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Ассоциация полиморфизмов хромосомы 4q25 у больных с фибрилляцией предсердий
Ассоциация полиморфизмов хромосомы 4q25 у больных с фибрилляцией предсердий
Шульман В.А., Никулина С.Ю., Поплавская Е.Е. и др. Ассоциация полиморфизмов хромосомы 4q25 у больных с фибрилляцией предсердий. КардиоСоматика. 2016; 7 (2): 21–23.
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Аннотация
В статье рассматривается вопрос о генетической детерминированности фибрилляции предсердий. В частности, показано, что редкий аллель Т полиморфизма rs2200733 на хромосоме 4q25 статистически чаще встречается (р=0,029) у больных с фибрилляцией предсердий по сравнению с данными контрольной группы. Обсуждается вопрос о функциональном значении данного полиморфизма в развитии электрической нестабильности миокарда предсердий.
Ключевые слова: фибрилляция предсердий, хромосома 4q25, rs2200733.
Key words: atrial fibrillation, chromosome 4q25, rs2200733.
Ключевые слова: фибрилляция предсердий, хромосома 4q25, rs2200733.
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Key words: atrial fibrillation, chromosome 4q25, rs2200733.
Полный текст
Список литературы
1. Диагностика и лечение фибрилляции предсердий. Рекомендации РКО, ВНОА и АССХ. Рос. кардиол. журн. 2013; 4 (Прил. 3). / Diagnostika i lechenie fibrilliatsii predserdii. Rekomendatsii RKO, VNOA i ASSKh. Ros. kardiol. zhurn. 2013; 4 (Pril. 3). [in Russian]
2. Gudbjartsson DF, Arnar DO, Helgadottir A et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448 (7151): 353–7.
3. Ferrán A, Alegret JM, Subirana I et al. Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. Rev Esp Cardiol (Engl Ed) 2014; 67 (10): 822–9.
4. Mohanty S, Santangeli P, Bai R et al. Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. J Cardiovasc Electrophysiol 2013; 24 (2): 155–61.
5. Olesen MS, Holst AG, Jabbari J et al. Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years. Can J Cardiol 2012; 28 (2): 191–5.
6. Kiliszek M, Franaszczyk M, Kozluk E et al. Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS One 2011; 6 (7): e21790.
7. Goodloe AH, Herron KJ, Olson TM. Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. Am J Cardiol 2011; 107 (12): 1802–5.
8. Lubitz SA, Sinner MF, Lunetta KL et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation 2010; 122 (10): 976–84.
9. Lee KT, Yeh HY, Tung CP et al. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology 2010; 116 (3): 151–6.
10. Viviani Anselmi C, Novelli V, Roncarati R et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. Heart 2008; 94 (11): 1394–6.
11. Shi L, Li C, Wang C et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 2009; 126 (6): 843–9.
12. Kirchhof P, Bax J, Blomstrom-Lundquist C et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009; 30 (24): 2969–77.
13. Page SP, Siddiqui MS, Finlay M et al. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol 2011; 22 (3): 265–70.
2. Gudbjartsson DF, Arnar DO, Helgadottir A et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448 (7151): 353–7.
3. Ferrán A, Alegret JM, Subirana I et al. Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. Rev Esp Cardiol (Engl Ed) 2014; 67 (10): 822–9.
4. Mohanty S, Santangeli P, Bai R et al. Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. J Cardiovasc Electrophysiol 2013; 24 (2): 155–61.
5. Olesen MS, Holst AG, Jabbari J et al. Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years. Can J Cardiol 2012; 28 (2): 191–5.
6. Kiliszek M, Franaszczyk M, Kozluk E et al. Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS One 2011; 6 (7): e21790.
7. Goodloe AH, Herron KJ, Olson TM. Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. Am J Cardiol 2011; 107 (12): 1802–5.
8. Lubitz SA, Sinner MF, Lunetta KL et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation 2010; 122 (10): 976–84.
9. Lee KT, Yeh HY, Tung CP et al. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology 2010; 116 (3): 151–6.
10. Viviani Anselmi C, Novelli V, Roncarati R et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. Heart 2008; 94 (11): 1394–6.
11. Shi L, Li C, Wang C et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 2009; 126 (6): 843–9.
12. Kirchhof P, Bax J, Blomstrom-Lundquist C et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009; 30 (24): 2969–77.
13. Page SP, Siddiqui MS, Finlay M et al. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol 2011; 22 (3): 265–70.
2. Gudbjartsson DF, Arnar DO, Helgadottir A et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448 (7151): 353–7.
3. Ferrán A, Alegret JM, Subirana I et al. Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. Rev Esp Cardiol (Engl Ed) 2014; 67 (10): 822–9.
4. Mohanty S, Santangeli P, Bai R et al. Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. J Cardiovasc Electrophysiol 2013; 24 (2): 155–61.
5. Olesen MS, Holst AG, Jabbari J et al. Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years. Can J Cardiol 2012; 28 (2): 191–5.
6. Kiliszek M, Franaszczyk M, Kozluk E et al. Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS One 2011; 6 (7): e21790.
7. Goodloe AH, Herron KJ, Olson TM. Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. Am J Cardiol 2011; 107 (12): 1802–5.
8. Lubitz SA, Sinner MF, Lunetta KL et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation 2010; 122 (10): 976–84.
9. Lee KT, Yeh HY, Tung CP et al. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology 2010; 116 (3): 151–6.
10. Viviani Anselmi C, Novelli V, Roncarati R et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. Heart 2008; 94 (11): 1394–6.
11. Shi L, Li C, Wang C et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 2009; 126 (6): 843–9.
12. Kirchhof P, Bax J, Blomstrom-Lundquist C et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009; 30 (24): 2969–77.
13. Page SP, Siddiqui MS, Finlay M et al. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol 2011; 22 (3): 265–70.
________________________________________________
2. Gudbjartsson DF, Arnar DO, Helgadottir A et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448 (7151): 353–7.
3. Ferrán A, Alegret JM, Subirana I et al. Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. Rev Esp Cardiol (Engl Ed) 2014; 67 (10): 822–9.
4. Mohanty S, Santangeli P, Bai R et al. Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta-analysis. J Cardiovasc Electrophysiol 2013; 24 (2): 155–61.
5. Olesen MS, Holst AG, Jabbari J et al. Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years. Can J Cardiol 2012; 28 (2): 191–5.
6. Kiliszek M, Franaszczyk M, Kozluk E et al. Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS One 2011; 6 (7): e21790.
7. Goodloe AH, Herron KJ, Olson TM. Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. Am J Cardiol 2011; 107 (12): 1802–5.
8. Lubitz SA, Sinner MF, Lunetta KL et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation 2010; 122 (10): 976–84.
9. Lee KT, Yeh HY, Tung CP et al. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology 2010; 116 (3): 151–6.
10. Viviani Anselmi C, Novelli V, Roncarati R et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. Heart 2008; 94 (11): 1394–6.
11. Shi L, Li C, Wang C et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 2009; 126 (6): 843–9.
12. Kirchhof P, Bax J, Blomstrom-Lundquist C et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009; 30 (24): 2969–77.
13. Page SP, Siddiqui MS, Finlay M et al. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol 2011; 22 (3): 265–70.
Авторы
В.А.Шульман*1, С.Ю.Никулина1, Е.Е.Поплавская1, В.Н.Максимов2, Н.В.Аксютина1, Б.В.Назаров1
1 ГБОУ ВПО Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого Минздрава России. 660022, Россия, Красноярск, ул. Партизана Железняка, д. 1;
2 ФГБНУ НИИ терапии и профилактической медицины. 630089, Россия, Новосибирск, ул. Бориса Богаткова, д. 175/1
*shulman36@mail.ru
1 Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation. 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1;
2 Scientific research institute of therapy and prophylactic medicine. 630089, Russian Federation, Novosibirsk, ul. Borisa Bogatkova, d. 175/1
*shulman36@mail.ru
1 ГБОУ ВПО Красноярский государственный медицинский университет им. проф. В.Ф.Войно-Ясенецкого Минздрава России. 660022, Россия, Красноярск, ул. Партизана Железняка, д. 1;
2 ФГБНУ НИИ терапии и профилактической медицины. 630089, Россия, Новосибирск, ул. Бориса Богаткова, д. 175/1
*shulman36@mail.ru
________________________________________________
1 Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation. 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1;
2 Scientific research institute of therapy and prophylactic medicine. 630089, Russian Federation, Novosibirsk, ul. Borisa Bogatkova, d. 175/1
*shulman36@mail.ru
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