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        • Журнал Терапевтический архив №10 Вопросы эндокринологии
        • Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке - Журнал Терапевтический архив №10 Вопросы эндокринологии 2025

        Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке - Журнал Терапевтический архив №10 Вопросы эндокринологии 2025

        Кондратьева Л.В., Попкова Т.В., Насонов Е.Л. Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке. Терапевтический архив. 2025;97(10):875–882. DOI: 10.26442/00403660.2025.10.203370

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.

        ________________________________________________

        Kondratyeva LV, Popkova TV, Nasonov EL. Type 2 diabetes mellitus in rheumatoid arthritis and systemic lupus erythematosus: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(10):875–882. DOI: 10.26442/00403660.2025.10.203370

        Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке

        Кондратьева Л.В., Попкова Т.В., Насонов Е.Л. Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке. Терапевтический архив. 2025;97(10):875–882. DOI: 10.26442/00403660.2025.10.203370

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.

        ________________________________________________

        Kondratyeva LV, Popkova TV, Nasonov EL. Type 2 diabetes mellitus in rheumatoid arthritis and systemic lupus erythematosus: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(10):875–882. DOI: 10.26442/00403660.2025.10.203370

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          Сахарный диабет 2-го типа при ревматоидном артрите и системной красной волчанке

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        • Аннотация
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        Аннотация
        Иммуновоспалительные ревматические заболевания (ИВРЗ), такие как ревматоидный артрит и системная красная волчанка, характеризуются едиными механизмами развития и сходной коморбидной патологией, включая сахарный диабет 2-го типа (СД 2). Больные ИВРЗ с сопутствующим СД представляют собой одну из наиболее тяжелых для курации групп из-за серьезных осложнений и вынужденной полипрагмазии. В статье рассмотрены факторы риска нарушений углеводного обмена, как традиционные, так и непосредственно связанные с ревматоидным артритом и системной красной волчанкой, в том числе влияние противовоспалительной терапии на инсулинорезистентность, риск СД 2 и контроль гликемии, позитивные для лечения ИВРЗ плейотропные свойства некоторых сахароснижающих препаратов, а также показаны перспективы дальнейших клинических исследований в данной области.

        Ключевые слова: ревматоидный артрит, системная красная волчанка, сахарный диабет 2-го типа, инсулинорезистентность, провоспалительные цитокины, интерферон I типа

        ________________________________________________

        Immunoinflammatory rheumatic diseases (IIRD), such as rheumatoid arthritis and systemic lupus erythematosus, are characterized by common mechanisms of development and similar comorbid pathology, including diabetes mellitus (DM) type 2. Patients with IIRD with concomitant DM represent one of the most difficult groups to manage due to serious complications and forced polypharmacy. The article considers risk factors for carbohydrate metabolism disorders, both traditional and directly associated with rheumatoid arthritis and systemic lupus erythematosus, including the effect of anti-inflammatory therapy on insulin resistance, the risk of DM type 2 and glycemic control, as well as positive pleiotropic properties of some hypoglycemic drugs for the treatment of IIRD, and shows the prospects for further clinical research in this area.

        Keywords: rheumatoid arthritis, systemic lupus erythematosus, type 2 diabetes mellitus, insulin resistance, proinflammatory cytokines, type I interferon

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        Авторы
        Л.В. Кондратьева*1, Т.В. Попкова1, Е.Л. Насонов1,2

        1ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», Москва, Россия;
        2ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия
        *kondratyeva.liubov@yandex.ru

        ________________________________________________

        Liubov V. Kondratyeva*1, Tatiana V. Popkova1, Evgeny L. Nasonov1,2

        1Nasonova Research Institute of Rheumatology, Moscow, Russia;
        2Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
        *kondratyeva.liubov@yandex.ru


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