Злокачественные новообразования у ВИЧ-инфицированных пациентов в России: реальная история сроком в 20 лет

Некрасова А.В., Рассохин В.В., Фалалеева Н.А., Гривцова Л.Ю., Гусев Д.А. Злокачественные новообразования у ВИЧ-инфицированных пациентов в России: история сроком в 20 лет. Современная Онкология. 2021;23(4):593–597. DOI: 10.26442/18151434.2021.4.201291

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Nekrasova AV, Rassokhin VV, Falaleeva NA, Grivtsova LYu, Gusev DA. Malignant neoplasms in HIV patients in Russia: the story over a 20-year period. Journal of Modern Oncology. 2021;23(4):593–597. DOI: 10.26442/18151434.2021.4.201291

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Аннотация

Согласно данным официальной статистики, к началу 2021 г. общее число выявленных случаев инфицирования ВИЧ в России превысило 1,1 млн. При этом на территории страны в течение последних лет выявляется порядка 100 тыс. новых ВИЧ-инфицированных пациентов ежегодно. Россия занимает одно из лидирующих мест по заболеваемости ВИЧ-инфекцией, и темпы прироста новых случаев инфицирования не снижаются. ВИЧ-инфицированные больные имеют более высокий уровень заболеваемости злокачественными новообразованиями (ЗНО) по сравнению с общей популяцией и более высокие показатели онкологической смертности. Проблема сочетания ВИЧ–ЗНО находится на стыке двух социально значимых вопросов, которым уделяется особое внимание в Российской Федерации. Становятся все более актуальными проблемы диагностики и лечения ЗНО, что обусловливает крайнюю важность дальнейшего изучения эпидемиологии ЗНО при ВИЧ в Российской Федерации. Это позволит создавать эффективные алгоритмы организации диспансерного наблюдения для ВИЧ-инфицированных, будет способствовать ранней диагностике, своевременному началу лечения и, как следствие, достижению лучших онкологических результатов.

Ключевые слова: вирус иммунодефицита человека, злокачественные новообразования, ВИЧ-ассоциированные опухоли

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According to the official statistics, by the beginning of 2021, the overall number of registered HIV cases in Russia exceeded 1.1 million. For about 100 000 new HIV-infected patients have been registered annually in Russia recent years. Russia occupies one of the leading places in the incidence of HIV infection, and the growth rate of new HIV cases is not decreasing. HIV-infected patients have higher incidence of malignant neoplasms (MN) in comparison with the overall population and have the highest cancer mortality rates. The problem of HIV-associated malignancies is at the junction of two socially significant issues, and this situation especially taking into account in Russian Federation. The problems of diagnosis and treatment of MN are becoming topical, and it is extremely important to study HIV-associated malignancies epidemiology in the Russian Federation. This will help to create effective algorithms for organizing dispensary observation for HIV infected people, will help to early diagnosis of the disease, timely initiation of treatment and, as a result, will help to achieve the best oncological results.

Keywords: human immunodeficiency virus, malignant neoplasms, HIV-associated malignant neoplasms

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3. Angeletti PC, Zhang L, Wood C. The viral etiology of AIDS-associated malignancies. Adv Pharmacol. 2008;56:509-57. DOI:10.1016/S1054-3589(07)56016-3
4. Chaturvedi AK, Madeleine MM, Biggar RJ, Engels EA. Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst. 2009;101(16):1120‑30. DOI:10.1093/jnci/djp205
5. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370(9581):59-67. DOI:10.1016/S0140-6736(07)61050-2
6. Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet HIV. 2017;4(11):e495-e504. DOI:10.1016/S2352-3018(17)30125-X
7. Meijide H, Pértega S, Rodríguez-Osorio I, et al. Increased incidence of cancer observed in HIV/hepatitis C virus patients versus HIV-monoinfected. AIDS. 2017;31(8):1099-107. DOI:10.1097/QAD.0000000000001448
8. Coghill AE, Han X, Suneja G, et al. Advanced stage at diagnosis and elevated mortality among US patients with cancer infected with HIV in the National Cancer Data Base. Cancer. 2019;125(16):2868-76. DOI:10.1002/cncr.32158
9. Dryden-Peterson S, Bvochora-Nsingo M, Suneja G, et al. HIV infection and survival among women with cervical cancer. J Clin Oncol. 2016;34(31):3749-57.
DOI:10.1200/JCO.2016.67.9613
10. Ferreira MP, Coghill AE, Chaves CB, et al. Outcomes of cervical cancer among HIV-infected and HIV-uninfected women treated at the Brazilian National Institute of Cancer. AIDS. 2017;31(4):523-31. DOI:10.1097/QAD.0000000000001367
11. Antiretroviral Therapy Cohort Collaboration. Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies. Lancet HIV. 2017;4(8):e349-e356. DOI:10.1016/S2352-3018(17)30066-8
12. Detels R, Munoz A, McFarlane G, et al. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators. JAMA. 1998;280(17):1497-503. DOI:10.1001/jama.280.17.1497
13. Frisch M, Biggar RJ, Engels EA, et al. Association of cancer with AIDS-related immunosuppression in adults. JAMA. 2001;285(13):1736-45.
DOI:10.1001/jama.285.13.1736
14. Goedert JJ, Cote TR, Virgo P, et al. Spectrum of AIDS-associated malignant disorders. Lancet. 1998;351(9119):1833-9. DOI:10.1016/s0140-6736(97)09028-4
15. Brock MV, Hooker CM, Engels EA, et al. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr. 2006;43(1):47-55. DOI:10.1097/01.qai.0000232260.95288.93
16. Cobucci RN, Lima PH, de Souza PC, et al. Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: a systematic review. J Infect Public Health. 2015;8(1):1-10.
DOI:10.1016/j.jiph.2014.08.003
17. Engels EA, Biggar RJ, Hall HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187-94. DOI:10.1002/ijc.23487
18. Engels EA, Pfeiffer RM, Goedert JJ, et al. Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS. 2006;20(12):1645-54.
DOI:10.1097/01.aids.0000238411.75324.59
19. Farahani M, Mulinder H, Farahani A, Marlink R. Prevalence and distribution of non-AIDS causes of death among HIV-infected individuals receiving antiretroviral therapy: a systematic review and meta-analysis. Int J STD AIDS. 2017;28(7):636‑50. DOI:10.1177/0956462416632428
20. Patel P, Hanson DL, Sullivan PS, et al. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann Intern Med. 2008;148(10):728-36.
DOI:10.7326/0003-4819-148-10-200805200-00005
21. Robbins HA, Pfeiffer RM, Shiels MS, et al. Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015;107(4):dju503.
DOI:10.1093/jnci/dju503
22. Shiels MS, Pfeiffer RM, Gail MH, et al. Cancer burden in the HIVinfected population in the United States. J Natl Cancer Inst. 2011;103(9):753-62. DOI:10.1093/jnci/djr076
23. Kaprin AD, Voronin EE, Rassokhin VV, et al. Malignant neoplasms associated with HIV infection. Problems and solutions (problem outline). Journal of Modern Oncology. 2021;23(3):502-7 (in Russian). DOI:10.26442/18151434.2021.3.201041
24. Robbins HA, Shiels MS, Pfeiffer RM, Engels EA. Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States. AIDS. 2014;28(6):881‑90. DOI:10.1097/QAD.0000000000000163
25. Park LS, Hernández-Ramírez RU, Silverberg MJ, et al. Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis. AIDS. 2016;30(2):273‑91. DOI:10.1097/QAD.0000000000000922
26. Helleberg M, Afzal S, Kronborg G, et al. Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study. Clin Infect Dis. 2013;56(5):727-34. DOI:10.1093/cid/cis933
27. McGinnis KA, Fultz SL, Skanderson M, et al. Hepatocellular carcinoma and non-Hodgkin's lymphoma: the roles of HIV, hepatitis C infection, and alcohol abuse. J Clin Oncol. 2006;24(31):5005-9. DOI:10.1200/JCO.2006.05.7984
28. Rentsch C, Tate JP, Akgun KM, et al. Alcohol-related diagnoses and all-cause hospitalization among HIV-infected and uninfected patients: a longitudinal analysis of United States veterans from 1997 to 2011. AIDS Behav. 2016;20(3):555‑64. DOI:10.1007/s10461-015-1025-y
29. Tesoriero JM, Gieryic SM, Carrascal A, Lavigne HE. Smoking among HIV positive New Yorkers: prevalence, frequency, and opportunities for cessation. AIDS Behav. 2010;14(4):824-35. DOI:10.1007/s10461-008-9449-2

Авторы

А.В. Некрасова*1, В.В. Рассохин2, Н.А. Фалалеева1, Л.Ю. Гривцова1, Д.А. Гусев3

1 Медицинский радиологический научный центр им. А.Ф. Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Обнинск, Россия;
2 ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России, Санкт-Петербург, Россия;
3 СПб ГБУЗ «Клиническая инфекционная больница им. С.П. Боткина», Санкт-Петербург, Россия
*nekrasova.anastasiya.doc@mail.ru

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Anastasyia V. Nekrasova*1, Vadim V. Rassokhin2, Natalia A. Falaleeva1, Lyudmila Y. Grivtsova1, Denis A. Gusev3

1 Tsyb Medical Radiological Scientific Center – branch of the National Medical Research Radiological Centre, Obninsk, Russia;
2 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
3 Botkin Hospital for Infictuous Diseases, Saint Petersburg, Russia
*nekrasova.anastasiya.doc@mail.ru

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