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Распространенность и риск синдрома избыточного бактериального роста в тонкой кишке у пациентов с розацеа: систематический обзор и метаанализ - Журнал Терапевтический архив №7 Vario 2025
Распространенность и риск синдрома избыточного бактериального роста в тонкой кишке у пациентов с розацеа: систематический обзор и метаанализ
Хурматуллина А.Р., Кучерявый Ю.А., Андреев Д.Н., Тамразова О.Б., Маев И.В. Распространенность и риск синдрома избыточного бактериального роста в тонкой кишке у пациентов с розацеа: систематический обзор и метаанализ. Терапевтический архив. 2025;97(7):580–586. DOI: 10.26442/00403660.2025.07.203297
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
© ООО «КОНСИЛИУМ МЕДИКУМ», 2025 г.
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Аннотация
Цель. Систематизация данных о распространенности и риске синдрома избыточного бактериального роста (СИБР) у пациентов, страдающих розацеа.
Материалы и методы. Поиск исследований проводили в базах данных MEDLINE/PubMed, EMBASE и Российском индексе научного цитирования с 1 января 1985 г. по 5 апреля 2025 г. Критерии включения: оригинальные клинические исследования на английском или русском языке с детальной описательной статистикой, описывающей распространенность СИБР у взрослых пациентов с розацеа. Анализ включал оценку распространенности СИБР, расчет относительного риска и 95% доверительного интервала (ДИ) с использованием модели случайных эффектов. Гетерогенность оценивали с помощью I2-статистики, а публикационное смещение – с помощью воронкообразных диаграмм и тестов Бегга–Мазумдара и Эггера.
Результаты. В метаанализ включено 6 исследований с общим числом участников 801 (581 человек – с розацеа, 220 – группа контроля). Суммарная распространенность СИБР у пациентов с розацеа составила 35,8% (95% ДИ 23,626–48,985) против 9,391% (95% ДИ 4,256–16,265) у группы контроля. Риск развития СИБР у пациентов с розацеа был в 3,501 раза выше (относительный риск 3,50, 95% ДИ 1,347–9,100; p=0,012). Лечение рифаксимином (1200 мг/сут в течение 10 дней) привело к значительному улучшению или ремиссии розацеа у 57,9% (95% ДИ 49,5–66,3) пациентов, при этом наибольшую эффективность (до 85,7%) наблюдали при успешной эрадикации СИБР.
Заключение. Результаты систематического обзора и метаанализа подтверждают потенциальную ассоциацию между СИБР и розацеа, а также демонстрируют эффективность применения рифаксимина в лечении кожных проявлений розацеа у этих пациентов. Необходимо рассмотреть включение диагностики СИБР в алгоритм обследования пациентов с розацеа, особенно при резистентных формах заболевания.
Ключевые слова: синдром избыточного бактериального роста, розацеа, рифаксимин, метаанализ
Materials and methods. The search for studies was conducted in the MEDLINE/PubMed, EMBASE, and the Russian Science Citation Index from January 1, 1985, to April 5, 2025. The inclusion criteria were original clinical studies in English or Russian with detailed descriptive statistics describing the prevalence of SIBO in adults with rosacea. The analysis included an assessment of the SIBO prevalence, calculation of relative risk, and 95% confidence interval (CI) using a random effects model. Heterogeneity was assessed using I2-statistics, and publication bias was examined with funnel plots and Begg–Mazumdar and Egger tests.
Results. The meta-analysis included 6 studies with 801 subjects (581 subjects with rosacea, 220 controls). The overall prevalence of SIBO in patients with rosacea was 35.8% (95% CI 23.626–48.985) compared to 9.391% (95% CI 4.256–16.265) in controls. The risk of developing SIBO in patients with rosacea was 3.501 times higher (relative risk 3.50; 95% CI 1.347–9.100; p=0.012). Treatment with rifaximin (1200 mg/day for 10 days) resulted in significant improvement or remission of rosacea in 57.9% (95% CI 49.5–66.3) of patients, with the highest effectiveness (up to 85.7%) observed in those with successful eradication of SIBO.
Conclusion. The results of a systematic review and meta-analysis confirm the potential association between SIBO and rosacea and demonstrate the effectiveness of rifaximin in treating cutaneous manifestations of rosacea in these patients. It is necessary to consider SIBO diagnosis when assessing patients with rosacea, especially in resistant forms of the disease.
Keywords: bacterial overgrowth syndrome, rosacea, rifaximin, meta-analysis
Материалы и методы. Поиск исследований проводили в базах данных MEDLINE/PubMed, EMBASE и Российском индексе научного цитирования с 1 января 1985 г. по 5 апреля 2025 г. Критерии включения: оригинальные клинические исследования на английском или русском языке с детальной описательной статистикой, описывающей распространенность СИБР у взрослых пациентов с розацеа. Анализ включал оценку распространенности СИБР, расчет относительного риска и 95% доверительного интервала (ДИ) с использованием модели случайных эффектов. Гетерогенность оценивали с помощью I2-статистики, а публикационное смещение – с помощью воронкообразных диаграмм и тестов Бегга–Мазумдара и Эггера.
Результаты. В метаанализ включено 6 исследований с общим числом участников 801 (581 человек – с розацеа, 220 – группа контроля). Суммарная распространенность СИБР у пациентов с розацеа составила 35,8% (95% ДИ 23,626–48,985) против 9,391% (95% ДИ 4,256–16,265) у группы контроля. Риск развития СИБР у пациентов с розацеа был в 3,501 раза выше (относительный риск 3,50, 95% ДИ 1,347–9,100; p=0,012). Лечение рифаксимином (1200 мг/сут в течение 10 дней) привело к значительному улучшению или ремиссии розацеа у 57,9% (95% ДИ 49,5–66,3) пациентов, при этом наибольшую эффективность (до 85,7%) наблюдали при успешной эрадикации СИБР.
Заключение. Результаты систематического обзора и метаанализа подтверждают потенциальную ассоциацию между СИБР и розацеа, а также демонстрируют эффективность применения рифаксимина в лечении кожных проявлений розацеа у этих пациентов. Необходимо рассмотреть включение диагностики СИБР в алгоритм обследования пациентов с розацеа, особенно при резистентных формах заболевания.
Ключевые слова: синдром избыточного бактериального роста, розацеа, рифаксимин, метаанализ
________________________________________________
Materials and methods. The search for studies was conducted in the MEDLINE/PubMed, EMBASE, and the Russian Science Citation Index from January 1, 1985, to April 5, 2025. The inclusion criteria were original clinical studies in English or Russian with detailed descriptive statistics describing the prevalence of SIBO in adults with rosacea. The analysis included an assessment of the SIBO prevalence, calculation of relative risk, and 95% confidence interval (CI) using a random effects model. Heterogeneity was assessed using I2-statistics, and publication bias was examined with funnel plots and Begg–Mazumdar and Egger tests.
Results. The meta-analysis included 6 studies with 801 subjects (581 subjects with rosacea, 220 controls). The overall prevalence of SIBO in patients with rosacea was 35.8% (95% CI 23.626–48.985) compared to 9.391% (95% CI 4.256–16.265) in controls. The risk of developing SIBO in patients with rosacea was 3.501 times higher (relative risk 3.50; 95% CI 1.347–9.100; p=0.012). Treatment with rifaximin (1200 mg/day for 10 days) resulted in significant improvement or remission of rosacea in 57.9% (95% CI 49.5–66.3) of patients, with the highest effectiveness (up to 85.7%) observed in those with successful eradication of SIBO.
Conclusion. The results of a systematic review and meta-analysis confirm the potential association between SIBO and rosacea and demonstrate the effectiveness of rifaximin in treating cutaneous manifestations of rosacea in these patients. It is necessary to consider SIBO diagnosis when assessing patients with rosacea, especially in resistant forms of the disease.
Keywords: bacterial overgrowth syndrome, rosacea, rifaximin, meta-analysis
Полный текст
Список литературы
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21. Drago F, Ciccarese G, Herzum A, et al. The association between cigarettes smoke, small intestine bacterial overgrowth and rosacea. G Ital Dermatol Venereol. 2019;154(6):727-2. DOI:10.23736/S0392-0488.18.05919-9
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2. Maev IV, Kucheryavyy YuA, Andreev DN, Ivashkina NYu. Small bowel bacterial overgrowth syndrome: clinical relevance, criteria of diagnostics and therapeutic management. Infectious diseases: News, Opinions, Training. 2016;3:118-25 (in Russian).
3. Losurdo G, Salvatore D'Abramo F, Indellicati G, et al. The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders. Int J Mol Sci. 2020;21(10):3531. DOI:10.3390/ijms21103531
4. Liu Chen Kiow J, Bellila R, Therrien A, et al. Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing. J Clin Med Res. 2020;12(10):655-61. DOI:10.14740/jocmr4320
5. Efremova I, Maslennikov R, Poluektova E, et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023;29(22):3400-41. DOI:10.3748/wjg.v29.i22.3400
6. Cortez APB, Fisberg M, de Morais MB. Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents. Pediatr Obes. 2021;16(5):e12741. DOI:10.1111/ijpo.12741
7. Dudukchyan DA, Sarkisyan DK, Andreev DN. Helicobacter pylori infection and dermatological diseases. Meditsinskiy sovet = Medical Council. 2024;(8):43-9 (in Russian). DOI:10.21518/ms2024-232
8. Simanenkov VI, Maev IV, Tkacheva ON, et al. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758 (in Russian). DOI:10.15829/1728-8800-2021-2758
9. Korsing S, Stieler K, Pleyer U, et al. Rosacea in childhood and adolescence: A review. J Dtsch Dermatol Ges. 2025. DOI:10.1111/ddg.15693
10. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179(2):282-8. DOI:10.1111/bjd.16481
11. Sharma A, Kroumpouzos G, Kassir M, et al. Rosacea management: A comprehensive review. J Cosmet Dermatol. 2022;21(5):1895-904. DOI:10.1111/jocd.14816
12. Dall'Oglio F, Fusto C, Micali G. Intrafamilial Transmission of Rosacea Spanning Six Generations: A Retrospective Observational Study. J Clin Aesthet Dermatol. 2022;15(2):35-9.
13. Deng Z, Chen M, Zhao Z, et al. Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea. Nat Commun. 2023;14(1):3958. DOI:10.1038/s41467-023-39761-2
14. Chen C, Wang P, Zhang L, et al. Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates. Biomedicines. 2023;11(8):2153. DOI:10.3390/biomedicines11082153
15. Nguyen C, Kuceki G, Birdsall M, et al. Rosacea: Practical Guidance and Challenges for Clinical Management. Clin Cosmet Investig Dermatol. 2024;17:175-90. DOI:10.2147/CCID.S391705
16. Egeberg A, Weinstock LB, Thyssen EP, et al. Rosacea and gastrointestinal disorders: a population-based cohort study. Br J Dermatol. 2017;176(1):100. DOI:10.1111/bjd.14930
17. Gravina A, Federico A, Ruocco E, et al. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea. United European Gastroenterol J. 2015;3(1):17-24. DOI:10.1177/2050640614559262
18. Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008;6(7):759-64. DOI:10.1016/j.cgh.2008.02.054
19. Weinstock LB, Steinhoff M. Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol. 2013;68(5):875-6. DOI:10.1016/j.jaad.2012.11.038
20. Drago F, De Col E, Agnoletti AF, et al. The role of small intestinal bacterial overgrowth in rosacea: A 3-year follow-up. J Am Acad Dermatol. 2016;75(3):e113-15. DOI:10.1016/j.jaad.2016.01.059
21. Drago F, Ciccarese G, Herzum A, et al. The association between cigarettes smoke, small intestine bacterial overgrowth and rosacea. G Ital Dermatol Venereol. 2019;154(6):727-2. DOI:10.23736/S0392-0488.18.05919-9
22. Nelson JM, Rizzo JM, Greene RK, et al. Evaluation of Helicobacter pylori and Small Intestinal Bacterial Overgrowth in Subjects With Rosacea. Cureus. 2024;16(10):e72363. DOI:10.7759/cureus.72363
23. Achufusi TGO, Sharma A, Zamora EA, Manocha D. Small Intestinal Bacterial Overgrowth: Comprehensive Review of Diagnosis, Prevention, and Treatment Methods. Cureus. 2020;12(6):e8860. DOI:10.7759/cureus.8860
24. Bushyhead D, Quigley EMM. Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management. Gastroenterology. 2022;163(3):593-607. DOI:10.1053/j.gastro.2022.04.002
25. Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2020;11(1):1-12. DOI:10.1007/s13555-020-00460-1
26. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012;166(2):510-21. DOI:10.1111/j.1476-5381.2012.01851.x
27. Xue Q, Pan JP, Qian D, et al. Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis. Clin Cosmet Investig Dermatol. 2025;18:191-200. DOI:10.2147/CCID.S495773
28. Montoro-Huguet MA, Belloc B, Domínguez-Cajal M. Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients. 2021;13(4):1254. DOI:10.3390/nu13041254
29. Schwab VD, Sulk M, Seeliger S, et al. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc. 2011;15(1):53-62. DOI:10.1038/jidsymp.2011.6
30. Del Rosso JQ, Brantman S, Baldwin H. Long-term inflammatory rosacea management with subantibiotic dose oral doxycycline 40 mg modified-release capsules once daily. Dermatol Ther. 2022;35(1):e15180. DOI:10.1111/dth.15180
31. Sbidian E, Vicaut É, Chidiack H, et al. A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea. J Invest Dermatol. 2016;136(6):1124-219. DOI:10.1016/j.jid.2016.01.025
32. Wang FY, Chi CC. Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea. Adv Ther. 2021;38(3):1415-44. DOI:10.1007/s12325-021-01624-x
33. Liao L, Su BB, Xu SP. Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis. BMC Microbiol. 2023;23(1):386. DOI:10.1186/s12866-023-03063-w
34. Silva BCD, Ramos GP, Barros LL, et al. Diagnosis and treatment of small intestinal bacterial overgrowth: an official position paper from the Brazilian Federation of Gastroenterology. Arq Gastroenterol. 2025;62:e24107. DOI:10.1590/S0004-2803.24612024-107
35. Ivashkin VT, Fomin VV, Tkacheva ON, et al. Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(2):14-34 (in Russian). DOI:10.22416/1382-4376-2024-954
36. Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017;45(5):604-16. DOI:10.1111/apt.13928
37. Wang J, Zhang L, Hou X. Efficacy of rifaximin in treating with small intestine bacterial overgrowth: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2021;15(12):1385-439. DOI:10.1080/17474124.2021.2005579
2. Маев И.В., Кучерявый Ю.А., Андреев Д.Н., Ивашкина Н.Ю. Синдром избыточного бактериального роста в тонкой кишке: клиническое значение, критерии диагностики и терапевтическая тактика. Инфекционные болезни: Новости. Мнения. Обучение. 2016;3:118-25 [Maev IV, Kucheryavyy YuA, Andreev DN, Ivashkina NYu. Small bowel bacterial overgrowth syndrome: clinical relevance, criteria of diagnostics and therapeutic management. Infectious diseases: News, Opinions, Training. 2016;3:118-25 (in Russian)].
3. Losurdo G, Salvatore D'Abramo F, Indellicati G, et al. The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders. Int J Mol Sci. 2020;21(10):3531. DOI:10.3390/ijms21103531
4. Liu Chen Kiow J, Bellila R, Therrien A, et al. Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing. J Clin Med Res. 2020;12(10):655-61. DOI:10.14740/jocmr4320
5. Efremova I, Maslennikov R, Poluektova E, et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023;29(22):3400-41. DOI:10.3748/wjg.v29.i22.3400
6. Cortez APB, Fisberg M, de Morais MB. Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents. Pediatr Obes. 2021;16(5):e12741. DOI:10.1111/ijpo.12741
7. Дудукчян Д.А., Саркисян Д.К., Андреев Д.Н. Инфекция Helicobacter pylori и заболевания дерматологического профиля. Медицинский Совет. 2024;(8):43-9 [Dudukchyan DA, Sarkisyan DK, Andreev DN. Helicobacter pylori infection and dermatological diseases. Meditsinskiy sovet = Medical Council. 2024;(8):43-9 (in Russian)]. DOI:10.21518/ms2024-232
8. Симаненков В.И., Маев И.В., Ткачева О.Н., и др. Синдром повышенной эпителиальной проницаемости в клинической практике. Мультидисциплинарный национальный консенсус. Кардиоваскулярная терапия и профилактика. 2021;20(1):2758 [Simanenkov VI, Maev IV, Tkacheva ON, et al. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758 (in Russian)]. DOI:10.15829/1728-8800-2021-2758
9. Korsing S, Stieler K, Pleyer U, et al. Rosacea in childhood and adolescence: A review. J Dtsch Dermatol Ges. 2025. DOI:10.1111/ddg.15693
10. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179(2):282-8. DOI:10.1111/bjd.16481
11. Sharma A, Kroumpouzos G, Kassir M, et al. Rosacea management: A comprehensive review. J Cosmet Dermatol. 2022;21(5):1895-904. DOI:10.1111/jocd.14816
12. Dall'Oglio F, Fusto C, Micali G. Intrafamilial Transmission of Rosacea Spanning Six Generations: A Retrospective Observational Study. J Clin Aesthet Dermatol. 2022;15(2):35-9.
13. Deng Z, Chen M, Zhao Z, et al. Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea. Nat Commun. 2023;14(1):3958. DOI:10.1038/s41467-023-39761-2
14. Chen C, Wang P, Zhang L, et al. Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates. Biomedicines. 2023;11(8):2153. DOI:10.3390/biomedicines11082153
15. Nguyen C, Kuceki G, Birdsall M, et al. Rosacea: Practical Guidance and Challenges for Clinical Management. Clin Cosmet Investig Dermatol. 2024;17:175-90. DOI:10.2147/CCID.S391705
16. Egeberg A, Weinstock LB, Thyssen EP, et al. Rosacea and gastrointestinal disorders: a population-based cohort study. Br J Dermatol. 2017;176(1):100. DOI:10.1111/bjd.14930
17. Gravina A, Federico A, Ruocco E, et al. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea. United European Gastroenterol J. 2015;3(1):17-24. DOI:10.1177/2050640614559262
18. Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008;6(7):759-64. DOI:10.1016/j.cgh.2008.02.054
19. Weinstock LB, Steinhoff M. Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol. 2013;68(5):875-6. DOI:10.1016/j.jaad.2012.11.038
20. Drago F, De Col E, Agnoletti AF, et al. The role of small intestinal bacterial overgrowth in rosacea: A 3-year follow-up. J Am Acad Dermatol. 2016;75(3):e113-15. DOI:10.1016/j.jaad.2016.01.059
21. Drago F, Ciccarese G, Herzum A, et al. The association between cigarettes smoke, small intestine bacterial overgrowth and rosacea. G Ital Dermatol Venereol. 2019;154(6):727-2. DOI:10.23736/S0392-0488.18.05919-9
22. Nelson JM, Rizzo JM, Greene RK, et al. Evaluation of Helicobacter pylori and Small Intestinal Bacterial Overgrowth in Subjects With Rosacea. Cureus. 2024;16(10):e72363. DOI:10.7759/cureus.72363
23. Achufusi TGO, Sharma A, Zamora EA, Manocha D. Small Intestinal Bacterial Overgrowth: Comprehensive Review of Diagnosis, Prevention, and Treatment Methods. Cureus. 2020;12(6):e8860. DOI:10.7759/cureus.8860
24. Bushyhead D, Quigley EMM. Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management. Gastroenterology. 2022;163(3):593-607. DOI:10.1053/j.gastro.2022.04.002
25. Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2020;11(1):1-12. DOI:10.1007/s13555-020-00460-1
26. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012;166(2):510-21. DOI:10.1111/j.1476-5381.2012.01851.x
27. Xue Q, Pan JP, Qian D, et al. Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis. Clin Cosmet Investig Dermatol. 2025;18:191-200. DOI:10.2147/CCID.S495773
28. Montoro-Huguet MA, Belloc B, Domínguez-Cajal M. Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients. 2021;13(4):1254. DOI:10.3390/nu13041254
29. Schwab VD, Sulk M, Seeliger S, et al. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc. 2011;15(1):53-62. DOI:10.1038/jidsymp.2011.6
30. Del Rosso JQ, Brantman S, Baldwin H. Long-term inflammatory rosacea management with subantibiotic dose oral doxycycline 40 mg modified-release capsules once daily. Dermatol Ther. 2022;35(1):e15180. DOI:10.1111/dth.15180
31. Sbidian E, Vicaut É, Chidiack H, et al. A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea. J Invest Dermatol. 2016;136(6):1124-219. DOI:10.1016/j.jid.2016.01.025
32. Wang FY, Chi CC. Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea. Adv Ther. 2021;38(3):1415-44. DOI:10.1007/s12325-021-01624-x
33. Liao L, Su BB, Xu SP. Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis. BMC Microbiol. 2023;23(1):386. DOI:10.1186/s12866-023-03063-w
34. Silva BCD, Ramos GP, Barros LL, et al. Diagnosis and treatment of small intestinal bacterial overgrowth: an official position paper from the Brazilian Federation of Gastroenterology. Arq Gastroenterol. 2025;62:e24107. DOI:10.1590/S0004-2803.24612024-107
35. Ивашкин В.Т., Фомин В.В., Ткачева О.Н., и др. Синдром избыточного бактериального роста в практике врачей различных специальностей (Обзор литературы и резолюция Экспертного совета). Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2024;34(2):14-34 [Ivashkin VT, Fomin VV, Tkacheva ON, et al. Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(2):14-34 (in Russian)]. DOI:10.22416/1382-4376-2024-954
36. Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017;45(5):604-16. DOI:10.1111/apt.13928
37. Wang J, Zhang L, Hou X. Efficacy of rifaximin in treating with small intestine bacterial overgrowth: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2021;15(12):1385-439. DOI:10.1080/17474124.2021.2005579
________________________________________________
2. Maev IV, Kucheryavyy YuA, Andreev DN, Ivashkina NYu. Small bowel bacterial overgrowth syndrome: clinical relevance, criteria of diagnostics and therapeutic management. Infectious diseases: News, Opinions, Training. 2016;3:118-25 (in Russian).
3. Losurdo G, Salvatore D'Abramo F, Indellicati G, et al. The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders. Int J Mol Sci. 2020;21(10):3531. DOI:10.3390/ijms21103531
4. Liu Chen Kiow J, Bellila R, Therrien A, et al. Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing. J Clin Med Res. 2020;12(10):655-61. DOI:10.14740/jocmr4320
5. Efremova I, Maslennikov R, Poluektova E, et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023;29(22):3400-41. DOI:10.3748/wjg.v29.i22.3400
6. Cortez APB, Fisberg M, de Morais MB. Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents. Pediatr Obes. 2021;16(5):e12741. DOI:10.1111/ijpo.12741
7. Dudukchyan DA, Sarkisyan DK, Andreev DN. Helicobacter pylori infection and dermatological diseases. Meditsinskiy sovet = Medical Council. 2024;(8):43-9 (in Russian). DOI:10.21518/ms2024-232
8. Simanenkov VI, Maev IV, Tkacheva ON, et al. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758 (in Russian). DOI:10.15829/1728-8800-2021-2758
9. Korsing S, Stieler K, Pleyer U, et al. Rosacea in childhood and adolescence: A review. J Dtsch Dermatol Ges. 2025. DOI:10.1111/ddg.15693
10. Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179(2):282-8. DOI:10.1111/bjd.16481
11. Sharma A, Kroumpouzos G, Kassir M, et al. Rosacea management: A comprehensive review. J Cosmet Dermatol. 2022;21(5):1895-904. DOI:10.1111/jocd.14816
12. Dall'Oglio F, Fusto C, Micali G. Intrafamilial Transmission of Rosacea Spanning Six Generations: A Retrospective Observational Study. J Clin Aesthet Dermatol. 2022;15(2):35-9.
13. Deng Z, Chen M, Zhao Z, et al. Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea. Nat Commun. 2023;14(1):3958. DOI:10.1038/s41467-023-39761-2
14. Chen C, Wang P, Zhang L, et al. Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates. Biomedicines. 2023;11(8):2153. DOI:10.3390/biomedicines11082153
15. Nguyen C, Kuceki G, Birdsall M, et al. Rosacea: Practical Guidance and Challenges for Clinical Management. Clin Cosmet Investig Dermatol. 2024;17:175-90. DOI:10.2147/CCID.S391705
16. Egeberg A, Weinstock LB, Thyssen EP, et al. Rosacea and gastrointestinal disorders: a population-based cohort study. Br J Dermatol. 2017;176(1):100. DOI:10.1111/bjd.14930
17. Gravina A, Federico A, Ruocco E, et al. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea. United European Gastroenterol J. 2015;3(1):17-24. DOI:10.1177/2050640614559262
18. Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008;6(7):759-64. DOI:10.1016/j.cgh.2008.02.054
19. Weinstock LB, Steinhoff M. Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol. 2013;68(5):875-6. DOI:10.1016/j.jaad.2012.11.038
20. Drago F, De Col E, Agnoletti AF, et al. The role of small intestinal bacterial overgrowth in rosacea: A 3-year follow-up. J Am Acad Dermatol. 2016;75(3):e113-15. DOI:10.1016/j.jaad.2016.01.059
21. Drago F, Ciccarese G, Herzum A, et al. The association between cigarettes smoke, small intestine bacterial overgrowth and rosacea. G Ital Dermatol Venereol. 2019;154(6):727-2. DOI:10.23736/S0392-0488.18.05919-9
22. Nelson JM, Rizzo JM, Greene RK, et al. Evaluation of Helicobacter pylori and Small Intestinal Bacterial Overgrowth in Subjects With Rosacea. Cureus. 2024;16(10):e72363. DOI:10.7759/cureus.72363
23. Achufusi TGO, Sharma A, Zamora EA, Manocha D. Small Intestinal Bacterial Overgrowth: Comprehensive Review of Diagnosis, Prevention, and Treatment Methods. Cureus. 2020;12(6):e8860. DOI:10.7759/cureus.8860
24. Bushyhead D, Quigley EMM. Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management. Gastroenterology. 2022;163(3):593-607. DOI:10.1053/j.gastro.2022.04.002
25. Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2020;11(1):1-12. DOI:10.1007/s13555-020-00460-1
26. Fernandes ES, Fernandes MA, Keeble JE. The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol. 2012;166(2):510-21. DOI:10.1111/j.1476-5381.2012.01851.x
27. Xue Q, Pan JP, Qian D, et al. Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis. Clin Cosmet Investig Dermatol. 2025;18:191-200. DOI:10.2147/CCID.S495773
28. Montoro-Huguet MA, Belloc B, Domínguez-Cajal M. Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients. 2021;13(4):1254. DOI:10.3390/nu13041254
29. Schwab VD, Sulk M, Seeliger S, et al. Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc. 2011;15(1):53-62. DOI:10.1038/jidsymp.2011.6
30. Del Rosso JQ, Brantman S, Baldwin H. Long-term inflammatory rosacea management with subantibiotic dose oral doxycycline 40 mg modified-release capsules once daily. Dermatol Ther. 2022;35(1):e15180. DOI:10.1111/dth.15180
31. Sbidian E, Vicaut É, Chidiack H, et al. A Randomized-Controlled Trial of Oral Low-Dose Isotretinoin for Difficult-To-Treat Papulopustular Rosacea. J Invest Dermatol. 2016;136(6):1124-219. DOI:10.1016/j.jid.2016.01.025
32. Wang FY, Chi CC. Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea. Adv Ther. 2021;38(3):1415-44. DOI:10.1007/s12325-021-01624-x
33. Liao L, Su BB, Xu SP. Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis. BMC Microbiol. 2023;23(1):386. DOI:10.1186/s12866-023-03063-w
34. Silva BCD, Ramos GP, Barros LL, et al. Diagnosis and treatment of small intestinal bacterial overgrowth: an official position paper from the Brazilian Federation of Gastroenterology. Arq Gastroenterol. 2025;62:e24107. DOI:10.1590/S0004-2803.24612024-107
35. Ivashkin VT, Fomin VV, Tkacheva ON, et al. Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(2):14-34 (in Russian). DOI:10.22416/1382-4376-2024-954
36. Gatta L, Scarpignato C. Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017;45(5):604-16. DOI:10.1111/apt.13928
37. Wang J, Zhang L, Hou X. Efficacy of rifaximin in treating with small intestine bacterial overgrowth: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2021;15(12):1385-439. DOI:10.1080/17474124.2021.2005579
Авторы
А.Р. Хурматуллина1, Ю.А. Кучерявый2, Д.Н. Андреев*3, О.Б. Тамразова4, И.В. Маев3
1ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2АО «Ильинская больница», Красногорск, Россия;
3ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
4ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы», Москва, Россия
*dna-mit8@mail.ru
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
2Ilyinskaya Hospital JSC, Krasnogorsk, Russia;
3Russian University of Medicine, Moscow, Russia;
4Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia
*dna-mit8@mail.ru
1ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
2АО «Ильинская больница», Красногорск, Россия;
3ФГБОУ ВО «Российский университет медицины» Минздрава России, Москва, Россия;
4ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы», Москва, Россия
*dna-mit8@mail.ru
________________________________________________
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
2Ilyinskaya Hospital JSC, Krasnogorsk, Russia;
3Russian University of Medicine, Moscow, Russia;
4Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia
*dna-mit8@mail.ru
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