Злокачественное новообразование бронхов и легкого

Лактионов К.К., Артамонова Е.В., Борисова Т.Н., Бредер В.В., Бычков Ю.М., Владимирова Л.Ю., Волков Н.М., Ергнян С.М., Жабина А.С., Кононец П.В., Кузьминов А.Е., Левченко Е.В., Малихова О.А., Маринов Д.Т., Миллер С.В., Моисеенко Ф.В., Мочальникова В.В., Новиков С.Н., Пикин О.В., Реутова Е.В., Родионов Е.О., Сакаева Д.Д., Семенова А.И., Смолин А.В., Сотников В.М., Тузиков С.А., Туркин И.Н., Тюрин И.Е., Чхиквадзе В.Д., Колбанов К.И., Черниченко А.В., Феденко А.А., Филоненко Е.В., Невольских А.А., Иванов С.А., Хайлова Ж.В., Геворкян Т.Г., Бутенко А.В., Гильмутдинова И.Р., Гриднева И.В., Еремушкин М.А., Зернова М.А., Каспаров Б.С., Ковлен Д.В., Кондратьева К.О., Кончугова Т.В., Короткова С.Б., Крутов А.А., Обухова О.А., Пономаренко Г.Н., Семиглазова Т.Ю., Степанова А.М., Ткаченко Г.А., Хуламханова М.М. Злокачественное новообразование бронхов и легкого. Современная Онкология. 2021; 23 (3): 369–402.
DOI: 10.26442/18151434.2021.3.201048

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Laktionov KK, Artamonova EV, Borisova TN, Breder VV, Bychkov IuM, Vladimirova LIu, Volkov NM, Ergnian SM, Zhabina AS, Kononets PV, Kuz’minov AE, Levchenko EV, Malikhova OA, Marinov DT, Miller SV, Moiseenko FV, Mochal’nikova VV, Novikov SN, Pikin OV, Reutova EV, Rodionov EO, Sakaeva DD, Semenova AI, Smolin AV, Sotnikov VM, Tuzikov SA, Turkin IN, Tiurin IE, Chkhikvadze VD, Kolbanov KI, Chernichenko AV, Fedenko AA, Filonenko EV, Nevol’skikh AA, Ivanov SA, Khailova ZhV, Gevorkian TG, Butenko AV, Gil’mutdinova IR, Gridneva IV, Eremushkin MA, Zernova MA, Kasparov BS, Kovlen DV, Kondrat’eva KO, Konchugova TV, Korotkova SB, Krutov AA, Obukhova OA, Ponomarenko GN, Semiglazova TIu, Stepanova AM, Tkachenko GA, Khulamkhanova MM. Malignant neoplasm of the bronchi and lung: Russian clinical guidelines. Journal of Modern Oncology. 2021; 23 (3): 369–402.
DOI: 10.26442/18151434.2021.3.201048

Злокачественное новообразование бронхов и легкого

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Аннотация

Ключевые слова: рак легкого, рак бронхов, клинические рекомендации

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Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.

Keywords: lung cancer, clinical guidelines

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Авторы

К.К. Лактионов1, Е.В. Артамонова1, Т.Н. Борисова1, В.В. Бредер1, Ю.М. Бычков2, Л.Ю. Владимирова1, Н.М. Волков3, С.М. Ергнян4, А.С. Жабина3, П.В. Кононец1, А.Е. Кузьминов1, Е.В. Левченко4, О.А. Малихова1, Д.Т. Маринов1, С.В. Миллер5, Ф.В. Моисеенко3, В.В. Мочальникова1, С.Н. Новиков4, О.В. Пикин6, Е.В. Реутова1, Е.О. Родионов5, Д.Д. Сакаева7, А.И. Семенова4, А.В. Смолин8, В.М. Сотников2, С.А. Тузиков5, И.Н. Туркин9, И.Е. Тюрин10, В.Д. Чхиквадзе2, К.И. Колбанов6, А.В. Черниченко6, А.А. Феденко6, Е.В. Филоненко6, А.А. Невольских11, С.А. Иванов11, Ж.В. Хайлова11, Т.Г. Геворкян1, А.В. Бутенко1, И.Р. Гильмутдинова12, И.В. Гриднева13, М.А. Еремушкин12, М.А. Зернова4, Б.С. Каспаров4, Д.В. Ковлен14,
К.О. Кондратьева4, Т.В. Кончугова12, С.Б. Короткова13, А.А. Крутов4, О.А. Обухова1, Г.Н. Пономаренко14,15, Т.Ю. Семиглазова4,16, А.М. Степанова17, Г.А. Ткаченко1, М.М. Хуламханова1

1 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, Москва, Россия;
2 ФГБУ «Российский научный центр рентгенорадиологии» Минздрава России, Москва, Россия;
3 ГБУЗ «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)», Санкт-Петербург, Россия;
4 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России, Санкт-Петербург, Россия;
5 ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук», Томск, Россия;
6 Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Москва, Россия;
7 ГБУЗ «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Башкортостан», Уфа, Россия;
8 ФГБУ «Главный военный клинический госпиталь им. акад. Н.Н. Бурденко» Минобороны России, Москва, Россия;
9 ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России, Ростов-на-Дону, Россия;
10 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия;
11 Медицинский радиологический научный центр им. А.Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Обнинск, Россия;
12 ФГБУ «Национальный медицинский исследовательский центр реабилитации и курортологии» Минздрава России, Москва, Россия;
13 ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России, Воронеж, Россия;
14 Филиал ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны России, Москва, Россия;
15 ФГБУ «Федеральный научный центр реабилитации инвалидов им. Г.А. Альбрехта» Минтруда России, Санкт-Петербург, Россия;
16 ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-Петербург, Россия;
17 Центр диагностики и реабилитации «Восстановление», Москва, Россия

________________________________________________

Konstantin K. Laktionov1, Elena V. Artamonova1, Tatiana N. Borisova1, Valerii V. Breder1, Iurii M. Bychkov2,
Liubov Iu. Vladimirova1, Nikita M. Volkov3, Stepan M. Ergnian4, Albina S. Zhabina3, Pavel V. Kononets1,
Aleksandr E. Kuz’minov1, Evgenii V. Levchenko4, Olga A. Malikhova1, Dimitr T. Marinov1, Sergei V. Miller5,
Fedor V. Moiseenko3, Valeriia V. Mochal’nikova1, Sergei N. Novikov4, Oleg V. Pikin6, Elena V. Reutova1, Evgenii O. Rodionov5, Dina D. Sakaeva7, Anna I. Semenova4, Aleksei V. Smolin8, Vladimir M. Sotnikov2, Sergei A. Tuzikov5, Igor N. Turkin9,
Igor E. Tiurin10, Vladimir D. Chkhikvadze2, Konstantin I. Kolbanov6, Andrei V. Chernichenko6, Aleksandr A. Fedenko6,
Elena V. Filonenko6, Aleksei A. Nevol’skikh11, Sergei A. Ivanov11, Zhanna V. Khailova11, Tigran G. Gevorkian1, Aleksei V. Butenko1, Ilmira R. Gil’mutdinova12, Irina V. Gridneva13, Mikhail A. Eremushkin12, Margarita A. Zernova4, Boris S. Kasparov4, Denis V. Kovlen14, Kristina O. Kondrat’eva4, Tatiana V. Konchugova12, Svetlana B. Korotkova13, Anton A. Krutov4, Olga A. Obukhova1, Gennadii N. Ponomarenko14,15, Tatiana Iu. Semiglazova4,16, Aleksandra M. Stepanova17, Galina A. Tkachenko1, Marina M. Khulamkhanova1

1 Blokhin National Medical Research Center of Oncology, Moscow, Russia;
2 Russian Scientific Center of Roentgenoradiology, Moscow, Russia;
3 Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care (Oncologic), Saint Petersburg, Russia;
4 Petrov National Medical Research Center of Oncology, Saint Petersburg, Russia;
5 Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia;
6 Herzen Moscow Scientifuc Research Institute of Oncology – branch of the National Medical Research Center for Radiology, Moscow, Russia;
7 Republican Clinical Oncology Center of Ministry of Healthcare of the Republic of Bashkortostan, Ufa, Russia;
8 Burdenko Main Military Clinical Hospital, Moscow, Russia;
9 Rostov Research Institute of Oncology, Rostov-on-Don, Russia;
10 Russian Medical Academy of Continuous Professional Education, Moscow, Russia;
11 Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Center for Radiology, Obninsk, Russia;
12 National Medical Research Center of Rehabilitation and Balneology, Moscow, Russia;
13 Burdenko Voronezh State Medical University, Voronezh, Russia;
14 Branch of Kirov Military Medical Academy, Moscow, Russia;
15 Albrecht Federal Scientific Center for Rehabilitation of Disabled People, Saint Petersburg, Russia;
16 Mechnikov North-Western State Medical University, Saint Petersburg, Russia;
17 Diagnostic and Rehabilitation Center “Recovery”, Moscow, Russia

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