1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003; 81 (9): 646–56. Available at: /pmc/articles/PMC2572542/?report=abstract. 
2. Brooks P. Issues with chronic musculoskeletal pain. Rheumatology (Oxford). 2005; 44 (7): 831–3. DOI:10.1093/rheumatology/keh648
3. Connelly LB, Woolf A, Brooks P. Cost-Efectiveness of Interventions for Musculoskeletal Conditions. 2006. Available at: http://www.ncbi.nlm.nih.gov/books/NBK11713/
4. Oren O, Ablin J. Precision medicine: the emerging approach to the chronic pain patient. Int J Clin Rheumtol 2013; 8 (4): 491–9. DOI:10.2217/ijr.13.34
5. Cimmino MA, Ferrone C, Cutolo M. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2011; 25 (2): 173–83. DOI:10.1016/j.berh.2010.01.012
6. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology and its clinical relevance. Br J Anaesth 2013; 111 (1): 13–8. DOI:10.1093/bja/aet123
7. Practice guidelines for chronic pain management: an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology 2010; 112 (4): 810–33. DOI:10.1097/ALN.0b013e3181c43103
8. Langford RM. Pain management today – what have we learned? Clin Rheumatol 2006; 25 (Suppl. 1): S2–8. DOI:10.1007/s10067-006-0311-5
9. Dieppe P. Chronic musculoskeletal pain. BMJ 2013; 346 (6): f3146. DOI: 10.1136/bmj.f3146
10. Berna C, Leknes S, Holmes EA et al. Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 2010; 67 (11): 1083–90. DOI:10.1016/j.biopsych.2010.01.014
11. Hall-Flavin DK. Pain and depression: Is there a link? Mayo Clinic. http://www.mayoclinic.org/diseases-conditions/depression/expert-answers/pain-and-depression/faq-2005...
12. Serhan CN, Brain SD, Buckley CD et al. Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007; 21 (2): 325–32. DOI:10.1096/fj.06-7227rev
13. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev 2011; 111 (10): 5922–43. DOI:10.1021/cr100396c
14. Bannenberg GL et al. Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins. J Immunol 2005; 174: 4345–55.
15. Ji R-R, Xu Z-Z, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci 2011; 34 (11): 599–609. DOI: 10.1016/j.tins.2011.08.005
16. Schultz GS, Davidson JM et al. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen 2011; 19 (2): 134–48. DOI:10.1111/j.1524-475X.2011.00673.x
17. Xu R, Boudreau A, Bissell MJ. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev 2009; 28 (1–2): 167–76. DOI: 10.1007/s10555-008-9178-z
18. Sorokin L. The impact of the extracellular matrix on inflammation. Nat Rev Immunol 2010; 10 (10): 712–23. DOI:10.1038/nri2852
19. Vaday GLO. Extracellular matrix moieties, cytokines, and enzymes: dynamic efects on immune cell behavior and inflammation. J Leukoc Biol 2000; 67: 149–59.
20. Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 – inflammatory profile of pain syndromes. Med Hypotheses 2007; 69 (6): 1169–78. DOI:10.1016/j.mehy.2007.06.033
21. Buttle DJ. Factors controlling matrix turnover in health and disease. Biochem Soc Trans 2007; 35 (Pt 4): 643–6. DOI:10.1042/BST0350643
22. Carnes D, Homer K, Underwood M et al. Pain management for chronic musculoskeletal conditions: the development of an evidence-based and theory-informed pain self-management course. BMJ Open 2013; 3 (11): e003534. DOI:10.1136/bmjopen-2013-003534
23. Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 2011; 31 (5): 986–1000. DOI:10.1161/ATVBAHA.110.207449
24. Clark JD. The pitfalls of profoundly efective analgesic therapies. Clin J Pain 2008; 24 (9): 825–31. DOI:10.1097/AJP.0b013e3181773b7f
25. Woolf CJ. Review series introduction What is this thing called pain? 2010; 120 (11). DOI:10.1172/JCI45178.3742.
26. Al RG et al. Efectiveness of Heel Products in Treating Neurosis-Like Disorders in Osteochondrosis of the Cervical Spine. Biol Med 1997; 2: 47–52.
27. Reckeweg HH. Homotoxikologie: Ganzheitsschau einer Synthese der Medizin. Baden-Baden, Germany: Aurelia, 1975.
28. Biotherapeutic Index A Medical Compendium for Health Care Professionals. 2012.
29. Csermely PVÁ, Pongor S. The eiciency of multi-target drugs: the network approach might help drug design. TRENDS Pharmacol Sci 2005; 26: 178–82.
30. Schneider C. Traumeel – an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuries. Int J Gen Med 2011; 4: 225–34. DOI: 10.2147/IJGMS16709.
31. Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7. DOI: 10.1016/j.ctim.2007.04.004
32. Wagner H. Multitarget therapy – The future of treatment for more than just functional dyspepsia. Phytomedicine 2006; 13: 122–9.
33. González de Vega C, Speed C, Wolfarth B, González J. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract 2013; 67 (10): 979–89. DOI: 10.1111/ijcp.12219
34. Wodick RE, Steininger KZS. The biological treatment of articular afections – results of a study conducted with 498 patients. Biol Medizin 1993; 3: 127–35.
35. Zenner S. Application possibilities of Traumeel® S injection solution: results of a multicentric drug monitoring trial conducted on 3,241 patients. Biol Ther 1992; 10 (4): 301–10.
36. Zell J, Connert WD, Mau J. Behandlung von akuten Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats. Fortschr Med 1988; 106 (5): 96–100.
37. Schneider C, Schneider B, Hanisch J van HR. The role of a homeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7.
38. Dakin SG, Dudhia J, Smith RKW. Resolving an inflammatory concept: The importance of inflammation and resolution in tendinopathy. Vet Immunol Immunopathol. 2014; 158 (3–4): 121–7. DOI:10.1016/j.vetimm.2014.01.007
39. Butterfield TA, Best TM, Merrick MA. The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair. J Athl Train 2006; 41 (4): 457–65. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1748424&tool=pmcentrez&rendertype=abstract
40. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiologywhere do lifestyle factors fit in? Br J Pain 2013; 7 (4): 209–217. DOI:10.1177/2049463713493264
41. Dubois MY, Gallagher RM, Lippe PM. Pain medicine position paper. Pain Med 2009; 10 (6): 972–1000. DOI:10.1111/j.1526-4637.2009.00696.x.
42. Jäggi R, Würgler U, Grandjean F, Weiser M. Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical eicacy and favourable gastrointestinal tolerability. Inflamm Res 2004; 53 (4): 150–7. DOI:10.1007/s00011-003-1236-y

________________________________________________

1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003; 81 (9): 646–56. Available at: /pmc/articles/PMC2572542/?report=abstract. 
2. Brooks P. Issues with chronic musculoskeletal pain. Rheumatology (Oxford). 2005; 44 (7): 831–3. DOI:10.1093/rheumatology/keh648
3. Connelly LB, Woolf A, Brooks P. Cost-Efectiveness of Interventions for Musculoskeletal Conditions. 2006. Available at: http://www.ncbi.nlm.nih.gov/books/NBK11713/
4. Oren O, Ablin J. Precision medicine: the emerging approach to the chronic pain patient. Int J Clin Rheumtol 2013; 8 (4): 491–9. DOI:10.2217/ijr.13.34
5. Cimmino MA, Ferrone C, Cutolo M. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2011; 25 (2): 173–83. DOI:10.1016/j.berh.2010.01.012
6. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology and its clinical relevance. Br J Anaesth 2013; 111 (1): 13–8. DOI:10.1093/bja/aet123
7. Practice guidelines for chronic pain management: an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology 2010; 112 (4): 810–33. DOI:10.1097/ALN.0b013e3181c43103
8. Langford RM. Pain management today – what have we learned? Clin Rheumatol 2006; 25 (Suppl. 1): S2–8. DOI:10.1007/s10067-006-0311-5
9. Dieppe P. Chronic musculoskeletal pain. BMJ 2013; 346 (6): f3146. DOI: 10.1136/bmj.f3146
10. Berna C, Leknes S, Holmes EA et al. Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 2010; 67 (11): 1083–90. DOI:10.1016/j.biopsych.2010.01.014
11. Hall-Flavin DK. Pain and depression: Is there a link? Mayo Clinic. http://www.mayoclinic.org/diseases-conditions/depression/expert-answers/pain-and-depression/faq-2005...
12. Serhan CN, Brain SD, Buckley CD et al. Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007; 21 (2): 325–32. DOI:10.1096/fj.06-7227rev
13. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev 2011; 111 (10): 5922–43. DOI:10.1021/cr100396c
14. Bannenberg GL et al. Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins. J Immunol 2005; 174: 4345–55.
15. Ji R-R, Xu Z-Z, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci 2011; 34 (11): 599–609. DOI: 10.1016/j.tins.2011.08.005
16. Schultz GS, Davidson JM et al. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen 2011; 19 (2): 134–48. DOI:10.1111/j.1524-475X.2011.00673.x
17. Xu R, Boudreau A, Bissell MJ. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev 2009; 28 (1–2): 167–76. DOI: 10.1007/s10555-008-9178-z
18. Sorokin L. The impact of the extracellular matrix on inflammation. Nat Rev Immunol 2010; 10 (10): 712–23. DOI:10.1038/nri2852
19. Vaday GLO. Extracellular matrix moieties, cytokines, and enzymes: dynamic efects on immune cell behavior and inflammation. J Leukoc Biol 2000; 67: 149–59.
20. Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 – inflammatory profile of pain syndromes. Med Hypotheses 2007; 69 (6): 1169–78. DOI:10.1016/j.mehy.2007.06.033
21. Buttle DJ. Factors controlling matrix turnover in health and disease. Biochem Soc Trans 2007; 35 (Pt 4): 643–6. DOI:10.1042/BST0350643
22. Carnes D, Homer K, Underwood M et al. Pain management for chronic musculoskeletal conditions: the development of an evidence-based and theory-informed pain self-management course. BMJ Open 2013; 3 (11): e003534. DOI:10.1136/bmjopen-2013-003534
23. Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 2011; 31 (5): 986–1000. DOI:10.1161/ATVBAHA.110.207449
24. Clark JD. The pitfalls of profoundly efective analgesic therapies. Clin J Pain 2008; 24 (9): 825–31. DOI:10.1097/AJP.0b013e3181773b7f
25. Woolf CJ. Review series introduction What is this thing called pain? 2010; 120 (11). DOI:10.1172/JCI45178.3742.
26. Al RG et al. Efectiveness of Heel Products in Treating Neurosis-Like Disorders in Osteochondrosis of the Cervical Spine. Biol Med 1997; 2: 47–52.
27. Reckeweg HH. Homotoxikologie: Ganzheitsschau einer Synthese der Medizin. Baden-Baden, Germany: Aurelia, 1975.
28. Biotherapeutic Index A Medical Compendium for Health Care Professionals. 2012.
29. Csermely PVÁ, Pongor S. The eiciency of multi-target drugs: the network approach might help drug design. TRENDS Pharmacol Sci 2005; 26: 178–82.
30. Schneider C. Traumeel – an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuries. Int J Gen Med 2011; 4: 225–34. DOI: 10.2147/IJGMS16709.
31. Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7. DOI: 10.1016/j.ctim.2007.04.004
32. Wagner H. Multitarget therapy – The future of treatment for more than just functional dyspepsia. Phytomedicine 2006; 13: 122–9.
33. González de Vega C, Speed C, Wolfarth B, González J. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract 2013; 67 (10): 979–89. DOI: 10.1111/ijcp.12219
34. Wodick RE, Steininger KZS. The biological treatment of articular afections – results of a study conducted with 498 patients. Biol Medizin 1993; 3: 127–35.
35. Zenner S. Application possibilities of Traumeel® S injection solution: results of a multicentric drug monitoring trial conducted on 3,241 patients. Biol Ther 1992; 10 (4): 301–10.
36. Zell J, Connert WD, Mau J. Behandlung von akuten Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats. Fortschr Med 1988; 106 (5): 96–100.
37. Schneider C, Schneider B, Hanisch J van HR. The role of a homeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med 2008; 16 (1): 22–7.
38. Dakin SG, Dudhia J, Smith RKW. Resolving an inflammatory concept: The importance of inflammation and resolution in tendinopathy. Vet Immunol Immunopathol. 2014; 158 (3–4): 121–7. DOI:10.1016/j.vetimm.2014.01.007
39. Butterfield TA, Best TM, Merrick MA. The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair. J Athl Train 2006; 41 (4): 457–65. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1748424&tool=pmcentrez&rendertype=abstract
40. Van Hecke O, Torrance N, Smith BH. Chronic pain epidemiologywhere do lifestyle factors fit in? Br J Pain 2013; 7 (4): 209–217. DOI:10.1177/2049463713493264
41. Dubois MY, Gallagher RM, Lippe PM. Pain medicine position paper. Pain Med 2009; 10 (6): 972–1000. DOI:10.1111/j.1526-4637.2009.00696.x.
42. Jäggi R, Würgler U, Grandjean F, Weiser M. Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical eicacy and favourable gastrointestinal tolerability. Inflamm Res 2004; 53 (4): 150–7. DOI:10.1007/s00011-003-1236-y