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Белок Klotho, фактор роста фибробластов 23 и склеростин при хронической сердечной недостаточности: обзор литературы - Научно-практический журнал Cardioсоматика Том 15, №1 (2024)
Белок Klotho, фактор роста фибробластов 23 и склеростин при хронической сердечной недостаточности: обзор литературы
Алиева А.М., Резник Е.В., Котикова И.А., Никитин И.Г. Белок Klotho, фактор роста фибробластов 23 и склеростин при хронической сердечной недостаточности: oбзор литературы. CardioСоматика // 2024.
Т. 15, № 1. С. 41–53. DOI: https://doi.org/10.17816/CS625473
Т. 15, № 1. С. 41–53. DOI: https://doi.org/10.17816/CS625473
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Аннотация
Хроническая сердечная недостаточность (ХСН) является глобальной медицинской, социальной и экономической проблемой. ХСН — это синдром, обусловленный дисбалансом нейрогуморальной регуляции сердечно-сосудистой системы, который сопровождается нарушением систолической и/или диастолической функции сердца. В настоящее время продолжаются поиск и изучение новых биологических маркёров, способных обеспечить раннюю диагностику ХСН, служить лабораторным инструментом для оценки эффективности проводящегося лечения или использоваться в качестве прогностических маркёров и критериев стратификации риска. Интерес исследователей сосредоточен на изучении роли белка Klotho, фактора роста фибробластов 23 (FGF23) и склеростина у пациентов с ХСН. Интенсивность экспрессии Klotho уменьшается по мере старения организма, дефекты его выработки были зарегистрированы при различных заболеваниях, ассоциированных со старением. Ось FGF23 / Klotho играет ключевую регуляторную роль при кардиоваскулярной патологии. Триангуляция данных лабораторных, клинических и генетических исследований позволяет предположить, что склеростин связан с заболеваниями сердца, хотя полученные к настоящему времени данные не вполне согласуются друг с другом. Проведённые клинические исследования, посвящённые изучению белка Klotho, FGF-23 и склеростина, указывают на потенциально важную диагностическую и прогностическую значимость их анализа у пациентов с ХСН. Вопросы, связанные с серийным тестированием этих биологических маркёров, в том числе и в аспекте мультибиомаркёрной модели, нуждаются в дальнейшем изучении.
Ключевые слова: биологические маркёры, сердечно-сосудистые заболевания, белок Klotho, фактор роста фибробластов 23, склеростин
Keywords: biological markers, cardiovascular diseases, Klotho protein, fibroblast growth factor 23, sclerostin
Ключевые слова: биологические маркёры, сердечно-сосудистые заболевания, белок Klotho, фактор роста фибробластов 23, склеростин
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Keywords: biological markers, cardiovascular diseases, Klotho protein, fibroblast growth factor 23, sclerostin
Полный текст
Список литературы
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Авторы
А.М. Алиева*, Е.В. Резник, И.А. Котикова, И.Г. Никитин
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия
*amisha_alieva@mail.ru
Pirogov Russian National Research Medical University, Moscow, Russia
*amisha_alieva@mail.ru
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия
*amisha_alieva@mail.ru
________________________________________________
Pirogov Russian National Research Medical University, Moscow, Russia
*amisha_alieva@mail.ru
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