От пурпуры Шенлейна–Геноха до IgА-васкулита: патогенетические аспекты болезни - Журнал Терапевтический архив № 10 Вопросы эндокринологии 2018
От пурпуры Шенлейна–Геноха до IgА-васкулита: патогенетические аспекты болезни
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Аннотация
В статье изложена история изучения IgA-васкулита и представлена его номенклатурная эволюция. Подробно анализируется патогенетическая роль нарушения IgA-иммунитета в механизме поражения почек и кожи. Обсуждается альтернативная концепция развития кожного васкулита, опосредованного системной эндотоксемией. Приводятся данные отечественной и зарубежной литературы.
Ключевые слова: системные васкулиты, пурпура Шенлейна–Геноха, геморрагический васкулит, IgA-васкулит, IgA-нефропатия, дефектное гликозилирование IgA, реакция Шварцмана, эндотоксемия.
Keywords: systemic vasculitides, Schönlein–Henoch purpura, hemorrhagic vasculitis, IgA-vasculitis, IgA-nephropathy, defective IgA glycosylation, Shwartzman reaction, endotoxemia.
Ключевые слова: системные васкулиты, пурпура Шенлейна–Геноха, геморрагический васкулит, IgA-васкулит, IgA-нефропатия, дефектное гликозилирование IgA, реакция Шварцмана, эндотоксемия.
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Keywords: systemic vasculitides, Schönlein–Henoch purpura, hemorrhagic vasculitis, IgA-vasculitis, IgA-nephropathy, defective IgA glycosylation, Shwartzman reaction, endotoxemia.
Список литературы
1. Heberden W. Commentaries on history and cure diseases. London; 1802.
2. Schönlein JL, in: Allgemeine und specielle Pathologie und Therapie. Vol. 2. 3rd ed. Wurzburg: Herisau; 1837. P. 48.
3. Henoch EH. Uber eine eigenthumbliche form von purpura. Berl Klin Wochnschr. 1874;11:641-643.
4. Henoch EH. Die hamorrhagische diathese-purpura. In: Vorlesungen uber Kinderkrankheiten. Berlin: Hirschwald; 1895. Bd 9. S. 847.
5. Osler W. The Visceral Lesions of Purpura and Allied Conditions. Brit Med J. 1914;1:517.
6. Frank E. Hamorrhagische Diathesen. In: Schittenhelm Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Berlin: Springer; 1925.
7. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187-192.
8. Насонова В.А. Геморрагический васкулит (Болезнь Шенлейна—Геноха). Москва: Медгиз; 1959. 175 с. [Nasonova VA. Gemorragicheskiy vaskulit (Bolezn' Shenleyna—Genokha) [Hemorrhagic vasculitis (Schönlein-Henoch disease)]. Moscow: Medgiz; 1959. 175 p. (In Russ.)].
9. Jennette JC, Falk RJ, Bacon PA. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
10. Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-695.
11. Kauffmann RH, Herrmann WA, Meÿer CJ, et al. Circulating IgA-immune complexes in Henoch-Schönlein purpura. A longitudinal study of their relationship to disease activity and vascular deposition of IgA. Am J Med. 1980;69(6):859-866.
12. Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821-832. doi: 10.1038/nri3322
13. Jacob CM, Pastorino AC, Fahl K, et al. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol. 2008;28 Suppl 1:S56-61. doi: 10.1007/s10875-007-9163-2
14. Novak J, Moldoveanu Z, Renfrow MB. IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contrib Nephrol. 2007;157:134-138. doi: 10.1159/000102455
15. Heineke MH, Ballering AV, Jamin A. New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmun Rev. 2017;16(12):1246-1253. doi: 10.1016/j.autrev.2017.10.009
16. Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y. Protective role of IgA1 glycans against IgA1self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9:2048-2054.
17. Novak J, Julian BA, Tomana M, et al. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin Nephrol. 2008;28:78-87. doi: 10.1016/j.semnephrol.2007.10.009
18. Davin JC, Ten Berge IJ, Weening JJ. What is the difference between IgA nephropathy and Henoch-Schonlein purpura nephritis? Kidney Int. 2001;59:823-834. doi: 10.1046/j.1523-1755.2001.059003823.x
19. Waldo FB. Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis. 1988;12(5):373-377.
20. Smith AC, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17(12):3520-3528. doi: 10.1681/ASN.2006060658
21. Launay P, Grossetete B, Arcos-Fajardo M, et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med. 2000;191:1999-2009.
22. Haddad E, Moura IC, Arcos-Fajardo M, Macher MA, Baudouin V, Alberti C, Loirat C, Monteiro RC, Peuchmaur M. Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol. 2003;14:327-337.
23. Wyatt RJ. The complement system in IgA nephropathy and Henoch-Schönlein purpura: functional and genetic aspects. Contrib Nephrology. 1993;104:82-91.
24. Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA-nephropathy. Nephrol Dial Transplant. 1998;13:1984-1990.
25. Allen AC, Willis FR, Beattie TJ, Feehally J. Abnormal IgA glycosylation in Schönlein–Henoch purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant. 1998;13:930-934.
26. Vuong MT, Hahn-Zoric M, Lundberg S, et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int. 2001;78:1281-1287.
27. Van der Helm-van Mil AH, Smith AC, Pouria S, et al. Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. Br J Haematol. 2003;122(6):915-917.
28. Van Hale HM, Gibson LE, Schroeter AL. Henoch-Schönlein vasculitis: direct immunofluorescence study of uninvolved skin. J Am Acad Dermatol. 1986;15(4 Pt 1):665-670.
29. Faille-Kuyper EH, Kater L, Kuijten RH, et al. Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease. Kidney Int. 1976;9(5):424-429.
30. Thompson AJ, Chan YL, Woodroffe AJ, et al. Vascular IgA deposits in clinically normal skin of patients with renal disease. Pathology. 1980;12(3):407-413.
31. Hené RJ, Velthuis P, van de Wiel A. et al. The relevance of IgA deposits in vessel walls of clinically normal skin. A prospective study. Arch Intern Med. 1986 Apr;146(4):745-749.
32. Saklayen MG, Schroeter AL, Nafz MA, Jalil K. IgA deposition in the skin of patients with alcoholic liver disease. J Cutan Pathol. 1996;23(1):12-18.
33. Мухин Н.А., Гуляев С.В., Кривошеев О.Г. и др. Клиническое и прогностическое значение поражения желудочно-кишечного тракта при системных сосудистых пурпурах. Терапевтический архив. 2003;75(2):50-54 [Mukhin NA, Gulyaev SV, Krivosheev ОG, et al. Clinical and prognostic implications of gastrointestinal tract lesions in systemic vascular purpuras. Terapevticheskiy Arkhiv = Therapeutic Archive. 2003;75(2):50-54 (In Russ.)].
34. Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol. 2003;17(4):575-592.
35. Shwartzman G. A new phenomenon of local skin reactivity to B. Typhosus culture filtrate. Exptl Biol Med. 1928;25(7):560-561.
36. Кривошеев О.Г. Системные сосудистые пурпуры – клинико-этиологические варианты: Дис. канд. мед. наук. Москва; 1999 [Krivosheev OG. Sistemnye sosudistye purpury – kliniko-etiologicheskie varianty [Systemic vascular purpuras: clinical and etiologic types]. Dis. … kand. med. sci. Moscow; 1999 (In Russ.)].
37. Davin JC, Forget P, Mahieu PR. Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand. 1988;77(1):118-124.
38. Davin JC, Mahieu PR. Sequential measurements of intestinal permeability to [51Cr] EDTA in children with Henoch-Schönlein purpura nephritis. Nephron. 1992;60(4):498-499.
2. Schönlein JL, in: Allgemeine und specielle Pathologie und Therapie. Vol. 2. 3rd ed. Wurzburg: Herisau; 1837. P. 48.
3. Henoch EH. Uber eine eigenthumbliche form von purpura. Berl Klin Wochnschr. 1874;11:641-643.
4. Henoch EH. Die hamorrhagische diathese-purpura. In: Vorlesungen uber Kinderkrankheiten. Berlin: Hirschwald; 1895. Bd 9. S. 847.
5. Osler W. The Visceral Lesions of Purpura and Allied Conditions. Brit Med J. 1914;1:517.
6. Frank E. Hamorrhagische Diathesen. In: Schittenhelm Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Berlin: Springer; 1925.
7. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187-192.
8. [Hemorrhagic vasculitis (Schönlein-Henoch disease)]. Moscow: Medgiz; 1959. 175 p. (In Russ.)].
9. Jennette JC, Falk RJ, Bacon PA. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
10. Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-695.
11. Kauffmann RH, Herrmann WA, Meÿer CJ, et al. Circulating IgA-immune complexes in Henoch-Schönlein purpura. A longitudinal study of their relationship to disease activity and vascular deposition of IgA. Am J Med. 1980;69(6):859-866.
12. Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821-832. doi: 10.1038/nri3322
13. Jacob CM, Pastorino AC, Fahl K, et al. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol. 2008;28 Suppl 1:S56-61. doi: 10.1007/s10875-007-9163-2
14. Novak J, Moldoveanu Z, Renfrow MB. IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contrib Nephrol. 2007;157:134-138. doi: 10.1159/000102455
15. Heineke MH, Ballering AV, Jamin A. New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmun Rev. 2017;16(12):1246-1253. doi: 10.1016/j.autrev.2017.10.009
16. Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y. Protective role of IgA1 glycans against IgA1self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9:2048-2054.
17. Novak J, Julian BA, Tomana M, et al. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin Nephrol. 2008;28:78-87. doi: 10.1016/j.semnephrol.2007.10.009
18. Davin JC, Ten Berge IJ, Weening JJ. What is the difference between IgA nephropathy and Henoch-Schonlein purpura nephritis? Kidney Int. 2001;59:823-834. doi: 10.1046/j.1523-1755.2001.059003823.x
19. Waldo FB. Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis. 1988;12(5):373-377.
20. Smith AC, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17(12):3520-3528. doi: 10.1681/ASN.2006060658
21. Launay P, Grossetete B, Arcos-Fajardo M, et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med. 2000;191:1999-2009.
22. Haddad E, Moura IC, Arcos-Fajardo M, Macher MA, Baudouin V, Alberti C, Loirat C, Monteiro RC, Peuchmaur M. Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol. 2003;14:327-337.
23. Wyatt RJ. The complement system in IgA nephropathy and Henoch-Schönlein purpura: functional and genetic aspects. Contrib Nephrology. 1993;104:82-91.
24. Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA-nephropathy. Nephrol Dial Transplant. 1998;13:1984-1990.
25. Allen AC, Willis FR, Beattie TJ, Feehally J. Abnormal IgA glycosylation in Schönlein–Henoch purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant. 1998;13:930-934.
26. Vuong MT, Hahn-Zoric M, Lundberg S, et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int. 2001;78:1281-1287.
27. Van der Helm-van Mil AH, Smith AC, Pouria S, et al. Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. Br J Haematol. 2003;122(6):915-917.
28. Van Hale HM, Gibson LE, Schroeter AL. Henoch-Schönlein vasculitis: direct immunofluorescence study of uninvolved skin. J Am Acad Dermatol. 1986;15(4 Pt 1):665-670.
29. Faille-Kuyper EH, Kater L, Kuijten RH, et al. Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease. Kidney Int. 1976;9(5):424-429.
30. Thompson AJ, Chan YL, Woodroffe AJ, et al. Vascular IgA deposits in clinically normal skin of patients with renal disease. Pathology. 1980;12(3):407-413.
31. Hené RJ, Velthuis P, van de Wiel A. et al. The relevance of IgA deposits in vessel walls of clinically normal skin. A prospective study. Arch Intern Med. 1986 Apr;146(4):745-749.
32. Saklayen MG, Schroeter AL, Nafz MA, Jalil K. IgA deposition in the skin of patients with alcoholic liver disease. J Cutan Pathol. 1996;23(1):12-18.
33. [Mukhin NA, Gulyaev SV, Krivosheev ОG, et al. Clinical and prognostic implications of gastrointestinal tract lesions in systemic vascular purpuras. Terapevticheskiy Arkhiv = Therapeutic Archive. 2003;75(2):50-54 (In Russ.)].
34. Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol. 2003;17(4):575-592.
35. Shwartzman G. A new phenomenon of local skin reactivity to B. Typhosus culture filtrate. Exptl Biol Med. 1928;25(7):560-561.
36. [Krivosheev OG. Sistemnye sosudistye purpury – kliniko-etiologicheskie varianty [Systemic vascular purpuras: clinical and etiologic types]. Dis. … kand. med. sci. Moscow; 1999 (In Russ.)].
37. Davin JC, Forget P, Mahieu PR. Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand. 1988;77(1):118-124.
38. Davin JC, Mahieu PR. Sequential measurements of intestinal permeability to [51Cr] EDTA in children with Henoch-Schönlein purpura nephritis. Nephron. 1992;60(4):498-499.
2. Schönlein JL, in: Allgemeine und specielle Pathologie und Therapie. Vol. 2. 3rd ed. Wurzburg: Herisau; 1837. P. 48.
3. Henoch EH. Uber eine eigenthumbliche form von purpura. Berl Klin Wochnschr. 1874;11:641-643.
4. Henoch EH. Die hamorrhagische diathese-purpura. In: Vorlesungen uber Kinderkrankheiten. Berlin: Hirschwald; 1895. Bd 9. S. 847.
5. Osler W. The Visceral Lesions of Purpura and Allied Conditions. Brit Med J. 1914;1:517.
6. Frank E. Hamorrhagische Diathesen. In: Schittenhelm Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Berlin: Springer; 1925.
7. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187-192.
8. Насонова В.А. Геморрагический васкулит (Болезнь Шенлейна—Геноха). Москва: Медгиз; 1959. 175 с. [Nasonova VA. Gemorragicheskiy vaskulit (Bolezn' Shenleyna—Genokha) [Hemorrhagic vasculitis (Schönlein-Henoch disease)]. Moscow: Medgiz; 1959. 175 p. (In Russ.)].
9. Jennette JC, Falk RJ, Bacon PA. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
10. Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-695.
11. Kauffmann RH, Herrmann WA, Meÿer CJ, et al. Circulating IgA-immune complexes in Henoch-Schönlein purpura. A longitudinal study of their relationship to disease activity and vascular deposition of IgA. Am J Med. 1980;69(6):859-866.
12. Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821-832. doi: 10.1038/nri3322
13. Jacob CM, Pastorino AC, Fahl K, et al. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol. 2008;28 Suppl 1:S56-61. doi: 10.1007/s10875-007-9163-2
14. Novak J, Moldoveanu Z, Renfrow MB. IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contrib Nephrol. 2007;157:134-138. doi: 10.1159/000102455
15. Heineke MH, Ballering AV, Jamin A. New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmun Rev. 2017;16(12):1246-1253. doi: 10.1016/j.autrev.2017.10.009
16. Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y. Protective role of IgA1 glycans against IgA1self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9:2048-2054.
17. Novak J, Julian BA, Tomana M, et al. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin Nephrol. 2008;28:78-87. doi: 10.1016/j.semnephrol.2007.10.009
18. Davin JC, Ten Berge IJ, Weening JJ. What is the difference between IgA nephropathy and Henoch-Schonlein purpura nephritis? Kidney Int. 2001;59:823-834. doi: 10.1046/j.1523-1755.2001.059003823.x
19. Waldo FB. Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis. 1988;12(5):373-377.
20. Smith AC, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17(12):3520-3528. doi: 10.1681/ASN.2006060658
21. Launay P, Grossetete B, Arcos-Fajardo M, et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med. 2000;191:1999-2009.
22. Haddad E, Moura IC, Arcos-Fajardo M, Macher MA, Baudouin V, Alberti C, Loirat C, Monteiro RC, Peuchmaur M. Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol. 2003;14:327-337.
23. Wyatt RJ. The complement system in IgA nephropathy and Henoch-Schönlein purpura: functional and genetic aspects. Contrib Nephrology. 1993;104:82-91.
24. Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA-nephropathy. Nephrol Dial Transplant. 1998;13:1984-1990.
25. Allen AC, Willis FR, Beattie TJ, Feehally J. Abnormal IgA glycosylation in Schönlein–Henoch purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant. 1998;13:930-934.
26. Vuong MT, Hahn-Zoric M, Lundberg S, et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int. 2001;78:1281-1287.
27. Van der Helm-van Mil AH, Smith AC, Pouria S, et al. Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. Br J Haematol. 2003;122(6):915-917.
28. Van Hale HM, Gibson LE, Schroeter AL. Henoch-Schönlein vasculitis: direct immunofluorescence study of uninvolved skin. J Am Acad Dermatol. 1986;15(4 Pt 1):665-670.
29. Faille-Kuyper EH, Kater L, Kuijten RH, et al. Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease. Kidney Int. 1976;9(5):424-429.
30. Thompson AJ, Chan YL, Woodroffe AJ, et al. Vascular IgA deposits in clinically normal skin of patients with renal disease. Pathology. 1980;12(3):407-413.
31. Hené RJ, Velthuis P, van de Wiel A. et al. The relevance of IgA deposits in vessel walls of clinically normal skin. A prospective study. Arch Intern Med. 1986 Apr;146(4):745-749.
32. Saklayen MG, Schroeter AL, Nafz MA, Jalil K. IgA deposition in the skin of patients with alcoholic liver disease. J Cutan Pathol. 1996;23(1):12-18.
33. Мухин Н.А., Гуляев С.В., Кривошеев О.Г. и др. Клиническое и прогностическое значение поражения желудочно-кишечного тракта при системных сосудистых пурпурах. Терапевтический архив. 2003;75(2):50-54 [Mukhin NA, Gulyaev SV, Krivosheev ОG, et al. Clinical and prognostic implications of gastrointestinal tract lesions in systemic vascular purpuras. Terapevticheskiy Arkhiv = Therapeutic Archive. 2003;75(2):50-54 (In Russ.)].
34. Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol. 2003;17(4):575-592.
35. Shwartzman G. A new phenomenon of local skin reactivity to B. Typhosus culture filtrate. Exptl Biol Med. 1928;25(7):560-561.
36. Кривошеев О.Г. Системные сосудистые пурпуры – клинико-этиологические варианты: Дис. канд. мед. наук. Москва; 1999 [Krivosheev OG. Sistemnye sosudistye purpury – kliniko-etiologicheskie varianty [Systemic vascular purpuras: clinical and etiologic types]. Dis. … kand. med. sci. Moscow; 1999 (In Russ.)].
37. Davin JC, Forget P, Mahieu PR. Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand. 1988;77(1):118-124.
38. Davin JC, Mahieu PR. Sequential measurements of intestinal permeability to [51Cr] EDTA in children with Henoch-Schönlein purpura nephritis. Nephron. 1992;60(4):498-499.
________________________________________________
2. Schönlein JL, in: Allgemeine und specielle Pathologie und Therapie. Vol. 2. 3rd ed. Wurzburg: Herisau; 1837. P. 48.
3. Henoch EH. Uber eine eigenthumbliche form von purpura. Berl Klin Wochnschr. 1874;11:641-643.
4. Henoch EH. Die hamorrhagische diathese-purpura. In: Vorlesungen uber Kinderkrankheiten. Berlin: Hirschwald; 1895. Bd 9. S. 847.
5. Osler W. The Visceral Lesions of Purpura and Allied Conditions. Brit Med J. 1914;1:517.
6. Frank E. Hamorrhagische Diathesen. In: Schittenhelm Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Berlin: Springer; 1925.
7. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187-192.
8. [Hemorrhagic vasculitis (Schönlein-Henoch disease)]. Moscow: Medgiz; 1959. 175 p. (In Russ.)].
9. Jennette JC, Falk RJ, Bacon PA. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
10. Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-695.
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Авторы
С.В. Гуляев, Л.А. Стрижаков, С.В. Моисеев, В.В. Фомин
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University), Moscow, Russia
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
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I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University), Moscow, Russia
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