В обзорной статье представлены данные о проблеме коморбидной сердечно-сосудистой патологии у больных хронической обструктивной болезнью легких (ХОБЛ). Анализируется проблема фенотипирования больных ХОБЛ с целью выделения групп пациентов со сходными клинико-функциональными характеристиками и прогностической эффективностью терапии. Рассматриваются патогенетические параллели, эпидемиология, взаимное влияние на течение и прогноз артериальной гипертонии (АГ) и ХОБЛ. Общность основных патогенетических механизмов формирования и прогрессирования ХОБЛ и АГ определяет необходимость изучения клинико-функциональных особенностей данной коморбидной патологии.
The paper provides a review of prevalence and outcomes of cardiovascular comorbidities in patients with chronic obstructive pulmonary disease (COPD). From a clinical and patient-centered perspective, a COPD phenotype should be able to classify patients into distinct subgroups that provide prognostic information and allow to better determine appropriate therapy that alters clinically meaningful outcomes. It is hypothesized that both COPD and artherial hypertension (AH) have common pathway linking these comorbidities and explaining why they significantly complicate the management and influence the prognosis of patients with COPD and AH. Further studies will be required to explore this hypothesis and understand the relationship between COPD and AH.
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Кафедра терапии и семейной медицины ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава РФ
*vera0212@yandex.ru
Department of Therapy and Family Medicine, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation
*vera0212@yandex.ru