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Распространенность анемии и ее ассоциации с другими гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ
Распространенность анемии и ее ассоциации с другими гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ
Ховасова Н.О., Воробьева Н.М., Ткачева О.Н., Котовская Ю.В., Наумов А.В., Селезнева Е.В., Овчарова Л.Н. Распространенность анемии и ее ассоциации с другими гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ. Терапевтический архив. 2022;94(1):24–31. DOI: 10.26442/00403660.2022.01.201316
DOI: 10.26442/00403660.2022.01.201316
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DOI: 10.26442/00403660.2022.01.201316
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Аннотация
Обоснование. Снижение гемоглобина у людей пожилого возраста ухудшает функциональный и когнитивный статусы, ассоциируется с риском падений и переломов, саркопенией, мальнутрицией, депрессией, старческой астенией и снижением автономности. Эпидемиологических данных о распространенности анемии в гериатрической популяции в нашей стране нет.
Цель. Оценить распространенность анемии и проанализировать ее ассоциации с гериатрическими синдромами (ГС) у лиц в возрасте ≥65 лет.
Материалы и методы. Обследованы 4308 человек (30% мужчин) в возрасте от 65 до 107 лет, проживающих в 11 регионах Российской Федерации, которых распределили на возрастные группы (65–74 года, 75–84 года и ≥85 лет). Всем участникам выполнена комплексная гериатрическая оценка и определен гемоглобин.
Результаты. Распространенность анемии у пожилых людей составила 23,9%. Показано, что при повышении возраста на каждый 1 год риск выявления анемии увеличивается на 4%. Частота анемии оказалась выше у мужчин, чем у женщин (28,1% против 22,1%; р<0,001). В большинстве случаев анемия имела легкое течение. По результатам комплексной гериатрической оценки у пациентов с анемией были ниже сила сжатия кисти, величина индекса Бартела, сумма баллов по шкале Лоутона, шкале MNA, тесту Мини-Ког и выше – сумма баллов по Гериатрической шкале депрессии и шкале «Возраст не помеха». Пациенты с анемией чаще пользовались слуховым аппаратом, абсорбирующим бельем и вспомогательными средствами при движении. У пациентов с анемией была выше частота всех ГС, за исключением ортостатической гипотензии и хронического болевого синдрома. Наличие ГС ассоциируется с увеличением риска анемии в 1,3–3,4 раза.
Заключение. В исследовании ЭВКАЛИПТ получены отечественные данные о распространенности анемии у пожилых пациентов и изучены ассоциации между низким гемоглобином и ГС.
Ключевые слова: анемия, гериатрический синдром, комплексная гериатрическая оценка, пожилой возраст, функциональный статус
Aim. To assess the prevalence of anemia and analyze its associations with geriatric syndromes (GS) in subjects aged ≥65 years.
Materials and methods. 4308 subjects (30% of men) aged 65–107 years, living in 11 regions of the Russian Federation, were examined and divided into age groups (65–74 years, 75–84 years and ≥85 years). All the participants underwent a comprehensive geriatric assessment and determined hemoglobin level.
Results. The anemia prevalence in older adults was 23.9%. It has been shown that with an increase in age per 1 year, the risk of anemia detection increases by 4%. The incidence of anemia was higher in males than females (28.1% versus 22.1%; p<0.001). In most cases, anemia was mild. The results of a comprehensive geriatric assessment show that patients with anemia had lower hand grip force, Barthel Index, the sum of points on Lawton instrumental activities of daily living scale, Mini Nutritional Assessment scale, the Mini-Cog test and higher – the sum of points on the Geriatric Depression Scale (GDS-15) and the Age Is No Barrier scale. Patients with anemia were more likely to use hearing aids, absorbent underwear, and assistive devices during movement. Patients with anemia had a higher incidence of all GS, except for orthostatic hypotension and chronic pain syndrome. The presence of GS is associated with an increased risk of anemia by 1.3–3.4 times.
Conclusion. EVKALIPT study obtained domestic data on the prevalence of anemia in older patients and examined its associations with other GS.
Keywords: anemia, geriatric syndrome, comprehensive geriatric assessment, advanced age, functional status
Цель. Оценить распространенность анемии и проанализировать ее ассоциации с гериатрическими синдромами (ГС) у лиц в возрасте ≥65 лет.
Материалы и методы. Обследованы 4308 человек (30% мужчин) в возрасте от 65 до 107 лет, проживающих в 11 регионах Российской Федерации, которых распределили на возрастные группы (65–74 года, 75–84 года и ≥85 лет). Всем участникам выполнена комплексная гериатрическая оценка и определен гемоглобин.
Результаты. Распространенность анемии у пожилых людей составила 23,9%. Показано, что при повышении возраста на каждый 1 год риск выявления анемии увеличивается на 4%. Частота анемии оказалась выше у мужчин, чем у женщин (28,1% против 22,1%; р<0,001). В большинстве случаев анемия имела легкое течение. По результатам комплексной гериатрической оценки у пациентов с анемией были ниже сила сжатия кисти, величина индекса Бартела, сумма баллов по шкале Лоутона, шкале MNA, тесту Мини-Ког и выше – сумма баллов по Гериатрической шкале депрессии и шкале «Возраст не помеха». Пациенты с анемией чаще пользовались слуховым аппаратом, абсорбирующим бельем и вспомогательными средствами при движении. У пациентов с анемией была выше частота всех ГС, за исключением ортостатической гипотензии и хронического болевого синдрома. Наличие ГС ассоциируется с увеличением риска анемии в 1,3–3,4 раза.
Заключение. В исследовании ЭВКАЛИПТ получены отечественные данные о распространенности анемии у пожилых пациентов и изучены ассоциации между низким гемоглобином и ГС.
Ключевые слова: анемия, гериатрический синдром, комплексная гериатрическая оценка, пожилой возраст, функциональный статус
________________________________________________
Aim. To assess the prevalence of anemia and analyze its associations with geriatric syndromes (GS) in subjects aged ≥65 years.
Materials and methods. 4308 subjects (30% of men) aged 65–107 years, living in 11 regions of the Russian Federation, were examined and divided into age groups (65–74 years, 75–84 years and ≥85 years). All the participants underwent a comprehensive geriatric assessment and determined hemoglobin level.
Results. The anemia prevalence in older adults was 23.9%. It has been shown that with an increase in age per 1 year, the risk of anemia detection increases by 4%. The incidence of anemia was higher in males than females (28.1% versus 22.1%; p<0.001). In most cases, anemia was mild. The results of a comprehensive geriatric assessment show that patients with anemia had lower hand grip force, Barthel Index, the sum of points on Lawton instrumental activities of daily living scale, Mini Nutritional Assessment scale, the Mini-Cog test and higher – the sum of points on the Geriatric Depression Scale (GDS-15) and the Age Is No Barrier scale. Patients with anemia were more likely to use hearing aids, absorbent underwear, and assistive devices during movement. Patients with anemia had a higher incidence of all GS, except for orthostatic hypotension and chronic pain syndrome. The presence of GS is associated with an increased risk of anemia by 1.3–3.4 times.
Conclusion. EVKALIPT study obtained domestic data on the prevalence of anemia in older patients and examined its associations with other GS.
Keywords: anemia, geriatric syndrome, comprehensive geriatric assessment, advanced age, functional status
Полный текст
Список литературы
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3. Jablonka A, Wetzke M, Sogkas G, et al. Prevalence and Types of Anemia in a Large Refugee Cohort in Western Europe in 2015. J Immigr Minor Health. 2018;20(6):1332-8. DOI:10.1007/s10903-018-0725-6
4. Chueh HW, Jung HL, Shim YJ, et al; on the behalf of the Red Blood Cell Disorder Working Party of The Korean Society of Hematology. High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES. BMC Geriatr. 2020;20(1):509. DOI:10.1186/s12877-020-01918-9
5. Bach V, Schruckmayer G, Sam I, et al. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging. 2014;9:1187-96. DOI:10.2147/CIA.S61125
6. Lee CT, Chen MZ, Yip CYC, et al. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
7. Röhrig G, Becker I, Schulz RJ, et al. Association between hematologic parameters and functional impairment among geriatric in patients: Data of a prospective cross-sectional multicenter study (“GeriPrävalenz2013”). Maturitas. 2016;90:37-41. DOI:10.1016/j.maturitas.2016.04.020
8. Ткачева О.Н., Котовская Ю.В., Рунихина Н.К., и др. Клинические рекомендации «Старческая астения». Российский журнал гериатрической медицины. 2020;1:11-46 [Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical Guidelines Frailty. Russian Journal of Geriatric Medicine. 2020;1:11-46 (in Russian)].
DOI:10.37586/2686-8636-1-2020-11-46
9. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatr Gerontol Int. 2021;21(7):549-54. DOI:10.1111/ggi.14183
10. Röhrig G, Gütgemann I, Leischker A, Kolb G. Anemia in the aged – a geriatric syndrome?: Second position paper on anemia in the aged by the working group anemia of the German Geriatric Society. Z Gerontol Geriatr. 2018;51(8):921-3 (in German). DOI:10.1007/s00391-018-1457-x
11. Contreras Mdel M, Formiga F, Ferrer A, et al; Grupo Octabaix. Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol. 2015;50(5):211-5 (in Spanish). DOI:10.1016/j.regg.2014.11.004
12. Zilinski J, Zillmann R, Becker I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 2014;93(10):1645-54. DOI:10.1007/s00277-014-2110-4
13. Andro M, Le Squere P, Estivin S, Gentric A. Anemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. 2013;20(9):1234-40. DOI:10.1111/ene.12175
14. Trevisan C, Veronese N, Bolzetta F, et al. Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study. J Clin Psychiatry. 2016;77(12):e1549-56. DOI:10.4088/JCP.15m10270
15. Röhrig G, Becker I, Polidori MC, et al. Association of anemia and hypoalbuminemia in German geriatric inpatients: Relationship to nutritional status and comprehensive geriatric assessment. Z Gerontol Geriatr. 2015;48(7):619-24. DOI:10.1007/s00391-015-0872-5
16. Palmer K, Vetrano DL, Marengoni A, et al. The Relationship between Anemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies. J Nutr Health Aging. 2018;22(8):965-74. DOI:10.1007/s12603-018-1049-x
17. Вёрткин А.Л. Коморбидность: история, современное представление, профилактика и лечение. Кардиоваскулярная терапия и профилактика. 2015;14(2):74-9 [Vertkin AL. Comorbidity: history, recent views, prevention and treatment. Cardiovascular Therapy and Prevention. 2015;14(2):74-9 (in Russian)]. DOI:10.15829/1728-8800-2015-2-74-79
18. Ткачева О.Н., Котовская Ю.В., Рунихина Н.К., и др. Клинические рекомендации «Старческая астения». Часть 2. Российский журнал гериатрической медицины. 2020;2:115-30 [Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Сlinical guidelines frailty. Russian Journal of Geriatric Medicine. 2020;2:115-30 (in Russian)].
DOI:10.37586/2686-8636-2-2020-115-130
19. Воробьёва Н.М., Ткачёва О.Н., Котовская Ю.В., и др. от имени исследователей ЭВКАЛИПТ. Российское эпидемиологическое исследование ЭВКАЛИПТ: протокол и базовые характеристики участников. Российский журнал гериатрической медицины. 2021;1(5):35-43 [Vorobyeva NM, Tkacheva ON, Kotovskaya YuV, et al on behalf of EVKALIPT study. Russian epidemiological study EVKALIPT: protocol and basic characteristics of participants. Russian Journal of Geriatric Medicine. 2021;1(5):35-43 (in Russian)]. DOI:10.37586/2686-8636-1-2021-35-43
20. Nutritional anemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37. PMID:4975372
21. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12(4):444-54. DOI:10.1017/S1368980008002401
22. Sahin S, Tasar PT, Simsek H, et al. Prevalence of anemia and malnutrition and their association in elderly nursing home residents. Aging Clin Exp Res. 2016;28(5):857‐62. DOI:10.1007/s40520-015-0490-5
23. Marzban M, Nabipour I, Farhadi A, et al. Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program. BMC Geriatr. 2021;21(1):329. DOI:10.1186/s12877-021-02285-9
24. Onder G, Penninx BW, Cesari M, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005;60(9):1168-72. DOI:10.1093/gerona/60.9.1168
25. Merchant RA. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
26. Santos PHS, Carmo ÉA, Carneiro JAO, et al. Handgrip strength: An effective screening instrument for anemia in the elderly women. Public Health Nurs. 2019;36(2):178-83. DOI:10.1111/phn.12579
27. Ng TP, Lu Y, Choo RWM, et al. Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell. 2018;17(6):e12842. DOI:10.1111/acel.12842
28. Bani Hassan E, Vogrin S, Hernandez Viña I, et al. Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons. Calcif Tissue Int. 2020;107(2):135-42. DOI:10.1007/s00223-020-00706-2
29. Yeung SSY, Reijnierse EM, Pham VK, et al. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(3):485-500. DOI:10.1002/jcsm.12411
30. Mohammed SH, Shab-Bidar S, Abuzerr S, et al. Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis. BMC Res Notes. 2019;12(1):283. DOI:10.1186/s13104-019-4323-z
31. Leverton T. Hearing loss is important in dementia. BMJ. 2015;350:h3650. DOI:10.1136/bmj.h3650
32. Deal JA, Sharrett AR, Albert MS, et al. Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol. 2015;181(9):680-90. DOI:10.1093/aje/kwu333
2. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-8. DOI:10.1182/blood-2004-05-1812
3. Jablonka A, Wetzke M, Sogkas G, et al. Prevalence and Types of Anemia in a Large Refugee Cohort in Western Europe in 2015. J Immigr Minor Health. 2018;20(6):1332-8. DOI:10.1007/s10903-018-0725-6
4. Chueh HW, Jung HL, Shim YJ, et al; on the behalf of the Red Blood Cell Disorder Working Party of The Korean Society of Hematology. High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES. BMC Geriatr. 2020;20(1):509. DOI:10.1186/s12877-020-01918-9
5. Bach V, Schruckmayer G, Sam I, et al. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging. 2014;9:1187-96. DOI:10.2147/CIA.S61125
6. Lee CT, Chen MZ, Yip CYC, et al. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
7. Röhrig G, Becker I, Schulz RJ, et al. Association between hematologic parameters and functional impairment among geriatric in patients: Data of a prospective cross-sectional multicenter study (“GeriPrävalenz2013”). Maturitas. 2016;90:37-41. DOI:10.1016/j.maturitas.2016.04.020
8. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical Guidelines Frailty. Russian Journal of Geriatric Medicine. 2020;1:11-46 (in Russian).
DOI:10.37586/2686-8636-1-2020-11-46
9. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatr Gerontol Int. 2021;21(7):549-54. DOI:10.1111/ggi.14183
10. Röhrig G, Gütgemann I, Leischker A, Kolb G. Anemia in the aged – a geriatric syndrome?: Second position paper on anemia in the aged by the working group anemia of the German Geriatric Society. Z Gerontol Geriatr. 2018;51(8):921-3 (in German). DOI:10.1007/s00391-018-1457-x
11. Contreras Mdel M, Formiga F, Ferrer A, et al; Grupo Octabaix. Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol. 2015;50(5):211-5 (in Spanish). DOI:10.1016/j.regg.2014.11.004
12. Zilinski J, Zillmann R, Becker I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 2014;93(10):1645-54. DOI:10.1007/s00277-014-2110-4
13. Andro M, Le Squere P, Estivin S, Gentric A. Anemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. 2013;20(9):1234-40. DOI:10.1111/ene.12175
14. Trevisan C, Veronese N, Bolzetta F, et al. Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study. J Clin Psychiatry. 2016;77(12):e1549-56. DOI:10.4088/JCP.15m10270
15. Röhrig G, Becker I, Polidori MC, et al. Association of anemia and hypoalbuminemia in German geriatric inpatients: Relationship to nutritional status and comprehensive geriatric assessment. Z Gerontol Geriatr. 2015;48(7):619-24. DOI:10.1007/s00391-015-0872-5
16. Palmer K, Vetrano DL, Marengoni A, et al. The Relationship between Anemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies. J Nutr Health Aging. 2018;22(8):965-74. DOI:10.1007/s12603-018-1049-x
17. Vertkin AL. Comorbidity: history, recent views, prevention and treatment. Cardiovascular Therapy and Prevention. 2015;14(2):74-9 (in Russian).
DOI:10.15829/1728-8800-2015-2-74-79
18. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Сlinical guidelines frailty. Russian Journal of Geriatric Medicine. 2020;2:115-30 (in Russian).
DOI:10.37586/2686-8636-2-2020-115-130
19. Vorobyeva NM, Tkacheva ON, Kotovskaya YuV, et al on behalf of EVKALIPT study. Russian epidemiological study EVKALIPT: protocol and basic characteristics of participants. Russian Journal of Geriatric Medicine. 2021;1(5):35-43 (in Russian). DOI:10.37586/2686-8636-1-2021-35-43
20. Nutritional anemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37. PMID:4975372
21. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12(4):444-54. DOI:10.1017/S1368980008002401
22. Sahin S, Tasar PT, Simsek H, et al. Prevalence of anemia and malnutrition and their association in elderly nursing home residents. Aging Clin Exp Res. 2016;28(5):857‐62. DOI:10.1007/s40520-015-0490-5
23. Marzban M, Nabipour I, Farhadi A, et al. Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program. BMC Geriatr. 2021;21(1):329. DOI:10.1186/s12877-021-02285-9
24. Onder G, Penninx BW, Cesari M, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005;60(9):1168-72. DOI:10.1093/gerona/60.9.1168
25. Merchant RA. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
26. Santos PHS, Carmo ÉA, Carneiro JAO, et al. Handgrip strength: An effective screening instrument for anemia in the elderly women. Public Health Nurs. 2019;36(2):178-83. DOI:10.1111/phn.12579
27. Ng TP, Lu Y, Choo RWM, et al. Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell. 2018;17(6):e12842. DOI:10.1111/acel.12842
28. Bani Hassan E, Vogrin S, Hernandez Viña I, et al. Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons. Calcif Tissue Int. 2020;107(2):135-42. DOI:10.1007/s00223-020-00706-2
29. Yeung SSY, Reijnierse EM, Pham VK, et al. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(3):485-500. DOI:10.1002/jcsm.12411
30. Mohammed SH, Shab-Bidar S, Abuzerr S, et al. Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis. BMC Res Notes. 2019;12(1):283. DOI:10.1186/s13104-019-4323-z
31. Leverton T. Hearing loss is important in dementia. BMJ. 2015;350:h3650. DOI:10.1136/bmj.h3650
32. Deal JA, Sharrett AR, Albert MS, et al. Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol. 2015;181(9):680-90. DOI:10.1093/aje/kwu333
2. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-8. DOI:10.1182/blood-2004-05-1812
3. Jablonka A, Wetzke M, Sogkas G, et al. Prevalence and Types of Anemia in a Large Refugee Cohort in Western Europe in 2015. J Immigr Minor Health. 2018;20(6):1332-8. DOI:10.1007/s10903-018-0725-6
4. Chueh HW, Jung HL, Shim YJ, et al; on the behalf of the Red Blood Cell Disorder Working Party of The Korean Society of Hematology. High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES. BMC Geriatr. 2020;20(1):509. DOI:10.1186/s12877-020-01918-9
5. Bach V, Schruckmayer G, Sam I, et al. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging. 2014;9:1187-96. DOI:10.2147/CIA.S61125
6. Lee CT, Chen MZ, Yip CYC, et al. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
7. Röhrig G, Becker I, Schulz RJ, et al. Association between hematologic parameters and functional impairment among geriatric in patients: Data of a prospective cross-sectional multicenter study (“GeriPrävalenz2013”). Maturitas. 2016;90:37-41. DOI:10.1016/j.maturitas.2016.04.020
8. Ткачева О.Н., Котовская Ю.В., Рунихина Н.К., и др. Клинические рекомендации «Старческая астения». Российский журнал гериатрической медицины. 2020;1:11-46 [Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical Guidelines Frailty. Russian Journal of Geriatric Medicine. 2020;1:11-46 (in Russian)].
DOI:10.37586/2686-8636-1-2020-11-46
9. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatr Gerontol Int. 2021;21(7):549-54. DOI:10.1111/ggi.14183
10. Röhrig G, Gütgemann I, Leischker A, Kolb G. Anemia in the aged – a geriatric syndrome?: Second position paper on anemia in the aged by the working group anemia of the German Geriatric Society. Z Gerontol Geriatr. 2018;51(8):921-3 (in German). DOI:10.1007/s00391-018-1457-x
11. Contreras Mdel M, Formiga F, Ferrer A, et al; Grupo Octabaix. Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol. 2015;50(5):211-5 (in Spanish). DOI:10.1016/j.regg.2014.11.004
12. Zilinski J, Zillmann R, Becker I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 2014;93(10):1645-54. DOI:10.1007/s00277-014-2110-4
13. Andro M, Le Squere P, Estivin S, Gentric A. Anemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. 2013;20(9):1234-40. DOI:10.1111/ene.12175
14. Trevisan C, Veronese N, Bolzetta F, et al. Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study. J Clin Psychiatry. 2016;77(12):e1549-56. DOI:10.4088/JCP.15m10270
15. Röhrig G, Becker I, Polidori MC, et al. Association of anemia and hypoalbuminemia in German geriatric inpatients: Relationship to nutritional status and comprehensive geriatric assessment. Z Gerontol Geriatr. 2015;48(7):619-24. DOI:10.1007/s00391-015-0872-5
16. Palmer K, Vetrano DL, Marengoni A, et al. The Relationship between Anemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies. J Nutr Health Aging. 2018;22(8):965-74. DOI:10.1007/s12603-018-1049-x
17. Вёрткин А.Л. Коморбидность: история, современное представление, профилактика и лечение. Кардиоваскулярная терапия и профилактика. 2015;14(2):74-9 [Vertkin AL. Comorbidity: history, recent views, prevention and treatment. Cardiovascular Therapy and Prevention. 2015;14(2):74-9 (in Russian)]. DOI:10.15829/1728-8800-2015-2-74-79
18. Ткачева О.Н., Котовская Ю.В., Рунихина Н.К., и др. Клинические рекомендации «Старческая астения». Часть 2. Российский журнал гериатрической медицины. 2020;2:115-30 [Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Сlinical guidelines frailty. Russian Journal of Geriatric Medicine. 2020;2:115-30 (in Russian)].
DOI:10.37586/2686-8636-2-2020-115-130
19. Воробьёва Н.М., Ткачёва О.Н., Котовская Ю.В., и др. от имени исследователей ЭВКАЛИПТ. Российское эпидемиологическое исследование ЭВКАЛИПТ: протокол и базовые характеристики участников. Российский журнал гериатрической медицины. 2021;1(5):35-43 [Vorobyeva NM, Tkacheva ON, Kotovskaya YuV, et al on behalf of EVKALIPT study. Russian epidemiological study EVKALIPT: protocol and basic characteristics of participants. Russian Journal of Geriatric Medicine. 2021;1(5):35-43 (in Russian)]. DOI:10.37586/2686-8636-1-2021-35-43
20. Nutritional anemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37. PMID:4975372
21. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12(4):444-54. DOI:10.1017/S1368980008002401
22. Sahin S, Tasar PT, Simsek H, et al. Prevalence of anemia and malnutrition and their association in elderly nursing home residents. Aging Clin Exp Res. 2016;28(5):857‐62. DOI:10.1007/s40520-015-0490-5
23. Marzban M, Nabipour I, Farhadi A, et al. Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program. BMC Geriatr. 2021;21(1):329. DOI:10.1186/s12877-021-02285-9
24. Onder G, Penninx BW, Cesari M, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005;60(9):1168-72. DOI:10.1093/gerona/60.9.1168
25. Merchant RA. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
26. Santos PHS, Carmo ÉA, Carneiro JAO, et al. Handgrip strength: An effective screening instrument for anemia in the elderly women. Public Health Nurs. 2019;36(2):178-83. DOI:10.1111/phn.12579
27. Ng TP, Lu Y, Choo RWM, et al. Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell. 2018;17(6):e12842. DOI:10.1111/acel.12842
28. Bani Hassan E, Vogrin S, Hernandez Viña I, et al. Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons. Calcif Tissue Int. 2020;107(2):135-42. DOI:10.1007/s00223-020-00706-2
29. Yeung SSY, Reijnierse EM, Pham VK, et al. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(3):485-500. DOI:10.1002/jcsm.12411
30. Mohammed SH, Shab-Bidar S, Abuzerr S, et al. Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis. BMC Res Notes. 2019;12(1):283. DOI:10.1186/s13104-019-4323-z
31. Leverton T. Hearing loss is important in dementia. BMJ. 2015;350:h3650. DOI:10.1136/bmj.h3650
32. Deal JA, Sharrett AR, Albert MS, et al. Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol. 2015;181(9):680-90. DOI:10.1093/aje/kwu333
________________________________________________
2. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-8. DOI:10.1182/blood-2004-05-1812
3. Jablonka A, Wetzke M, Sogkas G, et al. Prevalence and Types of Anemia in a Large Refugee Cohort in Western Europe in 2015. J Immigr Minor Health. 2018;20(6):1332-8. DOI:10.1007/s10903-018-0725-6
4. Chueh HW, Jung HL, Shim YJ, et al; on the behalf of the Red Blood Cell Disorder Working Party of The Korean Society of Hematology. High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES. BMC Geriatr. 2020;20(1):509. DOI:10.1186/s12877-020-01918-9
5. Bach V, Schruckmayer G, Sam I, et al. Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging. 2014;9:1187-96. DOI:10.2147/CIA.S61125
6. Lee CT, Chen MZ, Yip CYC, et al. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
7. Röhrig G, Becker I, Schulz RJ, et al. Association between hematologic parameters and functional impairment among geriatric in patients: Data of a prospective cross-sectional multicenter study (“GeriPrävalenz2013”). Maturitas. 2016;90:37-41. DOI:10.1016/j.maturitas.2016.04.020
8. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Clinical Guidelines Frailty. Russian Journal of Geriatric Medicine. 2020;1:11-46 (in Russian).
DOI:10.37586/2686-8636-1-2020-11-46
9. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatr Gerontol Int. 2021;21(7):549-54. DOI:10.1111/ggi.14183
10. Röhrig G, Gütgemann I, Leischker A, Kolb G. Anemia in the aged – a geriatric syndrome?: Second position paper on anemia in the aged by the working group anemia of the German Geriatric Society. Z Gerontol Geriatr. 2018;51(8):921-3 (in German). DOI:10.1007/s00391-018-1457-x
11. Contreras Mdel M, Formiga F, Ferrer A, et al; Grupo Octabaix. Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol. 2015;50(5):211-5 (in Spanish). DOI:10.1016/j.regg.2014.11.004
12. Zilinski J, Zillmann R, Becker I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol. 2014;93(10):1645-54. DOI:10.1007/s00277-014-2110-4
13. Andro M, Le Squere P, Estivin S, Gentric A. Anemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. 2013;20(9):1234-40. DOI:10.1111/ene.12175
14. Trevisan C, Veronese N, Bolzetta F, et al. Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study. J Clin Psychiatry. 2016;77(12):e1549-56. DOI:10.4088/JCP.15m10270
15. Röhrig G, Becker I, Polidori MC, et al. Association of anemia and hypoalbuminemia in German geriatric inpatients: Relationship to nutritional status and comprehensive geriatric assessment. Z Gerontol Geriatr. 2015;48(7):619-24. DOI:10.1007/s00391-015-0872-5
16. Palmer K, Vetrano DL, Marengoni A, et al. The Relationship between Anemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies. J Nutr Health Aging. 2018;22(8):965-74. DOI:10.1007/s12603-018-1049-x
17. Vertkin AL. Comorbidity: history, recent views, prevention and treatment. Cardiovascular Therapy and Prevention. 2015;14(2):74-9 (in Russian).
DOI:10.15829/1728-8800-2015-2-74-79
18. Tkacheva ON, Kotovskaya YuV, Runikhina NK, et al. Сlinical guidelines frailty. Russian Journal of Geriatric Medicine. 2020;2:115-30 (in Russian).
DOI:10.37586/2686-8636-2-2020-115-130
19. Vorobyeva NM, Tkacheva ON, Kotovskaya YuV, et al on behalf of EVKALIPT study. Russian epidemiological study EVKALIPT: protocol and basic characteristics of participants. Russian Journal of Geriatric Medicine. 2021;1(5):35-43 (in Russian). DOI:10.37586/2686-8636-1-2021-35-43
20. Nutritional anemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5-37. PMID:4975372
21. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12(4):444-54. DOI:10.1017/S1368980008002401
22. Sahin S, Tasar PT, Simsek H, et al. Prevalence of anemia and malnutrition and their association in elderly nursing home residents. Aging Clin Exp Res. 2016;28(5):857‐62. DOI:10.1007/s40520-015-0490-5
23. Marzban M, Nabipour I, Farhadi A, et al. Association between anemia, physical performance and cognitive function in Iranian elderly people: evidence from Bushehr Elderly Health (BEH) program. BMC Geriatr. 2021;21(1):329. DOI:10.1186/s12877-021-02285-9
24. Onder G, Penninx BW, Cesari M, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2005;60(9):1168-72. DOI:10.1093/gerona/60.9.1168
25. Merchant RA. Prevalence of Anemia and Its Association with Frailty, Physical Function and Cognition in Community-Dwelling Older Adults: Findings from the HOPE Study. J Nutr Health Aging. 2021;25(5):679-87. DOI:10.1007/s12603-021-1625-3
26. Santos PHS, Carmo ÉA, Carneiro JAO, et al. Handgrip strength: An effective screening instrument for anemia in the elderly women. Public Health Nurs. 2019;36(2):178-83. DOI:10.1111/phn.12579
27. Ng TP, Lu Y, Choo RWM, et al. Dysregulated homeostatic pathways in sarcopenia among frail older adults. Aging Cell. 2018;17(6):e12842. DOI:10.1111/acel.12842
28. Bani Hassan E, Vogrin S, Hernandez Viña I, et al. Hemoglobin Levels are Low in Sarcopenic and Osteosarcopenic Older Persons. Calcif Tissue Int. 2020;107(2):135-42. DOI:10.1007/s00223-020-00706-2
29. Yeung SSY, Reijnierse EM, Pham VK, et al. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(3):485-500. DOI:10.1002/jcsm.12411
30. Mohammed SH, Shab-Bidar S, Abuzerr S, et al. Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis. BMC Res Notes. 2019;12(1):283. DOI:10.1186/s13104-019-4323-z
31. Leverton T. Hearing loss is important in dementia. BMJ. 2015;350:h3650. DOI:10.1136/bmj.h3650
32. Deal JA, Sharrett AR, Albert MS, et al. Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol. 2015;181(9):680-90. DOI:10.1093/aje/kwu333
Авторы
Н.О. Ховасова*1,2, Н.М. Воробьева1, О.Н. Ткачева1,2, Ю.В. Котовская1, А.В. Наумов1, Е.В. Селезнева3, Л.Н. Овчарова3
1 ОСП «Российский геронтологический научно-клинический центр» ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
3 ФГАОУ ВО «Национальный исследовательский университет “Высшая школа экономики”», Москва, Россия
*natashahov@mail.ru
1 Russian Clinical and Research Center of Gerontology, Moscow, Russia;
2 Pirogov Russian National Research Medical University, Moscow, Russia;
3 National Research University “Higher School of Economics”, Moscow, Russia
natashahov@mail.ru
1 ОСП «Российский геронтологический научно-клинический центр» ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
3 ФГАОУ ВО «Национальный исследовательский университет “Высшая школа экономики”», Москва, Россия
*natashahov@mail.ru
________________________________________________
1 Russian Clinical and Research Center of Gerontology, Moscow, Russia;
2 Pirogov Russian National Research Medical University, Moscow, Russia;
3 National Research University “Higher School of Economics”, Moscow, Russia
natashahov@mail.ru
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