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Стратегии выбора антиретровирусной терапии у пациентов с ВИЧ-инфекцией и сердечно-сосудистыми заболеваниями - Журнал Терапевтический архив №4 Вопросы диагностики внутренних болезней 2025
Стратегии выбора антиретровирусной терапии у пациентов с ВИЧ-инфекцией и сердечно-сосудистыми заболеваниями
Шахгильдян В.И., Мацкеплишвили С.Т. Стратегии выбора антиретровирусной терапии у пациентов с ВИЧ-инфекцией и сердечно-сосудистыми заболеваниями. Терапевтический архив. 2025;97(4):367–377. DOI: 10.26442/00403660.2025.04.203157
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
Инфекция ВИЧ ассоциирована с повышенным риском сердечно-сосудистых заболеваний (ССЗ) и почечных осложнений. Сопутствующая патология постепенно становится одним из основных драйверов ранней смертности больных ВИЧ-инфекцией в Российской Федерации. С 2007 по 2022 г. частота летальных исходов у пациентов с ВИЧ-инфекцией от причин, не связанных с оппортунистическими инфекциями, увеличилась более чем в 2 раза. Лицам, живущим с ВИЧ, присущи все факторы сердечно-сосудистого риска, характерные для общей популяции, помимо этого особую роль играет нарушенная функция почек, вклад которой в риск ССЗ и их осложнений часто недооценивают. В публикации рассмотрены подходы к выбору современной антиретровирусной терапии у больных ВИЧ-инфекцией и сопутствующими ССЗ или высоким риском их развития. Проведен сравнительный анализ антиретровирусных препаратов, указанных зарубежными клиническими рекомендациями в качестве схем 1-й линии и доступных в России (схемы на основе долутегравира, биктегравира и доравирина). Детальное рассмотрение критериев выбора при определении схемы антиретровирусной терапии предполагает учет эффективности современных антиретровирусных препаратов при высокой вирусной нагрузке, низких показателях клеточного звена иммунитета, возможной низкой приверженности пациента лечению, профиля резистентности к препаратам, а также наличия таких сопутствующих заболеваний и состояний, как ССЗ, избыточная масса тела и патология почек. Кроме того, в статье затронуты вопросы междисциплинарного взаимодействия врачей-инфекционистов, терапевтов и кардиологов.
Ключевые слова: вирус иммунодефицита человека, ВИЧ, сердечно-сосудистые заболевания, антиретровирусная терапия, сопутствующая патология
Keywords: human immunodeficiency virus, HIV, cardiovascular disease, antiretroviral therapy, concomitant disease
Ключевые слова: вирус иммунодефицита человека, ВИЧ, сердечно-сосудистые заболевания, антиретровирусная терапия, сопутствующая патология
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Keywords: human immunodeficiency virus, HIV, cardiovascular disease, antiretroviral therapy, concomitant disease
Полный текст
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3. Mayne ES, Louw S. Good Fences Make Good Neighbors: Human Immunodeficiency Virus and Vascular Disease. Open Forum Infect Dis. 2019;6(11):ofz303. DOI:10.1093/ofid/ofz303
4. Kravchenko AV, Ladnaia NN, Pokrovsky VV, et al. Causes of death in people infected with the human immunodeficiency virus. Epidemiology and Infectious Diseases. Current Items. 2023;13(3):56-63 (in Russian). DOI:10.18565/epidem.2023.13.3.56-63
5. Feinstein MJ, Bahiru E, Achenbach C, et al. Patterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013. Am J Cardiol. 2016;117(2):214-20. DOI:10.1016/j.amjcard.2015.10.030
6. Gwag T, Meng Z, Sui Y, et al. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol. 2019;70(5):930-40. DOI:10.1016/j.jhep.2018.12.038
7. Martini S, Pisaturo M, Russo A, et al. Evaluation of Lipid Profile and Intima Media Thickness in Antiretroviral-Experienced HIV-Infected Patients Treated with Protease Inhibitor-Based Regimens versus Protease Inhibitor-Sparing Regimens. Pathogens. 2023;12(7):925. DOI:10.3390/pathogens12070925
8. Taramasso L, Tatarelli P, Ricci E, et al. Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA). BMC Infect Dis. 2018;18(1):357. DOI:10.1186/s12879-018-3268-5
9. Gurung S, Simpson KN, Grov C, et al. Cardiovascular Risk Assessment Among Adolescents and Youths Living With HIV: Evaluation of Electronic Health Record Findings and Implications. Interact J Med Res. 2023;12:e41574. DOI:10.2196/41574
10. Hsue PY, Waters DD. Time to Recognize HIV Infection as a Major Cardiovascular Risk Factor. Circulation. 2018;138(11):1113-5. DOI:10.1161/CIRCULATIONAHA.118.036211
11. Nou E, Lo J, Hadigan C, Grinspoon SK. Pathophysiology and management of cardiovascular disease in patients with HIV. Lancet Diabetes Endocrinol. 2016;4(7):598-610. DOI:10.1016/S2213-8587(15)00388-5
12. Ntsekhe M, Baker JV. Cardiovascular Disease Among Persons Living With HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context. Circulation. 2023;147(1):83-100. DOI:10.1161/CIRCULATIONAHA.122.057443
13. Carr A. Pathogenesis of cardiovascular disease in HIV infection. Curr Opin HIV AIDS. 2008;3(3):234-9. DOI:10.1097/COH.0b013e3282fb7be0
14. So-Armah K, Benjamin LA, Bloomfield GS, et al. HIV and cardiovascular disease. Lancet HIV. 2020;7(4):e279-93. DOI:10.1016/S2352-3018(20)30036-9
15. Vasan RS, Sullivan LM, Wilson PWF, et al. Relative Importance of Borderline and Elevated Levels of Coronary Heart Disease Risk Factors. Ann Intern Med. 2005;142(6):393. DOI:10.7326/0003-4819-142-6-200503150-00005
16. SCORE2 working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439-54. DOI:10.1093/eurheartj/ehab309
17. Shahbaz S. Cardiovascular disease in human immunodeficiency virus infected patients: A true or perceived risk? WJC. 2015;7(10):633. DOI:10.4330/wjc.v7.i10.633
18. Heywood JT, Fonarow GC, Costanzo MR, et al. High Prevalence of Renal Dysfunction and Its Impact on Outcome in 118,465 Patients Hospitalized With Acute Decompensated Heart Failure: A Report From the ADHERE Database. J Card Fail. 2007;13(6):422-30. DOI:10.1016/j.cardfail.2007.03.011
19. Sarnak MJ, Katz R, Newman A, et al. Association of Urinary Injury Biomarkers with Mortality and Cardiovascular Events. J Am Soc Nephrol. 2014;25(7):1545-53. DOI:10.1681/ASN.2013070713
20. Go AS, Chertow GM, Fan D, et al. Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization. N Engl J Med. 2004;351(13):1296-305. DOI:10.1056/NEJMoa041031
21. Choi AI, Li Y, Deeks SG, et al. Association Between Kidney Function and Albuminuria With Cardiovascular Events in HIV-Infected Persons. Circulation. 2010;121(5):651-8. DOI:10.1161/CIRCULATIONAHA.109.898585
22. Jotwani V, Scherzer R, Abraham A, et al. Does HIV Infection Promote Early Kidney Injury in Women? Antivir Ther. 2014;19(1):79-87. DOI:10.3851/IMP2677
23. Boyd MA, Mocroft A, Ryom L, et al. Cardiovascular disease (CVD) and chronic kidney disease (CKD) event rates in HIV-positive persons at high predicted CVD and CKD risk: A prospective analysis of the D:A:D observational study. PLoS Med. 2017;14(11):e1002424. DOI:10.1371/journal.pmed.1002424
24. Smirnov AV, Dobronravov VA, Kayukov IG. Cardiorenal continuum, pathogenetical grounds of preventive nephrology. Nephrology (Saint-Petersburg). 2005;9(3):7-15 (in Russian). DOI:10.24884/1561-6274-2005-9-3-7-15
25. García-Donaire JA, Ruilope LM. Cardiorenal Continuum. In: Berbari AE, Mancia G, eds. Cardiorenal Syndrome. Springer Milan; 2010:67-79. DOI:10.1007/978-88-470-1463-3_5
26. Amair MP, Arocha Rodulfo I. El continuo cardiorrenal: una propuesta para la prevención de las enfermedades cardiovasculares y renales. Rev Colomb Nefrol. 2020;7(1):60-9. DOI:10.22265/acnef.7.1.356
27. Zoccali C, Zannad F. Refocusing cardio-renal problems: the cardiovascular-kidney-metabolic syndrome and the chronic cardiovascular-kidney disorder. Nephrol Dial Transplant. 2024;39(9):1378-80. DOI:10.1093/ndt/gfae086
28. Budoff MJ, Rader DJ, Reilly MP, et al. Relationship of Estimated GFR and Coronary Artery Calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis. 2011;58(4):519-26. DOI:10.1053/j.ajkd.2011.04.024
29. Jotwani V, Katz R, Ix JH, et al. Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in Elders. Am J Kidney Dis. 2018;72(2):205-13. DOI:10.1053/j.ajkd.2017.12.013
30. Lai M, Madden E, Shlipak MG, et al. Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV. AIDS. 2024;38(4):465-75. DOI:10.1097/QAD.0000000000003761
31. Vos AG, Venter WDF. Cardiovascular toxicity of contemporary antiretroviral therapy. Curr Opin HIV AIDS. 2021;16(6):286-91. DOI:10.1097/COH.0000000000000702
32. Bavinger C, Bendavid E, Niehaus K, et al. Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review. PLoS One. 2013;8(3):e59551. DOI:10.1371/journal.pone.0059551
33. Taramasso L, Andreoni M, Antinori A, et al. Pillars of long-term antiretroviral therapy success. Pharmacol Res. 2023;196:106898. DOI:10.1016/j.phrs.2023.106898
34. Lazarus JV, Wohl DA, Cascio M, et al. Long-term success for people living with HIV : A framework to guide practice. HIV Med. 2023;24(Suppl. 2):8-19. DOI:10.1111/hiv.13460
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2. Волкова С.Б., Подымова А.С. Демографические и клинические характеристики ВИЧ-инфицированных пациентов г. Екатеринбурга. ВИЧ-инфекция и иммуносупрессия. 2023;15(4):73-84 [Volkova SB, Podymova AS. Demographic and clinical characteristics of HIV-infected patients in Ekaterinburg. HIV Infection and Immunosuppressive Disorders. 2023;15(4):73-85 (in Russian)]. DOI:10.22328/2077-9828-2023-15-4-73-85
3. Mayne ES, Louw S. Good Fences Make Good Neighbors: Human Immunodeficiency Virus and Vascular Disease. Open Forum Infect Dis. 2019;6(11):ofz303. DOI:10.1093/ofid/ofz303
4. Кравченко А.В., Ладная Н.Н., Покровский В.В., и др. Причины летальных исходов у лиц, инфицированных вирусом иммунодефицита человека. Эпидемиология и инфекционные болезни. Актуальные вопросы. 2023;13(3):56-63 [Kravchenko AV, Ladnaia NN, Pokrovsky VV, et al. Causes of death in people infected with the human immunodeficiency virus. Epidemiology and Infectious Diseases. Current Items. 2023;13(3):56-63 (in Russian)]. DOI:10.18565/epidem.2023.13.3.56-63
5. Feinstein MJ, Bahiru E, Achenbach C, et al. Patterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013. Am J Cardiol. 2016;117(2):214-20. DOI:10.1016/j.amjcard.2015.10.030
6. Gwag T, Meng Z, Sui Y, et al. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol. 2019;70(5):930-40. DOI:10.1016/j.jhep.2018.12.038
7. Martini S, Pisaturo M, Russo A, et al. Evaluation of Lipid Profile and Intima Media Thickness in Antiretroviral-Experienced HIV-Infected Patients Treated with Protease Inhibitor-Based Regimens versus Protease Inhibitor-Sparing Regimens. Pathogens. 2023;12(7):925. DOI:10.3390/pathogens12070925
8. Taramasso L, Tatarelli P, Ricci E, et al. Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA). BMC Infect Dis. 2018;18(1):357. DOI:10.1186/s12879-018-3268-5
9. Gurung S, Simpson KN, Grov C, et al. Cardiovascular Risk Assessment Among Adolescents and Youths Living With HIV: Evaluation of Electronic Health Record Findings and Implications. Interact J Med Res. 2023;12:e41574. DOI:10.2196/41574
10. Hsue PY, Waters DD. Time to Recognize HIV Infection as a Major Cardiovascular Risk Factor. Circulation. 2018;138(11):1113-5. DOI:10.1161/CIRCULATIONAHA.118.036211
11. Nou E, Lo J, Hadigan C, Grinspoon SK. Pathophysiology and management of cardiovascular disease in patients with HIV. Lancet Diabetes Endocrinol. 2016;4(7):598-610. DOI:10.1016/S2213-8587(15)00388-5
12. Ntsekhe M, Baker JV. Cardiovascular Disease Among Persons Living With HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context. Circulation. 2023;147(1):83-100. DOI:10.1161/CIRCULATIONAHA.122.057443
13. Carr A. Pathogenesis of cardiovascular disease in HIV infection. Curr Opin HIV AIDS. 2008;3(3):234-9. DOI:10.1097/COH.0b013e3282fb7be0
14. So-Armah K, Benjamin LA, Bloomfield GS, et al. HIV and cardiovascular disease. Lancet HIV. 2020;7(4):e279-93. DOI:10.1016/S2352-3018(20)30036-9
15. Vasan RS, Sullivan LM, Wilson PWF, et al. Relative Importance of Borderline and Elevated Levels of Coronary Heart Disease Risk Factors. Ann Intern Med. 2005;142(6):393. DOI:10.7326/0003-4819-142-6-200503150-00005
16. SCORE2 working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439-54. DOI:10.1093/eurheartj/ehab309
17. Shahbaz S. Cardiovascular disease in human immunodeficiency virus infected patients: A true or perceived risk? WJC. 2015;7(10):633. DOI:10.4330/wjc.v7.i10.633
18. Heywood JT, Fonarow GC, Costanzo MR, et al. High Prevalence of Renal Dysfunction and Its Impact on Outcome in 118,465 Patients Hospitalized With Acute Decompensated Heart Failure: A Report From the ADHERE Database. J Card Fail. 2007;13(6):422-30. DOI:10.1016/j.cardfail.2007.03.011
19. Sarnak MJ, Katz R, Newman A, et al. Association of Urinary Injury Biomarkers with Mortality and Cardiovascular Events. J Am Soc Nephrol. 2014;25(7):1545-53. DOI:10.1681/ASN.2013070713
20. Go AS, Chertow GM, Fan D, et al. Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization. N Engl J Med. 2004;351(13):1296-305. DOI:10.1056/NEJMoa041031
21. Choi AI, Li Y, Deeks SG, et al. Association Between Kidney Function and Albuminuria With Cardiovascular Events in HIV-Infected Persons. Circulation. 2010;121(5):651-8. DOI:10.1161/CIRCULATIONAHA.109.898585
22. Jotwani V, Scherzer R, Abraham A, et al. Does HIV Infection Promote Early Kidney Injury in Women? Antivir Ther. 2014;19(1):79-87. DOI:10.3851/IMP2677
23. Boyd MA, Mocroft A, Ryom L, et al. Cardiovascular disease (CVD) and chronic kidney disease (CKD) event rates in HIV-positive persons at high predicted CVD and CKD risk: A prospective analysis of the D:A:D observational study. PLoS Med. 2017;14(11):e1002424. DOI:10.1371/journal.pmed.1002424
24. Смирнов А.В., Добронравов В.А., Каюков И.Г. Кардио-ренальный континуум: патогенетические основы превентивной нефрологии. Нефрология. 2005;9(3):7-15 [Smirnov AV, Dobronravov VA, Kayukov IG. Cardiorenal continuum, pathogenetical grounds of preventive nephrology. Nephrology (Saint-Petersburg). 2005;9(3):7-15 (in Russian)]. DOI:10.24884/1561-6274-2005-9-3-7-15
25. García-Donaire JA, Ruilope LM. Cardiorenal Continuum. In: Berbari AE, Mancia G, eds. Cardiorenal Syndrome. Springer Milan; 2010:67-79. DOI:10.1007/978-88-470-1463-3_5
26. Amair MP, Arocha Rodulfo I. El continuo cardiorrenal: una propuesta para la prevención de las enfermedades cardiovasculares y renales. Rev Colomb Nefrol. 2020;7(1):60-9. DOI:10.22265/acnef.7.1.356
27. Zoccali C, Zannad F. Refocusing cardio-renal problems: the cardiovascular-kidney-metabolic syndrome and the chronic cardiovascular-kidney disorder. Nephrol Dial Transplant. 2024;39(9):1378-80. DOI:10.1093/ndt/gfae086
28. Budoff MJ, Rader DJ, Reilly MP, et al. Relationship of Estimated GFR and Coronary Artery Calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis. 2011;58(4):519-26. DOI:10.1053/j.ajkd.2011.04.024
29. Jotwani V, Katz R, Ix JH, et al. Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in Elders. Am J Kidney Dis. 2018;72(2):205-13. DOI:10.1053/j.ajkd.2017.12.013
30. Lai M, Madden E, Shlipak MG, et al. Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV. AIDS. 2024;38(4):465-75. DOI:10.1097/QAD.0000000000003761
31. Vos AG, Venter WDF. Cardiovascular toxicity of contemporary antiretroviral therapy. Curr Opin HIV AIDS. 2021;16(6):286-91. DOI:10.1097/COH.0000000000000702
32. Bavinger C, Bendavid E, Niehaus K, et al. Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review. PLoS One. 2013;8(3):e59551. DOI:10.1371/journal.pone.0059551
33. Taramasso L, Andreoni M, Antinori A, et al. Pillars of long-term antiretroviral therapy success. Pharmacol Res. 2023;196:106898. DOI:10.1016/j.phrs.2023.106898
34. Lazarus JV, Wohl DA, Cascio M, et al. Long-term success for people living with HIV : A framework to guide practice. HIV Med. 2023;24(Suppl. 2):8-19. DOI:10.1111/hiv.13460
35. EACS Guidelines version 12.0. EACS Guidelines version 12.0. Published online 2023. Available at: https://www.eacsociety.org/guidelines/eacs-guidelines/ Accessed: 13.07.2024.
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39. Boffito M, Waters L, Cahn P, et al. Perspectives on the Barrier to Resistance for Dolutegravir + Lamivudine, a Two-Drug Antiretroviral Therapy for HIV-1 Infection. AIDS ResHum Retroviruses. 2020;36(1):13-8. DOI:10.1089/aid.2019.0171
40. Martin EA, Lai MT, Ngo W, et al. Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development. J Acquir Immune Defic Syndr. 2020;85(5):635-42. DOI:10.1097/QAI.0000000000002496
41. Sax PE, Arribas JR, Orkin C, et al.; GS-US-380-1489 and GS-US-380-1490 study investigators. Bictegravir/emtricitabine/tenofovir alafenamide as initial treatment for HIV-1: five-year follow-up from two randomized trials. EClinicalMedicine. 2023;59:101991. DOI:10.1016/j.eclinm.2023.101991
42. Schapiro JM, Perno CF, et al. Poster P088. Expanded multivariable models to assist patient selection for long-acting cabotegravir+rilpivirine treatment: clinical utility of a combination of patient, drug concentration, and viral factors associated with virologic failure over 152 weeks. Presented at HIV Glasgow 2022, October 23–26, 2022, Glasgow, UK and virtually.
43. White KL, Osman N, Cuadra-Foy E, et al. Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes. Antimicrob Agents Chemother. 2021;65(5):e02406-20. DOI:10.1128/AAC.02406-20
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46. Carr A, Mackie NE, Paredes R, Ruxrungtham K. HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective. Antivir Ther. 2023;28(5):13596535231201162. DOI:10.1177/13596535231201162
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51. Chu C, Tao K, Kouamou V, et al. Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review. Viruses. 2024;16(3):399. DOI:10.3390/v16030399
52. Steegen K, Moorhouse M, Wensing AM, et al. Is there a role for doravirine in African HIV treatment programmes? A large observational resistance study in South Africa. Journal of the International AIDS Society. 2021;24(5):e25706. DOI:10.1002/jia2.25706
53. Loosli T, Hossmann S, Ingle SM, et al. HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis. Lancet HIV. 2023;10(11):e733-41. DOI:10.1016/S2352-3018(23)00228-X
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61. Hsue P, Behrens G, Xu ZJ, et al. Cardiovascular risk assessment after continuing or switching to a doravirine-based regimen using the atherosclerotic cardiovascular disease (ASCVD) risk score model. EACS 2023, October 18–21, 2023, Warsaw. Abstract OS2.03.
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34. Lazarus JV, Wohl DA, Cascio M, et al. Long-term success for people living with HIV : A framework to guide practice. HIV Med. 2023;24(Suppl. 2):8-19. DOI:10.1111/hiv.13460
35. EACS Guidelines version 12.0. EACS Guidelines version 12.0. Published online 2023. Available at: https://www.eacsociety.org/guidelines/eacs-guidelines/ Accessed: 13.07.2024.
36. HIV infection in adults. Clinical guidelines. 2024. Available at: https://cr.minzdrav.gov.ru/recomend/79_2. Accessed: 13.08.2024 (in Russian).
37. Department of Health and Human Services. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. 2024. Available at: https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv. Accessed: 07.04.2024.
38. Kardas P, Urbański F, Lichwierowicz A, et al. Prevalence and Age Structure of Polypharmacy in Poland: Results of the Analysis of the National Real-World Database of 38 Million Citizens. Front Pharmacol. 2021;12. DOI:10.3389/fphar.2021.655364
39. Boffito M, Waters L, Cahn P, et al. Perspectives on the Barrier to Resistance for Dolutegravir + Lamivudine, a Two-Drug Antiretroviral Therapy for HIV-1 Infection. AIDS ResHum Retroviruses. 2020;36(1):13-8. DOI:10.1089/aid.2019.0171
40. Martin EA, Lai MT, Ngo W, et al. Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development. J Acquir Immune Defic Syndr. 2020;85(5):635-42. DOI:10.1097/QAI.0000000000002496
41. Sax PE, Arribas JR, Orkin C, et al.; GS-US-380-1489 and GS-US-380-1490 study investigators. Bictegravir/emtricitabine/tenofovir alafenamide as initial treatment for HIV-1: five-year follow-up from two randomized trials. EClinicalMedicine. 2023;59:101991. DOI:10.1016/j.eclinm.2023.101991
42. Schapiro JM, Perno CF, et al. Poster P088. Expanded multivariable models to assist patient selection for long-acting cabotegravir+rilpivirine treatment: clinical utility of a combination of patient, drug concentration, and viral factors associated with virologic failure over 152 weeks. Presented at HIV Glasgow 2022, October 23–26, 2022, Glasgow, UK and virtually.
43. White KL, Osman N, Cuadra-Foy E, et al. Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes. Antimicrob Agents Chemother. 2021;65(5):e02406-20. DOI:10.1128/AAC.02406-20
44. Laseeva MG, Vlasova TI, Dvoretskova SY. The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia. HIV Infection and Immunosuppressive Disorders. 2022;14(4):21-8 (in Russian). DOI:10.22328/2077-9828-2022-14-4-21-28
45. Branda F, Giovanetti M, Sernicola L, et al. Comprehensive Analysis of HIV-1 Integrase Resistance-Related Mutations in African Countries. Pathogens. 2024;13(2):102. DOI:10.3390/pathogens13020102
46. Carr A, Mackie NE, Paredes R, Ruxrungtham K. HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective. Antivir Ther. 2023;28(5):13596535231201162. DOI:10.1177/13596535231201162
47. Musengimana G, Tuyishime E, Kiromera A, et al. Acquired HIV drug resistance among adults living with HIV receiving first-line antiretroviral therapy in Rwanda: A cross-sectional nationally representative survey. Antivir Ther. 2022;27(3):135965352211026. DOI:10.1177/13596535221102690
48. Kim SJ, Kwon OD, Han EB, et al. Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study. Medicine (United States). 2019;98(49). DOI:10.1097/MD.0000000000017825
49. Wakai E, Ikemura K, Kato C, Okuda M. Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension. PLoS One. 2021;16(6):e0252944. DOI:10.1371/journal.pone.0252944
50. Assawasuwannakit P, Braund R, Duffull S. Quantification of the Forgiveness of Drugs to Imperfect Adherence. CPT Pharmacometrics Syst Pharmacol. 2015;4(3):e00004. DOI:10.1002/psp4.4
51. Chu C, Tao K, Kouamou V, et al. Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review. Viruses. 2024;16(3):399. DOI:10.3390/v16030399
52. Steegen K, Moorhouse M, Wensing AM, et al. Is there a role for doravirine in African HIV treatment programmes? A large observational resistance study in South Africa. Journal of the International AIDS Society. 2021;24(5):e25706. DOI:10.1002/jia2.25706
53. Loosli T, Hossmann S, Ingle SM, et al. HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis. Lancet HIV. 2023;10(11):e733-41. DOI:10.1016/S2352-3018(23)00228-X
54. Andreatta K, Sax PE, Wohl DA, et al. 1561. Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) Versus Dolutegravir (DTG)-Based 3-Drug Regimens in Adults With HIV Who Have Suboptimal Antiretroviral Adherence. Open Forum Infect Dis. 2023;10(Suppl. 2):ofad500.1396. DOI:10.1093/ofid/ofad500.1396
55. Maggiolo F, Valenti D, Teocchi R, et al. Real World Data on Forgiveness to Uncomplete Adherence to Bictegravir/ Emtricitabine/Tenofovir Alafenamide. J Int Assoc Provid AIDS Care. 2022;21:232595822211402. DOI:10.1177/23259582221140208
56. Maggiolo F, Valenti D, Teocchi R, et al. Adherence to and Forgiveness of 3TC/DTG in a Real-World Cohort. J Int Assoc Provid AIDS Care. 2022;21:232595822211018. DOI:10.1177/23259582221101815
57. Dorjee K, Desai M, Choden T, et al. Acute myocardial infarction associated with abacavir and tenofovir based antiretroviral drug combinations in the United States. AIDS Res Ther. 2021;18(1):57. DOI:10.1186/s12981-021-00383-7
58. O’Halloran JA, Sahrmann J, Butler AM, et al. Brief Report: Integrase Strand Transfer Inhibitors Are Associated With Lower Risk of Incident Cardiovascular Disease in People Living With HIV. J Acquir Immune Defic Syndr. 2020;84(4):396-9. DOI:10.1097/QAI.0000000000002357
59. Surial B, Chammartin F, Damas J, et al. Impact of Integrase Inhibitors on Cardiovascular Disease Events in People With Human Immunodeficiency Virus Starting Antiretroviral Therapy. Clin Infect Dis. 2023;77(5):729-37. DOI:10.1093/cid/ciad286
60. Corti N, Menzaghi B, Orofino G, et al. Risk of Cardiovascular Events in People with HIV (PWH) Treated with Integrase Strand-Transfer Inhibitors: The Debate Is Not Over; Results of the SCOLTA Study. Viruses. 2024;16(4):613. DOI:10.3390/v16040613
61. Hsue P, Behrens G, Xu ZJ, et al. Cardiovascular risk assessment after continuing or switching to a doravirine-based regimen using the atherosclerotic cardiovascular disease (ASCVD) risk score model. EACS 2023, October 18–21, 2023, Warsaw. Abstract OS2.03.
62. Iannone V, Farinacci D, D’Angelillo A, et al. Cardiovascular Disease Risk in a Cohort of Virologically Suppressed People Living with HIV Switching to Doravirine: Preliminary Data from the Real Life. AIDS Res Hum Retroviruses. 2022;38(11):878-80. DOI:10.1089/aid.2022.0050
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Авторы
В.И. Шахгильдян*1, С.Т. Мацкеплишвили2
1ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва, Россия;
2ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*vishakh@yandex.ru
1Central Research Institute for Epidemiology, Moscow, Russia;
2Lomonosov Moscow State University, Moscow, Russia
*vishakh@yandex.ru
1ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, Москва, Россия;
2ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*vishakh@yandex.ru
________________________________________________
1Central Research Institute for Epidemiology, Moscow, Russia;
2Lomonosov Moscow State University, Moscow, Russia
*vishakh@yandex.ru
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