Целиакия, ассоциированная с язвенным колитом
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Krums L.M., Babaian A.F., Bykova S.V., et al. Celiac disease associated with ulcerative colitis. Therapeutic Archive. 2019; 91 (2): 8–90. DOI: 10.26442/00403660.2019.02.000152
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Ключевые слова: целиакия, язвенный колит, аглютеновая диета. антицитокиновая терапия.
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The article provides clinical observation of a patient who was diagnosed with celiac disease when he was 52 years (Marsh stage IIIB). Following gluten-free diet (GFD) clinical remission and restoration of small intestinal mucosa (SIM) structure occurred, however in 6 years ulcerative colitis developed and an impairment of SIM morphological structure was identified (Marsh stage IIIA). Ulcerative colitis and celiac disease remission is supported by GFD, anti-cytokine therapy (adalimumab) in combination with mesalazine.
Keywords: celiac disease, ulcerative colitis, gluten-free diet, anti-cytokine therapy.
2. Kocsis D, Toth Z, Csontos AA, Miheller P, Pak P, Herszenyi L, Toth M, Tulassay Z, Juhasz M. Prevalence of inflammatory bowel disease among celiac disease patients in a Hungarian celiac centre. BMC Gastroenterol. 2015;15:141. doi: 101186\s12876-015-0370-7
3. Jandaghi E, Hojatnia M, Vahedi H, Shahbaz-Khani B. Is the Prevalence of celiac disease Higher than general population in inflammatory bowel disease? Middle East J Dig Dis. 2015;7(2):82-7. PMCID: PMC4430796.
4. Casella G, Di Bella C, Salemme M, Villanacci V, Antonelli E, Baldini V, Bassotti G. Celiac disease. non-celiac gluten sensitivity and inflammatory bowel disease. Minevra Gastroenterol Dietol. 2015;61(4):267-71.
5. Быкова С.В., Сабельникова Е.А., Гудкова Р.Б., Дроздов В.Н., Щербаков П.Л., Кирова М.В., Хомерики С.Г., Варванина Г.Г., Беляева А.А., Парфенов А.И. Частота выявления целиакии у больных гастроэнтерологического профиля. Терапевтический архив. 2016;88(2):39-43 [Bykova SV, Sabelnikova EA, Gudkova PB, Drozdov VN, Shcherbakov PL, Kirova M.V., Khomeriki SG, Varvanina GG, Belyaeva AA, Parfenov AI. Celiac disease rate in gastroenterological patients. Therapeutic Archive. 2016;88(2):39-43 (In Russ.)]. doi: 101716/terarkh201688239-43
6. Casella G, D’Inca R, Oliva L, Daperno M, Salalino V, Zoli G, Vatall A. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicenter stude. Dig Liver Dis. 2010;42(3):175-8. doi: 10.1016/j.2009.08.005
7. Cytng SX, Raizner A, Phatak UP, Cho JY, Panshankar DS. Celiac disease in child with ulcerative colitis. A possible genetic association. J Clin Gastroenntrol. 2013;47(2):127-9. doi: 10.1097/МСG/0b013e318250e468
8. Eogamrani Y, Errami AA, Krati K. A rare association: celiac disease and ulcerative colitis. J Med Diagn Meth. 2016;5:223. doi: 10.4172/2168-9784.1000223
9. Krawiec P, Pawlowska-Kamienak F, Pac-Kozuchpwska E, Mroczkowska-Juchkiwcz A, Kominek K. Coexistencen of celiac disease and inflammatory bowel disease in children. Pol Merkur Lekarski. 2016;40(235):53-5.
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1. Paskual V, Dieli-Crimi R, Lopez-Palacios N, Bodas A, Medrano L, Nunez C. Inflammatory bowel disease and celiac disease: Overlaps and differences. World J Gastroennterol. 2014;20(17):4846-56. doi: 10.3748/wig.20i17.4846
2. Kocsis D, Toth Z, Csontos AA, Miheller P, Pak P, Herszenyi L, Toth M, Tulassay Z, Juhasz M. Prevalence of inflammatory bowel disease among celiac disease patients in a Hungarian celiac centre. BMC Gastroenterol. 2015;15:141. doi: 101186\s12876-015-0370-7
3. Jandaghi E, Hojatnia M, Vahedi H, Shahbaz-Khani B. Is the Prevalence of celiac disease Higher than general population in inflammatory bowel disease? Middle East J Dig Dis. 2015;7(2):82-7. PMCID: PMC4430796.
4. Casella G, Di Bella C, Salemme M, Villanacci V, Antonelli E, Baldini V, Bassotti G. Celiac disease. non-celiac gluten sensitivity and inflammatory bowel disease. Minevra Gastroenterol Dietol. 2015;61(4):267-71.
5. Быкова С.В., Сабельникова Е.А., Гудкова Р.Б., Дроздов В.Н., Щербаков П.Л., Кирова М.В., Хомерики С.Г., Варванина Г.Г., Беляева А.А., Парфенов А.И. Частота выявления целиакии у больных гастроэнтерологического профиля. Терапевтический архив. 2016;88(2):39-43 [Bykova SV, Sabelnikova EA, Gudkova PB, Drozdov VN, Shcherbakov PL, Kirova M.V., Khomeriki SG, Varvanina GG, Belyaeva AA, Parfenov AI. Celiac disease rate in gastroenterological patients. Therapeutic Archive. 2016;88(2):39-43 (In Russ.)]. doi: 101716/terarkh201688239-43
6. Casella G, D’Inca R, Oliva L, Daperno M, Salalino V, Zoli G, Vatall A. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicenter stude. Dig Liver Dis. 2010;42(3):175-8. doi: 10.1016/j.2009.08.005
7. Cytng SX, Raizner A, Phatak UP, Cho JY, Panshankar DS. Celiac disease in child with ulcerative colitis. A possible genetic association. J Clin Gastroenntrol. 2013;47(2):127-9. doi: 10.1097/МСG/0b013e318250e468
8. Eogamrani Y, Errami AA, Krati K. A rare association: celiac disease and ulcerative colitis. J Med Diagn Meth. 2016;5:223. doi: 10.4172/2168-9784.1000223
9. Krawiec P, Pawlowska-Kamienak F, Pac-Kozuchpwska E, Mroczkowska-Juchkiwcz A, Kominek K. Coexistencen of celiac disease and inflammatory bowel disease in children. Pol Merkur Lekarski. 2016;40(235):53-5.
ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения г. Москвы, Москва, Россия
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L.M. Krums, A.F. Babaian, S.V. Bykova, A.A. Lishchinskaia, S.G. Khomeriki, R.B. Gudkova, E.A. Sabel'nikova, O.V. Kniazev, A.I. Parfenov
A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow, Moscow, Russia