Shariya MA, Ustyuzhanin DV, Zhirov IV, Osmolovskaya YuF, Tereshchenko SN. Evaluation of the results of magnetic resonance imaging of the brain for cognitive impairment in patients with heart failure: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(9):909–913. DOI: 10.26442/00403660.2024.09.202853
Оценка результатов магнитно-резонансной томографии головного мозга при когнитивных нарушениях у пациентов с сердечной недостаточностью
Шария М.А., Устюжанин Д.В., Жиров И.В., Осмоловская Ю.Ф., Терещенко С.Н. Оценка результатов магнитно-резонансной томографии головного мозга при когнитивных нарушениях у пациентов с сердечной недостаточностью. Терапевтический архив. 2024;96(9):909–913. DOI: 10.26442/00403660.2024.09.202853
Shariya MA, Ustyuzhanin DV, Zhirov IV, Osmolovskaya YuF, Tereshchenko SN. Evaluation of the results of magnetic resonance imaging of the brain for cognitive impairment in patients with heart failure: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(9):909–913. DOI: 10.26442/00403660.2024.09.202853
Когнитивные нарушения (КН) являются очень частой сопутствующей патологией у больных с сердечной недостаточностью (СН). У пациентов с СН наблюдаются признаки ухудшения памяти, трудности с концентрацией и дефицит внимания. Когнитивная дисфункция при СН связана с неблагоприятным прогнозом. Тем не менее в рутинной клинической практике уделяется недостаточно внимания диагностике КН при СН. Для выявления КН доступны нейропсихологические скрининговые тесты, однако их редко используют. Следовательно, практический интерес представляет поиск магнитно-резонансных эквивалентов когнитивных расстройств. Обсуждаются вопросы использования магнитно-резонансной томографии как инструмента идентификации и количественной оценки нейронных коррелятов когнитивных функций.
Ключевые слова: сердечная недостаточность, магнитно-резонансная томография, когнитивные нарушения, фракция выброса левого желудочка, церебральная перфузия, очаговые изменения в белом веществе, атрофия серого вещества
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Cognitive impairment is a very common comorbidity in patients with heart failure (HF). Patients with HF show signs of memory decline, difficulty concentrating, and attention deficits. Cognitive dysfunction in HF is associated with a poor prognosis. However, the diagnosis of cognitive impairment in heart failure has received insufficient attention in routine clinical practice. Neuropsychological screening tests are available to screen for cognitive impairment, but they are used infrequently. Therefore, it is of practical interest to search for magnetic resonance equivalents of cognitive disorders. The use of magnetic resonance imaging as a tool for identifying and quantifying neural correlates of cognitive functions is discussed.
Keywords: heart failure, magnetic resonance imaging, cognitive impairment, left ventricular ejection fraction, cerebral perfusion, brain white matter hyperintensities, gray matter atrophy
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3. Markousis-Mavrogenis G, Noutsias M, Rigopoulos AG, et al. The Emerging Role of Combined Brain/Heart Magnetic Resonance Imaging for the Evaluation of Brain/Heart Interaction in Heart Failure. J Clin Med. 2022;11(14):4009. DOI:10.3390/jcm11144009
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8. Farokhian F, Yang C, Beheshti I, et al. Age-Related Gray and White Matter Changes in Normal Adult Brains. Aging Dis. 2017;8(6):899-909. DOI:10.14336/AD.2017.0502
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10. Almeida OP, Garrido GJ, Etherton-Beer C, et al. Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease. Eur J Heart Fail. 2013;15(8):850-8. DOI:10.1093/eurjhf/hft029
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14. Stegmann T, Chu ML, Witte VA, et al. Heart failure is independently associated with white matter lesions: insights from the population-based LIFE-Adult Study. ESC Heart Fail. 2021;8(1):697-704. DOI:10.1002/ehf2.13166
15. Mueller K, Thiel F, Beutner F, et al. Brain Damage with Heart Failure: Cardiac Biomarker Alterations and Gray Matter Decline. Circ Res. 2020;126(6):750-64. DOI:10.1161/CIRCRESAHA.119.315813
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18. Doehner W, Ural D, Haeusler KG, et al. Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association. Eur J Heart Fail. 2018;20(2):199-215. DOI:10.1002/ejhf.1100
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1. Pressler SJ, Kim J, Riley P, et al. Memory dysfunction, psychomotor slowing, and decreased executive function predict mortality in patients with heart failure and low ejection fraction. J Card Fail. 2010;16(9):750-60. DOI:10.1016/j.cardfail.2010.04.007
2. Jefferson AL, Himali JJ, Au R, et al. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol. 2011;108(9):1346-51. DOI:10.1016/j.amjcard.2011.06.056
3. Markousis-Mavrogenis G, Noutsias M, Rigopoulos AG, et al. The Emerging Role of Combined Brain/Heart Magnetic Resonance Imaging for the Evaluation of Brain/Heart Interaction in Heart Failure. J Clin Med. 2022;11(14):4009. DOI:10.3390/jcm11144009
4. Goh FQ, Kong WKF, Wong RCC, et al. Cognitive Impairment in Heart Failure-A Review. Biology (Basel). 2022;11(2):179. DOI:10.3390/biology11020179
5. Almeida OP, Garrido GJ, Beer C, et al. Cognitive and brain changes associated with ischaemic heart disease and heart failure. Eur Heart J. 2012;33(14):1769-76. DOI:10.1093/eurheartj/ehr467
6. Volel’ BA, Akhapkin RV, Ustyuzhanin DV, et al. Neuroimaging techniques in the diagnosis and treatment of depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2):163‑8 (in Russian). DOI:10.17116/jnevro201711721163-168
7. Zashezova MKh, Ustyuzhanin DV, Kaverina AR, et al. Features of activation of the default mode network in people with a high level of chronic stress. Russian Electronic Journal of Radiology. 2017;7(3):31-9 (in Russian). DOI:10.21569/2222-7415-2017-7-3-31-39
8. Farokhian F, Yang C, Beheshti I, et al. Age-Related Gray and White Matter Changes in Normal Adult Brains. Aging Dis. 2017;8(6):899-909. DOI:10.14336/AD.2017.0502
9. Woo MA, Macey PM, Fonarow GC, et al. Regional brain gray matter loss in heart failure. J Appl Physiol (1985). 2003;95(2):677-84. DOI:10.1152/japplphysiol.00101.2003
10. Almeida OP, Garrido GJ, Etherton-Beer C, et al. Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease. Eur J Heart Fail. 2013;15(8):850-8. DOI:10.1093/eurjhf/hft029
11. Frey A, Homola GA, Henneges C, et al. Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure-the COGNITION.MATTERS-HF cohort study. Eur Heart J. 2021;42(16):1569-78. DOI:10.1093/eurheartj/ehab003
12. Vogels RLС, van der Flier WM, Van Harten B, et al. Brain magnetic resonance imaging abnormalities in patients with heart failure. Eur J Hear Fail. 2007;9(10):1003-9. DOI:10.1016/j.ejheart.2007.07.006
13. Alosco ML, Brickman AM, Spitznagel MB, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congest Heart Fail. 2013;19(4):E29-34. DOI:10.1111/chf.12025
14. Stegmann T, Chu ML, Witte VA, et al. Heart failure is independently associated with white matter lesions: insights from the population-based LIFE-Adult Study. ESC Heart Fail. 2021;8(1):697-704. DOI:10.1002/ehf2.13166
15. Mueller K, Thiel F, Beutner F, et al. Brain Damage with Heart Failure: Cardiac Biomarker Alterations and Gray Matter Decline. Circ Res. 2020;126(6):750-64. DOI:10.1161/CIRCRESAHA.119.315813
16. Bennett J, van Dinther M, Voorter P, et al. Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease. Medicina (Kaunas). 2023;59(9):1596. DOI:10.3390/medicina59091596
17. Chen X, Wang J, Shan Y, et al. Cerebral small vessel disease: neuroimaging markers and clinical implication. J Neurol. 2019;266(10):2347-62. DOI:10.1007/s00415-018-9077-3
18. Doehner W, Ural D, Haeusler KG, et al. Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association. Eur J Heart Fail. 2018;20(2):199-215. DOI:10.1002/ejhf.1100
1ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России, Москва, Россия; 2ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия; 3ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Москва, Россия
*izhirov@mail.ru
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Merab A. Shariya1,2, Dmitry V. Ustyuzhanin1, Igor V. Zhirov*1,3, Yulia F. Osmolovskaya1, Sergey N. Tereshchenko1,3
1Chazov National Medical Research Center of Cardiology, Moscow, Russia; 2Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; 3Russian Medical Academy of Continuous Professional Education, Moscow, Russia
*izhirov@mail.ru