Сравнительная клинико-экономическая оценка применения фармакогенетического тестирования для персонализации дозирования дабигатрана у пациентов с фибрилляцией предсердий
Сравнительная клинико-экономическая оценка применения фармакогенетического тестирования для персонализации дозирования дабигатрана у пациентов с фибрилляцией предсердий
Абдуллаев Ш.П., Мирзаев К.Б., Сычев Д.А. Сравнительная клинико-экономическая оценка применения фармакогенетического тестирования для персонализации дозирования дабигатрана у пациентов с фибрилляцией предсердий. Терапевтический архив. 2019; 91 (8): 22–27. DOI: 10.26442/00403660.2019.08.000379
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Аннотация
Цель исследования. Оценить клинико-экономическую целесообразность применения фармакогенетического тестирования (ФГТ) при назначении дабигатарана этексилата при терапии неклапанной фибрилляции предсердий (нФП) в сравнении с тактикой без ФГТ.
Материалы и методы. Фармакоэкономическая модель построена на основании обобщенных данных опубликованных клинических, эпидемиологических и клинико-экономических исследований.
Результаты и обсуждение. Применение ФГТ по носительству аллельного варианта rs2244613 гена CES1 для корректировки дозировки назначаемого дабигатрана этексилата у пациентов с нФП может являться более экономически выгодной стратегией профилактики тромбоэмболических осложнений у пациентов с нФП. Так, за счет снижения числа нежелательных лекарственных реакций в виде малых и больших кровотечений разница в затратах на лечение в группе с ФГТ по сравнению с группой со стандартной тактикой фармакотерапии на 100 пациентов составила 11 827,65 руб. Ожидаемые затраты на одного пациента в год при стандартном лечении составили 36 051,35 руб., тогда как в группе с ФГТ они равнялись 35 933,07 руб. Разница составила 1182,76 руб. в пользу фармакогенетического подхода
Заключение. Подход с использованием ФГТ для корректировки дозировки дабигатрана может позволить снизить стоимость фармакотерапии за счет снижения риска побочных реакций в виде малых и больших кровотечений.
Ключевые слова: дабигатран, фармакоэкономика, фармакогенетическое тестирование, CES1.
Materials and methods. The pharmacoeconomic model was done using generalized data from published clinical, epidemiological and clinical-economic studies.
Results and discussion. Application of PGT on the carrier of allelic variant rs2244613 of CES1 gene for adjustment of dabigatrane etexilate dosage in patients with non-valve AF may be more cost-effective strategy for prevention of thromboembolic complications in patients with non-valve AF. Thus, due to the decrease in the number of undesirable drug reactions in the form of minor and major bleedings, the difference in treatment costs in the group with PGT compared to the group with standard pharmacotherapy tactics per 100 patients was 11 827.65 rubles. The expected cost per patient per year for standard treatment was 36 051.35 rubles, while in the group with PGT it was 35 933.07 rubles. The difference was 1182.76 rubles in favor of the pharmacogenetic approach
Conclusion. A PGT approach to correct dabigatrane dosage can reduce the cost of pharmacotherapy by reducing the risk of adverse reactions of minor and major bleeding.
Keywords: dabigatran, pharmacoeconomics, pharmacogenetic testing, CES1.
Материалы и методы. Фармакоэкономическая модель построена на основании обобщенных данных опубликованных клинических, эпидемиологических и клинико-экономических исследований.
Результаты и обсуждение. Применение ФГТ по носительству аллельного варианта rs2244613 гена CES1 для корректировки дозировки назначаемого дабигатрана этексилата у пациентов с нФП может являться более экономически выгодной стратегией профилактики тромбоэмболических осложнений у пациентов с нФП. Так, за счет снижения числа нежелательных лекарственных реакций в виде малых и больших кровотечений разница в затратах на лечение в группе с ФГТ по сравнению с группой со стандартной тактикой фармакотерапии на 100 пациентов составила 11 827,65 руб. Ожидаемые затраты на одного пациента в год при стандартном лечении составили 36 051,35 руб., тогда как в группе с ФГТ они равнялись 35 933,07 руб. Разница составила 1182,76 руб. в пользу фармакогенетического подхода
Заключение. Подход с использованием ФГТ для корректировки дозировки дабигатрана может позволить снизить стоимость фармакотерапии за счет снижения риска побочных реакций в виде малых и больших кровотечений.
Ключевые слова: дабигатран, фармакоэкономика, фармакогенетическое тестирование, CES1.
________________________________________________
Materials and methods. The pharmacoeconomic model was done using generalized data from published clinical, epidemiological and clinical-economic studies.
Results and discussion. Application of PGT on the carrier of allelic variant rs2244613 of CES1 gene for adjustment of dabigatrane etexilate dosage in patients with non-valve AF may be more cost-effective strategy for prevention of thromboembolic complications in patients with non-valve AF. Thus, due to the decrease in the number of undesirable drug reactions in the form of minor and major bleedings, the difference in treatment costs in the group with PGT compared to the group with standard pharmacotherapy tactics per 100 patients was 11 827.65 rubles. The expected cost per patient per year for standard treatment was 36 051.35 rubles, while in the group with PGT it was 35 933.07 rubles. The difference was 1182.76 rubles in favor of the pharmacogenetic approach
Conclusion. A PGT approach to correct dabigatrane dosage can reduce the cost of pharmacotherapy by reducing the risk of adverse reactions of minor and major bleeding.
Keywords: dabigatran, pharmacoeconomics, pharmacogenetic testing, CES1.
Список литературы
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3. Kim MH, Johnston SS, Chu BC, et al. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States. Circulation: Cardiovasc Qual Outcom. 2011;4:313-20. doi: 10.1161/CIRCOUTCOMES.110.958165
4. Patel NJ, Deshmukh A, Pant S, Singh V, Patel N, Arora S, Shah N, Chothani A, Savani GT, Mehta K, Parikh V, Rathod A, Badheka AO, Lafferty J, Kowalski M, Mehta JL, Mitrani RD, Viles-Gonzalez JF, Paydak H. Contemporary trends of hospitalization for atrial fibrillation in the United States, 2000 through 2010: implications for healthcare planning. Circulation. 2014;129(23):2371-9. doi: 10.1161/CIRCULATIONAHA.114.008201
5. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51. doi: 10.1056/NEJMoa0905561
6. Shi J, Wang X, Nguyen JH, Bleske BE, Liang Y, Liu L, et al. Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender. Biochem Pharmacol. 2016;119:76-84. doi: 10.1016/j.bcp.2016.09.003
7. Paré G, Eriksson N, Lehr T, Connolly S, Eikelboom J, Ezekowitz MD, Axelsson T, Haertter S, Oldgren J, Reilly P, Siegbahn A, Syvanen AC, Wadelius C, Wadelius M, Zimdahl-Gelling H, Yusuf S, Wallentin L. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation. 2013;127:1404-12. doi: 10.1161/CIRCULATIONAHA.112.001233
8. Dimatteo C, D'Andrea G, Vecchione G, Paoletti O, Cappucci F, Tiscia GL, Buono M, Grandone E, Testa S, Margaglione M. Pharmacogenetics of dabigatran etexilate interindividual variability. Thromb Res. 2016;144:1-5. doi: 10.1016/j.thromres.2016.05.025
9. Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharm Ther. 2017;102(3):397-404. doi: 10.1002/cpt.668
10. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin Pharm Ther. 2014;96(4):423-8. doi: 10.1038/clpt.2014.125
11. Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, Roden DM, Klein TE, Sabatine MS, Johnson JA, Shuldiner AR; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther. 2013;94(3):317-23. doi: 10.1038/clpt.2013.105
12. You JH. Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genom. 2014;24(1):6-14. doi: 10.1097/FPC.0000000000000014
13. Eckman MH, Rosand J, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation. Ann Intern Med. 2009;150(2):73-83. doi: 10.7326/0003-4819-150-2-200901200-00005
14. Fragoulakis V, Bartsakoulia M, Díaz-Villamarín X, Chalikiopoulou K, Kehagia K, Ramos JGS, Martínez-González LJ, Gkotsi M, Katrali E, Skoufas E, Vozikis A, John A, Ali BR, Wordsworth S, Dávila-Fajardo CL, Katsila T, Patrinos GP, Mitropoulou C. Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention. Pharmacogenomi J. 2019. [Epub ahead of print]. doi: 10.1038/s41397-019-0069-1
15. Verbelen M, Weale ME, Lewis CM. Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? Pharmacogenom J. 2017;17(5):395-402. doi: 10.1038/tpj.2017.21
16. Sychev DA, Abdullaev SP, Mirzaev KB, Ryzhikova KA, Shuyev GN, Sozaeva ZA, Grishina EA, Mammaev SN, Gafurov DM, Kitaeva EY, Shprakh VV, Suleymanov SS, Bolieva LZ, Sozaeva MS, Zhuchkova SM, Gimaldinova NE, Sidukova EE, Asoskova AV, Mumladze RB. Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis. Mol Biol Rep. 2019 [Epub ahead of print]. doi: 10.1007/s11033-019-04722-w
17. Hernandez I, Baik SH, Piñera A, Zhang Y. Risk of Bleeding With Dabigatran in Atrial Fibrillation. JAMA Intern Med. 2015;175(1):18-24. doi: 10.1001/jamainternmed.2014.5398
18. Инструкция по медицинскому применению Прадакса®. https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=bb76178c-cf95-4cbd-9883-6ba08ccb508d&t (Ссылка активна на 23.04.2019).
19. Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J, Yang S, Alings M, Kaatz S, Hohnloser SH, Diener HC, Franzosi MG, Huber K, Reilly P, Varrone J, Yusuf S. Risk of bleeding with 2 doses of dabigatran сompared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation. 2011;123(21):2363-72. doi: 10.1161/CIRCULATIONAHA.110.004747
20. https://www.medlux.ru/ (Ссылка активна на 15.04.2019).
21. https://apteka.ru/ (Ссылка активна на 15.04.2019).
22. Тарифное соглашение на оплату медицинской помощи, оказываемой по территориальной программе обязательного медицинского страхования города Москвы на 2019 год от 27 декабря 2018 года. http://www.mgfoms.ru/medicinskie-organizacii/tarifi (Ссылка активна на 22.04.2019).
23. Ягудина Р.И., Куликов А.Ю., Метелкин И.А. Методология анализа «затраты-эффективность» при проведении фармакоэкономических исследований. Фармакоэкономика. 2012;4(5):3-8 [Yagudina RI, Kulikov AYu, Metelkin IA. “Cost-benefit” analysis methodology for pharmacoeconomic research. Farmakoekonomika. 2012;4(5):3-8 (In Russ.)].
2. Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, Poe C, Hart M. The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. J Am Coll Cardiol. 2012;60(25 Suppl):S1-49. doi: 10.1016/j.jacc.2012.11.002
3. Kim MH, Johnston SS, Chu BC, et al. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States. Circulation: Cardiovasc Qual Outcom. 2011;4:313-20. doi: 10.1161/CIRCOUTCOMES.110.958165
4. Patel NJ, Deshmukh A, Pant S, Singh V, Patel N, Arora S, Shah N, Chothani A, Savani GT, Mehta K, Parikh V, Rathod A, Badheka AO, Lafferty J, Kowalski M, Mehta JL, Mitrani RD, Viles-Gonzalez JF, Paydak H. Contemporary trends of hospitalization for atrial fibrillation in the United States, 2000 through 2010: implications for healthcare planning. Circulation. 2014;129(23):2371-9. doi: 10.1161/CIRCULATIONAHA.114.008201
5. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51. doi: 10.1056/NEJMoa0905561
6. Shi J, Wang X, Nguyen JH, Bleske BE, Liang Y, Liu L, et al. Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender. Biochem Pharmacol. 2016;119:76-84. doi: 10.1016/j.bcp.2016.09.003
7. Paré G, Eriksson N, Lehr T, Connolly S, Eikelboom J, Ezekowitz MD, Axelsson T, Haertter S, Oldgren J, Reilly P, Siegbahn A, Syvanen AC, Wadelius C, Wadelius M, Zimdahl-Gelling H, Yusuf S, Wallentin L. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation. 2013;127:1404-12. doi: 10.1161/CIRCULATIONAHA.112.001233
8. Dimatteo C, D'Andrea G, Vecchione G, Paoletti O, Cappucci F, Tiscia GL, Buono M, Grandone E, Testa S, Margaglione M. Pharmacogenetics of dabigatran etexilate interindividual variability. Thromb Res. 2016;144:1-5. doi: 10.1016/j.thromres.2016.05.025
9. Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharm Ther. 2017;102(3):397-404. doi: 10.1002/cpt.668
10. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin Pharm Ther. 2014;96(4):423-8. doi: 10.1038/clpt.2014.125
11. Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, Roden DM, Klein TE, Sabatine MS, Johnson JA, Shuldiner AR; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther. 2013;94(3):317-23. doi: 10.1038/clpt.2013.105
12. You JH. Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genom. 2014;24(1):6-14. doi: 10.1097/FPC.0000000000000014
13. Eckman MH, Rosand J, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation. Ann Intern Med. 2009;150(2):73-83. doi: 10.7326/0003-4819-150-2-200901200-00005
14. Fragoulakis V, Bartsakoulia M, Díaz-Villamarín X, Chalikiopoulou K, Kehagia K, Ramos JGS, Martínez-González LJ, Gkotsi M, Katrali E, Skoufas E, Vozikis A, John A, Ali BR, Wordsworth S, Dávila-Fajardo CL, Katsila T, Patrinos GP, Mitropoulou C. Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention. Pharmacogenomi J. 2019. [Epub ahead of print]. doi: 10.1038/s41397-019-0069-1
15. Verbelen M, Weale ME, Lewis CM. Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? Pharmacogenom J. 2017;17(5):395-402. doi: 10.1038/tpj.2017.21
16. Sychev DA, Abdullaev SP, Mirzaev KB, Ryzhikova KA, Shuyev GN, Sozaeva ZA, Grishina EA, Mammaev SN, Gafurov DM, Kitaeva EY, Shprakh VV, Suleymanov SS, Bolieva LZ, Sozaeva MS, Zhuchkova SM, Gimaldinova NE, Sidukova EE, Asoskova AV, Mumladze RB. Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis. Mol Biol Rep. 2019 [Epub ahead of print]. doi: 10.1007/s11033-019-04722-w
17. Hernandez I, Baik SH, Piñera A, Zhang Y. Risk of Bleeding With Dabigatran in Atrial Fibrillation. JAMA Intern Med. 2015;175(1):18-24. doi: 10.1001/jamainternmed.2014.5398
18. Инструкция по медицинскому применению Прадакса®. https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=bb76178c-cf95-4cbd-9883-6ba08ccb508d&t (Ссылка активна на 23.04.2019).
19. Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J, Yang S, Alings M, Kaatz S, Hohnloser SH, Diener HC, Franzosi MG, Huber K, Reilly P, Varrone J, Yusuf S. Risk of bleeding with 2 doses of dabigatran сompared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation. 2011;123(21):2363-72. doi: 10.1161/CIRCULATIONAHA.110.004747
20. https://www.medlux.ru/ (Ссылка активна на 15.04.2019).
21. https://apteka.ru/ (Ссылка активна на 15.04.2019).
22. Тарифное соглашение на оплату медицинской помощи, оказываемой по территориальной программе обязательного медицинского страхования города Москвы на 2019 год от 27 декабря 2018 года. http://www.mgfoms.ru/medicinskie-organizacii/tarifi (Ссылка активна на 22.04.2019).
23. [Yagudina RI, Kulikov AYu, Metelkin IA. “Cost-benefit” analysis methodology for pharmacoeconomic research. Farmakoekonomika. 2012;4(5):3-8 (In Russ.)].
2. Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, Poe C, Hart M. The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. J Am Coll Cardiol. 2012;60(25 Suppl):S1-49. doi: 10.1016/j.jacc.2012.11.002
3. Kim MH, Johnston SS, Chu BC, et al. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States. Circulation: Cardiovasc Qual Outcom. 2011;4:313-20. doi: 10.1161/CIRCOUTCOMES.110.958165
4. Patel NJ, Deshmukh A, Pant S, Singh V, Patel N, Arora S, Shah N, Chothani A, Savani GT, Mehta K, Parikh V, Rathod A, Badheka AO, Lafferty J, Kowalski M, Mehta JL, Mitrani RD, Viles-Gonzalez JF, Paydak H. Contemporary trends of hospitalization for atrial fibrillation in the United States, 2000 through 2010: implications for healthcare planning. Circulation. 2014;129(23):2371-9. doi: 10.1161/CIRCULATIONAHA.114.008201
5. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51. doi: 10.1056/NEJMoa0905561
6. Shi J, Wang X, Nguyen JH, Bleske BE, Liang Y, Liu L, et al. Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender. Biochem Pharmacol. 2016;119:76-84. doi: 10.1016/j.bcp.2016.09.003
7. Paré G, Eriksson N, Lehr T, Connolly S, Eikelboom J, Ezekowitz MD, Axelsson T, Haertter S, Oldgren J, Reilly P, Siegbahn A, Syvanen AC, Wadelius C, Wadelius M, Zimdahl-Gelling H, Yusuf S, Wallentin L. Genetic determinants of dabigatran plasma levels and their relation to bleeding. Circulation. 2013;127:1404-12. doi: 10.1161/CIRCULATIONAHA.112.001233
8. Dimatteo C, D'Andrea G, Vecchione G, Paoletti O, Cappucci F, Tiscia GL, Buono M, Grandone E, Testa S, Margaglione M. Pharmacogenetics of dabigatran etexilate interindividual variability. Thromb Res. 2016;144:1-5. doi: 10.1016/j.thromres.2016.05.025
9. Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. Clin Pharm Ther. 2017;102(3):397-404. doi: 10.1002/cpt.668
10. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin Pharm Ther. 2014;96(4):423-8. doi: 10.1038/clpt.2014.125
11. Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, Roden DM, Klein TE, Sabatine MS, Johnson JA, Shuldiner AR; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther. 2013;94(3):317-23. doi: 10.1038/clpt.2013.105
12. You JH. Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genom. 2014;24(1):6-14. doi: 10.1097/FPC.0000000000000014
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12. You JH. Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysis. Pharmacogenet Genom. 2014;24(1):6-14. doi: 10.1097/FPC.0000000000000014
13. Eckman MH, Rosand J, Greenberg SM, Gage BF. Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation. Ann Intern Med. 2009;150(2):73-83. doi: 10.7326/0003-4819-150-2-200901200-00005
14. Fragoulakis V, Bartsakoulia M, Díaz-Villamarín X, Chalikiopoulou K, Kehagia K, Ramos JGS, Martínez-González LJ, Gkotsi M, Katrali E, Skoufas E, Vozikis A, John A, Ali BR, Wordsworth S, Dávila-Fajardo CL, Katsila T, Patrinos GP, Mitropoulou C. Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention. Pharmacogenomi J. 2019. [Epub ahead of print]. doi: 10.1038/s41397-019-0069-1
15. Verbelen M, Weale ME, Lewis CM. Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? Pharmacogenom J. 2017;17(5):395-402. doi: 10.1038/tpj.2017.21
16. Sychev DA, Abdullaev SP, Mirzaev KB, Ryzhikova KA, Shuyev GN, Sozaeva ZA, Grishina EA, Mammaev SN, Gafurov DM, Kitaeva EY, Shprakh VV, Suleymanov SS, Bolieva LZ, Sozaeva MS, Zhuchkova SM, Gimaldinova NE, Sidukova EE, Asoskova AV, Mumladze RB. Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis. Mol Biol Rep. 2019 [Epub ahead of print]. doi: 10.1007/s11033-019-04722-w
17. Hernandez I, Baik SH, Piñera A, Zhang Y. Risk of Bleeding With Dabigatran in Atrial Fibrillation. JAMA Intern Med. 2015;175(1):18-24. doi: 10.1001/jamainternmed.2014.5398
18. Инструкция по медицинскому применению Прадакса®. https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=bb76178c-cf95-4cbd-9883-6ba08ccb508d&t (Ссылка активна на 23.04.2019).
19. Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J, Yang S, Alings M, Kaatz S, Hohnloser SH, Diener HC, Franzosi MG, Huber K, Reilly P, Varrone J, Yusuf S. Risk of bleeding with 2 doses of dabigatran сompared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation. 2011;123(21):2363-72. doi: 10.1161/CIRCULATIONAHA.110.004747
20. https://www.medlux.ru/ (Ссылка активна на 15.04.2019).
21. https://apteka.ru/ (Ссылка активна на 15.04.2019).
22. Тарифное соглашение на оплату медицинской помощи, оказываемой по территориальной программе обязательного медицинского страхования города Москвы на 2019 год от 27 декабря 2018 года. http://www.mgfoms.ru/medicinskie-organizacii/tarifi (Ссылка активна на 22.04.2019).
23. [Yagudina RI, Kulikov AYu, Metelkin IA. “Cost-benefit” analysis methodology for pharmacoeconomic research. Farmakoekonomika. 2012;4(5):3-8 (In Russ.)].
Авторы
Ш.П. Абдуллаев, К.Б. Мирзаев, Д.А. Сычев
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
Russian Medical Academy of Continuous Professional Education, Moscow, Russia
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
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Russian Medical Academy of Continuous Professional Education, Moscow, Russia
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.