Сартаны в лечении артериальной гипертензии: фокус на телмисартан и азилсартан

1. Mehta JK, Kaur G, Buttar HS, et al. Role of the renin-angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products. Front Physiol. 2023;14:1034170. DOI:10.3389/fphys.2023.1034170
2. Bhardwaj G. How the antihypertensive losartan was discovered. Expert Opin Drug Discov. 2006;1(6):609-18. DOI:10.1517/17460441.1.6.609
3. Государственный реестр лекарственных средств. Режим доступа: https://grls.rosminzdrav.ru/Default.aspx. Ссылка активна на 15.07.2023 [State register of medicines. Available at: https://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.07.2023 (in Russian)].
4. Turnbull F; Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527-35. DOI:10.1016/s0140-6736(03)14739-3
5. Baguet JP, Robitail S, Boyer L, et al. A meta-analytical approach to the efficacy of antihypertensive drugs in reducing blood pressure. Am J Cardiovasc Drugs.
2005;5(2):131-40. DOI:10.2165/00129784-200505020-00007
6. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665. DOI:10.1136/bmj.b1665
7. Wei J, Galaviz KI, Kowalski AJ, et al. Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications: A Systematic Review and Network Meta-analysis. JAMA Netw Open. 2020;3(2):e1921618. DOI:10.1001/jamanetworkopen.2019.21618
8. Klingbeil AU, Schneider M, Martus P, et al. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med. 2003;115(1):41-6. DOI:10.1016/s0002-9343(03)00158-x
9. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021‑104. DOI:10.1093/eurheartj/ehy339
10. Messerli FH, Bangalore S, Bavishi C, Rimoldi SF. Angiotensin-Converting Enzyme Inhibitors in Hypertension: To Use or Not to Use? J Am Coll Cardiol. 2018;71(13):1474-82. DOI:10.1016/j.jacc.2018.01.058
11. Wu VC, Lin YF, Teng NC, et al. Angiotensin II Receptor Blocker Associated With Less Outcome Risk in Patients With Acute Kidney Disease. Front Pharmacol. 2022;13:714658. DOI:10.3389/fphar.2022.714658
12. Yang SY, Huang TM, Lai TS, et al. Nsarf Study Group. Angiotensin II Receptor Blockers but Not Angiotensin-Converting Enzyme Inhibitors Are Associated With a Reduced Risk of Acute Kidney Injury After Major Surgery. Front Pharmacol. 2021;12:662301. DOI:10.3389/fphar.2021.662301
13. Zaiken K, Cheng JW. Azilsartan medoxomil: a new Angiotensin receptor blocker. Clin Ther. 2011;33(11):1577-89. DOI:10.1016/j.clinthera.2011.10.007
14. Ojima M, Igata H, Tanaka M, et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011;336(3):801-8. DOI:10.1124/jpet.110.176636
15. Westerink J, Visseren F. Cardiovasc Pharmacological and nonpharmacological interventions to influence adipose tissue function. Cardiovasc Diabetol. 2011;10(13):18. DOI:10.1186/1475-2840-10-13
16. Ayza MA, Zewdie KA, Tesfaye BA, et al. Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity. Diabetes Metab Syndr Obes. 2020;13:3627-35. DOI:10.2147/DMSO.S265399
17. Benndorf RA, Rudolph T, Appel D, et al. Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension. Metabolism. 2006;55(9):1159-64. DOI:10.1016/j.metabol.2006.04.013
18. Usui I, Fujisaka S, Yamazaki K, et al. Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients. Diabetes Res Clin Pract. 2007;77(2):210-4. DOI:10.1016/j.diabres.2006.11.014
19. Kiyici S, Guclu M, Budak F, et al. Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome. Metab Syndr Relat Disord. 2019;17(3):167-72. DOI:10.1089/met.2018.0129
20. Shimabukuro M, Tanaka H, Shimabukuro T. Effects of telmisartan on fat distribution in individuals with the metabolic syndrome. J Hypertens. 2007;25(4):841-8. DOI:10.1097/HJH.0b013e3280287a83
21. Suksomboon N, Poolsup N, Prasit T. Systematic review of the effect of telmisartan on insulin sensitivity in hypertensive patients with insulin resistance or diabetes. J Clin Pharm Ther. 2012;37(3):319-27. DOI:10.1111/j.1365-2710.2011.01295.x
22. Takagi H, Umemoto T; All-Literature Investigation of Cardiovascular Evidence Group. A meta-analysis of randomized trials of telmisartan versus active controls for insulin resistance in hypertensive patients. J Am Soc Hypertens. 2014;8(8):578-92. DOI:10.1016/j.jash.2014.05.006
23. Parati G, Schumacher H, Bilo G, Mancia G. Evaluating 24-h antihypertensive efficacy by the smoothness index: a meta-analysis of an ambulatory blood pressure monitoring database. J Hypertens. 2010;28(11):2177-83. DOI:10.1097/HJH.0b013e32833e1150
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28. Lacourcière Y, Neutel JM, Davidai G, et al. A multicenter, 14-week study of telmisartan and ramipril in patients with mild-to-moderate hypertension using ambulatory blood pressure monitoring. Am J Hypertens. 2006;19:104-12. DOI:10.1016/j.amjhyper.2005.10.001
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35. Wang JG, Zhang M, Feng YQ, et al. Is the newest angiotensin-receptor blocker azilsartan medoxomil more efficacious in lowering blood pressure than the older ones? A systematic review and network meta-analysis. J Clin Hypertens (Greenwich). 2021;23(5):901-14. DOI:10.1111/jch.14227
36. Kumari K, Toppo MS, Majhi L, Kumar A. Blood pressure-lowering effect of telmisartan compared to losartan among mild to moderate essential hypertensive adult subjects: A meta-analysis. J Family Med Prim Care. 2022;11(10):6227-35. DOI:10.4103/jfmpc.jfmpc_787_22
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47. Rakugi H, Enya K, Sugiura K, Ikeda Y. Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study. Hypertens Res. 2012;35(5):552-8. DOI:10.1038/hr.2012.8
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51. Baker WL, White WB. Azilsartan medoxomil: a new angiotensin II receptor antagonist for treatment of hypertension. Ann Pharmacother. 2011;45(12):1506-15. DOI:10.1345/aph.1Q468
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65. Asmar R, Gosse P, Topouchian J, et al. Effects of telmisartan on arterial stiffness in Type 2 diabetes patients with essential hypertension. J Renin Angiotensin Aldosterone Syst. 2003;3:176-80. DOI:10.3317/jraas.2002.038
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1. Mehta JK, Kaur G, Buttar HS, et al. Role of the renin-angiotensin system in the pathophysiology of coronary heart disease and heart failure: Diagnostic biomarkers and therapy with drugs and natural products. Front Physiol. 2023;14:1034170. DOI:10.3389/fphys.2023.1034170
2. Bhardwaj G. How the antihypertensive losartan was discovered. Expert Opin Drug Discov. 2006;1(6):609-18. DOI:10.1517/17460441.1.6.609
3. State register of medicines. Available at: https://grls.rosminzdrav.ru/Default.aspx. Accessed: 15.07.2023 (in Russian).
4. Turnbull F; Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527-35. DOI:10.1016/s0140-6736(03)14739-3
5. Baguet JP, Robitail S, Boyer L, et al. A meta-analytical approach to the efficacy of antihypertensive drugs in reducing blood pressure. Am J Cardiovasc Drugs.
2005;5(2):131-40. DOI:10.2165/00129784-200505020-00007
6. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665. DOI:10.1136/bmj.b1665
7. Wei J, Galaviz KI, Kowalski AJ, et al. Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications: A Systematic Review and Network Meta-analysis. JAMA Netw Open. 2020;3(2):e1921618. DOI:10.1001/jamanetworkopen.2019.21618
8. Klingbeil AU, Schneider M, Martus P, et al. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med. 2003;115(1):41-6. DOI:10.1016/s0002-9343(03)00158-x
9. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021‑104. DOI:10.1093/eurheartj/ehy339
10. Messerli FH, Bangalore S, Bavishi C, Rimoldi SF. Angiotensin-Converting Enzyme Inhibitors in Hypertension: To Use or Not to Use? J Am Coll Cardiol. 2018;71(13):1474-82. DOI:10.1016/j.jacc.2018.01.058
11. Wu VC, Lin YF, Teng NC, et al. Angiotensin II Receptor Blocker Associated With Less Outcome Risk in Patients With Acute Kidney Disease. Front Pharmacol. 2022;13:714658. DOI:10.3389/fphar.2022.714658
12. Yang SY, Huang TM, Lai TS, et al. Nsarf Study Group. Angiotensin II Receptor Blockers but Not Angiotensin-Converting Enzyme Inhibitors Are Associated With a Reduced Risk of Acute Kidney Injury After Major Surgery. Front Pharmacol. 2021;12:662301. DOI:10.3389/fphar.2021.662301
13. Zaiken K, Cheng JW. Azilsartan medoxomil: a new Angiotensin receptor blocker. Clin Ther. 2011;33(11):1577-89. DOI:10.1016/j.clinthera.2011.10.007
14. Ojima M, Igata H, Tanaka M, et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther. 2011;336(3):801-8. DOI:10.1124/jpet.110.176636
15. Westerink J, Visseren F. Cardiovasc Pharmacological and nonpharmacological interventions to influence adipose tissue function. Cardiovasc Diabetol. 2011;10(13):18. DOI:10.1186/1475-2840-10-13
16. Ayza MA, Zewdie KA, Tesfaye BA, et al. Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity. Diabetes Metab Syndr Obes. 2020;13:3627-35. DOI:10.2147/DMSO.S265399
17. Benndorf RA, Rudolph T, Appel D, et al. Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension. Metabolism. 2006;55(9):1159-64. DOI:10.1016/j.metabol.2006.04.013
18. Usui I, Fujisaka S, Yamazaki K, et al. Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients. Diabetes Res Clin Pract. 2007;77(2):210-4. DOI:10.1016/j.diabres.2006.11.014
19. Kiyici S, Guclu M, Budak F, et al. Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome. Metab Syndr Relat Disord. 2019;17(3):167-72. DOI:10.1089/met.2018.0129
20. Shimabukuro M, Tanaka H, Shimabukuro T. Effects of telmisartan on fat distribution in individuals with the metabolic syndrome. J Hypertens. 2007;25(4):841-8. DOI:10.1097/HJH.0b013e3280287a83
21. Suksomboon N, Poolsup N, Prasit T. Systematic review of the effect of telmisartan on insulin sensitivity in hypertensive patients with insulin resistance or diabetes. J Clin Pharm Ther. 2012;37(3):319-27. DOI:10.1111/j.1365-2710.2011.01295.x
22. Takagi H, Umemoto T; All-Literature Investigation of Cardiovascular Evidence Group. A meta-analysis of randomized trials of telmisartan versus active controls for insulin resistance in hypertensive patients. J Am Soc Hypertens. 2014;8(8):578-92. DOI:10.1016/j.jash.2014.05.006
23. Parati G, Schumacher H, Bilo G, Mancia G. Evaluating 24-h antihypertensive efficacy by the smoothness index: a meta-analysis of an ambulatory blood pressure monitoring database. J Hypertens. 2010;28(11):2177-83. DOI:10.1097/HJH.0b013e32833e1150
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В.Д. Закиев*, Ю.В. Котовская, О.Н. Ткачева

ОСП «Российский геронтологический научно-клинический центр» ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия
*zakiev739@gmail.com

________________________________________________

Vadim D. Zakiev*, Yulia V. Kotovskaya, Olga N. Tkacheva

Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University, Moscow, Russia
*zakiev739@gmail.com