Метаболический синдром представляет собой сочетание основных факторов риска развития сердечно-сосудистых заболеваний, в основе развития которого лежит снижение чувствительности тканей к инсулину. До настоящего времени нет единого мнения о патогенезе взаимодействия основных составляющих его состояний. С открытием эндокринной функции жировой ткани появились данные, позволяющие предположить, что развитие и прогрессирование атеросклероза могут быть следствием дисбаланса адипокинов. Данная работа посвящена изучению взаимосвязи лептина и адипонектина с клинико-лабораторными показателями при наличии метаболических нарушений.
Metabolic syndrome represents a combination of different major risk factors of cardiovascular diseases and is mainly related to impaired insulin sensitivity in biological tissues. Common understanding of pathogenesis and relationship of different pathological conditions within metabolic syndrome is still missing. New data on endocrine function of adipose tissue suggests that development and progression of atherosclerosis in this situation may be related to adipokines dysbalance. This study investigates correlation of leptin and adiponectin with clinical and laboratory changes in patients with metabolic disorders.
1. Cook S, Weitzman M, Auinger P et al. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2010; 157 (8): 821–7.
2. De Bakker J, Van Capelle F, Janse M et al. Slow conduction in the infracted human heart, “zigzag” course of activation. Circulation 1999; 88 (3): 915–26.
3. EGIR definition of metabolic syndrome. Diabet Med 2002; 16: 442–3.
4. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity rasouli and kern. J Clin Endocrinol Metab 2008; 93: 64–73.
5. Beltowski J. Leptin and atherosclerosis. Atherosclerosis 2006; 189: 47–60.
6. Wannamethee SG et al. Adipokines and risk of type 2 diabetes in older men. Diabet Care 2007; 30: 1200–5.
7. Grundy SM, Cleeman JI, Daniels SR et al. Diagnosis and management of the metabolic syndrome: an American Heart Association. National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2007; 112 (17): 2735–52.
8. Guzder RN, Gatling W, Mullee MA, Byrne CD. Impact of metabolic syndrome criteria on cardiovascular disease risk in people with newly diagnosed type 2 diabetes. Diabetologia 2006; 49 (10): 49–55.
9. Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 2005; 45 (5): 828–33.
10. Sattar N, Gaw A, Scherbakova O et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003; 108 (4): 414–9.
11. Оганов Р.Г., Мамедов М.Н. Школа по диагностике и лечению метаболического синдрома. М.: Медицинская книга, 2007. / Oganov R.G., Mamedov M.N. Shkola po diagnostike i lecheniiu metabolicheskogo sindroma. M.: Meditsinskaia kniga, 2007. [in Russian]
12. Chen YH, Lin SJ, Lin FY et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 2007; 56: 1559–68.
13. Shaw LJ, Marwick TH, Zoghbi WA et al. Why all the focus on cardiac imaging? [Editorial]. JACC Cardiovasc Imaging 2010; 3: 789–94. [PMID: 20633864]; 92 (5): 650–7.
14. Dandona P, Aljada A, Chaudhuri A et al. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111 (11): 1448–54.
15. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003; 26 (8): 2442–50.
16. Vyssoulis G, Karpanou E, Adamopoulos D et al. Metabolic syndrome in patients with essential hypertension. Hypertension Unit, 1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece. Nutr Metab Cardiovasc Dis 2013; 23 (2): 109–14. Doi: 10.1016/j.numecd.2011.03.011.
17. Ghosh S, Karin M. Missing pieces in the NF-kappa-B puzzle. Cell 2002; 109 (Suppl.): S81–96.
18. Yamauchi T, Kamon J, Ito Y et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423 (6941): 762–9.
19. Группа экспертов Всероссийского научного общества кардиологов. Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома. Второй пересмотр. 2009. http://www.cardiosite.ru/recommendations/article / Gruppa ekspertov Vserossiiskogo nauchnogo obshchestva kardiologov. Rekomendatsii ekspertov Vserossiiskogo nauchnogo obshchestva kardiologov po diagnostike i lecheniiu metabolicheskogo sindroma. Vtoroi peresmotr. 2009. http://www.cardiosite.ru/recommendations/article [in Russian]
20. Маколкин В.И. и др. Необходимость гликемического контроля при лечении метаболического синдрома. Consillium Мedicum. 2007; 9 (5): 58–62. / Makolkin V.I. i dr. Neobkhodimost' glikemicheskogo kontrolia pri lechenii metabolicheskogo sindroma. Consillium Medicum. 2007; 9 (5): 58–62. [in Russian]
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1. Cook S, Weitzman M, Auinger P et al. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2010; 157 (8): 821–7.
2. De Bakker J, Van Capelle F, Janse M et al. Slow conduction in the infracted human heart, “zigzag” course of activation. Circulation 1999; 88 (3): 915–26.
3. EGIR definition of metabolic syndrome. Diabet Med 2002; 16: 442–3.
4. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity rasouli and kern. J Clin Endocrinol Metab 2008; 93: 64–73.
5. Beltowski J. Leptin and atherosclerosis. Atherosclerosis 2006; 189: 47–60.
6. Wannamethee SG et al. Adipokines and risk of type 2 diabetes in older men. Diabet Care 2007; 30: 1200–5.
7. Grundy SM, Cleeman JI, Daniels SR et al. Diagnosis and management of the metabolic syndrome: an American Heart Association. National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2007; 112 (17): 2735–52.
8. Guzder RN, Gatling W, Mullee MA, Byrne CD. Impact of metabolic syndrome criteria on cardiovascular disease risk in people with newly diagnosed type 2 diabetes. Diabetologia 2006; 49 (10): 49–55.
9. Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 2005; 45 (5): 828–33.
10. Sattar N, Gaw A, Scherbakova O et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003; 108 (4): 414–9.
11. Oganov R.G., Mamedov M.N. Shkola po diagnostike i lecheniiu metabolicheskogo sindroma. M.: Meditsinskaia kniga, 2007. [in Russian]
12. Chen YH, Lin SJ, Lin FY et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 2007; 56: 1559–68.
13. Shaw LJ, Marwick TH, Zoghbi WA et al. Why all the focus on cardiac imaging? [Editorial]. JACC Cardiovasc Imaging 2010; 3: 789–94. [PMID: 20633864]; 92 (5): 650–7.
14. Dandona P, Aljada A, Chaudhuri A et al. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111 (11): 1448–54.
15. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003; 26 (8): 2442–50.
16. Vyssoulis G, Karpanou E, Adamopoulos D et al. Metabolic syndrome in patients with essential hypertension. Hypertension Unit, 1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece. Nutr Metab Cardiovasc Dis 2013; 23 (2): 109–14. Doi: 10.1016/j.numecd.2011.03.011.
17. Ghosh S, Karin M. Missing pieces in the NF-kappa-B puzzle. Cell 2002; 109 (Suppl.): S81–96.
18. Yamauchi T, Kamon J, Ito Y et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423 (6941): 762–9.
19. Gruppa ekspertov Vserossiiskogo nauchnogo obshchestva kardiologov. Rekomendatsii ekspertov Vserossiiskogo nauchnogo obshchestva kardiologov po diagnostike i lecheniiu metabolicheskogo sindroma. Vtoroi peresmotr. 2009. http://www.cardiosite.ru/recommendations/article [in Russian]
20. Makolkin V.I. i dr. Neobkhodimost' glikemicheskogo kontrolia pri lechenii metabolicheskogo sindroma. Consillium Medicum. 2007; 9 (5): 58–62. [in Russian]