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        • Журнал Терапевтический архив №6 Вопросы нефрологии
        • Современные возможности фторхинолонов: пазуфлоксацин - Журнал Терапевтический архив №6 Вопросы нефрологии 2025

        Современные возможности фторхинолонов: пазуфлоксацин - Журнал Терапевтический архив №6 Вопросы нефрологии 2025

        Бутранова О.И., Зырянов С.К., Мельникова А.Р., Мацепуро А.Е. Современные возможности фторхинолонов: пазуфлоксацин. Терапевтический архив. 2025;97(6):509–521. DOI: 10.26442/00403660.2025.06.203268

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.

        ________________________________________________

        Butranova OI, Zyryanov SK, Melnikova AR, Matsepuro AE. Current prospects of fluoroquinolones: pazufloxacin. A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(6):509–521. DOI: 10.26442/00403660.2025.06.203268

        Современные возможности фторхинолонов: пазуфлоксацин

        Бутранова О.И., Зырянов С.К., Мельникова А.Р., Мацепуро А.Е. Современные возможности фторхинолонов: пазуфлоксацин. Терапевтический архив. 2025;97(6):509–521. DOI: 10.26442/00403660.2025.06.203268

        © ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.

        ________________________________________________

        Butranova OI, Zyryanov SK, Melnikova AR, Matsepuro AE. Current prospects of fluoroquinolones: pazufloxacin. A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(6):509–521. DOI: 10.26442/00403660.2025.06.203268

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          Современные возможности фторхинолонов: пазуфлоксацин

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        Аннотация
        Фторхинолоны (ФХ) являются одной из наиболее ценных групп антибактериальных препаратов в клинической практике. Ципрофлоксацин и левофлоксацин – препараты, вносящие наибольший вклад в структуру потребления ФХ как в Российской Федерации, так и в мире. Широкое применение ФХ в последние годы сопровождается интенсивным ростом антибиотикорезистентности основных возбудителей, включая группу ESKAPE, что ограничивает возможности эффективной антибиотикотерапии широкого спектра инфекционных заболеваний (ИЗ). В данной ситуации привлекательной выглядит возможность включения в схемы ведения пациентов с ИЗ нового для российского фармацевтического рынка ФХ – пазуфлоксацина, который представляет собой ФХ III поколения, чей спектр антибактериального действия, как продемонстрировано, приближен к таковому беталактамного антибактериального препарата цефтазидима. Рассмотренные в обзоре исследования свидетельствуют о высоком уровне клинической эффективности и безопасности приведенного ФХ, что указывает на широкие перспективы его применения в лечении ИЗ в условиях растущей антибиотикорезистентности.

        Ключевые слова: фторхинолоны, пазуфлоксацин, антибиотикорезистентность, инфекционные заболевания

        ________________________________________________

        Fluoroquinolones (FQ) are one of the most valuable groups of antibacterial drugs in clinical practice. Ciprofloxacin and levofloxacin are drugs with the largest contribution to the structure of FQ consumption both in the Russian Federation and in the world. The widespread use of FQ in recent years has been accompanied by an intensive growth of antibiotic resistance of the main pathogens, including those from the ESKAPE group, which limits the possibilities of effective antibiotic therapy for a wide range of infectious diseases. In this situation, we have an attractive possibility of including a new FQ for the Russian pharmaceutical market, pazufloxacin, in the treatment regimens for patients with infectious diseases. This is a third-generation FQ, whose spectrum of antibacterial action, as has been demonstrated in the published studies, is close to that of the beta-lactam ABP ceftazidime. The studies considered in our narrative review indicate a high level of clinical efficacy and safety of this FQ, which suggests broad prospects for its use in the treatment of infectious diseases taking in account accelerated antibiotic resistance.

        Keywords: fluoroquinolones, pazufloxacin, antibiotic resistance, infectious diseases

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        Авторы
        О.И. Бутранова*1, С.К. Зырянов1,2, А.Р. Мельникова1, А.Е. Мацепуро1

        1ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы», Москва, Россия;
        2ГБУЗ «Городская клиническая больница №24» Департамента здравоохранения г. Москвы, Москва, Россия
        *butranova-oi@rudn.ru

        ________________________________________________

        Olga I. Butranova*1, Sergey K. Zyryanov1,2, Anna R. Melnikova1, Anastasia E. Matsepuro1

        1Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia;
        2City Clinical Hospital No. 24, Moscow, Russia
        *butranova-oi@rudn.ru


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