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Прогностическая значимость продолжительности комплекса QRS у пациентов с хронической сердечной недостаточностью и фибрилляцией предсердий: ретроспективное исследование - Журнал Терапевтический архив №4 Вопросы диагностики внутренних болезней 2022
Прогностическая значимость продолжительности комплекса QRS у пациентов с хронической сердечной недостаточностью и фибрилляцией предсердий: ретроспективное исследование
Ускач Т.М., Шарапова Ю.Ш., Сафиуллина А.А., Зиновьева Е.В., Терещенко С.Н. Прогностическая значимость продолжительности комплекса QRS у пациентов с хронической сердечной недостаточностью и фибрилляцией предсердий: ретроспективное исследование. Терапевтический архив. 2022;94(4):503–510.
DOI: 10.26442/00403660.2022.04.201459
DOI: 10.26442/00403660.2022.04.201459
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Аннотация
Цель. Изучить особенности течения заболевания и прогноза у пациентов с хронической сердечной недостаточностью с низкой фракцией выброса (ХСНнФВ) и фибрилляцией предсердий (ФП) в зависимости от ширины комплекса QRS.
Материалы и методы. Изучены истории болезни 514 пациентов (возраст 60,2±13,84 года, 78% – мужчины) с ХСНнФВ, госпитализированных в «НМИЦ кардиологии им. акад. Е.И. Чазова» (Москва) за период с 1 января 2017 по 31 декабря 2018 г. Пациенты были разделены на 2 группы в зависимости от продолжительности комплекса QRS.
Результаты. Ретроспективный анализ историй болезней пациентов с ХСНнФВ в зависимости от продолжительности QRS показал преобладание пациентов с размером комплекса QRS<130 мс (60,7%). При хронической сердечной недостаточности расширение комплекса QRS сопровождалось повышением частоты повторной госпитализации у пациентов с синусовым ритмом (р=0,004). У больных с ФП частота госпитализаций оказалась существенно выше, чем при синусовом ритме, и не зависела от продолжительности QRS (р=0,001). Частота наступления неблагоприятных исходов повышалась в связи с присоединением ФП, что, вероятнее всего, является более значимым фактором риска, чем ширина QRS.
Заключение. Полученные результаты подчеркивают, что пациенты с ФП и узким комплексом QRS имеют такой же неблагоприятный прогноз, как и больные с широким комплексом QRS, и требуют пристального внимания кардиологов.
Ключевые слова: хроническая сердечная недостаточность, узкий комплекс QRS, широкий комплекс QRS, продолжительность комплекса QRS, фибрилляция предсердий
Materials and methods. We studied the case histories of 514 patients (aged 60.2±13.84 years, 78% men) with HFrEF, hospitalized at the Chazov National Medical Research Center of Cardiology (Moscow) for the period from Jan 1, 2017 to Dec 31, 2018. Patients were divided into 2 groups depending on the duration of the QRS complex.
Results. Clinical and statistical retrospective analysis of the medical histories of patients with HFrEF, depending on the QRS duration, showed the predominance of patients with a QRS complex size of less than 130 ms (60.7%). In HFrEF, the expansion of the QRS complex is accompanied by an increase in the rate of readmission in patients with sinus rhythm (p=0.004). In patients with AF, the rehospitalization rate is significantly higher than in sinus rhythm and does not depend on the QRS duration (p=0.001). The incidence of unfavorable outcomes increases in connection with the addition of AF, which is most likely a more significant risk factor than QRS width.
Conclusion. These results highlight that patients with AF and a narrow QRS complex have the same poor prognosis as those with a wide QRS complex and require the close attention of cardiologists.
Keywords: chronic heart failure, narrow QRS complex, wide QRS complex, QRS complex duration, atrial fibrillation
Материалы и методы. Изучены истории болезни 514 пациентов (возраст 60,2±13,84 года, 78% – мужчины) с ХСНнФВ, госпитализированных в «НМИЦ кардиологии им. акад. Е.И. Чазова» (Москва) за период с 1 января 2017 по 31 декабря 2018 г. Пациенты были разделены на 2 группы в зависимости от продолжительности комплекса QRS.
Результаты. Ретроспективный анализ историй болезней пациентов с ХСНнФВ в зависимости от продолжительности QRS показал преобладание пациентов с размером комплекса QRS<130 мс (60,7%). При хронической сердечной недостаточности расширение комплекса QRS сопровождалось повышением частоты повторной госпитализации у пациентов с синусовым ритмом (р=0,004). У больных с ФП частота госпитализаций оказалась существенно выше, чем при синусовом ритме, и не зависела от продолжительности QRS (р=0,001). Частота наступления неблагоприятных исходов повышалась в связи с присоединением ФП, что, вероятнее всего, является более значимым фактором риска, чем ширина QRS.
Заключение. Полученные результаты подчеркивают, что пациенты с ФП и узким комплексом QRS имеют такой же неблагоприятный прогноз, как и больные с широким комплексом QRS, и требуют пристального внимания кардиологов.
Ключевые слова: хроническая сердечная недостаточность, узкий комплекс QRS, широкий комплекс QRS, продолжительность комплекса QRS, фибрилляция предсердий
________________________________________________
Materials and methods. We studied the case histories of 514 patients (aged 60.2±13.84 years, 78% men) with HFrEF, hospitalized at the Chazov National Medical Research Center of Cardiology (Moscow) for the period from Jan 1, 2017 to Dec 31, 2018. Patients were divided into 2 groups depending on the duration of the QRS complex.
Results. Clinical and statistical retrospective analysis of the medical histories of patients with HFrEF, depending on the QRS duration, showed the predominance of patients with a QRS complex size of less than 130 ms (60.7%). In HFrEF, the expansion of the QRS complex is accompanied by an increase in the rate of readmission in patients with sinus rhythm (p=0.004). In patients with AF, the rehospitalization rate is significantly higher than in sinus rhythm and does not depend on the QRS duration (p=0.001). The incidence of unfavorable outcomes increases in connection with the addition of AF, which is most likely a more significant risk factor than QRS width.
Conclusion. These results highlight that patients with AF and a narrow QRS complex have the same poor prognosis as those with a wide QRS complex and require the close attention of cardiologists.
Keywords: chronic heart failure, narrow QRS complex, wide QRS complex, QRS complex duration, atrial fibrillation
Полный текст
Список литературы
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DOI:10.1016/s0002-9149(02)03373-8
8. Bleeker GB, Holman ER, Steendijk P, et al. Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol. 2006;48(11):2243-50. DOI:10.1016/j.jacc.2006.07.067
9. Tayal B, Gorcsan J 3rd, Bax JJ, et al. Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes. J Am Coll Cardiol. 2018;71(12):1325-33. DOI:10.1016/j.jacc.2018.01.042
10. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. DOI:10.1093/eurheartj/ehab368
11. Lund LH, Jurga J, Edner M, et al. Prevalence, correlates, and prognostic significance of QRS prolongation in heart failure with reduced and preserved ejection fraction. Eur Heart J. 2013;34(7):529-39. DOI:10.1093/eurheartj/ehs305
12. Orso F, Fabbri G, Maggioni AP. Epidemiology of Heart Failure. Handb Exp Pharmacol. 2017;243:15-33. DOI:10.1007/164_2016_74
13. Терещенко С.Н., Романова Н.В., Жиров И.В., и др. Российский регистр больных хронической сердечной недостаточностью и фибрилляцией предсердий (РИФ-ХСН): клинико-демографические характеристики выборки на момент включения в регистр. Сердечная недостаточность. 2016;17(6):418-26. [Tereshchenko SN, Romanova NV, Zhirov IV, et al. Russian Registry of Patients with Chronic Heart Failure and Atrial Fibrillation (RIF-CHF): Clinical and demographic characteristics of the sample upon inclusion into the Registry. Serdechnaia Nedostatochnost'. 2016;17(6):418-26 (in Russian)]. DOI:10.18087/RHFJ.2016.6.2276
14. Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27(22):2725-36. DOI:10.1093/eurheartj/ehl193
15. Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010;12(10):1076-84. DOI:10.1093/eurjhf/hfq154
16. Follath F, Yilmaz MB, Delgado JF, et al. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF). Intensive Care Med. 2011;37(4):619-26. DOI:10.1007/s00134-010-2113-0
17. Ghio S, Constantin C, Klersy C, et al. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25(7):571-8. DOI:10.1016/j.ehj.2003.09.030
18. Bleeker GB, Yu CM, Nihoyannopoulos P, et al. Optimal use of echocardiography in cardiac resynchronisation therapy. Heart. 2007;93(11):1339-50. DOI:10.1136/hrt.2005.076422
19. Moe GW. B-type natriuretic peptide in heart failure. Curr Opin Cardiol. 2006;21(3):208-14. DOI:10.1097/01.hco.0000221582.71619.84
20. Maisel AS, Duran JM, Wettersten N. Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides. Heart Fail Clin. 2018;14(1):13-25. DOI:10.1016/j.hfc.2017.08.002
21. Raphael CE, Whinnett ZI, Davies JE, et al. Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. Heart. 2009;95(1):56-62. DOI:10.1136/hrt.2007.134973
22. McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013;15(9):1062-73. DOI:10.1093/eurjhf/hft052
23. Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail.
2011;13(1):107-14. DOI:10.1093/eurjhf/hfq212
24. Weng LC, Preis SR, Hulme OL, et al. Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation. Circulation. 2018;137(10):1027-38. DOI:10.1161/CIRCULATIONAHA.117.031431
25. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646-59. DOI:10.1161/CIRCRESAHA.113.300268
26. Chioncel O, Lainscak M, Seferovic PM, et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574-85. DOI:10.1002/ejhf.813
27. Zafrir B, Lund LH, Laroche C, et al. Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry. Eur Heart J. 2018;39(48):4277-84. DOI:10.1093/eurheartj/ehy626
28. Conrad N, Judge A, Tran J, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018;391(10120):572-80. DOI:10.1016/S0140-6736(17)32520-5
29. Gerber Y, Weston SA, Redfield MM, et al. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med. 2015;175(6):996-1004. DOI:10.1001/jamainternmed.2015.0924
2. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart. 2007;93(9):1137-46. DOI:10.1136/hrt.2003.025270
3. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association [published correction appears in Circulation]. Circulation. 2012;125(1):e2-e220. DOI:10.1161/CIR.0b013e31823ac046
4. Kotecha D, Piccini JP. Atrial fibrillation in heart failure: what should we do? Eur Heart J. 2015;36(46):3250-7. DOI:10.1093/eurheartj/ehv513
5. Dhingra R, Ho Nam B, Benjamin EJ, et al. Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study. J Am Coll Cardiol. 2005;45(5):685-9. DOI:10.1016/j.jacc.2004.11.046
6. Ruschitzka F, Abraham WT, Singh JP, et al. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med. 2013;369(15):1395-405. DOI:10.1056/NEJMoa1306687
7. Maisel WH, Stevenson LW. Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol. 2003;91(6A):2D-8D.
DOI:10.1016/s0002-9149(02)03373-8
8. Bleeker GB, Holman ER, Steendijk P, et al. Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol. 2006;48(11):2243-50. DOI:10.1016/j.jacc.2006.07.067
9. Tayal B, Gorcsan J 3rd, Bax JJ, et al. Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes. J Am Coll Cardiol. 2018;71(12):1325-33. DOI:10.1016/j.jacc.2018.01.042
10. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. DOI:10.1093/eurheartj/ehab368
11. Lund LH, Jurga J, Edner M, et al. Prevalence, correlates, and prognostic significance of QRS prolongation in heart failure with reduced and preserved ejection fraction. Eur Heart J. 2013;34(7):529-39. DOI:10.1093/eurheartj/ehs305
12. Orso F, Fabbri G, Maggioni AP. Epidemiology of Heart Failure. Handb Exp Pharmacol. 2017;243:15-33. DOI:10.1007/164_2016_74
13. Tereshchenko SN, Romanova NV, Zhirov IV, et al. Russian Registry of Patients with Chronic Heart Failure and Atrial Fibrillation (RIF-CHF): Clinical and demographic characteristics of the sample upon inclusion into the Registry. Serdechnaia Nedostatochnost'. 2016;17(6):418-26 (in Russian). DOI:10.18087/RHFJ.2016.6.2276
14. Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27(22):2725-36. DOI:10.1093/eurheartj/ehl193
15. Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010;12(10):1076-84. DOI:10.1093/eurjhf/hfq154
16. Follath F, Yilmaz MB, Delgado JF, et al. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF). Intensive Care Med. 2011;37(4):619-26. DOI:10.1007/s00134-010-2113-0
17. Ghio S, Constantin C, Klersy C, et al. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25(7):571-8. DOI:10.1016/j.ehj.2003.09.030
18. Bleeker GB, Yu CM, Nihoyannopoulos P, et al. Optimal use of echocardiography in cardiac resynchronisation therapy. Heart. 2007;93(11):1339-50. DOI:10.1136/hrt.2005.076422
19. Moe GW. B-type natriuretic peptide in heart failure. Curr Opin Cardiol. 2006;21(3):208-14. DOI:10.1097/01.hco.0000221582.71619.84
20. Maisel AS, Duran JM, Wettersten N. Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides. Heart Fail Clin. 2018;14(1):13-25. DOI:10.1016/j.hfc.2017.08.002
21. Raphael CE, Whinnett ZI, Davies JE, et al. Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. Heart. 2009;95(1):56-62. DOI:10.1136/hrt.2007.134973
22. McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013;15(9):1062-73. DOI:10.1093/eurjhf/hft052
23. Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail.
2011;13(1):107-14. DOI:10.1093/eurjhf/hfq212
24. Weng LC, Preis SR, Hulme OL, et al. Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation. Circulation. 2018;137(10):1027-38. DOI:10.1161/CIRCULATIONAHA.117.031431
25. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646-59. DOI:10.1161/CIRCRESAHA.113.300268
26. Chioncel O, Lainscak M, Seferovic PM, et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574-85. DOI:10.1002/ejhf.813
27. Zafrir B, Lund LH, Laroche C, et al. Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry. Eur Heart J. 2018;39(48):4277-84. DOI:10.1093/eurheartj/ehy626
28. Conrad N, Judge A, Tran J, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018;391(10120):572-80. DOI:10.1016/S0140-6736(17)32520-5
29. Gerber Y, Weston SA, Redfield MM, et al. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med. 2015;175(6):996-1004. DOI:10.1001/jamainternmed.2015.0924
2. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart. 2007;93(9):1137-46. DOI:10.1136/hrt.2003.025270
3. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association [published correction appears in Circulation]. Circulation. 2012;125(1):e2-e220. DOI:10.1161/CIR.0b013e31823ac046
4. Kotecha D, Piccini JP. Atrial fibrillation in heart failure: what should we do? Eur Heart J. 2015;36(46):3250-7. DOI:10.1093/eurheartj/ehv513
5. Dhingra R, Ho Nam B, Benjamin EJ, et al. Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study. J Am Coll Cardiol. 2005;45(5):685-9. DOI:10.1016/j.jacc.2004.11.046
6. Ruschitzka F, Abraham WT, Singh JP, et al. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med. 2013;369(15):1395-405. DOI:10.1056/NEJMoa1306687
7. Maisel WH, Stevenson LW. Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol. 2003;91(6A):2D-8D.
DOI:10.1016/s0002-9149(02)03373-8
8. Bleeker GB, Holman ER, Steendijk P, et al. Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol. 2006;48(11):2243-50. DOI:10.1016/j.jacc.2006.07.067
9. Tayal B, Gorcsan J 3rd, Bax JJ, et al. Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes. J Am Coll Cardiol. 2018;71(12):1325-33. DOI:10.1016/j.jacc.2018.01.042
10. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. DOI:10.1093/eurheartj/ehab368
11. Lund LH, Jurga J, Edner M, et al. Prevalence, correlates, and prognostic significance of QRS prolongation in heart failure with reduced and preserved ejection fraction. Eur Heart J. 2013;34(7):529-39. DOI:10.1093/eurheartj/ehs305
12. Orso F, Fabbri G, Maggioni AP. Epidemiology of Heart Failure. Handb Exp Pharmacol. 2017;243:15-33. DOI:10.1007/164_2016_74
13. Терещенко С.Н., Романова Н.В., Жиров И.В., и др. Российский регистр больных хронической сердечной недостаточностью и фибрилляцией предсердий (РИФ-ХСН): клинико-демографические характеристики выборки на момент включения в регистр. Сердечная недостаточность. 2016;17(6):418-26. [Tereshchenko SN, Romanova NV, Zhirov IV, et al. Russian Registry of Patients with Chronic Heart Failure and Atrial Fibrillation (RIF-CHF): Clinical and demographic characteristics of the sample upon inclusion into the Registry. Serdechnaia Nedostatochnost'. 2016;17(6):418-26 (in Russian)]. DOI:10.18087/RHFJ.2016.6.2276
14. Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27(22):2725-36. DOI:10.1093/eurheartj/ehl193
15. Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010;12(10):1076-84. DOI:10.1093/eurjhf/hfq154
16. Follath F, Yilmaz MB, Delgado JF, et al. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF). Intensive Care Med. 2011;37(4):619-26. DOI:10.1007/s00134-010-2113-0
17. Ghio S, Constantin C, Klersy C, et al. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25(7):571-8. DOI:10.1016/j.ehj.2003.09.030
18. Bleeker GB, Yu CM, Nihoyannopoulos P, et al. Optimal use of echocardiography in cardiac resynchronisation therapy. Heart. 2007;93(11):1339-50. DOI:10.1136/hrt.2005.076422
19. Moe GW. B-type natriuretic peptide in heart failure. Curr Opin Cardiol. 2006;21(3):208-14. DOI:10.1097/01.hco.0000221582.71619.84
20. Maisel AS, Duran JM, Wettersten N. Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides. Heart Fail Clin. 2018;14(1):13-25. DOI:10.1016/j.hfc.2017.08.002
21. Raphael CE, Whinnett ZI, Davies JE, et al. Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. Heart. 2009;95(1):56-62. DOI:10.1136/hrt.2007.134973
22. McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013;15(9):1062-73. DOI:10.1093/eurjhf/hft052
23. Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail.
2011;13(1):107-14. DOI:10.1093/eurjhf/hfq212
24. Weng LC, Preis SR, Hulme OL, et al. Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation. Circulation. 2018;137(10):1027-38. DOI:10.1161/CIRCULATIONAHA.117.031431
25. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646-59. DOI:10.1161/CIRCRESAHA.113.300268
26. Chioncel O, Lainscak M, Seferovic PM, et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574-85. DOI:10.1002/ejhf.813
27. Zafrir B, Lund LH, Laroche C, et al. Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry. Eur Heart J. 2018;39(48):4277-84. DOI:10.1093/eurheartj/ehy626
28. Conrad N, Judge A, Tran J, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018;391(10120):572-80. DOI:10.1016/S0140-6736(17)32520-5
29. Gerber Y, Weston SA, Redfield MM, et al. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med. 2015;175(6):996-1004. DOI:10.1001/jamainternmed.2015.0924
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15. Maggioni AP, Dahlstrom U, Filippatos G, et al. EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010;12(10):1076-84. DOI:10.1093/eurjhf/hfq154
16. Follath F, Yilmaz MB, Delgado JF, et al. Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF). Intensive Care Med. 2011;37(4):619-26. DOI:10.1007/s00134-010-2113-0
17. Ghio S, Constantin C, Klersy C, et al. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25(7):571-8. DOI:10.1016/j.ehj.2003.09.030
18. Bleeker GB, Yu CM, Nihoyannopoulos P, et al. Optimal use of echocardiography in cardiac resynchronisation therapy. Heart. 2007;93(11):1339-50. DOI:10.1136/hrt.2005.076422
19. Moe GW. B-type natriuretic peptide in heart failure. Curr Opin Cardiol. 2006;21(3):208-14. DOI:10.1097/01.hco.0000221582.71619.84
20. Maisel AS, Duran JM, Wettersten N. Natriuretic Peptides in Heart Failure: Atrial and B-type Natriuretic Peptides. Heart Fail Clin. 2018;14(1):13-25. DOI:10.1016/j.hfc.2017.08.002
21. Raphael CE, Whinnett ZI, Davies JE, et al. Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. Heart. 2009;95(1):56-62. DOI:10.1136/hrt.2007.134973
22. McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013;15(9):1062-73. DOI:10.1093/eurjhf/hft052
23. Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail.
2011;13(1):107-14. DOI:10.1093/eurjhf/hfq212
24. Weng LC, Preis SR, Hulme OL, et al. Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation. Circulation. 2018;137(10):1027-38. DOI:10.1161/CIRCULATIONAHA.117.031431
25. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646-59. DOI:10.1161/CIRCRESAHA.113.300268
26. Chioncel O, Lainscak M, Seferovic PM, et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19(12):1574-85. DOI:10.1002/ejhf.813
27. Zafrir B, Lund LH, Laroche C, et al. Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14 964 patients in the European Society of Cardiology Heart Failure Long-Term Registry. Eur Heart J. 2018;39(48):4277-84. DOI:10.1093/eurheartj/ehy626
28. Conrad N, Judge A, Tran J, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2018;391(10120):572-80. DOI:10.1016/S0140-6736(17)32520-5
29. Gerber Y, Weston SA, Redfield MM, et al. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med. 2015;175(6):996-1004. DOI:10.1001/jamainternmed.2015.0924
Авторы
Т.М. Ускач1,2, Ю.Ш. Шарапова*1, А.А. Сафиуллина1, Е.В. Зиновьева1, С.Н. Терещенко1,2
1 ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России, Москва, Россия;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*yulduzsharapova@mail.ru
1 Chazov National Medical Research Center of Cardiology, Moscow, Russia;
2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*yulduzsharapova@mail.ru
1 ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России, Москва, Россия;
2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*yulduzsharapova@mail.ru
________________________________________________
1 Chazov National Medical Research Center of Cardiology, Moscow, Russia;
2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*yulduzsharapova@mail.ru
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