1. Kim SK, Guevarra RB, Kim YT, et al. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol. 2019;29(9):1335-40. DOI:10.4014/jmb.1906.06064
2. Liong MT. Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence. Int J Mol Sci. 2008;9(5):854-63. DOI:10.3390/ijms9050854
3. Mohd Fuad AS, Amran NA, Nasruddin NS, et al. The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management. Probiotics Antimicrob Proteins. 2023;15:1298-311. DOI:10.1007/s12602-022-09985-7
4. Holzapfel WH, Haberer P, Geisen R, et al. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr. 2001;73(2 Suppl.):365S-373S. DOI:10.1093/ajcn/73.2.365s
5. Wilkins T, Sequoia J. Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. Am Fam Physician. 2017;96(3):170-8.
6. Gao H, Li X, Chen X, et al. The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes. J Microbiol Biotechnol. 2022;32(10):1226-33. DOI:10.4014/jmb.2205.05041
7. Claesson MJ, van Sinderen D, O'Toole PW. The genus Lactobacillus – a genomic basis for understanding its diversity. FEMS Microbiol Lett. 2007;269(1):22-8. DOI:10.1111/j.1574-6968.2006.00596.x
8. Singh VP, Sharma J, Babu S, et al. Role of probiotics in health and disease: a review. J Pak Med Assoc. 2013;63(2):253-7.
9. EFSA Panel on Biological Hazards (BIOHAZ). Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 3: Suitability of taxonomic units notified to EFSA until September 2015. EFSA Journal. 2015;13(12):4331. DOI:10.2903/j.efsa.2015.4331
10. Jungersen M, Wind A, Johansen E, et al. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12((R)). Microorganisms. 2014;2(2):92-110. DOI:10.3390/microorganisms2020092
11. He F, Ouwehan AC, Hashimoto H, et al. Adhesion of Bifidobacterium spp. to human intestinal mucus. Microbiol Immunol. 2001;45(3):259-62. DOI:10.1111/j.1348-0421.2001.tb02615.x
12. Juntunen M, Kirjavainen PV, Ouwehand AC, et al. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol. 2001;8(2):293-6. DOI:10.1128/CDLI.8.2.293-296.2001
13. Martins FS, Silva AA, Vieira AT, et al. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol. 2009;191(8):623-30. DOI:10.1007/s00203-009-0491-x
14. Food and Drug Administration. GRAS Notice Inventory > Agency Response Letter GRAS Notice No GRN 000049. 2002.
15. Selvaraj V, Alsamman MA. Antibiotic-Associated Diarrhea Beyond C. Difficile: A Scoping Review. Brown J Hosp Med. 2023;2(1):39745. DOI:10.56305/001c.39745
16. Zhang SW, Zhi X, Wang MY, Shen DL. [A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26(10):1108-14 (in Chinese). DOI:10.7499/j.issn.1008-8830.2401129
17. Zhang L, Zeng X, Guo D, et al. Early use of probiotics might prevent antibiotic-associated diarrhea in elderly (>65 years): a systematic review and meta-analysis. BMC Geriatr. 2022;22(1):562. DOI:10.1186/s12877-022-03257-3
18. Long B, Gottlieb M. Probiotics for Preventing Antibiotic-Associated Diarrhea. Am Fam Physician. 2021;104(6):Online.
19. Chatterjee S, Kar P, Das T, et al. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea. J Assoc Physicians India. 2013;61(10):708-12.
20. Горелов А.В., Андреева И.В., Захаренко С.М., Синопальников А.И. Применение пробиотиков, содержащих комбинацию штаммов Lactobacillus acidophilus LA-5 и Bifidobacterium animalis subsp. lactis BB-12: метаанализ эффективности для профилактики антибиотик-ассоциированной диареи и в схемах эрадикационной терапии Helicobacter pylori. Терапия. 2023;10:74-82 [Gorelov AV, Andreeva IV, Zakharenko SM, Sinopalnikov AI. The use of probiotics containing a combination of lactobacillus acidophilus LA-5 and bifidobacterium animalis subsp. Lactis BB-12 strains: meta-analysis of efficacy in the prevention of antibiotic-associated diarrhea and in helicobacter pylori eradication therapy. Terapiia. 2023;10:74-82 (in Russian)]. DOI:10.18565/therapy.2023.10.74-82
21. Czepiel J, Drozdz M, Pituch H, et al. Clostridium difficile infection: review. Eur J Clin Microbiol Infect Dis. 2019;38(7):1211-21. DOI:10.1007/s10096-019-03539-6
22. Liu C, Monaghan T, Yadegar A, et al. Insights into the Evolving Epidemiology of Clostridioides difficile Infection and Treatment: A Global Perspective. Antibiotics (Basel). 2023;12(7):1141. DOI:10.3390/antibiotics12071141
23. Успенский Ю.П., Барышникова Н.В. Антибиотик-ассоциированная диарея в условиях стационара: частота встречаемости и вопросы профилактики. Медицинский алфавит. 2021;20:35-7 [Uspenskiy YuP, Baryshnikova NV. Antibiotic-associated diarrhea in hospital: frequency and prophylaxis. Meditsinskii Alfavit. 2021;20:35-7 (in Russian)]. DOI:10.33667/2078-5631-2021-20-35-37
24. Ермоленко К.Д., Потапова Т.В., Силав К.В., и др. Прогнозирование течения антибиотико-ассоциированной диареи, вызванной Clostridioides difficile, на основе клинико-лабораторных характеристик заболевания. Терапевтический архив. 2024;96(11):1042-8 [Ermolenko KD, Potapova TV, Silav KV, et al. Prediction of the course of antibiotic-associated diarrhea caused by Clostridioides difficile based on clinical and laboratory characteristics of the disease. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(11):1042-8 (in Russian)]. DOI:10.26442/00403660.2024.11.203040
25. Leffler DA, Lamont JT. Clostridium difficile Infection. N Engl J Med. 2015;373(3):287-8. DOI:10.1056/NEJMc1506004
26. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;346(5):334-9. DOI:10.1056/NEJMcp011603
27. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
28. Nyssen OP, Perez-Aisa A, Tepes B, et al. Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). Am J Gastroenterol. 2021;116(6):1220-9. DOI:10.14309/ajg.0000000000001246
29. Hafeez M, Qureshi ZA, Khattak AL, et al. Helicobacter Pylori Eradication Therapy: Still a Challenge. Cureus. 2021;13(5):e14872. DOI:10.7759/cureus.14872
30. Yang Z, Zhou Y, Han Z, et al. The effects of probiotics supplementation on Helicobacter pylori standard treatment: an umbrella review of systematic reviews with meta-analyses. Sci Rep. 2024;14(1):10069. DOI:10.1038/s41598-024-59399-4
31. Tanashat M, Abuelazm M, Abouzid M, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424-44. DOI:10.1016/j.clnesp.2024.11.016
32. Guarner F, Sanders ME, Szajewska H, et al. World Gastroenterology Organisation Global Guidelines. Probiotics and Prebiotics. 2023;52.
33. Российская гастроэнтерологическая ассоциация. Ассоциация «Эндоскопическое общество „РЭндО“». Межрегиональная ассоциация по клинической микробиологии и антимикробной химиотерапии. Межрегиональная общественная организация «Научное сообщество по содействию клиническому изучению микробиома человека». Клинические рекомендации. Гастрит и дуоденит. 2024 [Rossiiskaia gastroenterologicheskaia assotsiatsiia. Assotsiatsiia „Endoskopicheskoe obshchestvo „REndO“. Mezhregionalnaia assotsiatsiia po klinicheskoi mikrobiologii i antimikrobnoi khimioterapii. Mezhregionalnaia obshchestvennaia organizatsiia „Nauchnoe soobshchestvo po sodeistviiu klinicheskomu izucheniiu mikrobioma cheloveka“. Klinicheskie rekomendatsii. Gastrit i duodenit. 2024 (in Russian)].
34. Немятых О.Д., Зырянов С.К., Абрицов А.В. Лекарственные средства и биологически активные добавки: что и когда мы можем назначить нашему пациенту. Клинический разбор в общей медицине. 2023;4:85-93 [Nemyatyh OD, Zyryanov SK, Abricov AV. Drugs and dietary supplements: what can we prescribe to patient and when. Klinicheskii Razbor v Obshchei Meditsine. 2023;4:85-93 (in Russian)]. DOI:10.47407/kr2023.4.7.00292

________________________________________________

1. Kim SK, Guevarra RB, Kim YT, et al. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol. 2019;29(9):1335-40. DOI:10.4014/jmb.1906.06064
2. Liong MT. Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence. Int J Mol Sci. 2008;9(5):854-63. DOI:10.3390/ijms9050854
3. Mohd Fuad AS, Amran NA, Nasruddin NS, et al. The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management. Probiotics Antimicrob Proteins. 2023;15:1298-311. DOI:10.1007/s12602-022-09985-7
4. Holzapfel WH, Haberer P, Geisen R, et al. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr. 2001;73(2 Suppl.):365S-373S. DOI:10.1093/ajcn/73.2.365s
5. Wilkins T, Sequoia J. Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. Am Fam Physician. 2017;96(3):170-8.
6. Gao H, Li X, Chen X, et al. The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes. J Microbiol Biotechnol. 2022;32(10):1226-33. DOI:10.4014/jmb.2205.05041
7. Claesson MJ, van Sinderen D, O'Toole PW. The genus Lactobacillus – a genomic basis for understanding its diversity. FEMS Microbiol Lett. 2007;269(1):22-8. DOI:10.1111/j.1574-6968.2006.00596.x
8. Singh VP, Sharma J, Babu S, et al. Role of probiotics in health and disease: a review. J Pak Med Assoc. 2013;63(2):253-7.
9. EFSA Panel on Biological Hazards (BIOHAZ). Statement on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 3: Suitability of taxonomic units notified to EFSA until September 2015. EFSA Journal. 2015;13(12):4331. DOI:10.2903/j.efsa.2015.4331
10. Jungersen M, Wind A, Johansen E, et al. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12((R)). Microorganisms. 2014;2(2):92-110. DOI:10.3390/microorganisms2020092
11. He F, Ouwehan AC, Hashimoto H, et al. Adhesion of Bifidobacterium spp. to human intestinal mucus. Microbiol Immunol. 2001;45(3):259-62. DOI:10.1111/j.1348-0421.2001.tb02615.x
12. Juntunen M, Kirjavainen PV, Ouwehand AC, et al. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol. 2001;8(2):293-6. DOI:10.1128/CDLI.8.2.293-296.2001
13. Martins FS, Silva AA, Vieira AT, et al. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol. 2009;191(8):623-30. DOI:10.1007/s00203-009-0491-x
14. Food and Drug Administration. GRAS Notice Inventory > Agency Response Letter GRAS Notice No GRN 000049. 2002.
15. Selvaraj V, Alsamman MA. Antibiotic-Associated Diarrhea Beyond C. Difficile: A Scoping Review. Brown J Hosp Med. 2023;2(1):39745. DOI:10.56305/001c.39745
16. Zhang SW, Zhi X, Wang MY, Shen DL. [A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26(10):1108-14 (in Chinese). DOI:10.7499/j.issn.1008-8830.2401129
17. Zhang L, Zeng X, Guo D, et al. Early use of probiotics might prevent antibiotic-associated diarrhea in elderly (>65 years): a systematic review and meta-analysis. BMC Geriatr. 2022;22(1):562. DOI:10.1186/s12877-022-03257-3
18. Long B, Gottlieb M. Probiotics for Preventing Antibiotic-Associated Diarrhea. Am Fam Physician. 2021;104(6):Online.
19. Chatterjee S, Kar P, Das T, et al. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea. J Assoc Physicians India. 2013;61(10):708-12.
20. Gorelov AV, Andreeva IV, Zakharenko SM, Sinopalnikov AI. The use of probiotics containing a combination of lactobacillus acidophilus LA-5 and bifidobacterium animalis subsp. Lactis BB-12 strains: meta-analysis of efficacy in the prevention of antibiotic-associated diarrhea and in helicobacter pylori eradication therapy. Terapiia. 2023;10:74-82 (in Russian). DOI:10.18565/therapy.2023.10.74-82
21. Czepiel J, Drozdz M, Pituch H, et al. Clostridium difficile infection: review. Eur J Clin Microbiol Infect Dis. 2019;38(7):1211-21. DOI:10.1007/s10096-019-03539-6
22. Liu C, Monaghan T, Yadegar A, et al. Insights into the Evolving Epidemiology of Clostridioides difficile Infection and Treatment: A Global Perspective. Antibiotics (Basel). 2023;12(7):1141. DOI:10.3390/antibiotics12071141
23. Uspenskiy YuP, Baryshnikova NV. Antibiotic-associated diarrhea in hospital: frequency and prophylaxis. Meditsinskii Alfavit. 2021;20:35-7 (in Russian). DOI:10.33667/2078-5631-2021-20-35-37
24. Ermolenko KD, Potapova TV, Silav KV, et al. Prediction of the course of antibiotic-associated diarrhea caused by Clostridioides difficile based on clinical and laboratory characteristics of the disease. Terapevticheskii Arkhiv (Ter. Arkh.). 2024;96(11):1042-8 (in Russian). DOI:10.26442/00403660.2024.11.203040
25. Leffler DA, Lamont JT. Clostridium difficile Infection. N Engl J Med. 2015;373(3):287-8. DOI:10.1056/NEJMc1506004
26. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;346(5):334-9. DOI:10.1056/NEJMcp011603
27. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. 2022;gutjnl-2022-327745. DOI:10.1136/gutjnl-2022-327745
28. Nyssen OP, Perez-Aisa A, Tepes B, et al. Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). Am J Gastroenterol. 2021;116(6):1220-9. DOI:10.14309/ajg.0000000000001246
29. Hafeez M, Qureshi ZA, Khattak AL, et al. Helicobacter Pylori Eradication Therapy: Still a Challenge. Cureus. 2021;13(5):e14872. DOI:10.7759/cureus.14872
30. Yang Z, Zhou Y, Han Z, et al. The effects of probiotics supplementation on Helicobacter pylori standard treatment: an umbrella review of systematic reviews with meta-analyses. Sci Rep. 2024;14(1):10069. DOI:10.1038/s41598-024-59399-4
31. Tanashat M, Abuelazm M, Abouzid M, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424-44. DOI:10.1016/j.clnesp.2024.11.016
32. Guarner F, Sanders ME, Szajewska H, et al. World Gastroenterology Organisation Global Guidelines. Probiotics and Prebiotics. 2023;52.
33. Rossiiskaia gastroenterologicheskaia assotsiatsiia. Assotsiatsiia „Endoskopicheskoe obshchestvo „REndO“. Mezhregionalnaia assotsiatsiia po klinicheskoi mikrobiologii i antimikrobnoi khimioterapii. Mezhregionalnaia obshchestvennaia organizatsiia „Nauchnoe soobshchestvo po sodeistviiu klinicheskomu izucheniiu mikrobioma cheloveka“. Klinicheskie rekomendatsii. Gastrit i duodenit. 2024 (in Russian).
34. Nemyatyh OD, Zyryanov SK, Abricov AV. Drugs and dietary supplements: what can we prescribe to patient and when. Klinicheskii Razbor v Obshchei Meditsine. 2023;4:85-93 (in Russian). DOI:10.47407/kr2023.4.7.00292

А.В. Горелов*^1,2, Р.С. Козлов³, И.В. Андреева³, А.А. Арова⁴, И.А. Бавыкина⁵, М.С. Григорович⁶, Е.В. Довгань⁷, К.Д. Ермоленко⁸, О.В. Зайцева², С.М. Захаренко⁸, В.В. Зеленская⁹, С.К. Зырянов^10,11, Н.А. Ильенкова¹², М.А. Качковский¹³, Т.А. Когут¹⁴, Е.Г. Кондюрина⁹, В.В. Краснов¹⁵, Э.Э. Локшина², В.Ф. Приворотский¹⁶, М.Н. Репецкая¹⁷, М.Ф. Рзянкина¹⁸, С.Н. Серикова^19,20, О.У. Стецюк³, Д.В. Усенко¹, Л.В. Ханипова²¹, А.М. Шабалов²², М.А. Шевяков²³, Л.В. Яковлева<sup>24

1</sup>ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва, Россия;
²ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
³ФГБОУ ВО «Смоленский государственный медицинский университет» Минздрава России, Смоленск, Россия;
⁴ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России, Волгоград, Россия;
⁵ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России, Воронеж, Россия;
⁶ФГБОУ ВО «Кировский государственный медицинский университет» Минздрава России, Киров, Россия;
⁷ОГБУЗ «Смоленская областная клиническая больница», Смоленск, Россия;
⁸ФГБУ «Федеральный научно-клинический центр инфекционных болезней ФМБА», Санкт-Петербург, Россия;
⁹ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, Новосибирск, Россия;
¹⁰ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы», Москва, Россия;
¹¹ГБУЗ «Городская клиническая больница №24» Департамента здравоохранения г. Москвы, Москва, Россия;
¹²ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого», Красноярск, Россия;
¹³ЧУОО ВО «Медицинский университет «Реавиз», Самара, Россия;
¹⁴ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России, Ярославль, Россия;
¹⁵ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия;
¹⁶ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет», Санкт-Петербург, Россия;
¹⁷ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера», Пермь, Россия;
¹⁸ФГБОУ ВО «Дальневосточный государственный медицинский университет» Минздрава России, Хабаровск, Россия;
¹⁹ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России, Краснодар, Россия;
²⁰ГБУЗ «Краевая клиническая больница №2» Минздрава Краснодарского края, Краснодар, Россия;
²¹ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России, Тюмень, Россия;
²²ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны России, Санкт-Петербург, Россия;
²³ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Санкт-Петербург, Россия;
²⁴ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России, Уфа, Россия
*agorelov_05@mail.ru

________________________________________________

Aleksandr V. Gorelov*^1,2, Roman S. Kozlov³, Irina V. Andreeva³, Anna A. Arova⁴, Irina A. Bavykina⁵, Marina S. Grigorovich⁶, Evgenii V. Dovgan⁷, Konstantin D. Ermolenko⁸, Olga V. Zaytseva², Sergey M. Zakharenko⁸, Vera V. Zelenskaia⁹, Sergey K. Zyryanov^10,11, Natalya A. Ilyenkova¹², Mikhail A. Kachkovskii¹³, Tatiana A. Kogut¹⁴, Elena G. Kondyurina⁹, Victor V. Krasnov¹⁵, Evelina E. Lokshina², Valerij F. Privorotsky¹⁶, Marina N. Repetskaya¹⁷, Marina F. Rzyankina¹⁸, Svetlana N. Serikova^19,20, Olga U. Stetsiouk³, Denis V. Usenko¹, Lyudmila V. Khanipova²¹, Aleksandr M. Shabalov²², Mikhail A. Shevyakov²³, Ludmila V. Yakovleva<sup>24

1</sup>Central Research Institute of Epidemiology, Moscow, Russia;
²Russian University of Medicine, Moscow, Russia;
³Smolensk State Medical University, Smolensk, Russia;
⁴Volgograd State Medical University, Volgograd, Russia;
⁵Burdenko Voronezh State Medical University, Voronezh, Russia;
⁶Kirov State Medical University, Kirov, Russia;
⁷Smolensk Regional Clinical Hospital, Smolensk, Russia;
⁸Federal Scientific and Clinical Center for Infectious Diseases, Saint Petersburg, Russia;
⁹Novosibirsk State Medical University, Novosibirsk, Russia;
¹⁰Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia;
¹¹City Clinical Hospital No. 24, Moscow, Russia;
¹²Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia;
¹³Medical University „Reaviz“, Samara, Russia;
¹⁴Yaroslavl State Medical University, Yaroslavl, Russia;
¹⁵Privolzhsky Research Medical University, Nizhny Novgorod, Russia;
¹⁶Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia;
¹⁷Wagner Perm State Medical University, Perm, Russia;
¹⁸Far Eastern State Medical University, Khabarovsk, Russia;
¹⁹Kuban State Medical University, Krasnodar, Russia;
²⁰Regional Clinical Hospital No. 2, Krasnodar, Russia;
²¹Tyumen State Medical University, Tyumen, Russia;
²²Kirov Military Medical Academy, Saint Petersburg, Russia; 
²³Mechnikov North-Western State Medical University, Saint Petersburg, Russia;
²⁴Federal State Budgetary Educational Institution of Higher Education Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia
*agorelov_05@mail.ru