Патофизиологическая роль адипокинов в развитии бронхиальной астмы у больных с ожирением
Патофизиологическая роль адипокинов в развитии бронхиальной астмы у больных с ожирением
Кытикова О.Ю., Антонюк М.В., Гвозденко Т.А., Новгородцева Т.П. Патофизиологическая роль адипокинов в развитии бронхиальной астмы у больных с ожирением. Терапевтический архив. 2021; 93 (3): 327–332.
DOI: 10.26442/00403660.2021.03.200659
DOI: 10.26442/00403660.2021.03.200659
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Аннотация
Сочетанное течение бронхиальной астмы (БА) и ожирения представляет собой одну из актуальных медико-социальных проблем, требующих всестороннего и пристального изучения в связи со снижением качества жизни таких больных, повышением частоты, длительности госпитализации и высоким экономическим бременем для государства в целом. Взаимосвязь БА и ожирения в настоящее время подтверждена многочисленными исследованиями, в то же время, несмотря на вариабельность предложенных механизмов патогенетического действия ожирения на течение БА, метаболические аспекты взаимосвязи данных заболеваний нуждаются в дальнейшем изучении. Гормоны жировой ткани ответственны за энергетический гомеостаз организма, поэтому избыточное накопление жировой ткани сопровождается развитием дисбаланса метаболических процессов в различных органах и тканях. В связи с появлением новых научных данных о роли и функции жировой ткани в организме метаболические эффекты адипокинов рассматриваются в фокусе их патофизиологической ассоциации с ожирением и БА. В данном обзоре освещены современные представления о роли метаболических эффектов наиболее изученных адипокинов (резистин, ретинолсвязывающий белок, лептин и адипонектин) в развитии ожирения и БА. Описаны гендерные и возрастзависимые особенности уровней адипокинов при БА и ожирении. Представлены данные о подтвержденной роли адипонектина и лептина в прогрессировании БА, сочетанной с ожирением. Показано, что роль резистина и ретинолсвязывающего белка в развитии БА, сочетанной с ожирением, не изучена. Продемонстрировано, что дальнейшее изучение метаболической активности адипокинов при БА является актуальным и перспективным направлением исследований, позволит разработать новые диагностические и терапевтические стратегии у больных БА с ожирением.
Ключевые слова: бронхиальная астма, ожирение, адипокины
Keywords: bronchial asthma, obesity, adipokines
Ключевые слова: бронхиальная астма, ожирение, адипокины
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Keywords: bronchial asthma, obesity, adipokines
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2. Peterson CM, Su H, Thomas DM, et al. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. JAMA Pediatr. 2017;171:629-36. doi: 10.1001/jamapediatrics.2017.0460
3. Kytikova OYu, Gvozdenko TA, Antonyuk MV. Modern aspects of prevalence of chronic bronchopulmonary diseases. . Bulletin of Respiratory Physiology and Pathology. 2017;64:94-100 (In Russ.) doi: 10.12737/article_5936346fdfc1f3.32482903
4. Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295-304. doi: 10.1111/all.12876
5. Kytikova OYu, Gvozdenko TA, Antonyuk MV. The role of systemic inflammation in bronchial asthma and obesity. Klin. med. 2018;96(9):784-90 (In Russ.)
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doi: 10.1164/rccm.201910-2031ED
7. Kang M, Sohn S-J, Shin M-H. Association between Body Mass Index and Prevalence of Asthma in Korean Adults. Chonnam Med J. 2020;56(1):62-7.
doi: 10.4068/cmj.2020.56.1.62
8. Huang F, Del-Río-Navarro BE, Torres-Alcántara S, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54(2):153-61. doi: 10.1080/02770903.2016.1200611
9. Sideleva O, Suratt B, Black K, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598-605. doi: 10.1164/rccm.201203-0573oc
10. Kytikova OYu. The relationship of the immune, lipoperoxide and antioxidant systems in chronic inflammation. International Journal of Experimental Education. 2014;8:64-5 (In Russ.)
11. Maniscalco M, Paris D, Melck DJ, et al. Coexistence of obesity and asthma determines a distinct respiratory metabolic phenotype. J Allergy Clin Immunol. 2017;139:1536-47.e5. doi: 10.1016/j.jaci.2016.08.038
12. Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodceva TP. Metabolic aspects of the relationship between obesity and bronchial asthma. Ozhirenie i metabolizm. 2018;15 (4):9-14 (In Russ.) doi: 10.14341/omet9578
13. De Lima Azambuja R, da Costa Santos Azambuja L, Costa S, et al. Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease? Lung. 2015;193(5):749-55. doi: 10.1007/s00408-015-9793-8
14. Kwak S, Kim YD, Na HG, et al. Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)30735-6. doi: 10.1016/j.bbrc.2018.03.206
15. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011;22:259-65. doi: 10.1016/j.tem.2011.03.005
16. Osborne LC, Joyce KL, Alenghat T, et al. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. J Immunol. 2013;190:2292-300. doi: 10.4049/jimmunol.1200706
17. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73. doi: 10.1074/jbc.m110.200022
18. Jiang S, Park DW, Tadie JM, et al. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014;192(10):4795-803. doi:10.4049/jimmunol.1302764
19. Pirvulescu M, Manduteanu I, Gan AM, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Communications. 2012;422:321-6. doi: 10.1016/j.bbrc.2012.04.159
20. Fang C, Meng Q, Wu H. Resistin-like molecule-β is a human airway remodelling mediator. Eur Respir J. 2012;39(2):458-66. doi: 10.1183/09031936.00107811
21. Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma. Clin Exp Allergy. 2016;46(8):1056-65. doi: 10.1111/cea.12742
22. Kim KW, Shin YH, Lee KE, et al. Relationship between adipokines and manifestations of childhood asthma. Ped Allergy Immunol. 2008;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x
23. Verbovoy AF, Kosareva OV, Akhmerova RI. Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(10):37-41 (In Russ.)
doi: 10.17116/terarkh2015871037-41
24. Blaner WS. Retinol-binding protein: The serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16. doi: 10.1210/edrv-10-3-308
25. Klisić A, Kavarić N, Bjelaković B, et al. The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls. Acta Clin Croat. 2017;56(1):92-8. doi: 10.20471/acc.2017.56.01.14
26. Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116:57-62. doi: 10.3109/13813451003631421
27. Lee S-A, Yuen JJ, Jiang H, et al. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016;64:1534-46. doi: 10.1002/hep.28659
28. Majerczyk M, Kocełak P, Choręza P, et al. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4(RBP4) in a cohort of people aged 65 years and older. J Endocrinol Invest. 2018. doi: 10.1007/s40618-018-0856-6
29. Comerford KB, Buchan W, Karakas SE. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 2014;46:224-31. doi: 10.1055/s-0033-1353204
30. Park YH, Kim KW, Lee KE, et al. Clinical implications of serum retinol-binding protein 4 in asthmatic children. J Korean Med Sci. 2009;24(6):1010-4. doi: 10.3346/jkms.2009.24.6.1010
31. Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013;50(8):828-35. doi: 10.3109/02770903.2013.816725
32. Palit SP, Patel R, Jadeja SD, et al. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci Rep. 2020;10(1):2904. doi: 10.1038/s41598-020-59845-z
33. Ishida M, Tatsumi K, Okumoto K, Kaji H. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells Dev. 2020. doi: 10.1089/scd.2019.0250
34. Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy. 2013; p. 1–15. doi: 10.1155/2013/785835
35. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Адипонектин в плазме крови при бронхиальной астме. Уральский научный вестник. 2014;34(113):34-41 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. Plasma adiponectin in asthma. 2014;34(113):34-41 (In Russ.)] doi: 10.24884/1607-4181-2014-21-3-34-40
36. Nigro E, Daniele A, Scudiero O, et al. Adiponectin in Asthma: Implications for Phenotyping. Curr Protein Pept Sci. 2015;16(3):182-7.
doi: 10.2174/1389203716666150120095342
37. Sutherland TJT, Sears MR, McLachlan CR, et al. Leptin, adiponectin, and asthma: findings from a population-based cohort study. Ann Allergy Asthma Immunol. 2009;103(2):101-7. doi: 10.1016/s1081-1206(10)60161-5
38. Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Ped Allergy Immunol. 2009;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x
39. Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and leptin. J Clin Lab Anal. 2019;33(6):e22915.
doi: 10.1002/jcla.22915
40. Kirillova OO, Vorozhko IV, Gapparova KM, et al. Adipokines and the metabolism of key nutrients in patients with obesity. Terapevticheskii Arkhiv (Ter. Arkh.). 2014;86(1):45-8 (In Russ.)
41. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18:363-74. doi: 10.1038/nm.2627
42. Muc M, Todo-Bom A, Mota-Pinto A, et al. Leptin and resistin in overweight patients with and without asthma. Allergol Immunopathol (Madr). 2014;42(5):415-21. doi: 10.1016/j.aller.2013.03.004
43. Souza-Almeida G, D’Avila H, Almeida PE, et al. Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. Front Immunol. 2018;9:111. doi: 10.3389/fimmu.2018. 00111
44. Tsaroucha A, Daniil Z, Malli F, et al. Leptin, adiponectin and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma. 2013;50(2):188-97. doi: 10.3109/02770903.2012.747101
45. Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. The role of adipokines in bronchial asthma. In the book: Proceedings of the IX All-Russian Scientific and Practical Conference "Health-the basis of human potential. Problems and ways to solve them". 2014; p. 532-3 (In Russ.)
46. Gurkan F, Atamer Y, Ece A, et al. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol. 2004;93(3):277-80. doi: 10.1016/s1081-1206(10)61501-3
47. Lessard A, St-Laurent J, Turcotte H, Boulet L-P. Leptin and adiponectin in obese and non-obese subjects with asthma. Biomarkers. 2011;16(3):271-3. doi: 10.3109/1354750x.2010.550013
48. Dixon AE, Johnson SE, Griffes LV. Relationship of adipokines with immune response and lung function in obese asthmatic and non-asthmatic women. J Asthma. 2011;48(8):811-7. doi: 10.3109/02770903.2011.613507
49. Chubrieva SJu, Gluhov NV, Zaĭchik AM. Adipose tissue as an endocrine regulator. Vestn. S.-Peterb. un-ta. 2008;11(1):1-43 (In Russ.)
50. Seoane-Collazo P, Martínez-Sánchez N, Milbank E, Contreras C. Incendiary Leptin. Nutrients. 2020;12(2). pii: E472. doi: 10.3390/nu12020472
51. Suratt BT, Ubags NDJ, Rastogi D, et al. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017;14:1050-9. doi: 10.1513/AnnalsATS.201703-263WS
52. Yu Q, Wang D, Wen X, et al. Adipose-derived Exosomes Protect the Pulmonary Endothelial Barrier in Ventilator-induced Lung Injury by Inhibiting the TRPV4/Ca2+ Signaling Pathway. Аm J Physiol Lung Cell Mol Physiol. 2020. doi: 10.1152/ajplung.00255.2019
2. Peterson CM, Su H, Thomas DM, et al. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. JAMA Pediatr. 2017;171:629-36. doi: 10.1001/jamapediatrics.2017.0460
3. Кытикова О.Ю., Гвозденко Т.А., Антонюк М.В. Современные аспекты распространенности хронических бронхолегочных заболеваний. Бюл. физиологии и патологии дыхания. 2017;64:94-100 [Kytikova OYu, Gvozdenko TA, Antonyuk MV. Modern aspects of prevalence of chronic bronchopulmonary diseases. . Bulletin of Respiratory Physiology and Pathology. 2017;64:94-100 (In Russ.)]. doi: 10.12737/article_5936346fdfc1f3.32482903
4. Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295-304. doi: 10.1111/all.12876
5. Кытикова О.Ю., Гвозденко Т.А., Антонюк М.В. Роль системного воспаления при бронхиальной астме и ожирении. Клин. мед. 2018;96(9):784-90 [Kytikova OYu, Gvozdenko TA, Antonyuk MV. The role of systemic inflammation in bronchial asthma and obesity. Klin. med. 2018;96(9):784-90 (In Russ.)].
6. Forno Е. Moving Beyond the Confines of Body Mass Index in the Quest to Understand Obese Asthma. Am J Respir Crit Care Med. 2020;201(3):271-2.
doi: 10.1164/rccm.201910-2031ED
7. Kang M, Sohn S-J, Shin M-H. Association between Body Mass Index and Prevalence of Asthma in Korean Adults. Chonnam Med J. 2020;56(1):62-7. doi: 10.4068/cmj.2020.56.1.62
8. Huang F, Del-Río-Navarro BE, Torres-Alcántara S, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54(2):153-61. doi: 10.1080/02770903.2016.1200611
9. Sideleva O, Suratt B, Black K, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598-605. doi: 10.1164/rccm.201203-0573oc
10. Кытикова О.Ю. Взаимоотношения иммунной, липопероксидной и антиоксидантной систем при хроническом воспалении. Международный журнал экспериментального образования. 2014;8:64-5 [Kytikova OYu. The relationship of the immune, lipoperoxide and antioxidant systems in chronic inflammation. International Journal of Experimental Education. 2014;8:64-5 (In Russ.)].
11. Maniscalco M, Paris D, Melck DJ, et al. Coexistence of obesity and asthma determines a distinct respiratory metabolic phenotype. J Allergy Clin Immunol. 2017;139:1536-47.e5. doi: 10.1016/j.jaci.2016.08.038
12. Кытикова О.Ю. Антонюк М.В., Гвозденко Т.А., Новгородцева Т.П. Метаболические аспекты взаимосвязи ожирения и бронхиальной астмы. Ожирение и метаболизм. 2018;15 (4):9-14 [Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodceva TP. Metabolic aspects of the relationship between obesity and bronchial asthma. Ozhirenie i metabolizm. 2018;15 (4):9-14 (In Russ.)]. doi: 10.14341/omet9578
13. De Lima Azambuja R, da Costa Santos Azambuja L, Costa S, et al. Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease? Lung. 2015;193(5):749-55. doi: 10.1007/s00408-015-9793-8
14. Kwak S, Kim YD, Na HG, et al. Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)30735-6. doi: 10.1016/j.bbrc.2018.03.206
15. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011;22:259-65. doi: 10.1016/j.tem.2011.03.005
16. Osborne LC, Joyce KL, Alenghat T, et al. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. J Immunol. 2013;190:2292-300. doi: 10.4049/jimmunol.1200706
17. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73. doi: 10.1074/jbc.m110.200022
18. Jiang S, Park DW, Tadie JM, et al. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014;192(10):4795-803.
doi: 10.4049/jimmunol.1302764
19. Pirvulescu M, Manduteanu I, Gan AM, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Communications. 2012;422:321-6. doi: 10.1016/j.bbrc.2012.04.159
20. Fang C, Meng Q, Wu H. Resistin-like molecule-β is a human airway remodelling mediator. Eur Respir J. 2012;39(2):458-66. doi: 10.1183/09031936.00107811
21. Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma. Clin Exp Allergy. 2016;46(8):1056-65. doi: 10.1111/cea.12742
22. Kim KW, Shin YH, Lee KE, et al. Relationship between adipokines and manifestations of childhood asthma. Ped Allergy Immunol. 2008;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x
23. Вербовой А.Ф., Косарева О.В., Ахмерова Р.И. Лептин, резистин и гормонально-метаболические показатели у женщин с сахарным диабетом 2-го типа и при его сочетании с бронхиальной астмой. Терапевтический архив. 2015;87(10):37-41 [Verbovoy AF, Kosareva OV, Akhmerova RI. Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(10):37-41 (In Russ.)].
doi: 10.17116/terarkh2015871037-41
24. Blaner WS. Retinol-binding protein: The serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16. doi: 10.1210/edrv-10-3-308
25. Klisić A, Kavarić N, Bjelaković B, et al. The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls. Acta Clin Croat. 2017;56(1):92-8. doi: 10.20471/acc.2017.56.01.14
26. Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116:57-62. doi: 10.3109/13813451003631421
27. Lee S-A, Yuen JJ, Jiang H, et al. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016;64:1534-46. doi: 10.1002/hep.28659
28. Majerczyk M, Kocełak P, Choręza P, et al. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4(RBP4) in a cohort of people aged 65 years and older. J Endocrinol Invest. 2018. doi: 10.1007/s40618-018-0856-6
29. Comerford KB, Buchan W, Karakas SE. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 2014;46:224-31.
doi: 10.1055/s-0033-1353204
30. Park YH, Kim KW, Lee KE, et al. Clinical implications of serum retinol-binding protein 4 in asthmatic children. J Korean Med Sci. 2009;24(6):1010-4. doi: 10.3346/jkms.2009.24.6.1010
31. Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013;50(8):828-35. doi: 10.3109/02770903.2013.816725
32. Palit SP, Patel R, Jadeja SD, et al. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci Rep. 2020;10(1):2904. doi: 10.1038/s41598-020-59845-z
33. Ishida M, Tatsumi K, Okumoto K, Kaji H. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells Dev. 2020. doi: 10.1089/scd.2019.0250
34. Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy. 2013; p. 1–15. doi: 10.1155/2013/785835
35. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Адипонектин в плазме крови при бронхиальной астме. Уральский научный вестник. 2014;34(113):34-41 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. Plasma adiponectin in asthma. 2014;34(113):34-41 (In Russ.)] doi: 10.24884/1607-4181-2014-21-3-34-40
36. Nigro E, Daniele A, Scudiero O, et al. Adiponectin in Asthma: Implications for Phenotyping. Curr Protein Pept Sci. 2015;16(3):182-7. doi: 10.2174/1389203716666150120095342
37. Sutherland TJT, Sears MR, McLachlan CR, et al. Leptin, adiponectin, and asthma: findings from a population-based cohort study. Ann Allergy Asthma Immunol. 2009;103(2):101-7. doi: 10.1016/s1081-1206(10)60161-5
38. Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Ped Allergy Immunol. 2009;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x
39. Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and leptin. J Clin Lab Anal. 2019;33(6):e22915. doi: 10.1002/jcla.22915
40. Кириллова О.О., Ворожко И.В., Гаппарова К.М., и др. Адипокины и метаболизм ключевых пищевых веществ у больных с ожирением. Терапевтический архив. 2014;86(1):45-8 [Kirillova OO, Vorozhko IV, Gapparova KM, et al. Adipokines and the metabolism of key nutrients in patients with obesity. Terapevticheskii Arkhiv (Ter. Arkh.). 2014;86(1):45-8 (In Russ.)].
41. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18:363-74. doi: 10.1038/nm.2627
42. Muc M, Todo-Bom A, Mota-Pinto A, et al. Leptin and resistin in overweight patients with and without asthma. Allergol Immunopathol (Madr). 2014;42(5):415-21. doi: 10.1016/j.aller.2013.03.004
43. Souza-Almeida G, D’Avila H, Almeida PE, et al. Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. Front Immunol. 2018;9:111. doi: 10.3389/fimmu.2018. 00111
44. Tsaroucha A, Daniil Z, Malli F, et al. Leptin, adiponectin and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma. 2013;50(2):188-97. doi: 10.3109/02770903.2012.747101
45. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Роль адипокинов при бронхиальной астме. В кн.: Сборник трудов IX Всероссийской научно-практической конференции «Здоровье – основа человеческого потенциала. Проблемы и пути их решения». 2014; с. 532-3 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. The role of adipokines in bronchial asthma. In the book: Proceedings of the IX All-Russian Scientific and Practical Conference "Health-the basis of human potential. Problems and ways to solve them". 2014; p. 532-3 (In Russ.)].
46. Gurkan F, Atamer Y, Ece A, et al. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol. 2004;93(3):277-80. doi: 10.1016/s1081-1206(10)61501-3
47. Lessard A, St-Laurent J, Turcotte H, Boulet L-P. Leptin and adiponectin in obese and non-obese subjects with asthma. Biomarkers. 2011;16(3):271-3. doi: 10.3109/1354750x.2010.550013
48. Dixon AE, Johnson SE, Griffes LV. Relationship of adipokines with immune response and lung function in obese asthmatic and non-asthmatic women. J Asthma. 2011;48(8):811-7.
doi: 10.3109/02770903.2011.613507
49. Чубриева С.Ю., Глухов Н.В., Зайчик А.М. Жировая ткань как эндокринный регулятор. Вестн. С.-Петерб. ун-та. 2008;11(1):1-43 [Chubrieva SJu, Gluhov NV, Zaĭchik AM. Adipose tissue as an endocrine regulator. Vestn. S.-Peterb. un-ta. 2008;11(1):1-43 (In Russ.)].
50. Seoane-Collazo P, Martínez-Sánchez N, Milbank E, Contreras C. Incendiary Leptin. Nutrients. 2020;12(2). pii: E472. doi: 10.3390/nu12020472
51. Suratt BT, Ubags NDJ, Rastogi D, et al. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017;14:1050-9. doi: 10.1513/AnnalsATS.201703-263WS
52. Yu Q, Wang D, Wen X, et al. Adipose-derived Exosomes Protect the Pulmonary Endothelial Barrier in Ventilator-induced Lung Injury by Inhibiting the TRPV4/Ca2+ Signaling Pathway. Аm J Physiol Lung Cell Mol Physiol. 2020. doi: 10.1152/ajplung.00255.2019
________________________________________________
2. Peterson CM, Su H, Thomas DM, et al. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. JAMA Pediatr. 2017;171:629-36. doi: 10.1001/jamapediatrics.2017.0460
3. Kytikova OYu, Gvozdenko TA, Antonyuk MV. Modern aspects of prevalence of chronic bronchopulmonary diseases. . Bulletin of Respiratory Physiology and Pathology. 2017;64:94-100 (In Russ.) doi: 10.12737/article_5936346fdfc1f3.32482903
4. Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295-304. doi: 10.1111/all.12876
5. Kytikova OYu, Gvozdenko TA, Antonyuk MV. The role of systemic inflammation in bronchial asthma and obesity. Klin. med. 2018;96(9):784-90 (In Russ.)
6. Forno Е. Moving Beyond the Confines of Body Mass Index in the Quest to Understand Obese Asthma. Am J Respir Crit Care Med. 2020;201(3):271-2.
doi: 10.1164/rccm.201910-2031ED
7. Kang M, Sohn S-J, Shin M-H. Association between Body Mass Index and Prevalence of Asthma in Korean Adults. Chonnam Med J. 2020;56(1):62-7.
doi: 10.4068/cmj.2020.56.1.62
8. Huang F, Del-Río-Navarro BE, Torres-Alcántara S, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54(2):153-61. doi: 10.1080/02770903.2016.1200611
9. Sideleva O, Suratt B, Black K, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598-605. doi: 10.1164/rccm.201203-0573oc
10. Kytikova OYu. The relationship of the immune, lipoperoxide and antioxidant systems in chronic inflammation. International Journal of Experimental Education. 2014;8:64-5 (In Russ.)
11. Maniscalco M, Paris D, Melck DJ, et al. Coexistence of obesity and asthma determines a distinct respiratory metabolic phenotype. J Allergy Clin Immunol. 2017;139:1536-47.e5. doi: 10.1016/j.jaci.2016.08.038
12. Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodceva TP. Metabolic aspects of the relationship between obesity and bronchial asthma. Ozhirenie i metabolizm. 2018;15 (4):9-14 (In Russ.) doi: 10.14341/omet9578
13. De Lima Azambuja R, da Costa Santos Azambuja L, Costa S, et al. Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease? Lung. 2015;193(5):749-55. doi: 10.1007/s00408-015-9793-8
14. Kwak S, Kim YD, Na HG, et al. Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)30735-6. doi: 10.1016/j.bbrc.2018.03.206
15. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011;22:259-65. doi: 10.1016/j.tem.2011.03.005
16. Osborne LC, Joyce KL, Alenghat T, et al. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. J Immunol. 2013;190:2292-300. doi: 10.4049/jimmunol.1200706
17. Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73. doi: 10.1074/jbc.m110.200022
18. Jiang S, Park DW, Tadie JM, et al. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014;192(10):4795-803. doi:10.4049/jimmunol.1302764
19. Pirvulescu M, Manduteanu I, Gan AM, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Communications. 2012;422:321-6. doi: 10.1016/j.bbrc.2012.04.159
20. Fang C, Meng Q, Wu H. Resistin-like molecule-β is a human airway remodelling mediator. Eur Respir J. 2012;39(2):458-66. doi: 10.1183/09031936.00107811
21. Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma. Clin Exp Allergy. 2016;46(8):1056-65. doi: 10.1111/cea.12742
22. Kim KW, Shin YH, Lee KE, et al. Relationship between adipokines and manifestations of childhood asthma. Ped Allergy Immunol. 2008;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x
23. Verbovoy AF, Kosareva OV, Akhmerova RI. Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(10):37-41 (In Russ.)
doi: 10.17116/terarkh2015871037-41
24. Blaner WS. Retinol-binding protein: The serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16. doi: 10.1210/edrv-10-3-308
25. Klisić A, Kavarić N, Bjelaković B, et al. The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls. Acta Clin Croat. 2017;56(1):92-8. doi: 10.20471/acc.2017.56.01.14
26. Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116:57-62. doi: 10.3109/13813451003631421
27. Lee S-A, Yuen JJ, Jiang H, et al. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016;64:1534-46. doi: 10.1002/hep.28659
28. Majerczyk M, Kocełak P, Choręza P, et al. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4(RBP4) in a cohort of people aged 65 years and older. J Endocrinol Invest. 2018. doi: 10.1007/s40618-018-0856-6
29. Comerford KB, Buchan W, Karakas SE. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 2014;46:224-31. doi: 10.1055/s-0033-1353204
30. Park YH, Kim KW, Lee KE, et al. Clinical implications of serum retinol-binding protein 4 in asthmatic children. J Korean Med Sci. 2009;24(6):1010-4. doi: 10.3346/jkms.2009.24.6.1010
31. Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013;50(8):828-35. doi: 10.3109/02770903.2013.816725
32. Palit SP, Patel R, Jadeja SD, et al. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci Rep. 2020;10(1):2904. doi: 10.1038/s41598-020-59845-z
33. Ishida M, Tatsumi K, Okumoto K, Kaji H. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells Dev. 2020. doi: 10.1089/scd.2019.0250
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Авторы
О.Ю. Кытикова*, М.В. Антонюк, Т.А. Гвозденко, Т.П. Новгородцева
Владивостокский филиал ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт медицинской климатологии и восстановительного лечения, Владивосток, Россия
*kytikova@yandex.ru
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok, Russia
*kytikova@yandex.ru
Владивостокский филиал ФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания» – Научно-исследовательский институт медицинской климатологии и восстановительного лечения, Владивосток, Россия
*kytikova@yandex.ru
________________________________________________
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok, Russia
*kytikova@yandex.ru
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