Современные возможности коррекции резорбции субхондральной кости как главного патогенетического фактора прогрессирования остеоартроза
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Ключевые слова: остеоартроз, субхондральная кость, резорбция, цитокины, металлопротеиназы, хондроитина сульфат, глюкозамин, витамин D3, комбинированные препараты хондроитина и глюкозамина.
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The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.
Key words: osteochondrosis, subchondral bone, resorption, cytokines, metalloproteinase, chondroitin sulfate, glucosamine, vita-min D3, combined chondroitin and glucosamine drug
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Кафедра терапии, клинической фармакологии и скорой медицинской помощи ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
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A.V. NAUMOV
Department of Therapy, Clinical Pharmacology, and Emergency Medical Care, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow