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Роль воспалительного старения в развитии хронической сердечной недостаточности и остеопороза: обзор литературы - Научно-практический журнал Cardioсоматика Том 15, №3 (2024)
Роль воспалительного старения в развитии хронической сердечной недостаточности и остеопороза: обзор литературы
Ларина В.Н., Щербина Е.С. Роль воспалительного старения в развитии хронической сердечной недостаточности и остеопороза: обзор литературы // CardioСоматика. 2024. Т. 15, № 3. С. 231–242.
DOI: https://doi.org/10.17816/CS632927
DOI: https://doi.org/10.17816/CS632927
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Аннотация
Проблема взаимосвязи хронической сердечной недостаточности (ХСН) и остеопороза у мультиморбидного пациента актуальна в свете старения населения. Концепция «inflammaging» (воспалительного старения) позволяет рассматривать продолжительный процесс субклинического воспаления как адаптацию. В зависимости от положительного или отрицательного влияния этого фактора на организм человека результатом может быть здоровое долголетие или старение, сопровождающееся гериатрическими синдромами и возникновением различных патологий, включая развитие ХСН и остеопороза. В данной статье освещена проблема воспалительного старения как системного фактора в контексте развития ХСН и остеопороза: обсуждается функция воспалительных маркеров, а также роль инфламмасомы NLRP3 в иммуновоспалительном пути развития как ХСН, так и остеопороза посредством влияния на формирование провоспалительных цитокинов. Рассматриваются способы влияния на различные звенья патогенеза, что может лежать в основе разработки новых методов терапии.
Ключевые слова: сердечная недостаточность, остеопороз, воспалительное старение
Keywords: heart failure. osteoporosis, inflammaging
Ключевые слова: сердечная недостаточность, остеопороз, воспалительное старение
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Keywords: heart failure. osteoporosis, inflammaging
Полный текст
Список литературы
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3. Franceschi C., Bonafe M., Valensin S., et al. Inflamm-aging. An evolutionary perspective on immunosenescence // Ann N Y Acad Sci. 2000. Vol. 908. Р. 208–218.
doi: 10.1111/j.1749-6632.2000.tb06651.x
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Авторы
В.Н. Ларина, Е.С. Щербина*
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия
*semushinamarina@yandex.ru
Pirogov Russian National Research Medical University, Moscow, Russia
*semushinamarina@yandex.ru
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия
*semushinamarina@yandex.ru
________________________________________________
Pirogov Russian National Research Medical University, Moscow, Russia
*semushinamarina@yandex.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.