Бабезиозы человека: клинические случаи в европейской части Российской Федерации

1. Щепина М.О., Федулина О.О., Козлова И.В., Сунцова О.В., Рар В.А., Дорощенко Е.К., Лисак О.В. Представители рода Babesia, их распространенность, генетическое разнообразие и роль в патологии человека и животных. Известия Иркутского государственного университета. Серия «Биология. Экология». 2014;7:80-90 [Shchepina MO, Fedulina OO, Kozlova IV, Suntsova OV, Rar VA, Doroshchenko EK, Lisak ОV. Members of the Genus Babesia, their Occurence, Genetic Diversity and Significance in Human and Animal Pathology. Izvestiya Irkutskogo gosudarstvennogo universiteta. Seria “Biologiya. Ecologiya”.  2014;7:80-90 (In Russ.)].
2. Solano-Gallego L, Sainz Á, Roura X, Estrada-Peña A, Miró G. A review of canine babesiosis: the European perspective. Parasites a Vectors. 2016;9:336. doi: 10.1186/s13071-016-1596-0
3. Kavanaugh MJ, Decker CF. Babesiosis. Dis Mon. 2012;58(6):355-60. doi: 10.1016/j.disamonth.2012.03.007
4. Vannier E, Krause PJ. Human Babesiosis. N Engl J Med. 2012;366(25): 2397-407. doi: 10.1056/NEJMra1202018
5. Hersh MH, Tibbetts M, Strauss M, Ostfeld RS, Keesing F. Reservoir Competence of Wildlife Host Species for Babesia microti. Emerg Infect Dis. 2012;18(12):1951-7. doi: 10.3201/eid1812.111392
6. Leiby DA. Transfusion-Transmitted Babesia spp.: Bull’s-Eye on Babesia microti. Clin Microbiol Rev. 2011;24(1):14-28. doi:10.1128/CMR.00022-10
7. Brennan MB, Herwaldt BL, Kazmierczak JJ, Weiss JW, Klein CL, Leith CP, He R, Oberley MJ, Tonnetti L, Wilkins PP, Gauthier GM. Transmission of Babesia microti Parasites by Solid Organ Transplantation.  Emerg Infect Dis. 2016;22(11):1869-76. doi: 10.3201/ eid2211.151028
8. Zhou X, Xia S, Huang J-L, Tambo E, Zhuge H-X, Zhou X-N. Human babesiosis, an emerging tick-borne disease in the People’s Republic of China. Parasites a Vectors. 2014;7:509. doi: 10.1186/s13071-014-0509-3
9. Arsuaga M, González LM, Padial ES, Dinkessa AW, Sevilla E, Trigo E, Puente S, Gray J, Montero E. Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. Emerg Infect Dis. 2018;24(8):1588-9. doi: 10.3201/eid2408.180180
10. Рабинович С.А., Воронина З.К., Степанова Н.И. Первое обнаружение бабезиоза человека в СССР и краткий анализ случаев, описанных в литературе. Медицинская паразитология и паразитарные болезни. 1978;(3):97-107 [Rabinovich SA, Voronina ZK, Stepanova NI. The first detection of human babesiosis in the USSR and a brief analysis of the cases described in the literature. Med Parazitol (Mosk).  1978;(3):97-107 (In Russ.)].
11. Малов В.А., Токмалаев А.К., Еровиченков А.А., Цветкова Н.А., Садыкова В.Д., Сметанина С.В., Немилостива Е.А., Богданова М.В. Бабезиоз человека. Терапевтический архив. 2013;85(11):62-6 [Malov VA, Tokmalaev AK, Erovichenkov AA, Tsvetkova NA, Sadykova VD, Smetanina SV, Nemilostiva EA, Bogdanova MV. Human babesiasis. Therapeutic Archive. 2013;85(11):62-6 (In Russ.)].
12. Kukina IV, Guzeeva TM, Zelya OP, Ganushkina LA.  Fatal human babesiosis caused by Babesia divergens in an asplenic host. IDCases. 2018;14:e00414. doi: 10.1016/j.idcr.2018.e00414
13. Коренберг Э.И., Нефедова В.В., Ковалевский Ю.В., Сорокина Ю.В., Горелова Н.Б. Паразитологические факторы, препятствующие передаче возбудителя бабезиоза (Babesia microti) человеку клещом Ixodes persulcatus. Паразитология. 2015;49(1):27-41 [Korenberg EI, Nefedova VV, Kovalevsky YuV, Sorokina YuV, Gorelova NB. Parasitological factors impeding the transmission of the agent of babesiosis (Babesia microti) to man from the tick Ixodes persulcatus. Parazitologiia. 2015;49(1):27-41 (In Russ.)].
14. Rar VA, Epichina TI, Livanova NN, Panov VV. Genetic diversity of Babesia in Ixodes persulcatus and small mammals from North Ural and West Siberia, Russia. Parasitology. 2011;138(2):175-82. doi: 10.1017/S0031182010001162
15. Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infect Dis Clin North Am. 2008;22(3):469-88. doi: 10.1016/j.idc.2008.03.010
16. Hunfeld KP, Lambert A, Kampen H, Albert S, Epe C, Brade V, Tenter AM. Seroprevalence of Babesia Infections in Humans Exposed to Ticks in Midwestern Germany. J Clin Microbiol. 2002;40(7):2431-6. doi: 10.1128/jcm.40.7.2431-2436.2002
17. Krause PJ, Daily J, Telford SR, Vannier E, Lantos P, Spielman A. Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol. 2007;23(12):605-10. doi: 10.1016/j.pt.2007.09.005
18. Genda J, Negron EA, Lotfipour M, Balabhadra S, Desai DS, Craft DW, Katzman M. Severe Babesia microti Infection in an Immunocompetent Host in Pennsylvania. J Investigative Medicine High. 2016:1-4. doi: 10.1177/2324709616663774
19. Merino A. Blood film findings in severe babesiosis. Br J Haematol. 2016;172(6):839. doi: 10.1111/bjh.13845
20. Smotrys M, Magge T, Alkhuja S, Gandotra SD. Babesiosis as a cause of false-positive HIV serology. BMJ. 2018; pii: bcr-2017-223738. doi: 10.1136/bcr-2017-223738
21. Akel T, Mobarakai N. Hematologic manifestations of babesiosis. Ann Clin Microbiol Antimicrob. 2017;16(1):6. doi: 10.1186/s12941-017-0179-z
22. Joseph JT, Purtill K, Wong SJ, Munoz J, Teal A, Madison-Antenucci S, Horowitz HW, Aguero-Rosenfeld ME, Moore JM, Abramowsky C, Wormser GP. Vertical Transmission of Babesia microti, United States. Emerg Infect Dis. 2012;18(8):1318-21. doi: 10.3201/eid1808.110988
23. Vannier EG, Diuk-Wasser MA, Mamoun CB, Krause PJ. Babesiosis. Infect Dis Clin North Am. 2015;29(2):357-70. doi:10.1016/j.idc.2015. 02.008
24. Cursino-Santos JR, Singh M, Senaldi E, Manwani D, Yazdanbakhsh K, Lobo CA. Altered parasite life-cycle processes characterize  Babesia  divergens infection in human sickle cell anemia. Haematologia. 2019; pii: haematol. 2018.214304. doi: 10.3324/haematol.2018.214304
25. Chen Q, Schlichtherle M, Wahlgren M. Molecular Aspects of Severe Malaria. Clin Microbiol Rev. 2000;13(3):439-50. doi: 10.1128/cmr.13.3. 439-450.2000
26. Lobo CA, Rodriguez M, Cursino-Santos JR. Babesia and red cell invasion. Curr Opin Hematol. 2012;19(3):170-5. doi: 10.1097/MOH. 0b013e328352245a
27. Djokic V, Primus S, Akoolo L, Chakraborti M, Parveen N. Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity. Front Immunol. 2018;9:2891. doi: 10.3389/fimmu.2018.02891
28. Hunfeld KP, Hildebrandt A, Gray JS. Babesiosis: recent insights into an ancient disease. Int J Parasitol. 2008;38(11):1219-37. doi: 10.1016/j.ijpa ra.2008.03.001
29. Ripoll JG, Rizvi MS, King RL, Daniels CE. Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host. BMJ Case Rep. 2018;2018. pii: bcr-2018-224647. doi: 10.1136/bcr-2018-224647
30. Токмалаев А.К., Кожевникова Г.М. Клиническая паразитология: протозоозы и гельминтозы: руководство для врачей. Изд 2-е доп. М.: ООО «МИА», 2017:392 с. [Tokmalaev AK, Kozevnikova GM. Clinical parasitology: protozoa and helminthiasis. Leadership for doctors. Second edition.  Moscow: MIA, 2017:392 p (In Russ.)].
31. Rosenblatt JE. Laboratory Diagnosis of Infections Due to Blood and Tissue Parasites. Clin Infect Dis. 2009;49(7):1103-8. doi: 10.1086/60 5574
32. Diuk-Wasser MA, Vannier EPJ. Krause Coinfection by the tick-borne pathogens Babesia microti and Borrelia burgdorferi: ecological, epidemiological and clinical consequences. Trends Parasitol. 2016;32(1):30-42. doi:10.1016/j.pt.2015.09.008
33. Daga Ruiz D, Fonseca San Miguel F, González de Molina FJ, Úbeda-Iglesias A, Navas Pérez A, Jannone Forés R. Plasmapheresis and other extracorporeal filtration techniques in critical patients. Medicina Intensiva (English Edition). 2017;41(3):174-87. doi: 10.1016/j.medin.2016.10.005

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1. [Shchepina MO, Fedulina OO, Kozlova IV, Suntsova OV, Rar VA, Doroshchenko EK, Lisak ОV. Members of the Genus Babesia, their Occurence, Genetic Diversity and Significance in Human and Animal Pathology. Izvestiya Irkutskogo gosudarstvennogo universiteta. Seria “Biologiya. Ecologiya”.  2014;7:80-90 (In Russ.)].
2. Solano-Gallego L, Sainz Á, Roura X, Estrada-Peña A, Miró G. A review of canine babesiosis: the European perspective. Parasites a Vectors. 2016;9:336. doi: 10.1186/s13071-016-1596-0
3. Kavanaugh MJ, Decker CF. Babesiosis. Dis Mon. 2012;58(6):355-60. doi: 10.1016/j.disamonth.2012.03.007
4. Vannier E, Krause PJ. Human Babesiosis. N Engl J Med. 2012;366(25): 2397-407. doi: 10.1056/NEJMra1202018
5. Hersh MH, Tibbetts M, Strauss M, Ostfeld RS, Keesing F. Reservoir Competence of Wildlife Host Species for Babesia microti. Emerg Infect Dis. 2012;18(12):1951-7. doi: 10.3201/eid1812.111392
6. Leiby DA. Transfusion-Transmitted Babesia spp.: Bull’s-Eye on Babesia microti. Clin Microbiol Rev. 2011;24(1):14-28. doi:10.1128/CMR.00022-10
7. Brennan MB, Herwaldt BL, Kazmierczak JJ, Weiss JW, Klein CL, Leith CP, He R, Oberley MJ, Tonnetti L, Wilkins PP, Gauthier GM. Transmission of Babesia microti Parasites by Solid Organ Transplantation.  Emerg Infect Dis. 2016;22(11):1869-76. doi: 10.3201/ eid2211.151028
8. Zhou X, Xia S, Huang J-L, Tambo E, Zhuge H-X, Zhou X-N. Human babesiosis, an emerging tick-borne disease in the People’s Republic of China. Parasites a Vectors. 2014;7:509. doi: 10.1186/s13071-014-0509-3
9. Arsuaga M, González LM, Padial ES, Dinkessa AW, Sevilla E, Trigo E, Puente S, Gray J, Montero E. Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. Emerg Infect Dis. 2018;24(8):1588-9. doi: 10.3201/eid2408.180180
10. [Rabinovich SA, Voronina ZK, Stepanova NI. The first detection of human babesiosis in the USSR and a brief analysis of the cases described in the literature. Med Parazitol (Mosk).  1978;(3):97-107 (In Russ.)].
11. [Malov VA, Tokmalaev AK, Erovichenkov AA, Tsvetkova NA, Sadykova VD, Smetanina SV, Nemilostiva EA, Bogdanova MV. Human babesiasis. Therapeutic Archive. 2013;85(11):62-6 (In Russ.)].
12. Kukina IV, Guzeeva TM, Zelya OP, Ganushkina LA.  Fatal human babesiosis caused by Babesia divergens in an asplenic host. IDCases. 2018;14:e00414. doi: 10.1016/j.idcr.2018.e00414
13. [Korenberg EI, Nefedova VV, Kovalevsky YuV, Sorokina YuV, Gorelova NB. Parasitological factors impeding the transmission of the agent of babesiosis (Babesia microti) to man from the tick Ixodes persulcatus. Parazitologiia. 2015;49(1):27-41 (In Russ.)].
14. Rar VA, Epichina TI, Livanova NN, Panov VV. Genetic diversity of Babesia in Ixodes persulcatus and small mammals from North Ural and West Siberia, Russia. Parasitology. 2011;138(2):175-82. doi: 10.1017/S0031182010001162
15. Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infect Dis Clin North Am. 2008;22(3):469-88. doi: 10.1016/j.idc.2008.03.010
16. Hunfeld KP, Lambert A, Kampen H, Albert S, Epe C, Brade V, Tenter AM. Seroprevalence of Babesia Infections in Humans Exposed to Ticks in Midwestern Germany. J Clin Microbiol. 2002;40(7):2431-6. doi: 10.1128/jcm.40.7.2431-2436.2002
17. Krause PJ, Daily J, Telford SR, Vannier E, Lantos P, Spielman A. Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol. 2007;23(12):605-10. doi: 10.1016/j.pt.2007.09.005
18. Genda J, Negron EA, Lotfipour M, Balabhadra S, Desai DS, Craft DW, Katzman M. Severe Babesia microti Infection in an Immunocompetent Host in Pennsylvania. J Investigative Medicine High. 2016:1-4. doi: 10.1177/2324709616663774
19. Merino A. Blood film findings in severe babesiosis. Br J Haematol. 2016;172(6):839. doi: 10.1111/bjh.13845
20. Smotrys M, Magge T, Alkhuja S, Gandotra SD. Babesiosis as a cause of false-positive HIV serology. BMJ. 2018; pii: bcr-2017-223738. doi: 10.1136/bcr-2017-223738
21. Akel T, Mobarakai N. Hematologic manifestations of babesiosis. Ann Clin Microbiol Antimicrob. 2017;16(1):6. doi: 10.1186/s12941-017-0179-z
22. Joseph JT, Purtill K, Wong SJ, Munoz J, Teal A, Madison-Antenucci S, Horowitz HW, Aguero-Rosenfeld ME, Moore JM, Abramowsky C, Wormser GP. Vertical Transmission of Babesia microti, United States. Emerg Infect Dis. 2012;18(8):1318-21. doi: 10.3201/eid1808.110988
23. Vannier EG, Diuk-Wasser MA, Mamoun CB, Krause PJ. Babesiosis. Infect Dis Clin North Am. 2015;29(2):357-70. doi:10.1016/j.idc.2015. 02.008
24. Cursino-Santos JR, Singh M, Senaldi E, Manwani D, Yazdanbakhsh K, Lobo CA. Altered parasite life-cycle processes characterize  Babesia  divergens infection in human sickle cell anemia. Haematologia. 2019; pii: haematol. 2018.214304. doi: 10.3324/haematol.2018.214304
25. Chen Q, Schlichtherle M, Wahlgren M. Molecular Aspects of Severe Malaria. Clin Microbiol Rev. 2000;13(3):439-50. doi: 10.1128/cmr.13.3. 439-450.2000
26. Lobo CA, Rodriguez M, Cursino-Santos JR. Babesia and red cell invasion. Curr Opin Hematol. 2012;19(3):170-5. doi: 10.1097/MOH. 0b013e328352245a
27. Djokic V, Primus S, Akoolo L, Chakraborti M, Parveen N. Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity. Front Immunol. 2018;9:2891. doi: 10.3389/fimmu.2018.02891
28. Hunfeld KP, Hildebrandt A, Gray JS. Babesiosis: recent insights into an ancient disease. Int J Parasitol. 2008;38(11):1219-37. doi: 10.1016/j.ijpa ra.2008.03.001
29. Ripoll JG, Rizvi MS, King RL, Daniels CE. Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host. BMJ Case Rep. 2018;2018. pii: bcr-2018-224647. doi: 10.1136/bcr-2018-224647
30. [Tokmalaev AK, Kozevnikova GM. Clinical parasitology: protozoa and helminthiasis. Leadership for doctors. Second edition.  Moscow: MIA, 2017:392 p (In Russ.)].
31. Rosenblatt JE. Laboratory Diagnosis of Infections Due to Blood and Tissue Parasites. Clin Infect Dis. 2009;49(7):1103-8. doi: 10.1086/60 5574
32. Diuk-Wasser MA, Vannier EPJ. Krause Coinfection by the tick-borne pathogens Babesia microti and Borrelia burgdorferi: ecological, epidemiological and clinical consequences. Trends Parasitol. 2016;32(1):30-42. doi:10.1016/j.pt.2015.09.008
33. Daga Ruiz D, Fonseca San Miguel F, González de Molina FJ, Úbeda-Iglesias A, Navas Pérez A, Jannone Forés R. Plasmapheresis and other extracorporeal filtration techniques in critical patients. Medicina Intensiva (English Edition). 2017;41(3):174-87. doi: 10.1016/j.medin.2016.10.005

А.К. Токмалаев 1, В.Б. Ченцов 2, В.А. Малов 3, В.В. Малеев 4, Г.М. Кожевникова 1, Н.А. Половинкина 1, В.П. Голуб 1, В.В. Коннов 1, Т.В. Харламова 1

1 ФГАОУ ВО «Российский университет дружбы народов» (РУДН), Москва, Россия; 
2 ГБУЗ «Инфекционная клиническая больница №2» Департамента здравоохранения г. Москвы, Москва, Россия; 
3 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия; 
4 ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва, Россия

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A.K. Tokmalaev 1, V.B. Chentsov 2, V.A. Malov 3, V.V. Maleyev 4, G.M. Kozhevnikova 1, N.A. Polovinkina 1, V.P. Golub 1, V.V. Konnov 1, T.V. Kharlamova 1

1 Peoples Friendship University of Russia (RUDN), Moscow, Russia;  
2 Infectious Clinical Hospital №2, Moscow City Health Department, Moscow, Russia; 
3 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 
4 Central Research Institute of Epidemiology, Moscow, Russia