Патофизиологическая роль адипокинов в развитии бронхиальной астмы у больных с ожирением
DOI: 10.26442/00403660.2021.03.200659
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Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodtseva TP. The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity. Terapevticheskii Arkhiv (Ter. Arkh.). 2021; 93 (3): 327–332. DOI: 10.26442/00403660.2021.03.200659
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Ключевые слова: бронхиальная астма, ожирение, адипокины
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The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.
Keywords: bronchial asthma, obesity, adipokines
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1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2014.
2. Peterson CM, Su H, Thomas DM, et al. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. JAMA Pediatr. 2017;171:629-36. doi: 10.1001/jamapediatrics.2017.0460
3. Kytikova OYu, Gvozdenko TA, Antonyuk MV. Modern aspects of prevalence of chronic bronchopulmonary diseases. . Bulletin of Respiratory Physiology and Pathology. 2017;64:94-100 (In Russ.) doi: 10.12737/article_5936346fdfc1f3.32482903
4. Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295-304. doi: 10.1111/all.12876
5. Kytikova OYu, Gvozdenko TA, Antonyuk MV. The role of systemic inflammation in bronchial asthma and obesity. Klin. med. 2018;96(9):784-90 (In Russ.)
6. Forno Е. Moving Beyond the Confines of Body Mass Index in the Quest to Understand Obese Asthma. Am J Respir Crit Care Med. 2020;201(3):271-2.
doi: 10.1164/rccm.201910-2031ED
7. Kang M, Sohn S-J, Shin M-H. Association between Body Mass Index and Prevalence of Asthma in Korean Adults. Chonnam Med J. 2020;56(1):62-7.
doi: 10.4068/cmj.2020.56.1.62
8. Huang F, Del-Río-Navarro BE, Torres-Alcántara S, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54(2):153-61. doi: 10.1080/02770903.2016.1200611
9. Sideleva O, Suratt B, Black K, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598-605. doi: 10.1164/rccm.201203-0573oc
10. Kytikova OYu. The relationship of the immune, lipoperoxide and antioxidant systems in chronic inflammation. International Journal of Experimental Education. 2014;8:64-5 (In Russ.)
11. Maniscalco M, Paris D, Melck DJ, et al. Coexistence of obesity and asthma determines a distinct respiratory metabolic phenotype. J Allergy Clin Immunol. 2017;139:1536-47.e5. doi: 10.1016/j.jaci.2016.08.038
12. Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodceva TP. Metabolic aspects of the relationship between obesity and bronchial asthma. Ozhirenie i metabolizm. 2018;15 (4):9-14 (In Russ.) doi: 10.14341/omet9578
13. De Lima Azambuja R, da Costa Santos Azambuja L, Costa S, et al. Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease? Lung. 2015;193(5):749-55. doi: 10.1007/s00408-015-9793-8
14. Kwak S, Kim YD, Na HG, et al. Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)30735-6. doi: 10.1016/j.bbrc.2018.03.206
15. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011;22:259-65. doi: 10.1016/j.tem.2011.03.005
16. Osborne LC, Joyce KL, Alenghat T, et al. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. J Immunol. 2013;190:2292-300. doi: 10.4049/jimmunol.1200706
17. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73. doi: 10.1074/jbc.m110.200022
18. Jiang S, Park DW, Tadie JM, et al. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014;192(10):4795-803. doi:10.4049/jimmunol.1302764
19. Pirvulescu M, Manduteanu I, Gan AM, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Communications. 2012;422:321-6. doi: 10.1016/j.bbrc.2012.04.159
20. Fang C, Meng Q, Wu H. Resistin-like molecule-β is a human airway remodelling mediator. Eur Respir J. 2012;39(2):458-66. doi: 10.1183/09031936.00107811
21. Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma. Clin Exp Allergy. 2016;46(8):1056-65. doi: 10.1111/cea.12742
22. Kim KW, Shin YH, Lee KE, et al. Relationship between adipokines and manifestations of childhood asthma. Ped Allergy Immunol. 2008;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x
23. Verbovoy AF, Kosareva OV, Akhmerova RI. Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(10):37-41 (In Russ.)
doi: 10.17116/terarkh2015871037-41
24. Blaner WS. Retinol-binding protein: The serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16. doi: 10.1210/edrv-10-3-308
25. Klisić A, Kavarić N, Bjelaković B, et al. The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls. Acta Clin Croat. 2017;56(1):92-8. doi: 10.20471/acc.2017.56.01.14
26. Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116:57-62. doi: 10.3109/13813451003631421
27. Lee S-A, Yuen JJ, Jiang H, et al. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016;64:1534-46. doi: 10.1002/hep.28659
28. Majerczyk M, Kocełak P, Choręza P, et al. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4(RBP4) in a cohort of people aged 65 years and older. J Endocrinol Invest. 2018. doi: 10.1007/s40618-018-0856-6
29. Comerford KB, Buchan W, Karakas SE. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 2014;46:224-31. doi: 10.1055/s-0033-1353204
30. Park YH, Kim KW, Lee KE, et al. Clinical implications of serum retinol-binding protein 4 in asthmatic children. J Korean Med Sci. 2009;24(6):1010-4. doi: 10.3346/jkms.2009.24.6.1010
31. Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013;50(8):828-35. doi: 10.3109/02770903.2013.816725
32. Palit SP, Patel R, Jadeja SD, et al. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci Rep. 2020;10(1):2904. doi: 10.1038/s41598-020-59845-z
33. Ishida M, Tatsumi K, Okumoto K, Kaji H. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells Dev. 2020. doi: 10.1089/scd.2019.0250
34. Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy. 2013; p. 1–15. doi: 10.1155/2013/785835
35. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Адипонектин в плазме крови при бронхиальной астме. Уральский научный вестник. 2014;34(113):34-41 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. Plasma adiponectin in asthma. 2014;34(113):34-41 (In Russ.)] doi: 10.24884/1607-4181-2014-21-3-34-40
36. Nigro E, Daniele A, Scudiero O, et al. Adiponectin in Asthma: Implications for Phenotyping. Curr Protein Pept Sci. 2015;16(3):182-7.
doi: 10.2174/1389203716666150120095342
37. Sutherland TJT, Sears MR, McLachlan CR, et al. Leptin, adiponectin, and asthma: findings from a population-based cohort study. Ann Allergy Asthma Immunol. 2009;103(2):101-7. doi: 10.1016/s1081-1206(10)60161-5
38. Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Ped Allergy Immunol. 2009;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x
39. Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and leptin. J Clin Lab Anal. 2019;33(6):e22915.
doi: 10.1002/jcla.22915
40. Kirillova OO, Vorozhko IV, Gapparova KM, et al. Adipokines and the metabolism of key nutrients in patients with obesity. Terapevticheskii Arkhiv (Ter. Arkh.). 2014;86(1):45-8 (In Russ.)
41. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18:363-74. doi: 10.1038/nm.2627
42. Muc M, Todo-Bom A, Mota-Pinto A, et al. Leptin and resistin in overweight patients with and without asthma. Allergol Immunopathol (Madr). 2014;42(5):415-21. doi: 10.1016/j.aller.2013.03.004
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Владивостокский филиал ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт медицинской климатологии и восстановительного лечения, Владивосток, Россия
*kytikova@yandex.ru
________________________________________________
Oksana Yu. Kytikova*, Marina V. Antonyuk, Tatiana A. Gvozdenko, Tatiana P. Novgorodtseva
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok, Russia
*kytikova@yandex.ru