На примере обзора исследования JUPITER обсуждается возможность применения статинов у практически здоровых людей с некоторыми факторами риска. Приведены положительные результаты применения розувастатина у лиц с пониженным или нормальным уровнем холестерина липопротеидов низкой плотности. Поскольку наблюдаемые больные имели лишь один фактор риска – высокий уровень С-реактивного белка, обсуждается роль воспаления в атерогенезе и значение многочисленных плейотропных эффектов статинов, в частности розувастатина. Показана зависимость плейотропных эффектов статинов от дозы и длительности приема.
Whether statins can be used in apparently healthy individuals with some risk factors is discussed by the example of this review. The latter gives the positive results of using rosuvastatin in subjects with lower or normal low-density lipoprotein cholesterol levels. Because the patients observed have only one risk factor – high C-reactive protein values, the author discusses the role of inflammation in atherogenesis and the significance of multiple pleiotropic effects of statins, rosuvastatin in particular. The pleiotropic effects of statins are shown to be related to their dose and intake duration.
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Авторы
Д.М.Аронов
ФГУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития РФ, Москва
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D.M.Aronov
State Research Center of Preventive Medicine, Ministry of Health and Social Development of the Russian Federation