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МикроРНК-499a при заболеваниях сердца: перспективы использования в диагностике - Журнал Терапевтический архив №4 Вопросы диагностики внутренних болезней 2025
МикроРНК-499a при заболеваниях сердца: перспективы использования в диагностике
Писклова М.В., Баулина Н.М., Киселев И.С., Фаворова О.О. МикроРНК-499a при заболеваниях сердца: перспективы использования в диагностике. Терапевтический архив. 2025;97(4):353–359. DOI: 10.26442/00403660.2025.04.203161
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
Кардиоспецифическая микроРНК-499а (miR-499a) – небольшая (21–22 нуклеотида) некодирующая РНК, которая вовлечена в регуляцию функционирования сердца как в норме, так и при различных патологических состояниях. С каждым годом появляются все новые исследования, расширяющие круг известных биологических процессов, которые подвержены воздействиям miR-499a в миокарде. При острых и хронических заболеваниях сердечно-сосудистой системы, сопровождающихся повреждением кардиомиоцитов, miR-499a попадает в кровоток и может длительное время там циркулировать. При этом она выявляется в плазме значительно раньше традиционных белковых маркеров, что делает ее новым перспективным биомаркером для ранней диагностики и прогнозирования распространенных заболеваний сердца. В обзоре описаны функции miR-499a человека и ее вовлеченность в развитие заболеваний сердца. Приводятся данные, свидетельствующие о высокой диагностической значимости определения уровня этой микроРНК в крови.
Ключевые слова: микроРНК, miR-499a, сердечно-сосудистая система, заболевания сердца, экспрессия гена, регуляция экспрессии
Keywords: microRNA, miR-499a, cardiovascular system, heart diseases, gene expression, expression regulation
Ключевые слова: микроРНК, miR-499a, сердечно-сосудистая система, заболевания сердца, экспрессия гена, регуляция экспрессии
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Keywords: microRNA, miR-499a, cardiovascular system, heart diseases, gene expression, expression regulation
Полный текст
Список литературы
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10. Lee LA, Broadwell LJ, Buvoli M, Leinwand LA. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. J Am Heart Assoc. 2021;10(14):e020965. DOI:10.1161/JAHA.121.020965
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14. Han YH, Ma DY, Lee SJ, et al. Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape. Cancer Genomics Proteomics. 2023;20(4):383-97. DOI:10.21873/cgp.20390
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16. Zhang L, Zhang J, Li P, et al. Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3. Cell Death Dis. 2022;13(1):32. DOI:10.1038/s41419-021-04345-9
17. Giagnorio E, Malacarne C, Mantegazza R, et al. MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis. J Cell Sci. 2021;134(12):jcs258349. DOI:10.1242/jcs.258349
18. Kaur A, Mackin ST, Schlosser K, et al. Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease. Cardiovasc Res. 2020;116(6):1113-24. DOI:10.1093/cvr/cvz302
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20. Wilson KD, Hu S, Venkatasubrahmanyam S, et al. Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells. Circulation: Cardiovascular Genetics. 2010;3(5):426-35. DOI:10.1161/CIRCGENETICS.109.934281
21. Xin Y, Yang C, Han Z. Circulating miR-499 as a potential biomarker for acute myocardial infarction. Ann Transl Med. 2016;4(7):135. DOI:10.21037/atm.2016.03.40
22. Gonçalves TJM, Boutillon F, Lefebvre S, et al. Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation. Sci Rep. 2019;9(1):5878. DOI:10.1038/s41598-019-42296-6
23. Shi Y, Han Y, Niu L, et al. MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6. Biotechnol Lett. 2019;41(6):837-47. DOI:10.1007/s10529-019-02685-3
24. Han X, Wang S, Yong Z, et al. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation. Open Med (Wars). 2023;18(1):20230654. DOI:10.1515/med-2023-0654
25. Šigutová R, Evin L, Stejskal D, et al. Specific microRNAs and heart failure: time for the next step toward application? Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022; p. 166. DOI:10.5507/bp.2022.028
26. Kmecova Z, Veteskova J, Lelkova-Zirova K, et al. Disease severity-related alterations of cardiac microRNAs in experimental pulmonary hypertension. J Cell Mol Med. 2020;24(12):6943-51. DOI:10.1111/jcmm.15352
27. Zhao L, Li W, Zhao H. Inhibition of long non-coding RNA TUG1 protects against diabetic cardiomyopathy induced diastolic dysfunction by regulating miR-499-5p. Am J Transl Res. 2020;12(3):718-30.
28. Chistiakov DA, Orekhov AN, Bobryshev YV. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction). J Mol Cell Cardiol. 2016;94:107-21. DOI:10.1016/j.yjmcc.2016.03.015
29. Lee GK, Hsieh YP, Hsu SW, Lan SJ. Exploring diagnostic and prognostic predictive values of microRNAs for acute myocardial infarction. Medicine (Baltimore). 2021;100(29):e26627. DOI:10.1097/MD.0000000000026627
30. Kuwabara Y, Ono K, Horie T, et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet. 2011;4(4):446-54. DOI:10.1161/CIRCGENETICS.110.958975
31. De Rosa S, Fichtlscherer S, Lehmann R, et al. Transcoronary concentration gradients of circulating microRNAs. Circulation. 2011;124(18):1936-44. DOI:10.1161/CIRCULATIONAHA.111.037572
32. Agiannitopoulos K, Pavlopoulou P, Tsamis K, et al. Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction. In Vivo. 2018;32(2):313-8. DOI:10.21873/invivo.11239
33. Li P, Li SY, Liu M, et al. Value of the expression of miR-208, miR-494, miR-499 and miR-1303 in early diagnosis of acute myocardial infarction. Life Sci. 2019;232:116547. DOI:10.1016/j.lfs.2019.116547
34. Cheng M, Yang J, Zhao X, et al. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun. 2019;10:959. DOI:10.1038/s41467-019-08895-7
35. Wang X, Tian L, Sun Q. Diagnostic and prognostic value of circulating miRNA-499 and miRNA-22 in acute myocardial infarction. J Clin Lab Anal. 2020;34(8):e23332. DOI:10.1002/jcla.23332
36. Wang W, Li T, Gao L, et al. Diagnostic and prognostic impact of circulating microRNA-208b and microRNA-499 in patients with acute coronary syndrome. Biomark Med. 2020;14(2):87-95. DOI:10.2217/bmm-2019-0257
37. Singh S, de Ronde MWJ, Kok MGM, et al. MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability. Open Heart. 2020;7(1):e001223. DOI:10.1136/openhrt-2019-001223
38. Schulte C, Barwari T, Joshi A, et al. Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circ Res. 2019;125(3):328-40. DOI:10.1161/CIRCRESAHA.119.314937
39. da Silva AMG, de Araújo JNG, de Oliveira KM, et al. Circulating miRNAs in acute new-onset atrial fibrillation and their target mRNA network. J Cardiovasc Electrophysiol. 2018;29(8):1159-66. DOI:10.1111/jce.13612
40. Ma R, Wang J, Wu X, et al. MiR-499 is a diagnostic biomarker of paroxysmal atrial fibrillation involved in the development of atrial fibrillation. Int J Clin Exp Pathol. 2017;10(4):4221-31.
41. Ling TY, Wang XL, Chai Q, et al. Regulation of the SK3 channel by MicroRNA-499 – potential role in atrial fibrillation. Heart Rhythm. 2013;10(7):1001-9. DOI:10.1016/j.hrthm.2013.03.005
42. Zhao Q, Yang W, Li X, et al. MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1. Mol Biol Rep. 2023;50(12):9757-67. DOI:10.1007/s11033-023-08755-0
43. Baulina NM, Kiselev IS, Chumakova OS, Favorova OO. Hypertrophic Cardiomyopathy as an Oligogenic Disease: Transcriptomic Arguments. Mol Biol. 2020;54(6):840-50. DOI:10.1134/S0026893320060023
44. Baulina N, Pisklova M, Kiselev I, et al. Circulating miR-499a-5p Is a Potential Biomarker of MYH7–Associated Hypertrophic Cardiomyopathy. Int J Mol Sci. 2022;23(7):3791. DOI:10.3390/ijms23073791
45. Thottakara T, Lund N, Krämer E, et al. A Novel miRNA Screen Identifies miRNA-4454 as a Candidate Biomarker for Ventricular Fibrosis in Patients with Hypertrophic Cardiomyopathy. Biomolecules. 2021;11(11):1718. DOI:10.3390/biom11111718
46. Foglieni C, Lombardi M, Lazzeroni D, et al. Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy. Biomedicines. 2022;10(9):2180. DOI:10.3390/biomedicines10092180
47. Montag J, Petersen B, Flögel AK, et al. Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs. Sci Rep. 2018;8:4786. DOI:10.1038/s41598-018-22936-z
48. Broadwell LJ, Smallegan MJ, Rigby KM, et al. Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart. J Biol Chem. 2021;296:100694. DOI:10.1016/j.jbc.2021.100694
49. Lu JY, Chen MH, Zhang JF, et al. Association between miR-499 rs3746444 polymorphism and coronary heart disease susceptibility: An evidence-based meta-analysis of 5063 cases and 4603 controls. Gene. 2019;698:34-40. DOI:10.1016/j.gene.2019.02.045
50. Yang Y, Shi X, Du Z, et al. Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review. Herz. 2022;47(6):524-35. DOI:10.1007/s00059-021-05086-3
51. Hromádka M, Černá V, Pešta M, et al. Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18. Dis Markers. 2019;2019:2925019. DOI:10.1155/2019/2925019
52. Robinson S, Follo M, Haenel D, et al. Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients. Acta Pharmacol Sin. 2018;39(7):1217-27. DOI:10.1038/aps.2017.136
53. Zhang L, Chen X, Su T, et al. Circulating miR-499 are novel and sensitive biomarker of acute myocardial infarction. J Thorac Dis. 2015;7(3):303-8. DOI:10.3978/j.issn.2072-1439.2015.02.05
54. Yao Y, Du J, Cao X, et al. Plasma Levels of MicroRNA-499 Provide an Early Indication of Perioperative Myocardial Infarction in Coronary Artery Bypass Graft Patients. PLoS One. 2014;9(8):e104618. DOI:10.1371/journal.pone.0104618
55. Liu G, Niu X, Meng X, Zhang Z. Sensitive miRNA markers for the detection and management of NSTEMI acute myocardial infarction patients. J Thorac Dis. 2018;10(6):3206-15. DOI:10.21037/jtd.2018.05.141
56. Pinchi E, Frati P, Aromatario M, et al. miR-1, miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction. J Cell Mol Med. 2019;23(9):6005-16. DOI:10.1111/jcmm.14463
57. Zhao J, Yu H, Yan P, et al. Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis. Dis Markers. 2019;2019:6121696. DOI:10.1155/2019/6121696
58. Wang W, Li T, Gao L, et al. Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease. Dis Markers. 2019;2019:9842427. DOI:10.1155/2019/9842427
59. Gacoń J, Badacz R, Stępień E, et al. Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study. Kardiol Pol. 2018;76(2):362-9. DOI:10.5603/KP.a2017.0243
60. Robinson S, Follo M, Haenel D, et al. Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction. Int J Cardiol. 2018;257:247-54. DOI:10.1016/j.ijcard.2017.10.111
61. Gao YP, Huang KJ, Wang BY, et al. Constructed a self-powered sensing platform based on nitrogen-doped hollow carbon nanospheres for ultra-sensitive detection and real-time tracking of double markers. Anal Chim Acta. 2023;1267:341333. DOI:10.1016/j.aca.2023.341333
62. Shi L, Liu C, Wang H, et al. Framework and Spherical Nucleic Acids Synergistically Enhanced Electrochemiluminescence Nanosensors for Rapidly Diagnosing Acute Myocardial Infarction Based on Circulating MicroRNA Levels. Anal Chem. 2022;94(41):14394-401. DOI:10.1021/acs.analchem.2c03144
63. Cheng X, Ren D, Xu G, et al. Metal-organic frameworks-assisted nonenzymatic cascade amplification multiplexed strategy for sensing acute myocardial infarction related microRNAs. Biosens Bioelectron. 2022;196:113706. DOI:10.1016/j.bios.2021.113706
64. Ren X, Ellis B, Ronan G, et al. A Multiplexed Ion-exchange Membrane-based miRNA (MIX.miR) Detection Platform for Rapid Diagnosis of Myocardial Infarction. Lab Chip. 2021;21(20):3876-87. DOI:10.1039/d1lc00685a
65. Li P, Ye Y, Li Y, et al. A MoS2 nanosheet-based CRISPR/Cas12a biosensor for efficient miRNA quantification for acute myocardial infarction. Biosens Bioelectron. 2024;251:116129. DOI:10.1016/j.bios.2024.116129
2. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front Endocrinol. 2018;9. DOI:10.3389/fendo.2018.00402
3. miRBase. Available at: https://www.mirbase.org/ Accessed: 17.03.2024.
4. Cui C, Cui Q. The relationship of human tissue microRNAs with those from body fluids. Sci Rep. 2020;10(1):5644. DOI:10.1038/s41598-020-62534-6
5. Nappi F, Avtaar Singh SS, Jitendra V, et al. The Roles of microRNAs in the Cardiovascular System. Int J Mol Sci. 2023;24(18):14277. DOI:10.3390/ijms241814277
6. Condrat CE, Thompson DC, Barbu MG, et al. miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells. 2020;9(2):276. DOI:10.3390/cells9020276
7. Kramna D, Riedlova P, Jirik V. MicroRNAs as a Potential Biomarker in the Diagnosis of Cardiovascular Diseases. Medicina. 2023;59(7):1329. DOI:10.3390/medicina59071329
8. Liang Y, Ridzon D, Wong L, Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007;8:166. DOI:10.1186/1471-2164-8-166
9. Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA. 2005;11(3):241-7. DOI:10.1261/rna.7240905
10. Lee LA, Broadwell LJ, Buvoli M, Leinwand LA. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. J Am Heart Assoc. 2021;10(14):e020965. DOI:10.1161/JAHA.121.020965
11. Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115(2):209-16. DOI:10.1016/s0092-8674(03)00801-8
12. miRTarBase: the experimentally validated microRNA-target interactions database. Available at: https://mirtarbase.cuhk.edu.cn/~miRTarBase/miRTarBase_2022/php/index.php. Accessed: 17.03.2024.
13. Zhong Z, Zhong W, Zhang Q, et al. Circulating microRNA expression profiling and bioinformatics analysis of patients with coronary artery disease by RNA sequencing. J Clin Lab Anal. 2019;34(1):e23020. DOI:10.1002/jcla.23020
14. Han YH, Ma DY, Lee SJ, et al. Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape. Cancer Genomics Proteomics. 2023;20(4):383-97. DOI:10.21873/cgp.20390
15. Liu HM, Ji F, Lu Y, Chen SY. MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway. Eur Rev Med Pharmacol Sci. 2021;25(20):6220-31. DOI:10.26355/eurrev_202110_26992
16. Zhang L, Zhang J, Li P, et al. Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3. Cell Death Dis. 2022;13(1):32. DOI:10.1038/s41419-021-04345-9
17. Giagnorio E, Malacarne C, Mantegazza R, et al. MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis. J Cell Sci. 2021;134(12):jcs258349. DOI:10.1242/jcs.258349
18. Kaur A, Mackin ST, Schlosser K, et al. Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease. Cardiovasc Res. 2020;116(6):1113-24. DOI:10.1093/cvr/cvz302
19. Espinoza-Lewis RA, Wang DZ. MicroRNAs in Heart Development. Curr Top Dev Biol. 2012;100:279-317. DOI:10.1016/B978-0-12-387786-4.00009-9
20. Wilson KD, Hu S, Venkatasubrahmanyam S, et al. Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells. Circulation: Cardiovascular Genetics. 2010;3(5):426-35. DOI:10.1161/CIRCGENETICS.109.934281
21. Xin Y, Yang C, Han Z. Circulating miR-499 as a potential biomarker for acute myocardial infarction. Ann Transl Med. 2016;4(7):135. DOI:10.21037/atm.2016.03.40
22. Gonçalves TJM, Boutillon F, Lefebvre S, et al. Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation. Sci Rep. 2019;9(1):5878. DOI:10.1038/s41598-019-42296-6
23. Shi Y, Han Y, Niu L, et al. MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6. Biotechnol Lett. 2019;41(6):837-47. DOI:10.1007/s10529-019-02685-3
24. Han X, Wang S, Yong Z, et al. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation. Open Med (Wars). 2023;18(1):20230654. DOI:10.1515/med-2023-0654
25. Šigutová R, Evin L, Stejskal D, et al. Specific microRNAs and heart failure: time for the next step toward application? Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022; p. 166. DOI:10.5507/bp.2022.028
26. Kmecova Z, Veteskova J, Lelkova-Zirova K, et al. Disease severity-related alterations of cardiac microRNAs in experimental pulmonary hypertension. J Cell Mol Med. 2020;24(12):6943-51. DOI:10.1111/jcmm.15352
27. Zhao L, Li W, Zhao H. Inhibition of long non-coding RNA TUG1 protects against diabetic cardiomyopathy induced diastolic dysfunction by regulating miR-499-5p. Am J Transl Res. 2020;12(3):718-30.
28. Chistiakov DA, Orekhov AN, Bobryshev YV. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction). J Mol Cell Cardiol. 2016;94:107-21. DOI:10.1016/j.yjmcc.2016.03.015
29. Lee GK, Hsieh YP, Hsu SW, Lan SJ. Exploring diagnostic and prognostic predictive values of microRNAs for acute myocardial infarction. Medicine (Baltimore). 2021;100(29):e26627. DOI:10.1097/MD.0000000000026627
30. Kuwabara Y, Ono K, Horie T, et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet. 2011;4(4):446-54. DOI:10.1161/CIRCGENETICS.110.958975
31. De Rosa S, Fichtlscherer S, Lehmann R, et al. Transcoronary concentration gradients of circulating microRNAs. Circulation. 2011;124(18):1936-44. DOI:10.1161/CIRCULATIONAHA.111.037572
32. Agiannitopoulos K, Pavlopoulou P, Tsamis K, et al. Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction. In Vivo. 2018;32(2):313-8. DOI:10.21873/invivo.11239
33. Li P, Li SY, Liu M, et al. Value of the expression of miR-208, miR-494, miR-499 and miR-1303 in early diagnosis of acute myocardial infarction. Life Sci. 2019;232:116547. DOI:10.1016/j.lfs.2019.116547
34. Cheng M, Yang J, Zhao X, et al. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun. 2019;10:959. DOI:10.1038/s41467-019-08895-7
35. Wang X, Tian L, Sun Q. Diagnostic and prognostic value of circulating miRNA-499 and miRNA-22 in acute myocardial infarction. J Clin Lab Anal. 2020;34(8):e23332. DOI:10.1002/jcla.23332
36. Wang W, Li T, Gao L, et al. Diagnostic and prognostic impact of circulating microRNA-208b and microRNA-499 in patients with acute coronary syndrome. Biomark Med. 2020;14(2):87-95. DOI:10.2217/bmm-2019-0257
37. Singh S, de Ronde MWJ, Kok MGM, et al. MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability. Open Heart. 2020;7(1):e001223. DOI:10.1136/openhrt-2019-001223
38. Schulte C, Barwari T, Joshi A, et al. Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circ Res. 2019;125(3):328-40. DOI:10.1161/CIRCRESAHA.119.314937
39. da Silva AMG, de Araújo JNG, de Oliveira KM, et al. Circulating miRNAs in acute new-onset atrial fibrillation and their target mRNA network. J Cardiovasc Electrophysiol. 2018;29(8):1159-66. DOI:10.1111/jce.13612
40. Ma R, Wang J, Wu X, et al. MiR-499 is a diagnostic biomarker of paroxysmal atrial fibrillation involved in the development of atrial fibrillation. Int J Clin Exp Pathol. 2017;10(4):4221-31.
41. Ling TY, Wang XL, Chai Q, et al. Regulation of the SK3 channel by MicroRNA-499 – potential role in atrial fibrillation. Heart Rhythm. 2013;10(7):1001-9. DOI:10.1016/j.hrthm.2013.03.005
42. Zhao Q, Yang W, Li X, et al. MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1. Mol Biol Rep. 2023;50(12):9757-67. DOI:10.1007/s11033-023-08755-0
43. Baulina NM, Kiselev IS, Chumakova OS, Favorova OO. Hypertrophic Cardiomyopathy as an Oligogenic Disease: Transcriptomic Arguments. Mol Biol. 2020;54(6):840-50. DOI:10.1134/S0026893320060023
44. Baulina N, Pisklova M, Kiselev I, et al. Circulating miR-499a-5p Is a Potential Biomarker of MYH7–Associated Hypertrophic Cardiomyopathy. Int J Mol Sci. 2022;23(7):3791. DOI:10.3390/ijms23073791
45. Thottakara T, Lund N, Krämer E, et al. A Novel miRNA Screen Identifies miRNA-4454 as a Candidate Biomarker for Ventricular Fibrosis in Patients with Hypertrophic Cardiomyopathy. Biomolecules. 2021;11(11):1718. DOI:10.3390/biom11111718
46. Foglieni C, Lombardi M, Lazzeroni D, et al. Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy. Biomedicines. 2022;10(9):2180. DOI:10.3390/biomedicines10092180
47. Montag J, Petersen B, Flögel AK, et al. Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs. Sci Rep. 2018;8:4786. DOI:10.1038/s41598-018-22936-z
48. Broadwell LJ, Smallegan MJ, Rigby KM, et al. Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart. J Biol Chem. 2021;296:100694. DOI:10.1016/j.jbc.2021.100694
49. Lu JY, Chen MH, Zhang JF, et al. Association between miR-499 rs3746444 polymorphism and coronary heart disease susceptibility: An evidence-based meta-analysis of 5063 cases and 4603 controls. Gene. 2019;698:34-40. DOI:10.1016/j.gene.2019.02.045
50. Yang Y, Shi X, Du Z, et al. Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review. Herz. 2022;47(6):524-35. DOI:10.1007/s00059-021-05086-3
51. Hromádka M, Černá V, Pešta M, et al. Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18. Dis Markers. 2019;2019:2925019. DOI:10.1155/2019/2925019
52. Robinson S, Follo M, Haenel D, et al. Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients. Acta Pharmacol Sin. 2018;39(7):1217-27. DOI:10.1038/aps.2017.136
53. Zhang L, Chen X, Su T, et al. Circulating miR-499 are novel and sensitive biomarker of acute myocardial infarction. J Thorac Dis. 2015;7(3):303-8. DOI:10.3978/j.issn.2072-1439.2015.02.05
54. Yao Y, Du J, Cao X, et al. Plasma Levels of MicroRNA-499 Provide an Early Indication of Perioperative Myocardial Infarction in Coronary Artery Bypass Graft Patients. PLoS One. 2014;9(8):e104618. DOI:10.1371/journal.pone.0104618
55. Liu G, Niu X, Meng X, Zhang Z. Sensitive miRNA markers for the detection and management of NSTEMI acute myocardial infarction patients. J Thorac Dis. 2018;10(6):3206-15. DOI:10.21037/jtd.2018.05.141
56. Pinchi E, Frati P, Aromatario M, et al. miR-1, miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction. J Cell Mol Med. 2019;23(9):6005-16. DOI:10.1111/jcmm.14463
57. Zhao J, Yu H, Yan P, et al. Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis. Dis Markers. 2019;2019:6121696. DOI:10.1155/2019/6121696
58. Wang W, Li T, Gao L, et al. Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease. Dis Markers. 2019;2019:9842427. DOI:10.1155/2019/9842427
59. Gacoń J, Badacz R, Stępień E, et al. Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study. Kardiol Pol. 2018;76(2):362-9. DOI:10.5603/KP.a2017.0243
60. Robinson S, Follo M, Haenel D, et al. Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction. Int J Cardiol. 2018;257:247-54. DOI:10.1016/j.ijcard.2017.10.111
61. Gao YP, Huang KJ, Wang BY, et al. Constructed a self-powered sensing platform based on nitrogen-doped hollow carbon nanospheres for ultra-sensitive detection and real-time tracking of double markers. Anal Chim Acta. 2023;1267:341333. DOI:10.1016/j.aca.2023.341333
62. Shi L, Liu C, Wang H, et al. Framework and Spherical Nucleic Acids Synergistically Enhanced Electrochemiluminescence Nanosensors for Rapidly Diagnosing Acute Myocardial Infarction Based on Circulating MicroRNA Levels. Anal Chem. 2022;94(41):14394-401. DOI:10.1021/acs.analchem.2c03144
63. Cheng X, Ren D, Xu G, et al. Metal-organic frameworks-assisted nonenzymatic cascade amplification multiplexed strategy for sensing acute myocardial infarction related microRNAs. Biosens Bioelectron. 2022;196:113706. DOI:10.1016/j.bios.2021.113706
64. Ren X, Ellis B, Ronan G, et al. A Multiplexed Ion-exchange Membrane-based miRNA (MIX.miR) Detection Platform for Rapid Diagnosis of Myocardial Infarction. Lab Chip. 2021;21(20):3876-87. DOI:10.1039/d1lc00685a
65. Li P, Ye Y, Li Y, et al. A MoS2 nanosheet-based CRISPR/Cas12a biosensor for efficient miRNA quantification for acute myocardial infarction. Biosens Bioelectron. 2024;251:116129. DOI:10.1016/j.bios.2024.116129
________________________________________________
2. O’Brien J, Hayder H, Zayed Y, Peng C. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front Endocrinol. 2018;9. DOI:10.3389/fendo.2018.00402
3. miRBase. Available at: https://www.mirbase.org/ Accessed: 17.03.2024.
4. Cui C, Cui Q. The relationship of human tissue microRNAs with those from body fluids. Sci Rep. 2020;10(1):5644. DOI:10.1038/s41598-020-62534-6
5. Nappi F, Avtaar Singh SS, Jitendra V, et al. The Roles of microRNAs in the Cardiovascular System. Int J Mol Sci. 2023;24(18):14277. DOI:10.3390/ijms241814277
6. Condrat CE, Thompson DC, Barbu MG, et al. miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells. 2020;9(2):276. DOI:10.3390/cells9020276
7. Kramna D, Riedlova P, Jirik V. MicroRNAs as a Potential Biomarker in the Diagnosis of Cardiovascular Diseases. Medicina. 2023;59(7):1329. DOI:10.3390/medicina59071329
8. Liang Y, Ridzon D, Wong L, Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007;8:166. DOI:10.1186/1471-2164-8-166
9. Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA. 2005;11(3):241-7. DOI:10.1261/rna.7240905
10. Lee LA, Broadwell LJ, Buvoli M, Leinwand LA. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. J Am Heart Assoc. 2021;10(14):e020965. DOI:10.1161/JAHA.121.020965
11. Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115(2):209-16. DOI:10.1016/s0092-8674(03)00801-8
12. miRTarBase: the experimentally validated microRNA-target interactions database. Available at: https://mirtarbase.cuhk.edu.cn/~miRTarBase/miRTarBase_2022/php/index.php. Accessed: 17.03.2024.
13. Zhong Z, Zhong W, Zhang Q, et al. Circulating microRNA expression profiling and bioinformatics analysis of patients with coronary artery disease by RNA sequencing. J Clin Lab Anal. 2019;34(1):e23020. DOI:10.1002/jcla.23020
14. Han YH, Ma DY, Lee SJ, et al. Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape. Cancer Genomics Proteomics. 2023;20(4):383-97. DOI:10.21873/cgp.20390
15. Liu HM, Ji F, Lu Y, Chen SY. MiR-499b-5p inhibits cervical cancer cell proliferation and induces apoptosis by targeting the Notch1 signaling pathway. Eur Rev Med Pharmacol Sci. 2021;25(20):6220-31. DOI:10.26355/eurrev_202110_26992
16. Zhang L, Zhang J, Li P, et al. Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3. Cell Death Dis. 2022;13(1):32. DOI:10.1038/s41419-021-04345-9
17. Giagnorio E, Malacarne C, Mantegazza R, et al. MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis. J Cell Sci. 2021;134(12):jcs258349. DOI:10.1242/jcs.258349
18. Kaur A, Mackin ST, Schlosser K, et al. Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease. Cardiovasc Res. 2020;116(6):1113-24. DOI:10.1093/cvr/cvz302
19. Espinoza-Lewis RA, Wang DZ. MicroRNAs in Heart Development. Curr Top Dev Biol. 2012;100:279-317. DOI:10.1016/B978-0-12-387786-4.00009-9
20. Wilson KD, Hu S, Venkatasubrahmanyam S, et al. Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells. Circulation: Cardiovascular Genetics. 2010;3(5):426-35. DOI:10.1161/CIRCGENETICS.109.934281
21. Xin Y, Yang C, Han Z. Circulating miR-499 as a potential biomarker for acute myocardial infarction. Ann Transl Med. 2016;4(7):135. DOI:10.21037/atm.2016.03.40
22. Gonçalves TJM, Boutillon F, Lefebvre S, et al. Collagen XXV promotes myoblast fusion during myogenic differentiation and muscle formation. Sci Rep. 2019;9(1):5878. DOI:10.1038/s41598-019-42296-6
23. Shi Y, Han Y, Niu L, et al. MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6. Biotechnol Lett. 2019;41(6):837-47. DOI:10.1007/s10529-019-02685-3
24. Han X, Wang S, Yong Z, et al. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation. Open Med (Wars). 2023;18(1):20230654. DOI:10.1515/med-2023-0654
25. Šigutová R, Evin L, Stejskal D, et al. Specific microRNAs and heart failure: time for the next step toward application? Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022; p. 166. DOI:10.5507/bp.2022.028
26. Kmecova Z, Veteskova J, Lelkova-Zirova K, et al. Disease severity-related alterations of cardiac microRNAs in experimental pulmonary hypertension. J Cell Mol Med. 2020;24(12):6943-51. DOI:10.1111/jcmm.15352
27. Zhao L, Li W, Zhao H. Inhibition of long non-coding RNA TUG1 protects against diabetic cardiomyopathy induced diastolic dysfunction by regulating miR-499-5p. Am J Transl Res. 2020;12(3):718-30.
28. Chistiakov DA, Orekhov AN, Bobryshev YV. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction). J Mol Cell Cardiol. 2016;94:107-21. DOI:10.1016/j.yjmcc.2016.03.015
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Авторы
М.В. Писклова*1,2, Н.М. Баулина1,2, И.С. Киселев1,2, О.О. Фаворова1,2
1ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет), Москва, Россия;
2ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России, Москва, Россия
*pisklova_maria@mail.ru
1Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia;
2Chazov National Medical Research Center of Cardiology, Moscow, Russia
*pisklova_maria@mail.ru
1ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет), Москва, Россия;
2ФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России, Москва, Россия
*pisklova_maria@mail.ru
________________________________________________
1Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia;
2Chazov National Medical Research Center of Cardiology, Moscow, Russia
*pisklova_maria@mail.ru
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