Фолликулярная лимфома: критерии выбора терапии первой линии
Фолликулярная лимфома: критерии выбора терапии первой линии
Нестерова Е.С., Кравченко С.К., Ковригина А.М. и др. Фолликулярная лимфома: критерии выбора терапии первой линии. Терапевтический архив. 2019; 91 (8): 75–83. DOI: 10.26442/00403660.2019.08.000388
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Фолликулярная лимфома (ФЛ) – это опухоль, развивающаяся из В-клеток герминального центра, характеризующаяся рецидивирующим и ремиттирующим течением; возможна трансформация в диффузную В-крупноклеточную лимфому (ДВККЛ). При генерализованном поражении и прогрессировании ФЛ наиболее часто применяются режимы терапии R-CHOP и R-B. Выбор схемы терапии в зависимости от различных цитологических, клинических и лабораторных характеристик пациентов остается предметом дискуссий.
Цель исследования – анализ клинических, лабораторных и морфологических характеристик пациентов с ФЛ, получивших полихимиотерапию (ПХТ) по схемам R-B и R-CHOP; определение критериев выбора индукционной терапии.
Материалы и методы. В исследование включено 203 пациента с ФЛ за период с 2000 по 2018 г. Курсы R-B проводились в пяти клиниках г. Москвы и четырех региональных клиниках России (в Кирове, Туле, Смоленске и Хабаровске). Терапию по схеме R-B на момент данного анализа получили 77 больных. Курсы R-CHOP проведены в НМИЦ гематологии Минздрава России. Лечение по схеме R-CHOP начато 126 пациентам, 14 из которых в дальнейшем получили высокодозную химиотерапию (ВХТ) (R-DHAP в составе: ритуксимаб, дексаметазон, цисплатин, цитарабин) без трансплантации аутологичных стволовых клеток крови (аутоТСКК), 21 пациент получил ВХТ с аутоТСКК; 89 больных получили лечение курсами R-CHOP и поддерживающей терапией ритуксимабом (двое больных, у которых заболевание прогрессировало, кроме терапии R-CHOP, получили лечение по программе mNHL-BFM-90). Эффективность различных схем терапии оценивается в данной работе в первую очередь по общей выживаемости.
Результаты и обсуждение. R-B. Терапию по схеме R-B получили 77 больных. Полная ремиссия заболевания достигнута у 47 (61%) пациентов (у трех из них в дальнейшем развился рецидив заболевания), частичная ремиссия – у 15 (19%) пациентов, в 13 случаях (17%) зафиксировано прогрессирование опухоли. Цитологический тип опухоли 1–2 имели 70 пациентов, цитологический тип 3А – 6 пациентов. У 6/13 (46%) больных с прогрессированием заболевания диагностирован цитологический тип 3А ФЛ. Медиана наблюдения (на момент анализа) – 34 мес. R-CHOP. ВХТ с R-CHOP (6–8 курсов) и поддерживающую терапию ритуксимабом получили 89 пациентов с ФЛ. У 39 (44%) больных достигнута и сохранялась ремиссия заболевания, у 50 (56%) – развился рецидив. 50 пациентов имели 1–2-й цитологический тип, 39 – 3-й цитологический тип. У 18 из 50 рецидивировавших пациентов (т. е. у 36%) диагностирован цитологический тип 3А. Медиана наблюдения – 93 мес. R-CHOP+ВХТ с аутоТСКК. В связи с недостаточным противоопухолевым ответом 21 пациенту после курсов R-CHOP лечение продолжена ВХТ, а также выполнена аутоТСКК. В 18 случаях из 21 (86%) достигнута и сохраняется полная ремиссия заболевания, в 3 случаях (14%) развился рецидив. 16 пациентов имели 1–2-й цитологический тип опухоли, 5 (рецидивировавших) пациента имели 3-й цитологический тип. Медиана наблюдения – 81 мес. R-CHOP + ВХТ без аутоТСКК. 14 пациентам в качестве индукционной терапии начата ПХТ по программе R-CHOP, однако потом (в связи с недостаточным противоопухолевым ответом) лечение продолжено высокодозной терапии (аутоТСКК этим пациентам по ряду причин не выполнялась). 10 больных имели 2-й цитологический тип, 4 больных – 3-й цитологический тип. 11 (79%) пациентов находятся в настоящее время в ремиссии заболевания, у 3 (21%) – случился рецидив. Медиана наблюдения – 80 мес. 7-летняя общая выживаемость больных ФЛ на терапии R-B составила 89% (95% ДИ 75–99), на R-CHOP – 85% (95% ДИ 73–90), на R-CHOP+ВХТ с аутоТСКК – 87% (95% ДИ 57–100), на R-CHOP+ВХТ без аутоТСКК – 82%. Бессобытийная 7-летняя выживаемость больных ФЛ на терапии R-B составила 70% (95% ДИ 75–99), на R-CHOP – 44% (95% ДИ 73–90), на R-CHOP+ВХТ с аутоТСКК – 74% (95% ДИ 57–100), на R-CHOP + ВХТ без аутоТСКК – 80%.
Заключение. Цитологический тип опухоли и характер опухолевого роста не имеют взаимооднозначного соответствия: при цитологических типах 3А и 3А+3В встречаются как нодулярный и нодулярно-диффузный, так и диффузный типы роста опухоли. Следовательно, при выборе индукционного режима терапии в первую очередь нужно руководствоваться цитологическим типом ФЛ. Режим R-B наиболее эффективен при 1-м и 2-м цитологических типах ФЛ. Предиктором резистентности к терапии R-B является высокий (>35%) индекс пролиферативной активности (Ki67). Химиорезистентность опухоли ассоциируется также с отсутствием интерфолликулярной Т-клеточной реакции в опухолевой ткани. Предиктором плохого ответа на терапию является наличие крупных опухолевых конгломератов (bulky), которые (у большинства больных) ассоциируются с индексом FLIPI со значениями от 3 до 5. Пациентам, имеющим в дебюте заболевания фактор bulky, высокий (>35%) индекс Ki67 и индекс FLIPI от 3 до 5 в качестве терапии первой линии предпочтительнее выбрать режим R-CHOP, а при отсутствии (после 4–6 курсов) полной или частичной ремиссии продолжить лечение ВХТ.
Ключевые слова: фолликулярная лимфома, ритуксимаб, бендамустин, CHOP, аутоТСКК, выживаемость.
Aim. To analyze the clinical, laboratory, morphological parameters of patients with FL, who got R-B and R-CHOP therapy; determine the criteria for selecting induction therapy.
Materials and methods. The study included 203 patients with FL from 2000 to 2018. R-CHOP treatment was initiated in 126 patients, 14 of whom later received high-dose therapy (HDT) (R-DHAP: rituximab, dexamethasone, cisplatin, cytarabine) without autologous stem cell transplantation (autoSCT), 21 – HDT with autoSCT; treatment of 89 patients was limited to courses of R-CHOP and maintenance therapy with rituximab, two patients (in whom the disease progressed, despite R-CHOP therapy) were assigned the mNHL-BFM-90 program. The efficacy of treatment on various treatment regimens was evaluated primarily by overall survival.
Results and discussion. R-B. 77 patients received R-B therapy. Complete remission of the disease was achieved in 47/77 (61%) patients (3 of them later developed a relapse of the disease), partial remission was achieved in 15/77 (19%) patients, in 13/77 (17%) cases progression was recorded tumors. 70 patients had 1–2 cytological type of tumor, 6 patients – 3A cytological type. In cases of progression, 3 of 13 patients (46%) were diagnosed with 3A cytological type FL. Median observation (at the time of analysis) – 34 months. R-CHOP. 89 patients with FL received high-dose therapy with R-CHOP (6–8 courses) and maintenance therapy with rituximab. In 39 (44%) patients, the disease remained in remission, and in 50 (56%), a relapse of the disease developed. 50 patients had 1–2 cytological types, 39 – 3 cytological types. In cases of recurrence of FL, a 3A cytologic type (36%) was diagnosed in 18/50 patients. Median observation – 93 months. R-CHOP + HDT and autoSCT. 21 patients after the R-CHOP courses continued (due to insufficient antitumor response) high-dose chemotherapy (HDT) and auto-SCT were performed. In 18/21 (86%) cases, complete remission of the disease was achieved and maintained, in 3 (14%) cases relapse developed. 16 patients had 1–2 cytological types, 5 – 3 cytological types. Median observation – 81 months. R-CHOP + HDT without autoSCT. 14 patients started therapy under the R-CHOP program as induction therapy, but then (due to insufficient antitumor response), the treatment was continued according to the HDT without autoSCT. 11 (79%) patients are currently in remission of the disease, in 3 (21%) – there was a relapse. 10 patients had 2 cytological types of PL, 4 – 3 cytological types. 11 (79%) patients are currently in remission of the disease, in 3 (21%) – there was a relapse. Median observation – 80 months. 7-year OS of patients with FL on RB therapy was 89% (95% CI 75–99), on R-CHOP therapy – 85% (95% CI 73–90), on R-CHOP + HDT and autoSCT – 87% (95% CI 57–100), on R-CHOP + HDT without autoSCT – 82%. 7-year PFS of FL patients on RB therapy was 70% (95% CI 75–99), on R-CHOP therapy – 44% (95% CI 73–90), on R-CHOP + HDT and autoSCT – 74% (95% CI 57–100), on R-CHOP + HDT without autoSCT – 80%.
Conclusion. The R-B is most effective in FL 1 and 2 cytological types. The cytological type does not correspond to the type of tumor growth: at 3A and 3A + 3B cytological types, nodular / nodular-diffuse and diffuse types of growth are found. When choosing an induction course, one should look at the cytological type of FL. A high proliferative activity index (according to Ki67) is a predictor of resistance to R-B therapy. The absence of an interfollicular T-cell reaction in tumor tissue FL is associated with tumor chemoresistance. The presence of the bulky factor is associated (in most patients) with the FLIPI index with values from 3 to 5, and is a predictor of a poor response to therapy. Patients with bulky, high (more than 35%) Ki67 index and FLIPI from 3 to 5 in the debut of the disease as the first line therapy, it is preferable to choose the R-CHOP mode, and in the absence of (after 4–6 courses) to complete or partial remission to continue conducting the HDT.
Keywords: follicular lymphoma, rituximab, bendamustine, CHOP, autologous stem cell transplantation, survival.
Цель исследования – анализ клинических, лабораторных и морфологических характеристик пациентов с ФЛ, получивших полихимиотерапию (ПХТ) по схемам R-B и R-CHOP; определение критериев выбора индукционной терапии.
Материалы и методы. В исследование включено 203 пациента с ФЛ за период с 2000 по 2018 г. Курсы R-B проводились в пяти клиниках г. Москвы и четырех региональных клиниках России (в Кирове, Туле, Смоленске и Хабаровске). Терапию по схеме R-B на момент данного анализа получили 77 больных. Курсы R-CHOP проведены в НМИЦ гематологии Минздрава России. Лечение по схеме R-CHOP начато 126 пациентам, 14 из которых в дальнейшем получили высокодозную химиотерапию (ВХТ) (R-DHAP в составе: ритуксимаб, дексаметазон, цисплатин, цитарабин) без трансплантации аутологичных стволовых клеток крови (аутоТСКК), 21 пациент получил ВХТ с аутоТСКК; 89 больных получили лечение курсами R-CHOP и поддерживающей терапией ритуксимабом (двое больных, у которых заболевание прогрессировало, кроме терапии R-CHOP, получили лечение по программе mNHL-BFM-90). Эффективность различных схем терапии оценивается в данной работе в первую очередь по общей выживаемости.
Результаты и обсуждение. R-B. Терапию по схеме R-B получили 77 больных. Полная ремиссия заболевания достигнута у 47 (61%) пациентов (у трех из них в дальнейшем развился рецидив заболевания), частичная ремиссия – у 15 (19%) пациентов, в 13 случаях (17%) зафиксировано прогрессирование опухоли. Цитологический тип опухоли 1–2 имели 70 пациентов, цитологический тип 3А – 6 пациентов. У 6/13 (46%) больных с прогрессированием заболевания диагностирован цитологический тип 3А ФЛ. Медиана наблюдения (на момент анализа) – 34 мес. R-CHOP. ВХТ с R-CHOP (6–8 курсов) и поддерживающую терапию ритуксимабом получили 89 пациентов с ФЛ. У 39 (44%) больных достигнута и сохранялась ремиссия заболевания, у 50 (56%) – развился рецидив. 50 пациентов имели 1–2-й цитологический тип, 39 – 3-й цитологический тип. У 18 из 50 рецидивировавших пациентов (т. е. у 36%) диагностирован цитологический тип 3А. Медиана наблюдения – 93 мес. R-CHOP+ВХТ с аутоТСКК. В связи с недостаточным противоопухолевым ответом 21 пациенту после курсов R-CHOP лечение продолжена ВХТ, а также выполнена аутоТСКК. В 18 случаях из 21 (86%) достигнута и сохраняется полная ремиссия заболевания, в 3 случаях (14%) развился рецидив. 16 пациентов имели 1–2-й цитологический тип опухоли, 5 (рецидивировавших) пациента имели 3-й цитологический тип. Медиана наблюдения – 81 мес. R-CHOP + ВХТ без аутоТСКК. 14 пациентам в качестве индукционной терапии начата ПХТ по программе R-CHOP, однако потом (в связи с недостаточным противоопухолевым ответом) лечение продолжено высокодозной терапии (аутоТСКК этим пациентам по ряду причин не выполнялась). 10 больных имели 2-й цитологический тип, 4 больных – 3-й цитологический тип. 11 (79%) пациентов находятся в настоящее время в ремиссии заболевания, у 3 (21%) – случился рецидив. Медиана наблюдения – 80 мес. 7-летняя общая выживаемость больных ФЛ на терапии R-B составила 89% (95% ДИ 75–99), на R-CHOP – 85% (95% ДИ 73–90), на R-CHOP+ВХТ с аутоТСКК – 87% (95% ДИ 57–100), на R-CHOP+ВХТ без аутоТСКК – 82%. Бессобытийная 7-летняя выживаемость больных ФЛ на терапии R-B составила 70% (95% ДИ 75–99), на R-CHOP – 44% (95% ДИ 73–90), на R-CHOP+ВХТ с аутоТСКК – 74% (95% ДИ 57–100), на R-CHOP + ВХТ без аутоТСКК – 80%.
Заключение. Цитологический тип опухоли и характер опухолевого роста не имеют взаимооднозначного соответствия: при цитологических типах 3А и 3А+3В встречаются как нодулярный и нодулярно-диффузный, так и диффузный типы роста опухоли. Следовательно, при выборе индукционного режима терапии в первую очередь нужно руководствоваться цитологическим типом ФЛ. Режим R-B наиболее эффективен при 1-м и 2-м цитологических типах ФЛ. Предиктором резистентности к терапии R-B является высокий (>35%) индекс пролиферативной активности (Ki67). Химиорезистентность опухоли ассоциируется также с отсутствием интерфолликулярной Т-клеточной реакции в опухолевой ткани. Предиктором плохого ответа на терапию является наличие крупных опухолевых конгломератов (bulky), которые (у большинства больных) ассоциируются с индексом FLIPI со значениями от 3 до 5. Пациентам, имеющим в дебюте заболевания фактор bulky, высокий (>35%) индекс Ki67 и индекс FLIPI от 3 до 5 в качестве терапии первой линии предпочтительнее выбрать режим R-CHOP, а при отсутствии (после 4–6 курсов) полной или частичной ремиссии продолжить лечение ВХТ.
Ключевые слова: фолликулярная лимфома, ритуксимаб, бендамустин, CHOP, аутоТСКК, выживаемость.
________________________________________________
Aim. To analyze the clinical, laboratory, morphological parameters of patients with FL, who got R-B and R-CHOP therapy; determine the criteria for selecting induction therapy.
Materials and methods. The study included 203 patients with FL from 2000 to 2018. R-CHOP treatment was initiated in 126 patients, 14 of whom later received high-dose therapy (HDT) (R-DHAP: rituximab, dexamethasone, cisplatin, cytarabine) without autologous stem cell transplantation (autoSCT), 21 – HDT with autoSCT; treatment of 89 patients was limited to courses of R-CHOP and maintenance therapy with rituximab, two patients (in whom the disease progressed, despite R-CHOP therapy) were assigned the mNHL-BFM-90 program. The efficacy of treatment on various treatment regimens was evaluated primarily by overall survival.
Results and discussion. R-B. 77 patients received R-B therapy. Complete remission of the disease was achieved in 47/77 (61%) patients (3 of them later developed a relapse of the disease), partial remission was achieved in 15/77 (19%) patients, in 13/77 (17%) cases progression was recorded tumors. 70 patients had 1–2 cytological type of tumor, 6 patients – 3A cytological type. In cases of progression, 3 of 13 patients (46%) were diagnosed with 3A cytological type FL. Median observation (at the time of analysis) – 34 months. R-CHOP. 89 patients with FL received high-dose therapy with R-CHOP (6–8 courses) and maintenance therapy with rituximab. In 39 (44%) patients, the disease remained in remission, and in 50 (56%), a relapse of the disease developed. 50 patients had 1–2 cytological types, 39 – 3 cytological types. In cases of recurrence of FL, a 3A cytologic type (36%) was diagnosed in 18/50 patients. Median observation – 93 months. R-CHOP + HDT and autoSCT. 21 patients after the R-CHOP courses continued (due to insufficient antitumor response) high-dose chemotherapy (HDT) and auto-SCT were performed. In 18/21 (86%) cases, complete remission of the disease was achieved and maintained, in 3 (14%) cases relapse developed. 16 patients had 1–2 cytological types, 5 – 3 cytological types. Median observation – 81 months. R-CHOP + HDT without autoSCT. 14 patients started therapy under the R-CHOP program as induction therapy, but then (due to insufficient antitumor response), the treatment was continued according to the HDT without autoSCT. 11 (79%) patients are currently in remission of the disease, in 3 (21%) – there was a relapse. 10 patients had 2 cytological types of PL, 4 – 3 cytological types. 11 (79%) patients are currently in remission of the disease, in 3 (21%) – there was a relapse. Median observation – 80 months. 7-year OS of patients with FL on RB therapy was 89% (95% CI 75–99), on R-CHOP therapy – 85% (95% CI 73–90), on R-CHOP + HDT and autoSCT – 87% (95% CI 57–100), on R-CHOP + HDT without autoSCT – 82%. 7-year PFS of FL patients on RB therapy was 70% (95% CI 75–99), on R-CHOP therapy – 44% (95% CI 73–90), on R-CHOP + HDT and autoSCT – 74% (95% CI 57–100), on R-CHOP + HDT without autoSCT – 80%.
Conclusion. The R-B is most effective in FL 1 and 2 cytological types. The cytological type does not correspond to the type of tumor growth: at 3A and 3A + 3B cytological types, nodular / nodular-diffuse and diffuse types of growth are found. When choosing an induction course, one should look at the cytological type of FL. A high proliferative activity index (according to Ki67) is a predictor of resistance to R-B therapy. The absence of an interfollicular T-cell reaction in tumor tissue FL is associated with tumor chemoresistance. The presence of the bulky factor is associated (in most patients) with the FLIPI index with values from 3 to 5, and is a predictor of a poor response to therapy. Patients with bulky, high (more than 35%) Ki67 index and FLIPI from 3 to 5 in the debut of the disease as the first line therapy, it is preferable to choose the R-CHOP mode, and in the absence of (after 4–6 courses) to complete or partial remission to continue conducting the HDT.
Keywords: follicular lymphoma, rituximab, bendamustine, CHOP, autologous stem cell transplantation, survival.
Список литературы
1. Swerdlow SH, Swerdlow S, Campo E, Harris N, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. World Health Organization, 2017; Vol. 2.
2. Anastasia A, Rossi G. Novel Drugs in Follicular Lymphoma. Mediterr J Hematol Infect Dis. 2016;8(1):e2016061. doi: 10.4084/MJHID.2016.061
3. Cheah CY, Fowler NH. Novel agents for relapsed and refractory follicular lymphoma. Best Pract Res Clin Haematol. 2018;31(1):41-8. doi: 10.1016/j.beha.2017.11.003
4. Dreyling M, Ghielmini M, Rule S, Salles G, Vitolo U, Ladetto M; ESMO Guidelines Committee. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl 5):v83-90. doi: 10.1093/annonc/mdx020
5. Поддубная И.В., Савченко В.Г., редакторы. Российские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний. М., 2018 [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii [Russian clinical guidelines for the diagnosis and treatment of lymphoproliferative diseases]. Moscow, 2018 (In Russ.)].
6. NCCN 2018-2019 oncology case manager and medical director program: diagnosis and management of hematologic malignancies. Version 2.2018. 2018 Jan 19.
7. Mondello P, Steiner N, Willenbacher W, Wasle I, Zaja F, Zambello R, et al. Bendamustine plus rituximab versus R-CHOP as first-line treatment for patients with indolent non-Hodgkin’s lymphoma: evidence from a multicenter, retrospective study. Ann Hematol. 2016;95(7):1107-14. doi: 10.1007/s00277-016-2668-0. Epub 2016 Apr 22.
8. Luminari S, Goldaniga M, Cesaretti M, Orsucci L, Tucci A, Pulsoni A, et al. A phase II study of bendamustine in combination with rituximab as initial treatment for patients with indolent non-follicular non-Hodgkin lymphoma. Leuk Lymphoma. 2016;57(4):880-7. doi: 10.3109/10428194.2015.1091934. Epub 2016 Feb 8.
9. Mondello P, Steiner N, Willenbacher W, Cerchione C, Nappi D, Mauro E, Ferrero S, Cuzzocrea S, Mian M. Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study. Oncologist. 2018 Apr;23(4):454-60. doi: 10.1634/theoncologist.2017-0037. Epub 2018 Jan 9.
10. Rummel MJ, Niederle N, Maschmeyer G, Banat GA, von Grünhagen U, Losem C, Kofahl-Krause D, Heil G, Welslau M, Balser C, Kaiser U, Weidmann E, Dürk H, Ballo H, Stauch M, Roller F, Barth J, Hoelzer D, Hinke A, Brugger W; Study group indolent Lymphomas (StiL). Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013 Apr 6;381(9873):1203-10. doi: 10.1016/S0140-6736(12)61763-2. Epub 2013 Feb 20.
11. Morschhauser F, Seymour J, Feugier P, Offner F, Lopez-Guillermo A, Bouabdallah R, Pedersen L, et al. Impact of induction chemotherapy regimen on response, safety and outcome in the PRIMA study. Ann Oncol. 2011;22:89-9. Presented at the 11th International conference on Malignant Lymphoma. doi: 10.1007/978-1-62703-408-19
12. Yamaguchi T, Morita T, Takahashi Y, Tsuda K, Mori J. Treatment for patients with indolent and mantle cell lymphoma. Lancet. 2013 Sep 28;382(9898):1094-5. doi: 10.1016/S0140-6736(13)62018-8
13. Morrison VA, Shou Y, Bell JA, Hamilton L, Ogbonnaya A, Raju A, Hennenfent K, Eaddy M, Galaznik A. Treatment Patterns and Survival Outcomes in Patients With Follicular Lymphoma: A 2007 to 2015 Humedica Database Study. Clin Lymphoma Myeloma Leuk. 2019 Jan 2. pii: S2152-2650(18)31126-1. doi: 10.1016/j.clml.2018.12.017
14. Нестерова Е.С., Кравченко С.К., Ковригина А.М. и др. Фолликулярная лимфома: результаты многоцентрового исследования терапии первой линии препаратами бендамустин и ритуксимаб; факторы риска неблагоприятных событий (протокол FL-RUS-2013). Онкогематология. 2018;13(3):10-24 [Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Follicular lymphoma: results of multicenter study of first-line therapy with bendamustine and rituximab; risk factors for adverse events (FL-RUS-2013 protocol). Onkogematolog iya = Oncohematology. 2018;13(3):10-24 (In Russ.)]. doi: 10.17650/1818-8346-2018-13-3-10-24
15. Нестерова Е.С., Кравченко С.К., Барях Е.А. и др. Tрансплантация аутологичных стволовых клеток крови в первой ремиссии фолликулярной лимфомы как «терапия спасения» пациентов с факторами неблагоприятного прогноза. Результаты первого проспективного исследования. Современная онкология. 2016;18(5):31-2 [Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cells transplantation in the first remission of follicular lymphoma as “rescue therapy” in patients with unfavorable prognosis factors. The first prospective study results. Sovremennaya Onkolog iya = Modern Oncology. 2016;18(5):31-2 (In Russ.)].
16. Нестерова Е.С., Кравченко С.К., Мангасарова Я.К. и др. Фолликулярная лимфома. Высокодозная иммунохимиотерапия с трансплантацией аутологичных стволовых клеток крови: результаты первого проспективного исследования в России. Терапевтический архив. 2016;88(7):62-71 [Nesterova ES, Kravchenko SK, Mangasarova YaK, et al. Follicular lymphoma. High-dose immunochemotherapy with autologous blood stem cell transplantation: Results of the first prospective study in Russia. Therapeutic Archive. 2016; 88(7):62-71 (In Russ.)]. doi: 10.17116/terarkh201688762-71
17. Wahlin BE, Yri OE, Kimby E, et al. Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. Br J Haematol. 2012;156 (2):225-33. doi: 10.1111/j.1365-2141.2011.08942.x. Epub 2011 Nov 30.
18. Senaras C, Pennell M, Chen W, Shana'ah A, Louissaint A, Hasserjian RP, Lozanski G, Gurcan MN. FOXP3-stained image analysis for follicular lymphoma: Optimal adaptive thresholding with maximal nucleus coverage. Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10140. doi: 10.1117/12.2255671. Epub 2017 Mar 1.
19. Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, Hohaus S, Duchez S, Quillet-Mary A, Laurent G, Brousset P, Valitutti S. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood. 2011 Nov 17;118(20):5371-9. doi: 10.1182/blood-2011-04-345777. Epub 2011 Aug 19.
20. Tarella C, Zanni M, Magni M, Benedetti F, Patti C, Barbui T, Pileri A, Boccadoro M, Ciceri F, Gallamini A, Cortelazzo S, Majolino I, Mirto S, Corradini P, Passera R, Pizzolo G, Gianni AM, Rambaldi A. Rituximab improves the efficacy of high-dose chemotherapy with autograft for high-risk follicular and diffuse large B-cell lymphoma: a multicenter Gruppo Italiano Terapie Innnovative nei linfomi survey. J Clin Oncol. 2008;26:3166-75. doi: 10.1200/JCO.2007.14.4204
21. Buske C, Dreyling M. Malignant B-Cell Lymphoma: Advances in the Therapy of Follicular Lymphoma and Mantle-cell Lymphoma. Dtsch Med Wochenschr. 2018 Jan;143(1):46-51. doi: 10.1055/s-0043-124004. Epub 2018 Jan 9.
22. Montoto S, Corradini P, Dreyling M, et al. Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma:a consensus project of the EBMT Lymphoma Working Party. Haematologica. 2013 Jul;98(7):1014-21.
23. Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J Clin Oncol. 2014;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800
24. Weiler-Sagie M, Buschelev O, Epelbaum R, et al. 18F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 2010;51:25-30. doi: 10.2967/jnumed.109.067892
25. Tsukamoto N, Kojima N, Hasegawa M, et al. The usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) and a comparison with 67Gallium scintigraphy in the evaluation of lymphoma. Cancer. 2007;110(3):652-9. doi: 10.1002/cncr.22807 PMid: 17582800
26. Delfau-Larue MH, van der Gucht A, Dupuis J, Jais JP, Nel I, Beldi-Ferchiou A, Hamdane S, Benmaad I, Laboure G, Verret B, Haioun C, Copie-Bergman C, Berriolo-Riedinger A, Robert P, Casasnovas RO, Itti E. Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. Blood Adv. 2018 Apr 10;2(7):807-16. doi: 10.1182/bloodadvances.2017015164
27. Abou-Nassar KE, Vanderplas A, Friedberg JW, Abel GA, Niland J, Rodriguez MA, Czuczman MS, Millenson M, Crosby A, Gordon LI, Zelenetz AD, Kaminski M, Lacasce AS. Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Leuk Lymphoma. 2013 Oct;54(10):2155-62. doi: 10.3109/10428194.2013.770151. Epub 2013 Feb 25.
28. Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cell transplantation (AutoSCT) in first remission of follicular lymphoma (FL) “save“ patients (pts) with poor prognosis. results of the first Russian prospective study. Blood. 2015;126(23):5079.
29. Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Front-line high dose therapy with following autologous stem cell transplantation (ASCT) for follicular lymphoma patients. Blood. 2014;124(21):5908.
30. Нестерова Е.С., Кравченко С.К., Гемджян Э.Г. и др. Итоги десятилетнего опыта лечения больных фолликулярной лимфомой. Гематология и трансфузиология. 2012;57(5):3-8 [Nesterova ES, Kravchenko SK, Gemdzhian EG, et al. The results of ten years’ experience treating patients with follicular lymphoma. Gematologiya i Transfuziologiya = Hematology and Transfusiology. 2012;57(5):3-8 (In Russ.)].
2. Anastasia A, Rossi G. Novel Drugs in Follicular Lymphoma. Mediterr J Hematol Infect Dis. 2016;8(1):e2016061. doi: 10.4084/MJHID.2016.061
3. Cheah CY, Fowler NH. Novel agents for relapsed and refractory follicular lymphoma. Best Pract Res Clin Haematol. 2018;31(1):41-8. doi: 10.1016/j.beha.2017.11.003
4. Dreyling M, Ghielmini M, Rule S, Salles G, Vitolo U, Ladetto M; ESMO Guidelines Committee. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl 5):v83-90. doi: 10.1093/annonc/mdx020
5. [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii [Russian clinical guidelines for the diagnosis and treatment of lymphoproliferative diseases]. Moscow, 2018 (In Russ.)].
6. NCCN 2018-2019 oncology case manager and medical director program: diagnosis and management of hematologic malignancies. Version 2.2018. 2018 Jan 19.
7. Mondello P, Steiner N, Willenbacher W, Wasle I, Zaja F, Zambello R, et al. Bendamustine plus rituximab versus R-CHOP as first-line treatment for patients with indolent non-Hodgkin’s lymphoma: evidence from a multicenter, retrospective study. Ann Hematol. 2016;95(7):1107-14. doi: 10.1007/s00277-016-2668-0. Epub 2016 Apr 22.
8. Luminari S, Goldaniga M, Cesaretti M, Orsucci L, Tucci A, Pulsoni A, et al. A phase II study of bendamustine in combination with rituximab as initial treatment for patients with indolent non-follicular non-Hodgkin lymphoma. Leuk Lymphoma. 2016;57(4):880-7. doi: 10.3109/10428194.2015.1091934. Epub 2016 Feb 8.
9. Mondello P, Steiner N, Willenbacher W, Cerchione C, Nappi D, Mauro E, Ferrero S, Cuzzocrea S, Mian M. Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study. Oncologist. 2018 Apr;23(4):454-60. doi: 10.1634/theoncologist.2017-0037. Epub 2018 Jan 9.
10. Rummel MJ, Niederle N, Maschmeyer G, Banat GA, von Grünhagen U, Losem C, Kofahl-Krause D, Heil G, Welslau M, Balser C, Kaiser U, Weidmann E, Dürk H, Ballo H, Stauch M, Roller F, Barth J, Hoelzer D, Hinke A, Brugger W; Study group indolent Lymphomas (StiL). Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013 Apr 6;381(9873):1203-10. doi: 10.1016/S0140-6736(12)61763-2. Epub 2013 Feb 20.
11. Morschhauser F, Seymour J, Feugier P, Offner F, Lopez-Guillermo A, Bouabdallah R, Pedersen L, et al. Impact of induction chemotherapy regimen on response, safety and outcome in the PRIMA study. Ann Oncol. 2011;22:89-9. Presented at the 11th International conference on Malignant Lymphoma. doi: 10.1007/978-1-62703-408-19
12. Yamaguchi T, Morita T, Takahashi Y, Tsuda K, Mori J. Treatment for patients with indolent and mantle cell lymphoma. Lancet. 2013 Sep 28;382(9898):1094-5. doi: 10.1016/S0140-6736(13)62018-8
13. Morrison VA, Shou Y, Bell JA, Hamilton L, Ogbonnaya A, Raju A, Hennenfent K, Eaddy M, Galaznik A. Treatment Patterns and Survival Outcomes in Patients With Follicular Lymphoma: A 2007 to 2015 Humedica Database Study. Clin Lymphoma Myeloma Leuk. 2019 Jan 2. pii: S2152-2650(18)31126-1. doi: 10.1016/j.clml.2018.12.017
14. [Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Follicular lymphoma: results of multicenter study of first-line therapy with bendamustine and rituximab; risk factors for adverse events (FL-RUS-2013 protocol). Onkogematolog iya = Oncohematology. 2018;13(3):10-24 (In Russ.)]. doi: 10.17650/1818-8346-2018-13-3-10-24
15. [Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cells transplantation in the first remission of follicular lymphoma as “rescue therapy” in patients with unfavorable prognosis factors. The first prospective study results. Sovremennaya Onkolog iya = Modern Oncology. 2016;18(5):31-2 (In Russ.)].
16. [Nesterova ES, Kravchenko SK, Mangasarova YaK, et al. Follicular lymphoma. High-dose immunochemotherapy with autologous blood stem cell transplantation: Results of the first prospective study in Russia. Therapeutic Archive. 2016; 88(7):62-71 (In Russ.)]. doi: 10.17116/terarkh201688762-71
17. Wahlin BE, Yri OE, Kimby E, et al. Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. Br J Haematol. 2012;156 (2):225-33. doi: 10.1111/j.1365-2141.2011.08942.x. Epub 2011 Nov 30.
18. Senaras C, Pennell M, Chen W, Shana'ah A, Louissaint A, Hasserjian RP, Lozanski G, Gurcan MN. FOXP3-stained image analysis for follicular lymphoma: Optimal adaptive thresholding with maximal nucleus coverage. Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10140. doi: 10.1117/12.2255671. Epub 2017 Mar 1.
19. Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, Hohaus S, Duchez S, Quillet-Mary A, Laurent G, Brousset P, Valitutti S. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood. 2011 Nov 17;118(20):5371-9. doi: 10.1182/blood-2011-04-345777. Epub 2011 Aug 19.
20. Tarella C, Zanni M, Magni M, Benedetti F, Patti C, Barbui T, Pileri A, Boccadoro M, Ciceri F, Gallamini A, Cortelazzo S, Majolino I, Mirto S, Corradini P, Passera R, Pizzolo G, Gianni AM, Rambaldi A. Rituximab improves the efficacy of high-dose chemotherapy with autograft for high-risk follicular and diffuse large B-cell lymphoma: a multicenter Gruppo Italiano Terapie Innnovative nei linfomi survey. J Clin Oncol. 2008;26:3166-75. doi: 10.1200/JCO.2007.14.4204
21. Buske C, Dreyling M. Malignant B-Cell Lymphoma: Advances in the Therapy of Follicular Lymphoma and Mantle-cell Lymphoma. Dtsch Med Wochenschr. 2018 Jan;143(1):46-51. doi: 10.1055/s-0043-124004. Epub 2018 Jan 9.
22. Montoto S, Corradini P, Dreyling M, et al. Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma:a consensus project of the EBMT Lymphoma Working Party. Haematologica. 2013 Jul;98(7):1014-21.
23. Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J Clin Oncol. 2014;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800
24. Weiler-Sagie M, Buschelev O, Epelbaum R, et al. 18F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 2010;51:25-30. doi: 10.2967/jnumed.109.067892
25. Tsukamoto N, Kojima N, Hasegawa M, et al. The usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) and a comparison with 67Gallium scintigraphy in the evaluation of lymphoma. Cancer. 2007;110(3):652-9. doi: 10.1002/cncr.22807 PMid: 17582800
26. Delfau-Larue MH, van der Gucht A, Dupuis J, Jais JP, Nel I, Beldi-Ferchiou A, Hamdane S, Benmaad I, Laboure G, Verret B, Haioun C, Copie-Bergman C, Berriolo-Riedinger A, Robert P, Casasnovas RO, Itti E. Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. Blood Adv. 2018 Apr 10;2(7):807-16. doi: 10.1182/bloodadvances.2017015164
27. Abou-Nassar KE, Vanderplas A, Friedberg JW, Abel GA, Niland J, Rodriguez MA, Czuczman MS, Millenson M, Crosby A, Gordon LI, Zelenetz AD, Kaminski M, Lacasce AS. Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Leuk Lymphoma. 2013 Oct;54(10):2155-62. doi: 10.3109/10428194.2013.770151. Epub 2013 Feb 25.
28. Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cell transplantation (AutoSCT) in first remission of follicular lymphoma (FL) “save“ patients (pts) with poor prognosis. results of the first Russian prospective study. Blood. 2015;126(23):5079.
29. Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Front-line high dose therapy with following autologous stem cell transplantation (ASCT) for follicular lymphoma patients. Blood. 2014;124(21):5908.
30. [Nesterova ES, Kravchenko SK, Gemdzhian EG, et al. The results of ten years’ experience treating patients with follicular lymphoma. Gematologiya i Transfuziologiya = Hematology and Transfusiology. 2012;57(5):3-8 (In Russ.)].
2. Anastasia A, Rossi G. Novel Drugs in Follicular Lymphoma. Mediterr J Hematol Infect Dis. 2016;8(1):e2016061. doi: 10.4084/MJHID.2016.061
3. Cheah CY, Fowler NH. Novel agents for relapsed and refractory follicular lymphoma. Best Pract Res Clin Haematol. 2018;31(1):41-8. doi: 10.1016/j.beha.2017.11.003
4. Dreyling M, Ghielmini M, Rule S, Salles G, Vitolo U, Ladetto M; ESMO Guidelines Committee. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl 5):v83-90. doi: 10.1093/annonc/mdx020
5. Поддубная И.В., Савченко В.Г., редакторы. Российские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний. М., 2018 [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii [Russian clinical guidelines for the diagnosis and treatment of lymphoproliferative diseases]. Moscow, 2018 (In Russ.)].
6. NCCN 2018-2019 oncology case manager and medical director program: diagnosis and management of hematologic malignancies. Version 2.2018. 2018 Jan 19.
7. Mondello P, Steiner N, Willenbacher W, Wasle I, Zaja F, Zambello R, et al. Bendamustine plus rituximab versus R-CHOP as first-line treatment for patients with indolent non-Hodgkin’s lymphoma: evidence from a multicenter, retrospective study. Ann Hematol. 2016;95(7):1107-14. doi: 10.1007/s00277-016-2668-0. Epub 2016 Apr 22.
8. Luminari S, Goldaniga M, Cesaretti M, Orsucci L, Tucci A, Pulsoni A, et al. A phase II study of bendamustine in combination with rituximab as initial treatment for patients with indolent non-follicular non-Hodgkin lymphoma. Leuk Lymphoma. 2016;57(4):880-7. doi: 10.3109/10428194.2015.1091934. Epub 2016 Feb 8.
9. Mondello P, Steiner N, Willenbacher W, Cerchione C, Nappi D, Mauro E, Ferrero S, Cuzzocrea S, Mian M. Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study. Oncologist. 2018 Apr;23(4):454-60. doi: 10.1634/theoncologist.2017-0037. Epub 2018 Jan 9.
10. Rummel MJ, Niederle N, Maschmeyer G, Banat GA, von Grünhagen U, Losem C, Kofahl-Krause D, Heil G, Welslau M, Balser C, Kaiser U, Weidmann E, Dürk H, Ballo H, Stauch M, Roller F, Barth J, Hoelzer D, Hinke A, Brugger W; Study group indolent Lymphomas (StiL). Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013 Apr 6;381(9873):1203-10. doi: 10.1016/S0140-6736(12)61763-2. Epub 2013 Feb 20.
11. Morschhauser F, Seymour J, Feugier P, Offner F, Lopez-Guillermo A, Bouabdallah R, Pedersen L, et al. Impact of induction chemotherapy regimen on response, safety and outcome in the PRIMA study. Ann Oncol. 2011;22:89-9. Presented at the 11th International conference on Malignant Lymphoma. doi: 10.1007/978-1-62703-408-19
12. Yamaguchi T, Morita T, Takahashi Y, Tsuda K, Mori J. Treatment for patients with indolent and mantle cell lymphoma. Lancet. 2013 Sep 28;382(9898):1094-5. doi: 10.1016/S0140-6736(13)62018-8
13. Morrison VA, Shou Y, Bell JA, Hamilton L, Ogbonnaya A, Raju A, Hennenfent K, Eaddy M, Galaznik A. Treatment Patterns and Survival Outcomes in Patients With Follicular Lymphoma: A 2007 to 2015 Humedica Database Study. Clin Lymphoma Myeloma Leuk. 2019 Jan 2. pii: S2152-2650(18)31126-1. doi: 10.1016/j.clml.2018.12.017
14. Нестерова Е.С., Кравченко С.К., Ковригина А.М. и др. Фолликулярная лимфома: результаты многоцентрового исследования терапии первой линии препаратами бендамустин и ритуксимаб; факторы риска неблагоприятных событий (протокол FL-RUS-2013). Онкогематология. 2018;13(3):10-24 [Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Follicular lymphoma: results of multicenter study of first-line therapy with bendamustine and rituximab; risk factors for adverse events (FL-RUS-2013 protocol). Onkogematolog iya = Oncohematology. 2018;13(3):10-24 (In Russ.)]. doi: 10.17650/1818-8346-2018-13-3-10-24
15. Нестерова Е.С., Кравченко С.К., Барях Е.А. и др. Tрансплантация аутологичных стволовых клеток крови в первой ремиссии фолликулярной лимфомы как «терапия спасения» пациентов с факторами неблагоприятного прогноза. Результаты первого проспективного исследования. Современная онкология. 2016;18(5):31-2 [Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cells transplantation in the first remission of follicular lymphoma as “rescue therapy” in patients with unfavorable prognosis factors. The first prospective study results. Sovremennaya Onkolog iya = Modern Oncology. 2016;18(5):31-2 (In Russ.)].
16. Нестерова Е.С., Кравченко С.К., Мангасарова Я.К. и др. Фолликулярная лимфома. Высокодозная иммунохимиотерапия с трансплантацией аутологичных стволовых клеток крови: результаты первого проспективного исследования в России. Терапевтический архив. 2016;88(7):62-71 [Nesterova ES, Kravchenko SK, Mangasarova YaK, et al. Follicular lymphoma. High-dose immunochemotherapy with autologous blood stem cell transplantation: Results of the first prospective study in Russia. Therapeutic Archive. 2016; 88(7):62-71 (In Russ.)]. doi: 10.17116/terarkh201688762-71
17. Wahlin BE, Yri OE, Kimby E, et al. Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. Br J Haematol. 2012;156 (2):225-33. doi: 10.1111/j.1365-2141.2011.08942.x. Epub 2011 Nov 30.
18. Senaras C, Pennell M, Chen W, Shana'ah A, Louissaint A, Hasserjian RP, Lozanski G, Gurcan MN. FOXP3-stained image analysis for follicular lymphoma: Optimal adaptive thresholding with maximal nucleus coverage. Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10140. doi: 10.1117/12.2255671. Epub 2017 Mar 1.
19. Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, Hohaus S, Duchez S, Quillet-Mary A, Laurent G, Brousset P, Valitutti S. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood. 2011 Nov 17;118(20):5371-9. doi: 10.1182/blood-2011-04-345777. Epub 2011 Aug 19.
20. Tarella C, Zanni M, Magni M, Benedetti F, Patti C, Barbui T, Pileri A, Boccadoro M, Ciceri F, Gallamini A, Cortelazzo S, Majolino I, Mirto S, Corradini P, Passera R, Pizzolo G, Gianni AM, Rambaldi A. Rituximab improves the efficacy of high-dose chemotherapy with autograft for high-risk follicular and diffuse large B-cell lymphoma: a multicenter Gruppo Italiano Terapie Innnovative nei linfomi survey. J Clin Oncol. 2008;26:3166-75. doi: 10.1200/JCO.2007.14.4204
21. Buske C, Dreyling M. Malignant B-Cell Lymphoma: Advances in the Therapy of Follicular Lymphoma and Mantle-cell Lymphoma. Dtsch Med Wochenschr. 2018 Jan;143(1):46-51. doi: 10.1055/s-0043-124004. Epub 2018 Jan 9.
22. Montoto S, Corradini P, Dreyling M, et al. Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma:a consensus project of the EBMT Lymphoma Working Party. Haematologica. 2013 Jul;98(7):1014-21.
23. Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J Clin Oncol. 2014;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800
24. Weiler-Sagie M, Buschelev O, Epelbaum R, et al. 18F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 2010;51:25-30. doi: 10.2967/jnumed.109.067892
25. Tsukamoto N, Kojima N, Hasegawa M, et al. The usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) and a comparison with 67Gallium scintigraphy in the evaluation of lymphoma. Cancer. 2007;110(3):652-9. doi: 10.1002/cncr.22807 PMid: 17582800
26. Delfau-Larue MH, van der Gucht A, Dupuis J, Jais JP, Nel I, Beldi-Ferchiou A, Hamdane S, Benmaad I, Laboure G, Verret B, Haioun C, Copie-Bergman C, Berriolo-Riedinger A, Robert P, Casasnovas RO, Itti E. Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. Blood Adv. 2018 Apr 10;2(7):807-16. doi: 10.1182/bloodadvances.2017015164
27. Abou-Nassar KE, Vanderplas A, Friedberg JW, Abel GA, Niland J, Rodriguez MA, Czuczman MS, Millenson M, Crosby A, Gordon LI, Zelenetz AD, Kaminski M, Lacasce AS. Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Leuk Lymphoma. 2013 Oct;54(10):2155-62. doi: 10.3109/10428194.2013.770151. Epub 2013 Feb 25.
28. Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cell transplantation (AutoSCT) in first remission of follicular lymphoma (FL) “save“ patients (pts) with poor prognosis. results of the first Russian prospective study. Blood. 2015;126(23):5079.
29. Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Front-line high dose therapy with following autologous stem cell transplantation (ASCT) for follicular lymphoma patients. Blood. 2014;124(21):5908.
30. Нестерова Е.С., Кравченко С.К., Гемджян Э.Г. и др. Итоги десятилетнего опыта лечения больных фолликулярной лимфомой. Гематология и трансфузиология. 2012;57(5):3-8 [Nesterova ES, Kravchenko SK, Gemdzhian EG, et al. The results of ten years’ experience treating patients with follicular lymphoma. Gematologiya i Transfuziologiya = Hematology and Transfusiology. 2012;57(5):3-8 (In Russ.)].
________________________________________________
2. Anastasia A, Rossi G. Novel Drugs in Follicular Lymphoma. Mediterr J Hematol Infect Dis. 2016;8(1):e2016061. doi: 10.4084/MJHID.2016.061
3. Cheah CY, Fowler NH. Novel agents for relapsed and refractory follicular lymphoma. Best Pract Res Clin Haematol. 2018;31(1):41-8. doi: 10.1016/j.beha.2017.11.003
4. Dreyling M, Ghielmini M, Rule S, Salles G, Vitolo U, Ladetto M; ESMO Guidelines Committee. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016;27(Suppl 5):v83-90. doi: 10.1093/annonc/mdx020
5. [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii [Russian clinical guidelines for the diagnosis and treatment of lymphoproliferative diseases]. Moscow, 2018 (In Russ.)].
6. NCCN 2018-2019 oncology case manager and medical director program: diagnosis and management of hematologic malignancies. Version 2.2018. 2018 Jan 19.
7. Mondello P, Steiner N, Willenbacher W, Wasle I, Zaja F, Zambello R, et al. Bendamustine plus rituximab versus R-CHOP as first-line treatment for patients with indolent non-Hodgkin’s lymphoma: evidence from a multicenter, retrospective study. Ann Hematol. 2016;95(7):1107-14. doi: 10.1007/s00277-016-2668-0. Epub 2016 Apr 22.
8. Luminari S, Goldaniga M, Cesaretti M, Orsucci L, Tucci A, Pulsoni A, et al. A phase II study of bendamustine in combination with rituximab as initial treatment for patients with indolent non-follicular non-Hodgkin lymphoma. Leuk Lymphoma. 2016;57(4):880-7. doi: 10.3109/10428194.2015.1091934. Epub 2016 Feb 8.
9. Mondello P, Steiner N, Willenbacher W, Cerchione C, Nappi D, Mauro E, Ferrero S, Cuzzocrea S, Mian M. Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study. Oncologist. 2018 Apr;23(4):454-60. doi: 10.1634/theoncologist.2017-0037. Epub 2018 Jan 9.
10. Rummel MJ, Niederle N, Maschmeyer G, Banat GA, von Grünhagen U, Losem C, Kofahl-Krause D, Heil G, Welslau M, Balser C, Kaiser U, Weidmann E, Dürk H, Ballo H, Stauch M, Roller F, Barth J, Hoelzer D, Hinke A, Brugger W; Study group indolent Lymphomas (StiL). Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013 Apr 6;381(9873):1203-10. doi: 10.1016/S0140-6736(12)61763-2. Epub 2013 Feb 20.
11. Morschhauser F, Seymour J, Feugier P, Offner F, Lopez-Guillermo A, Bouabdallah R, Pedersen L, et al. Impact of induction chemotherapy regimen on response, safety and outcome in the PRIMA study. Ann Oncol. 2011;22:89-9. Presented at the 11th International conference on Malignant Lymphoma. doi: 10.1007/978-1-62703-408-19
12. Yamaguchi T, Morita T, Takahashi Y, Tsuda K, Mori J. Treatment for patients with indolent and mantle cell lymphoma. Lancet. 2013 Sep 28;382(9898):1094-5. doi: 10.1016/S0140-6736(13)62018-8
13. Morrison VA, Shou Y, Bell JA, Hamilton L, Ogbonnaya A, Raju A, Hennenfent K, Eaddy M, Galaznik A. Treatment Patterns and Survival Outcomes in Patients With Follicular Lymphoma: A 2007 to 2015 Humedica Database Study. Clin Lymphoma Myeloma Leuk. 2019 Jan 2. pii: S2152-2650(18)31126-1. doi: 10.1016/j.clml.2018.12.017
14. [Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Follicular lymphoma: results of multicenter study of first-line therapy with bendamustine and rituximab; risk factors for adverse events (FL-RUS-2013 protocol). Onkogematolog iya = Oncohematology. 2018;13(3):10-24 (In Russ.)]. doi: 10.17650/1818-8346-2018-13-3-10-24
15. [Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cells transplantation in the first remission of follicular lymphoma as “rescue therapy” in patients with unfavorable prognosis factors. The first prospective study results. Sovremennaya Onkolog iya = Modern Oncology. 2016;18(5):31-2 (In Russ.)].
16. [Nesterova ES, Kravchenko SK, Mangasarova YaK, et al. Follicular lymphoma. High-dose immunochemotherapy with autologous blood stem cell transplantation: Results of the first prospective study in Russia. Therapeutic Archive. 2016; 88(7):62-71 (In Russ.)]. doi: 10.17116/terarkh201688762-71
17. Wahlin BE, Yri OE, Kimby E, et al. Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. Br J Haematol. 2012;156 (2):225-33. doi: 10.1111/j.1365-2141.2011.08942.x. Epub 2011 Nov 30.
18. Senaras C, Pennell M, Chen W, Shana'ah A, Louissaint A, Hasserjian RP, Lozanski G, Gurcan MN. FOXP3-stained image analysis for follicular lymphoma: Optimal adaptive thresholding with maximal nucleus coverage. Proc SPIE Int Soc Opt Eng. 2017 Feb 11;10140. doi: 10.1117/12.2255671. Epub 2017 Mar 1.
19. Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, Hohaus S, Duchez S, Quillet-Mary A, Laurent G, Brousset P, Valitutti S. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood. 2011 Nov 17;118(20):5371-9. doi: 10.1182/blood-2011-04-345777. Epub 2011 Aug 19.
20. Tarella C, Zanni M, Magni M, Benedetti F, Patti C, Barbui T, Pileri A, Boccadoro M, Ciceri F, Gallamini A, Cortelazzo S, Majolino I, Mirto S, Corradini P, Passera R, Pizzolo G, Gianni AM, Rambaldi A. Rituximab improves the efficacy of high-dose chemotherapy with autograft for high-risk follicular and diffuse large B-cell lymphoma: a multicenter Gruppo Italiano Terapie Innnovative nei linfomi survey. J Clin Oncol. 2008;26:3166-75. doi: 10.1200/JCO.2007.14.4204
21. Buske C, Dreyling M. Malignant B-Cell Lymphoma: Advances in the Therapy of Follicular Lymphoma and Mantle-cell Lymphoma. Dtsch Med Wochenschr. 2018 Jan;143(1):46-51. doi: 10.1055/s-0043-124004. Epub 2018 Jan 9.
22. Montoto S, Corradini P, Dreyling M, et al. Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma:a consensus project of the EBMT Lymphoma Working Party. Haematologica. 2013 Jul;98(7):1014-21.
23. Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J Clin Oncol. 2014;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800
24. Weiler-Sagie M, Buschelev O, Epelbaum R, et al. 18F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 2010;51:25-30. doi: 10.2967/jnumed.109.067892
25. Tsukamoto N, Kojima N, Hasegawa M, et al. The usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) and a comparison with 67Gallium scintigraphy in the evaluation of lymphoma. Cancer. 2007;110(3):652-9. doi: 10.1002/cncr.22807 PMid: 17582800
26. Delfau-Larue MH, van der Gucht A, Dupuis J, Jais JP, Nel I, Beldi-Ferchiou A, Hamdane S, Benmaad I, Laboure G, Verret B, Haioun C, Copie-Bergman C, Berriolo-Riedinger A, Robert P, Casasnovas RO, Itti E. Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. Blood Adv. 2018 Apr 10;2(7):807-16. doi: 10.1182/bloodadvances.2017015164
27. Abou-Nassar KE, Vanderplas A, Friedberg JW, Abel GA, Niland J, Rodriguez MA, Czuczman MS, Millenson M, Crosby A, Gordon LI, Zelenetz AD, Kaminski M, Lacasce AS. Patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography for initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network Non-Hodgkin Lymphoma Outcomes database. Leuk Lymphoma. 2013 Oct;54(10):2155-62. doi: 10.3109/10428194.2013.770151. Epub 2013 Feb 25.
28. Nesterova ES, Kravchenko SK, Baryakh EA, et al. Autologous stem cell transplantation (AutoSCT) in first remission of follicular lymphoma (FL) “save“ patients (pts) with poor prognosis. results of the first Russian prospective study. Blood. 2015;126(23):5079.
29. Nesterova ES, Kravchenko SK, Kovrigina AM, et al. Front-line high dose therapy with following autologous stem cell transplantation (ASCT) for follicular lymphoma patients. Blood. 2014;124(21):5908.
30. [Nesterova ES, Kravchenko SK, Gemdzhian EG, et al. The results of ten years’ experience treating patients with follicular lymphoma. Gematologiya i Transfuziologiya = Hematology and Transfusiology. 2012;57(5):3-8 (In Russ.)].
Авторы
Е.С. Нестерова, С.К. Кравченко, А.М. Ковригина, Э.Г. Гемджян, Л.В. Пластинина, Ф.Э. Бабаева, Т.Н. Обухова, А.У. Магомедова, Т.В. Гапонова, А.М. Кременецкая, А.И. Воробьев
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России, Москва, Россия
National Research Center for Hematology, Moscow, Russia
ФГБУ «Национальный медицинский исследовательский центр гематологии» Минздрава России, Москва, Россия
________________________________________________
National Research Center for Hematology, Moscow, Russia
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.