAMUS). Eur J Radiol 2012; 81 (4): 630–8.
32. Dong X, Sheng Y, Xu L et al. Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma. Chin Med J 2009; 122 (10): 1179–83.
33. Sorelli PG, Cosgrove DO, Svensson WE et al. Can contrast-enhanced sonography distinguish benign from malignant breast masses? J Clin Ultrasound 2010; 38: 177–81.
34. Котляров П.М., Сенча А.Н., Кашманова А.В. и др. Ультразвуковое исследование с контрастным усилением в диагностике очаговой патологии молочных желез у женщин и мужчин. Мед. визуализация. 2015; 2: 120–8.
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[Sencha A.N., Mogutov M.S., Patrunov Iu.N. et al. Vozmozhnosti ul'trazvukovogo issledovaniia s kontrastnym usileniem v diagnostike raka shchitovidnoi zhelezy. Ul'trazvukovaia i funktsional'naia diagnostika. 2015; 6: 10–26 (in Russian).]
36. Lieng M, Qvigstad E, Dahl GF et al. Flow differences between endometrial polyps and cancer: a prospective study using intravenous contrast-enhanced transvaginal color flow Doppler and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol 2008; 32 (7): 935–40. DOI: 10.1002/uog.6267. PMID: 19035544
37. Testa AC, Ferrandina G Fruscella E et al. The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases: A preliminary study. J Ultrasound Med 2005; 24 (9): 1267–78. PMID: 16123187. DOI: 10.7863/jum.2005.24.9.1267
38. Shi PL, Song DY, Shi TM. Application of real-time gray scale contrast-enhanced ultrasonography in differentiation of benign and malignant diseases in uterine cavity. Chinese J Med Imag Technol 2009; 25: 150–2.
39. Liu Y, Xu Y, Cheng W, Liu X. Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. Oncol Letters 2016; 12 (5): 3763–70. DOI: 10.3892/ol.2016.5206. PMID: 27895728
40. Fleischer AC, Lyshchik A, Jones HW Jr et al. Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: Preliminary findings. J Ultrasound Med 2008; 27 (7): 1011–8. PMID: 18577664. DOI: 10.7863/jum.2008.27.7.1011
41. Szymanski M, Socha MW, Kowalkowska ME et al. Differentiating between benign and malignant adnexal lesions with contrast-enhanced transvaginal ultrasonography. Int J Gynaecol Obstet 2015; 131 (2): 147–51. DOI: 10.1016/j.ijgo.2015.04.047
42. Wu Y, Peng H, Zhao X. Diagnostic performance of contrast-enhanced ultrasound for ovarian cancer: A meta-analysis. Ultrasound Med Biol 2015; 41 (4): 967–74. PMID: 25701533. DOI: 10.1016/j.ultrasmedbio.2014.11.018
43. Lixia L, Jianhui L, Aimin Z et al. Comparison of application value between CEUS and conventional ultrasound in preoperative and staging diagnosis of cervical cancer. Biomed Res (India) 2016; 27 (2): 553–6.
44. Zheng W, Xiong YH, Han J et al. Contrast-enhanced ultrasonography of cervical carcinoma: perfusion pattern and relationship with tumour angiogenesis. Br J Radiol 2016; 89 (1065): 436–45. DOI: 10.1259/bjr.20150887
45. Pálsdóttir K, Epstein E. A Pilot Study on Diagnostic Performance of Contrast-Enhanced Ultrasonography for Detection of Early Cervical Cancer. Ultrasound Med Biol 2018; 44 (8): 1664–71. DOI: 10.1016/j.ultrasmedbio.2018.04.018
46. Zheng W, Chen K, Peng C et al. Contrast-enhanced ultrasonography vs MRI for evaluation of local invasion by cervical cancer. Br J Radiol 2018; 91 (1091). DOI: 10.1259/bjr.20170858. PMID: 30028181
47. Peng C, Liu LZ, Zheng W et al. Can quantitative contrast-enhanced ultrasonography predict cervical tumor response to neoadjuvant chemotherapy? Eur J Radiol 2016; 85 (11): 2111–8. DOI: 10.1016/j.ejrad.2016.09.025. PMID: 27776666
48. Zhang XL, He XQ, Mao YJ et al. Contrast-enhanced ultrasound in assessing the effect of chemotherapy on cervical cancer. Chin J Med Imag Technol 2013; 29 (6): 998–1001. DOI: 10.1259/bjr.20150887. PMID: 27340932
49. Paul S, Sidhu, Vito Cantisani et al. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version). Ultraschall Med 2018; 39 (2): 154–80. DOI: 10.1055/ s-0044-101254. PMID: 29510440
________________________________________________
2. Kaprin A.D, Starinskii V.V., Petrova G.V. Malignant neoplasms in Russia in 2017 (morbidity and mortality). Moscow: MNIOI im. P.A.Gertsena – filial FGBU "NMITs radiologii" Minzdrava Rossii, 2018 (in Russian).
3. Sushinskaia T.V., Zhordania K.I., Paianidi Iu.G. Analiticheskie aspekty onkologicheskikh zabolevanii zhenskogo naseleniia Rossii. Onkoginekologiia. 2015; 3: 40–3 (in Russian).
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Авторы
З.Р.-Б. Мусаева*1,2, М.А. Чекалова1, А.А. Мещеряков1
1 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия;
2 ГБУ «Республиканский онкологический диспансер», Грозный, Россия
*zalina_9373.doctor@mail.ru
1 Blokhin National Medical Research Center of Oncology, Moscow, Russia;
2 Republican Oncology Center, Groznyi, Russia
*zalina_9373.doctor@mail.ru
1 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия;
2 ГБУ «Республиканский онкологический диспансер», Грозный, Россия
*zalina_9373.doctor@mail.ru
________________________________________________
1 Blokhin National Medical Research Center of Oncology, Moscow, Russia;
2 Republican Oncology Center, Groznyi, Russia
*zalina_9373.doctor@mail.ru
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