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Дефицит эндогенных эстрогенов и развитие хронической скелетно-мышечной боли - Журнал Терапевтический архив №5 Вопросы ревматологии 2022
Дефицит эндогенных эстрогенов и развитие хронической скелетно-мышечной боли
Паневин Т.С., Бобкова А.О., Каратеев А.Е., Зоткин Е.Г. Дефицит эндогенных эстрогенов и развитие хронической скелетно-мышечной боли. Терапевтический архив. 2022;94(5):683–688.
DOI: 10.26442/00403660.2022.05.201490
DOI: 10.26442/00403660.2022.05.201490
DOI: 10.26442/00403660.2022.05.201490
________________________________________________
DOI: 10.26442/00403660.2022.05.201490
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Аннотация
Половой диморфизм хронических заболеваний – феномен, определяемый различиями гормонального статуса мужчин и женщин.
В этом плане большой интерес представляют эстрогены, обладающие комплексным влиянием на организм. В частности, эстрогены играют важную роль в естественном контроле боли и воспаления. Снижение уровня эстрогенов, связанное с менопаузой или ятрогенным воздействием (гистерэктомия, применение ингибиторов ароматазы), а также мутации генов, отвечающих за синтез структурных компонентов мембранных рецепторов эстрогенов (ESR1 и ESR2), способны существенно снизить позитивные эффекты этих гормонов. Дефицит эстрогенов может стать одной из причин развития серьезных патологических изменений – в частности, формирования хронической боли, связанной с патологией скелетно-мышечной системы.
Ключевые слова: эстрогены, эстрогеновые рецепторы, хроническая боль, фибромиалгия, ревматоидный артрит
Кeywords: estrogens, estrogen receptors, chronic pain, fibromyalgia, rheumatoid arthritis
В этом плане большой интерес представляют эстрогены, обладающие комплексным влиянием на организм. В частности, эстрогены играют важную роль в естественном контроле боли и воспаления. Снижение уровня эстрогенов, связанное с менопаузой или ятрогенным воздействием (гистерэктомия, применение ингибиторов ароматазы), а также мутации генов, отвечающих за синтез структурных компонентов мембранных рецепторов эстрогенов (ESR1 и ESR2), способны существенно снизить позитивные эффекты этих гормонов. Дефицит эстрогенов может стать одной из причин развития серьезных патологических изменений – в частности, формирования хронической боли, связанной с патологией скелетно-мышечной системы.
Ключевые слова: эстрогены, эстрогеновые рецепторы, хроническая боль, фибромиалгия, ревматоидный артрит
________________________________________________
Кeywords: estrogens, estrogen receptors, chronic pain, fibromyalgia, rheumatoid arthritis
Полный текст
Список литературы
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11. Neeck G, Crofford LJ. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am. 2000;26(4):989-1002.
DOI:10.1016/s0889-857x(05)70180-0; PMID: 11084955
12. Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: a comparative study. Clin Rheumatol. 2009;28(5):561-4. DOI:10.1007/s10067-009-1087-1
13. Vincent A, Whipple MO, Luedtke CA, et al. Pain and other symptom severity in women with fibromyalgia and a previous hysterectomy. J Pain Res. 2011;4:325-9. DOI:10.2147/JPR.S25490
14. Arslan HS, Nursal AF, Inanir A, et al. Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women. Endocr Metab Immune Disord Drug Targets. 2021;21(7):1326-32. DOI:10.2174/1871530320666200910110915
15. Koca T, Koçyiğit B, Seyithanoğlu M, Berk E. The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Arch Rheumatol. 2019;34(4):419-25.
DOI:10.5606/ArchRheumatol.2019.7236
16. Smith SB, Reenilä I, Männistö PT, et al. Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Pain. 2014;155(11):2390-9. DOI:10.1016/j.pain.2014.09.009
17. Malyala A, Kelly MJ, Rønnekleiv OK. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. 2005;70(5-7):397-406. DOI:10.1016/j.steroids.2005.03.004
18. Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 1997;388(4):507-25.
DOI:10.1002/(sici)1096-9861(19971201)388:4<507::aid-cne1>3.0.co;2-6
19. Zhang W, Wu H, Xu Q, et al. Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats. Biol Sex Differ. 2020;11(1):2. DOI:10.1186/s13293-019-0271-5
20. Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur. Acta Histochem Cytochem. 2007;40(1):27-34. DOI:10.1267/ahc.06015
21. Carlsten H. Immune responses and bone loss: the estrogen connection. Immunol Rev. 2005;208:194-206. DOI:10.1111/j.0105-2896.2005.00326.x
22. Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res. 2007;56(7):269-73. DOI:10.1007/s00011-007-6198-z
23. Ushiyama T, Mori K, Inoue K, et al. Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis. Ann Rheum Dis. 1999;58(1):7-10. DOI:10.1136/ard.58.1.7
24. Blanton HL, Barnes RC, McHann MC, et al. Sex differences and the endocannabinoid system in pain. Pharmacol Biochem Behav. 2021;202:173107. DOI:10.1016/j.pbb.2021.173107
25. Yan XJ, Feng CC, Liu Q, et al. Vagal afferents mediate antinociception of estrogen in a rat model of visceral pain: the involvement of intestinal mucosal mast cells and 5-hydroxytryptamine 3 signaling. J Pain. 2014;15(2):204-17. DOI:10.1016/j.jpain.2013.10.012
26. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci. 1996;16(21):7021-9. DOI:10.1523/JNEUROSCI.16-21-07021.1996
27. Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol. 2002;23(1):41-100. DOI:10.1006/frne.2001.0225
28. Martikainen IK, Hirvonen J, Kajander J, et al. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res. 2007;1172:21-31. DOI:10.1016/j.brainres.2007.07.036
29. Osikowicz M, Mika J, Przewlocka B. The glutamatergic system as a target for neuropathic pain relief. Exp Physiol. 2013;98(2):372-84. DOI:10.1113/expphysiol.2012.069922
30. Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008;38(1):66-77. DOI:10.1007/s12035-008-8034-z
31. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26(12):696-705. DOI:10.1016/j.tins.2003.09.017
32. Yankova M, Hart SA, Woolley CS. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc Natl Acad Sci USA. 2001;98(6):3525-30. DOI:10.1073/pnas.051624598
33. Castrillon EE, Cairns BE, Wang K, et al. Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women. Pain. 2012;153(4):823-9. DOI:10.1016/j.pain.2012.01.003
34. Tashiro A, Okamoto K, Bereiter DA. Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience. 2009;164(4):1813-20. DOI:10.1016/j.neuroscience.2009.09.058
35. Bäckström T, Haage D, Löfgren M, et al. Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience. 2011;191:46-54. DOI:10.1016/j.neuroscience.2011.03.061
36. Schweizer-Schubert S, Gordon JL, Eisenlohr-Moul TA, et al. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions. Front Med (Lausanne). 2021;7:479646. DOI:10.3389/fmed.2020.479646
37. Gintzler AR, Schnell SA, Gupta DS, et al. Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception.J Pharmacol Exp Ther. 2008;326(3):725-31. DOI:10.1124/jpet.108.139816
38. Gintzler AR, Liu NJ. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems. Transl Res. 2021;234:31-42. DOI:10.1016/j.trsl.2021.02.002
39. Cao DY, Ji Y, Tang B, Traub RJ. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13(7):685-94. DOI:10.1016/j.jpain.2012.04.010
40. Molina-Martínez LM, Juárez J. Differential expression of μ-opioid receptors in the nucleus accumbens, amygdala and VTA depends on liking for alcohol, chronic alcohol intake and estradiol treatment. Behav Brain Res. 2020;378:112255. DOI:10.1016/j.bbr.2019.112255
41. Farooqui M, Geng ZH, Stephenson EJ, et al. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006;5(3):611-20.
DOI:10.1158/1535-7163.MCT-05-0016
42. Sapir-Koren R, Livshits G. Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4(+) T-cells, and their interactions? Mol Cell Endocrinol. 2016;431:145-63. DOI:10.1016/j.mce.2016.05.009
43. Andersson A, Stubelius A, Karlsson MN, et al. Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther. 2015;17(1):32. DOI:10.1186/s13075-015-0548-y
44. Chen RY, Fan YM, Zhang Q, et al. Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter. J Immunol. 2015;194(8):4019-28. DOI:10.4049/jimmunol.1400806
45. Hang X, Zhang Z, Niu R, et al. Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis. J Inflamm Res. 2021;14:843-58. DOI:10.2147/JIR.S295222
46. Qu Q, Jiang S, Li X. Correlation between estrogen receptor-α gene polymorphism and rheumatoid arthritis in females. Panminerva Med. 2020. DOI:10.23736/S0031-0808.19.03806-0
47. Dziedziejko V, Kurzawski M, Safranow K, et al. Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis. Scand J Rheumatol. 2011;40(5):329-33. DOI:10.3109/03009742.2011.563752
2. Watt FE. Musculoskeletal pain and menopause. Post Reprod Health. 2018;24(1):34-43. DOI:10.1177/2053369118757537
3. Adamian LV, Andreeva EN, Apolikhina IA, et al. Menopauza i klimaktericheskoe sostoianie u zhenshchiny. Klinicheskie rekomendatsii. Moscow: Rossiiskoe obshchestvo akusherov-ginekologov, 2021 (in Russian).
4. Barnabei VM, Cochrane BB, Aragaki AK, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol. 2005;105(5 Pt. 1):1063-73. DOI:10.1097/01.AOG.0000158120.47542.18
5. Ho SC, Chan SG, Yip YB, et al. Menopausal symptoms and symptom clustering in Chinese women. Maturitas. 1999;33(3):219-27. DOI:10.1016/s0378-5122(99)00056-0
6. Bardel A, Wallander MA, Wedel H, Svärdsudd K. Age-specific symptom prevalence in women 35-64 years old: a population-based study. BMC Public Health. 2009;9:37. DOI:10.1186/1471-2458-9-37
7. Horimoto Y, Saito M, Kasumi F. Arthralgia in 329 Patients Taking Aromatase Inhibitors. Breast Care (Basel). 2009;4(5):319-23. DOI:10.1159/000236050
8. Sestak I, Cuzick J, Sapunar F, et al. Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis. Lancet Oncol. 2008;9(9):866-72. DOI:10.1016/S1470-2045(08)70182-7
9. Laroche F, Coste J, Medkour T, et al. Classification of and risk factors for estrogen deprivation pain syndromes related to aromatase inhibitor treatments in women with breast cancer: a prospective multicenter cohort study. J Pain. 2014;15(3):293-303. DOI:10.1016/j.jpain.2013.11.004
10. Borrie AE, Rose FA, Choi YH, et al. Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients. Breast Cancer Res Treat. 2020;183(2):365-72. DOI:10.1007/s10549-020-05777-1
11. Neeck G, Crofford LJ. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am. 2000;26(4):989-1002.
DOI:10.1016/s0889-857x(05)70180-0; PMID: 11084955
12. Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: a comparative study. Clin Rheumatol. 2009;28(5):561-4. DOI:10.1007/s10067-009-1087-1
13. Vincent A, Whipple MO, Luedtke CA, et al. Pain and other symptom severity in women with fibromyalgia and a previous hysterectomy. J Pain Res. 2011;4:325-9. DOI:10.2147/JPR.S25490
14. Arslan HS, Nursal AF, Inanir A, et al. Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women. Endocr Metab Immune Disord Drug Targets. 2021;21(7):1326-32. DOI:10.2174/1871530320666200910110915
15. Koca T, Koçyiğit B, Seyithanoğlu M, Berk E. The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Arch Rheumatol. 2019;34(4):419-25.
DOI:10.5606/ArchRheumatol.2019.7236
16. Smith SB, Reenilä I, Männistö PT, et al. Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Pain. 2014;155(11):2390-9. DOI:10.1016/j.pain.2014.09.009
17. Malyala A, Kelly MJ, Rønnekleiv OK. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. 2005;70(5-7):397-406. DOI:10.1016/j.steroids.2005.03.004
18. Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 1997;388(4):507-25.
DOI:10.1002/(sici)1096-9861(19971201)388:4<507::aid-cne1>3.0.co;2-6
19. Zhang W, Wu H, Xu Q, et al. Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats. Biol Sex Differ. 2020;11(1):2. DOI:10.1186/s13293-019-0271-5
20. Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur. Acta Histochem Cytochem. 2007;40(1):27-34. DOI:10.1267/ahc.06015
21. Carlsten H. Immune responses and bone loss: the estrogen connection. Immunol Rev. 2005;208:194-206. DOI:10.1111/j.0105-2896.2005.00326.x
22. Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res. 2007;56(7):269-73. DOI:10.1007/s00011-007-6198-z
23. Ushiyama T, Mori K, Inoue K, et al. Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis. Ann Rheum Dis. 1999;58(1):7-10. DOI:10.1136/ard.58.1.7
24. Blanton HL, Barnes RC, McHann MC, et al. Sex differences and the endocannabinoid system in pain. Pharmacol Biochem Behav. 2021;202:173107. DOI:10.1016/j.pbb.2021.173107
25. Yan XJ, Feng CC, Liu Q, et al. Vagal afferents mediate antinociception of estrogen in a rat model of visceral pain: the involvement of intestinal mucosal mast cells and 5-hydroxytryptamine 3 signaling. J Pain. 2014;15(2):204-17. DOI:10.1016/j.jpain.2013.10.012
26. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci. 1996;16(21):7021-9. DOI:10.1523/JNEUROSCI.16-21-07021.1996
27. Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol. 2002;23(1):41-100. DOI:10.1006/frne.2001.0225
28. Martikainen IK, Hirvonen J, Kajander J, et al. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res. 2007;1172:21-31. DOI:10.1016/j.brainres.2007.07.036
29. Osikowicz M, Mika J, Przewlocka B. The glutamatergic system as a target for neuropathic pain relief. Exp Physiol. 2013;98(2):372-84. DOI:10.1113/expphysiol.2012.069922
30. Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008;38(1):66-77. DOI:10.1007/s12035-008-8034-z
31. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26(12):696-705. DOI:10.1016/j.tins.2003.09.017
32. Yankova M, Hart SA, Woolley CS. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc Natl Acad Sci USA. 2001;98(6):3525-30. DOI:10.1073/pnas.051624598
33. Castrillon EE, Cairns BE, Wang K, et al. Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women. Pain. 2012;153(4):823-9. DOI:10.1016/j.pain.2012.01.003
34. Tashiro A, Okamoto K, Bereiter DA. Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience. 2009;164(4):1813-20. DOI:10.1016/j.neuroscience.2009.09.058
35. Bäckström T, Haage D, Löfgren M, et al. Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience. 2011;191:46-54. DOI:10.1016/j.neuroscience.2011.03.061
36. Schweizer-Schubert S, Gordon JL, Eisenlohr-Moul TA, et al. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions. Front Med (Lausanne). 2021;7:479646. DOI:10.3389/fmed.2020.479646
37. Gintzler AR, Schnell SA, Gupta DS, et al. Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception.J Pharmacol Exp Ther. 2008;326(3):725-31. DOI:10.1124/jpet.108.139816
38. Gintzler AR, Liu NJ. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems. Transl Res. 2021;234:31-42. DOI:10.1016/j.trsl.2021.02.002
39. Cao DY, Ji Y, Tang B, Traub RJ. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13(7):685-94. DOI:10.1016/j.jpain.2012.04.010
40. Molina-Martínez LM, Juárez J. Differential expression of μ-opioid receptors in the nucleus accumbens, amygdala and VTA depends on liking for alcohol, chronic alcohol intake and estradiol treatment. Behav Brain Res. 2020;378:112255. DOI:10.1016/j.bbr.2019.112255
41. Farooqui M, Geng ZH, Stephenson EJ, et al. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006;5(3):611-20.
DOI:10.1158/1535-7163.MCT-05-0016
42. Sapir-Koren R, Livshits G. Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4(+) T-cells, and their interactions? Mol Cell Endocrinol. 2016;431:145-63. DOI:10.1016/j.mce.2016.05.009
43. Andersson A, Stubelius A, Karlsson MN, et al. Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther. 2015;17(1):32. DOI:10.1186/s13075-015-0548-y
44. Chen RY, Fan YM, Zhang Q, et al. Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter. J Immunol. 2015;194(8):4019-28. DOI:10.4049/jimmunol.1400806
45. Hang X, Zhang Z, Niu R, et al. Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis. J Inflamm Res. 2021;14:843-58. DOI:10.2147/JIR.S295222
46. Qu Q, Jiang S, Li X. Correlation between estrogen receptor-α gene polymorphism and rheumatoid arthritis in females. Panminerva Med. 2020. DOI:10.23736/S0031-0808.19.03806-0
47. Dziedziejko V, Kurzawski M, Safranow K, et al. Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis. Scand J Rheumatol. 2011;40(5):329-33. DOI:10.3109/03009742.2011.563752
2. Watt FE. Musculoskeletal pain and menopause. Post Reprod Health. 2018;24(1):34-43. DOI:10.1177/2053369118757537
3. Адамян Л.В., Андреева Е.Н., Аполихина И.А., и др. Менопауза и климактерическое состояние у женщины. Клинические рекомендации. М.: Российское общество акушеров-гинекологов, 2021 [Adamian LV, Andreeva EN, Apolikhina IA, et al. Menopauza i klimaktericheskoe sostoianie u zhenshchiny. Klinicheskie rekomendatsii. Moscow: Rossiiskoe obshchestvo akusherov-ginekologov, 2021 (in Russian)].
4. Barnabei VM, Cochrane BB, Aragaki AK, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol. 2005;105(5 Pt. 1):1063-73. DOI:10.1097/01.AOG.0000158120.47542.18
5. Ho SC, Chan SG, Yip YB, et al. Menopausal symptoms and symptom clustering in Chinese women. Maturitas. 1999;33(3):219-27. DOI:10.1016/s0378-5122(99)00056-0
6. Bardel A, Wallander MA, Wedel H, Svärdsudd K. Age-specific symptom prevalence in women 35-64 years old: a population-based study. BMC Public Health. 2009;9:37. DOI:10.1186/1471-2458-9-37
7. Horimoto Y, Saito M, Kasumi F. Arthralgia in 329 Patients Taking Aromatase Inhibitors. Breast Care (Basel). 2009;4(5):319-23. DOI:10.1159/000236050
8. Sestak I, Cuzick J, Sapunar F, et al. Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis. Lancet Oncol. 2008;9(9):866-72. DOI:10.1016/S1470-2045(08)70182-7
9. Laroche F, Coste J, Medkour T, et al. Classification of and risk factors for estrogen deprivation pain syndromes related to aromatase inhibitor treatments in women with breast cancer: a prospective multicenter cohort study. J Pain. 2014;15(3):293-303. DOI:10.1016/j.jpain.2013.11.004
10. Borrie AE, Rose FA, Choi YH, et al. Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients. Breast Cancer Res Treat. 2020;183(2):365-72. DOI:10.1007/s10549-020-05777-1
11. Neeck G, Crofford LJ. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am. 2000;26(4):989-1002.
DOI:10.1016/s0889-857x(05)70180-0; PMID: 11084955
12. Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: a comparative study. Clin Rheumatol. 2009;28(5):561-4. DOI:10.1007/s10067-009-1087-1
13. Vincent A, Whipple MO, Luedtke CA, et al. Pain and other symptom severity in women with fibromyalgia and a previous hysterectomy. J Pain Res. 2011;4:325-9. DOI:10.2147/JPR.S25490
14. Arslan HS, Nursal AF, Inanir A, et al. Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women. Endocr Metab Immune Disord Drug Targets. 2021;21(7):1326-32. DOI:10.2174/1871530320666200910110915
15. Koca T, Koçyiğit B, Seyithanoğlu M, Berk E. The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Arch Rheumatol. 2019;34(4):419-25.
DOI:10.5606/ArchRheumatol.2019.7236
16. Smith SB, Reenilä I, Männistö PT, et al. Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Pain. 2014;155(11):2390-9. DOI:10.1016/j.pain.2014.09.009
17. Malyala A, Kelly MJ, Rønnekleiv OK. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. 2005;70(5-7):397-406. DOI:10.1016/j.steroids.2005.03.004
18. Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 1997;388(4):507-25.
DOI:10.1002/(sici)1096-9861(19971201)388:4<507::aid-cne1>3.0.co;2-6
19. Zhang W, Wu H, Xu Q, et al. Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats. Biol Sex Differ. 2020;11(1):2. DOI:10.1186/s13293-019-0271-5
20. Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur. Acta Histochem Cytochem. 2007;40(1):27-34. DOI:10.1267/ahc.06015
21. Carlsten H. Immune responses and bone loss: the estrogen connection. Immunol Rev. 2005;208:194-206. DOI:10.1111/j.0105-2896.2005.00326.x
22. Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res. 2007;56(7):269-73. DOI:10.1007/s00011-007-6198-z
23. Ushiyama T, Mori K, Inoue K, et al. Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis. Ann Rheum Dis. 1999;58(1):7-10. DOI:10.1136/ard.58.1.7
24. Blanton HL, Barnes RC, McHann MC, et al. Sex differences and the endocannabinoid system in pain. Pharmacol Biochem Behav. 2021;202:173107. DOI:10.1016/j.pbb.2021.173107
25. Yan XJ, Feng CC, Liu Q, et al. Vagal afferents mediate antinociception of estrogen in a rat model of visceral pain: the involvement of intestinal mucosal mast cells and 5-hydroxytryptamine 3 signaling. J Pain. 2014;15(2):204-17. DOI:10.1016/j.jpain.2013.10.012
26. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci. 1996;16(21):7021-9. DOI:10.1523/JNEUROSCI.16-21-07021.1996
27. Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol. 2002;23(1):41-100. DOI:10.1006/frne.2001.0225
28. Martikainen IK, Hirvonen J, Kajander J, et al. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res. 2007;1172:21-31. DOI:10.1016/j.brainres.2007.07.036
29. Osikowicz M, Mika J, Przewlocka B. The glutamatergic system as a target for neuropathic pain relief. Exp Physiol. 2013;98(2):372-84. DOI:10.1113/expphysiol.2012.069922
30. Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008;38(1):66-77. DOI:10.1007/s12035-008-8034-z
31. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26(12):696-705. DOI:10.1016/j.tins.2003.09.017
32. Yankova M, Hart SA, Woolley CS. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc Natl Acad Sci USA. 2001;98(6):3525-30. DOI:10.1073/pnas.051624598
33. Castrillon EE, Cairns BE, Wang K, et al. Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women. Pain. 2012;153(4):823-9. DOI:10.1016/j.pain.2012.01.003
34. Tashiro A, Okamoto K, Bereiter DA. Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience. 2009;164(4):1813-20. DOI:10.1016/j.neuroscience.2009.09.058
35. Bäckström T, Haage D, Löfgren M, et al. Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience. 2011;191:46-54. DOI:10.1016/j.neuroscience.2011.03.061
36. Schweizer-Schubert S, Gordon JL, Eisenlohr-Moul TA, et al. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions. Front Med (Lausanne). 2021;7:479646. DOI:10.3389/fmed.2020.479646
37. Gintzler AR, Schnell SA, Gupta DS, et al. Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception.J Pharmacol Exp Ther. 2008;326(3):725-31. DOI:10.1124/jpet.108.139816
38. Gintzler AR, Liu NJ. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems. Transl Res. 2021;234:31-42. DOI:10.1016/j.trsl.2021.02.002
39. Cao DY, Ji Y, Tang B, Traub RJ. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13(7):685-94. DOI:10.1016/j.jpain.2012.04.010
40. Molina-Martínez LM, Juárez J. Differential expression of μ-opioid receptors in the nucleus accumbens, amygdala and VTA depends on liking for alcohol, chronic alcohol intake and estradiol treatment. Behav Brain Res. 2020;378:112255. DOI:10.1016/j.bbr.2019.112255
41. Farooqui M, Geng ZH, Stephenson EJ, et al. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006;5(3):611-20.
DOI:10.1158/1535-7163.MCT-05-0016
42. Sapir-Koren R, Livshits G. Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4(+) T-cells, and their interactions? Mol Cell Endocrinol. 2016;431:145-63. DOI:10.1016/j.mce.2016.05.009
43. Andersson A, Stubelius A, Karlsson MN, et al. Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther. 2015;17(1):32. DOI:10.1186/s13075-015-0548-y
44. Chen RY, Fan YM, Zhang Q, et al. Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter. J Immunol. 2015;194(8):4019-28. DOI:10.4049/jimmunol.1400806
45. Hang X, Zhang Z, Niu R, et al. Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis. J Inflamm Res. 2021;14:843-58. DOI:10.2147/JIR.S295222
46. Qu Q, Jiang S, Li X. Correlation between estrogen receptor-α gene polymorphism and rheumatoid arthritis in females. Panminerva Med. 2020. DOI:10.23736/S0031-0808.19.03806-0
47. Dziedziejko V, Kurzawski M, Safranow K, et al. Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis. Scand J Rheumatol. 2011;40(5):329-33. DOI:10.3109/03009742.2011.563752
________________________________________________
2. Watt FE. Musculoskeletal pain and menopause. Post Reprod Health. 2018;24(1):34-43. DOI:10.1177/2053369118757537
3. Adamian LV, Andreeva EN, Apolikhina IA, et al. Menopauza i klimaktericheskoe sostoianie u zhenshchiny. Klinicheskie rekomendatsii. Moscow: Rossiiskoe obshchestvo akusherov-ginekologov, 2021 (in Russian).
4. Barnabei VM, Cochrane BB, Aragaki AK, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative. Obstet Gynecol. 2005;105(5 Pt. 1):1063-73. DOI:10.1097/01.AOG.0000158120.47542.18
5. Ho SC, Chan SG, Yip YB, et al. Menopausal symptoms and symptom clustering in Chinese women. Maturitas. 1999;33(3):219-27. DOI:10.1016/s0378-5122(99)00056-0
6. Bardel A, Wallander MA, Wedel H, Svärdsudd K. Age-specific symptom prevalence in women 35-64 years old: a population-based study. BMC Public Health. 2009;9:37. DOI:10.1186/1471-2458-9-37
7. Horimoto Y, Saito M, Kasumi F. Arthralgia in 329 Patients Taking Aromatase Inhibitors. Breast Care (Basel). 2009;4(5):319-23. DOI:10.1159/000236050
8. Sestak I, Cuzick J, Sapunar F, et al. Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis. Lancet Oncol. 2008;9(9):866-72. DOI:10.1016/S1470-2045(08)70182-7
9. Laroche F, Coste J, Medkour T, et al. Classification of and risk factors for estrogen deprivation pain syndromes related to aromatase inhibitor treatments in women with breast cancer: a prospective multicenter cohort study. J Pain. 2014;15(3):293-303. DOI:10.1016/j.jpain.2013.11.004
10. Borrie AE, Rose FA, Choi YH, et al. Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients. Breast Cancer Res Treat. 2020;183(2):365-72. DOI:10.1007/s10549-020-05777-1
11. Neeck G, Crofford LJ. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am. 2000;26(4):989-1002.
DOI:10.1016/s0889-857x(05)70180-0; PMID: 11084955
12. Pamuk ON, Dönmez S, Cakir N. Increased frequencies of hysterectomy and early menopause in fibromyalgia patients: a comparative study. Clin Rheumatol. 2009;28(5):561-4. DOI:10.1007/s10067-009-1087-1
13. Vincent A, Whipple MO, Luedtke CA, et al. Pain and other symptom severity in women with fibromyalgia and a previous hysterectomy. J Pain Res. 2011;4:325-9. DOI:10.2147/JPR.S25490
14. Arslan HS, Nursal AF, Inanir A, et al. Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women. Endocr Metab Immune Disord Drug Targets. 2021;21(7):1326-32. DOI:10.2174/1871530320666200910110915
15. Koca T, Koçyiğit B, Seyithanoğlu M, Berk E. The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia. Arch Rheumatol. 2019;34(4):419-25.
DOI:10.5606/ArchRheumatol.2019.7236
16. Smith SB, Reenilä I, Männistö PT, et al. Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Pain. 2014;155(11):2390-9. DOI:10.1016/j.pain.2014.09.009
17. Malyala A, Kelly MJ, Rønnekleiv OK. Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes. Steroids. 2005;70(5-7):397-406. DOI:10.1016/j.steroids.2005.03.004
18. Shughrue PJ, Lane MV, Merchenthaler I. Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol. 1997;388(4):507-25.
DOI:10.1002/(sici)1096-9861(19971201)388:4<507::aid-cne1>3.0.co;2-6
19. Zhang W, Wu H, Xu Q, et al. Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats. Biol Sex Differ. 2020;11(1):2. DOI:10.1186/s13293-019-0271-5
20. Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur. Acta Histochem Cytochem. 2007;40(1):27-34. DOI:10.1267/ahc.06015
21. Carlsten H. Immune responses and bone loss: the estrogen connection. Immunol Rev. 2005;208:194-206. DOI:10.1111/j.0105-2896.2005.00326.x
22. Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res. 2007;56(7):269-73. DOI:10.1007/s00011-007-6198-z
23. Ushiyama T, Mori K, Inoue K, et al. Association of oestrogen receptor gene polymorphisms with age at onset of rheumatoid arthritis. Ann Rheum Dis. 1999;58(1):7-10. DOI:10.1136/ard.58.1.7
24. Blanton HL, Barnes RC, McHann MC, et al. Sex differences and the endocannabinoid system in pain. Pharmacol Biochem Behav. 2021;202:173107. DOI:10.1016/j.pbb.2021.173107
25. Yan XJ, Feng CC, Liu Q, et al. Vagal afferents mediate antinociception of estrogen in a rat model of visceral pain: the involvement of intestinal mucosal mast cells and 5-hydroxytryptamine 3 signaling. J Pain. 2014;15(2):204-17. DOI:10.1016/j.jpain.2013.10.012
26. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci. 1996;16(21):7021-9. DOI:10.1523/JNEUROSCI.16-21-07021.1996
27. Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front Neuroendocrinol. 2002;23(1):41-100. DOI:10.1006/frne.2001.0225
28. Martikainen IK, Hirvonen J, Kajander J, et al. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Res. 2007;1172:21-31. DOI:10.1016/j.brainres.2007.07.036
29. Osikowicz M, Mika J, Przewlocka B. The glutamatergic system as a target for neuropathic pain relief. Exp Physiol. 2013;98(2):372-84. DOI:10.1113/expphysiol.2012.069922
30. Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol. 2008;38(1):66-77. DOI:10.1007/s12035-008-8034-z
31. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26(12):696-705. DOI:10.1016/j.tins.2003.09.017
32. Yankova M, Hart SA, Woolley CS. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc Natl Acad Sci USA. 2001;98(6):3525-30. DOI:10.1073/pnas.051624598
33. Castrillon EE, Cairns BE, Wang K, et al. Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women. Pain. 2012;153(4):823-9. DOI:10.1016/j.pain.2012.01.003
34. Tashiro A, Okamoto K, Bereiter DA. Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience. 2009;164(4):1813-20. DOI:10.1016/j.neuroscience.2009.09.058
35. Bäckström T, Haage D, Löfgren M, et al. Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons. Neuroscience. 2011;191:46-54. DOI:10.1016/j.neuroscience.2011.03.061
36. Schweizer-Schubert S, Gordon JL, Eisenlohr-Moul TA, et al. Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions. Front Med (Lausanne). 2021;7:479646. DOI:10.3389/fmed.2020.479646
37. Gintzler AR, Schnell SA, Gupta DS, et al. Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception.J Pharmacol Exp Ther. 2008;326(3):725-31. DOI:10.1124/jpet.108.139816
38. Gintzler AR, Liu NJ. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems. Transl Res. 2021;234:31-42. DOI:10.1016/j.trsl.2021.02.002
39. Cao DY, Ji Y, Tang B, Traub RJ. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13(7):685-94. DOI:10.1016/j.jpain.2012.04.010
40. Molina-Martínez LM, Juárez J. Differential expression of μ-opioid receptors in the nucleus accumbens, amygdala and VTA depends on liking for alcohol, chronic alcohol intake and estradiol treatment. Behav Brain Res. 2020;378:112255. DOI:10.1016/j.bbr.2019.112255
41. Farooqui M, Geng ZH, Stephenson EJ, et al. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther. 2006;5(3):611-20.
DOI:10.1158/1535-7163.MCT-05-0016
42. Sapir-Koren R, Livshits G. Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4(+) T-cells, and their interactions? Mol Cell Endocrinol. 2016;431:145-63. DOI:10.1016/j.mce.2016.05.009
43. Andersson A, Stubelius A, Karlsson MN, et al. Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis. Arthritis Res Ther. 2015;17(1):32. DOI:10.1186/s13075-015-0548-y
44. Chen RY, Fan YM, Zhang Q, et al. Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter. J Immunol. 2015;194(8):4019-28. DOI:10.4049/jimmunol.1400806
45. Hang X, Zhang Z, Niu R, et al. Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis. J Inflamm Res. 2021;14:843-58. DOI:10.2147/JIR.S295222
46. Qu Q, Jiang S, Li X. Correlation between estrogen receptor-α gene polymorphism and rheumatoid arthritis in females. Panminerva Med. 2020. DOI:10.23736/S0031-0808.19.03806-0
47. Dziedziejko V, Kurzawski M, Safranow K, et al. Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis. Scand J Rheumatol. 2011;40(5):329-33. DOI:10.3109/03009742.2011.563752
Авторы
Т.С. Паневин*, А.О. Бобкова, А.Е. Каратеев, Е.Г. Зоткин
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия
*tarasel@list.ru
Nasonova Research Institute of Rheumatology, Moscow, Russia
*tarasel@list.ru
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия
*tarasel@list.ru
________________________________________________
Nasonova Research Institute of Rheumatology, Moscow, Russia
*tarasel@list.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.