В статье представлен обзор данных литературы о частоте больших, средних, малых и незначительных кровотечений, развивающихся у пациентов с ишемической болезнью сердца (ИБС) на фоне комбинированной антиагрегантной терапии. Рассмотрены вопросы безопасности антиагрегантной терапии у больных с хронической ИБС. Отражены существующие классификации кровопотерь, используемые в наблюдательных исследованиях при проведении терапии антиагрегантами. Приведены результаты ранее выполненного собственного исследования агрегации тромбоцитов в группе больных с малыми кровотечениями.
The article presents a review of literature data on the frequency of major, moderate, small and minor bleeding, developing in patients with CHD taking combined antiplatelet therapy. The safety of antiplatelet therapy in patients with chronic CHD is considered. The existing classifications of blood loss which is used in observational studies during antiplatelet therapy are rendered. The authors demonstrate the results of the previously performed own study of platelet aggregation in patients with small hemorrhages as well.
Key words: combined antiplatelet therapy, the risk of bleeding, platelet aggregation.
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Авторы
А.Б.Сумароков*1, Л.И.Бурячковская2, И.А.Учитель2
1 ГОУ ВПО Институт клинической кардиологии им А.Л.Мясникова Минздравсоцразвития РФ, Москва;
2 Институт экспериментальной кардиологии РКНПК Минздравсоцразвития РФ, Москва
*vokoramus@mail.ru
1 Department of Atherosclerosis problems, Institute of Clinical Cardiology named after AL. Myasnikov,
2 Laboratory of Adhesion Molecules, Institute of Experimental Cardiology, Ministry of Health and Social Development of the Russian Federation, Moscow
*vokoramus@mail.ru