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63. Школьников М.Е., Кривобородов Г.Г., Ефремов Н.С. Роль троспия хлорида (Спазмекс) в лечении мужчин с симптомами гиперактивного мочевого пузыря и аденомой предстательной железы. Consilium Medicum. 2011; 13 (7): 43–6. / Shkol'nikov M.E., Krivoborodov G.G., Efremov N.S. Rol' trospiia khlorida (Spazmeks) v lechenii muzhchin s simptomami giperaktivnogo mochevogo puzyria i adenomoi predstatel'noi zhelezy. Consilium Medicum. 2011; 13 (7): 43–6. [in Russian]
64. Применение троспия хлорида (Спазмекс®) у мужчин в амбулаторной урологии. Справочник поликлинического врача. 2014; 12: 46–9. / Primenenie trospiia khlorida (Spazmeks®) u muzhchin v ambulatornoi urologii. Handbook for Practitioners Doctors. 2014; 12: 46–9. [in Russian]
65. Kosilov K, Loparev S, Ivanovskaya M, Kosilova L. Additional correction of OAB symptoms by two anti-muscarinics for men over 50 years old with residual symptoms of moderate prostatic obstruction after treatment with Tamsulosin. Aging Male 2015; 18 (1): 44–8.
66. Kosilov KV, Loparev SA, Ivanovskaya MA, Kosilova LV. Effectiveness of Solifenacin and Trospium for Managing of Severe Symptoms of Overactive Bladder in Patients With Benign Prostatic Hyperplasia. Am J Mens Health 2016; 10 (2): 157–63.
67. Kosilov K, Loparev S, Kuzina I et al. The effective tool for self-assessment of adherence to treatment in patients with benign prostatic obstruction and overactive bladder symptoms. Aging Male 2017; 20 (1): 39–44.
68. Yan M, Xue P, Wang K et al. Does combination therapy with tamsulosin and trospium chloride improve lower urinary tract symptoms after SEEDS brachytherapy for prostate cancer compared with tamsulosin alone? A prospective, randomized, controlled trial. Strahlenther Onkol 2017; 193 (9): 714–21.
69. Глыбочко П.В., Аляев Ю.Г., Винаров А.З. и др. Применение м-холиноблокаторов в комплексном лечении недержания мочи после радикальной простатэктомии. Фарматека. 2013; 3: 57–60. / Glybochko P.V., Aliaev Iu.G., Vinarov A.Z. i dr. Primenenie m-kholinoblokatorov v kompleksnom lechenii nederzhaniia mochi posle radikal'noi prostatektomii. Farmateka. 2013; 3: 57–60. [in Russian]
70. Кульчавеня Е.В., Брижатюк Е.В., Бреусов А.А. Гиперактивный мочевой пузырь как маска хронического простатита. Урология. 2012; 6: 43–6. / Kul'chavenia E.V., Brizhatiuk E.V., Breusov A.A. Giperaktivnyi mochevoi puzyr' kak maska khronicheskogo prostatita. Urologiia. 2012; 6: 43–6. [in Russian]
71. Данилов В.В., Вольных И.Ю., Данилов В.В., Данилов Вит.В. Вопросы назначения М-холинолитиков после операции синтетического слинга у женщин. Consilium Medicum. 2017; 19 (7): 45–9. / Danilov V.V., Volnykh I.Yu., Danilov Val.V., Danilov Vit.V. On appointment of M-cholinolytics after synthetic sling operation in women. Consilium Medicum. 2017; 19 (7): 45–9. [in Russian]
72. Ильина И.Ю., Доброхотова Ю.Э., Чикишева А.А. и др. Расстройства мочеиспускания после родов: методы коррекции. Consilium Medicum. 2018; 20 (6): 66–9. / Ilyina I.Yu., Dobrohotova Yu.E., Chikisheva A.A. et al. Urination disorders after childbirth: treatment methods. Consilium Medicum. 2018; 20 (6): 66–9. [in Russian]
73. Актуальные вопросы урологии и андрологии. Справочник поликлинического врача. 2018; 6: 60–4. / Topical issues of urology and andrology. Handbook for Practitioners Doctors. 2018; 6: 60–4. [in Russian]

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5. Irwin DE, Milsom I, Hunskaar S et al. Incontinence. Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study. Eur Urol 2006; 50: 1306–15.
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17. Napier CM, Gupta P. Darifenacin is selective for the human recombinant M3 receptor subtype. Neurourol Urodyn 2002; 21: 445.
18. Staskin D, Kay G, Tannenbaum C et al. Trospium chloride is undetectable in the older human central nervous system. J Am Geriatr Soc 2010; 58 (8): 1618–9.
19. Staskin D, Kay G, Tannenbaum C et al. Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder. Int J Clin Pract 2010; 64 (9): 1294–300.
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21. Kerdraon J, Robain G, Jeandel C et al. Groupe de recherche appliquée à la pelvi-périnéologie de la personne âgée (GRAPPPA). Impact on cognitive function of anticholinergic drugs used for the treatment of overactive bladder in the elderly. Prog Urol 2014; 24 (11): 672–81.
22. Bexten M, Oswald S, Grube M et al. Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm 2015; 12 (1): 171–8.
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49. Shkol'nikov M.E., Krivoborodov G.G., Luchinskii S.A. i dr. Novye tendentsii farmakoterapii zhenshchin s sindromom giperaktivnogo mochevogo puzyria. Farmateka. 2012; 12: 31–5. [in Russian]
50. Danilova T.I., Danilov V.V., Luchinskii S.A., Danilov V.V. (ml.). Rasstroistva mocheispuskaniia i seksual'nye disfunktsii u zhenshchin: voprosy naznacheniia M-kholinolitika Spazmeksa. Farmateka. 2012; 12: 90–5. [in Russian]
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55. Geller EJ, Dumond JB, Bowling JM et al. Effect of Trospium Chloride on Cognitive Function in Women Aged 50 and Older: A Randomized Trial. Female Pelvic Med Reconstr Surg 2017; 23 (2): 118–23.
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61. MacDiarmid SA, Ellsworth PI, Ginsberg DA et al. Safety and efficacy of once-daily trospium chloride extended-release in male patients with overactive bladder. Urology 2011; 77 (1): 24–9.
62. Shkol'nikov M.E., Krivoborodov G.G., Efremov N.S. Trospiia khlorid (Spazmeks) v lechenii bol'nykh giperaktivnym mochevym puzyrem. Consilium Medicum. 2011; 13 (7): 16–8. [in Russian]
63. Shkol'nikov M.E., Krivoborodov G.G., Efremov N.S. Rol' trospiia khlorida (Spazmeks) v lechenii muzhchin s simptomami giperaktivnogo mochevogo puzyria i adenomoi predstatel'noi zhelezy. Consilium Medicum. 2011; 13 (7): 43–6. [in Russian]
64. Primenenie trospiia khlorida (Spazmeks®) u muzhchin v ambulatornoi urologii. Handbook for Practitioners Doctors. 2014; 12: 46–9. [in Russian]
65. Kosilov K, Loparev S, Ivanovskaya M, Kosilova L. Additional correction of OAB symptoms by two anti-muscarinics for men over 50 years old with residual symptoms of moderate prostatic obstruction after treatment with Tamsulosin. Aging Male 2015; 18 (1): 44–8.
66. Kosilov KV, Loparev SA, Ivanovskaya MA, Kosilova LV. Effectiveness of Solifenacin and Trospium for Managing of Severe Symptoms of Overactive Bladder in Patients With Benign Prostatic Hyperplasia. Am J Mens Health 2016; 10 (2): 157–63.
67. Kosilov K, Loparev S, Kuzina I et al. The effective tool for self-assessment of adherence to treatment in patients with benign prostatic obstruction and overactive bladder symptoms. Aging Male 2017; 20 (1): 39–44.
68. Yan M, Xue P, Wang K et al. Does combination therapy with tamsulosin and trospium chloride improve lower urinary tract symptoms after SEEDS brachytherapy for prostate cancer compared with tamsulosin alone? A prospective, randomized, controlled trial. Strahlenther Onkol 2017; 193 (9): 714–21.
69. Glybochko P.V., Aliaev Iu.G., Vinarov A.Z. i dr. Primenenie m-kholinoblokatorov v kompleksnom lechenii nederzhaniia mochi posle radikal'noi prostatektomii. Farmateka. 2013; 3: 57–60. [in Russian]
70. Kul'chavenia E.V., Brizhatiuk E.V., Breusov A.A. Giperaktivnyi mochevoi puzyr' kak maska khronicheskogo prostatita. Urologiia. 2012; 6: 43–6. [in Russian]
71. Danilov V.V., Volnykh I.Yu., Danilov Val.V., Danilov Vit.V. On appointment of M-cholinolytics after synthetic sling operation in women. Consilium Medicum. 2017; 19 (7): 45–9. [in Russian]
72. Ilyina I.Yu., Dobrohotova Yu.E., Chikisheva A.A. et al. Urination disorders after childbirth: treatment methods. Consilium Medicum. 2018; 20 (6): 66–9. [in Russian]
73. Topical issues of urology and andrology. Handbook for Practitioners Doctors. 2018; 6: 60–4. [in Russian]

Д.И.Трухан*1, Г.Л.Юренев2, Н.А.Чусова2

1 ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России. 644099, Россия, Омск, ул. Ленина, д. 12;
2 ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
dmitry_trukhan@mail.ru

________________________________________________

D.I.Trukhan*1, G.L.Yurenev2, N.A.Chusova2

1 Omsk State Medical University of the Ministry of Health of the Russian Federation. 644099, Russian Federation, Omsk, ul. Lenina, 12;
2 A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
dmitry_trukhan@mail.ru