Особенности течения COVID-19 и постковидного периода у пациентов с ожирением

Фролова Е.С., Веселовский П.П., Чумакова Г.А., Веселовская Н.Г., Отт А.В. Особенности течения COVID-19 и постковидного периода у пациентов с ожирением // CardioСоматика. 2024. Т. 15. № 4. С. 344–353. DOI: https://doi.org/10.17816/CS626503

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Frolova ES, Veselovsky PP, Chumakova GA, Veselovskaya NG, Ott AV. COVID-19 and post-disease features in patients with obesity. CardioSomatics. 2024;15(4):344–353. DOI: https://doi.org/10.17816/CS626503

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Аннотация

Пандемия COVID-19 затронула население всей планеты, нанеся значительный экономический и материальный ущерб и непоправимые человеческие потери. Многие страны были вынуждены оперативно перестроить систему здравоохранения для спасения пациентов с COVID-19. Патогенез и особенности течения данного заболевания изучены не до конца, однако одна закономерность прослеживается особенно отчётливо: люди, страдающие ожирением, переносят COVID-19 значительно тяжелее. Как известно, жировая ткань обладает свойством поддерживать хроническое низкоинтенсивное воспаление, а также имеет свою эндокринную активность. С течением времени стало очевидно, что у части пациентов после завершения острой фазы COVID-19 остаются последствия, которые в ряде случаев приводят к необратимым изменениям в организме и снижению качества жизни. Это состояние получило название «постковидный синдром». В данном обзоре мы рассматриваем влияние COVID-19 на разные системы органов в отдалённом периоде. Большое внимание уделяем патогенетическим механизмам течения инфекции и особенностям постковидного синдрома у пациентов с ожирением.

Ключевые слова: ожирение, COVID-19, постковидный синдром, патогенетические механизмы

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The COVID-19 pandemic has affected the global population, causing significant economic effect, material damage, and irreparable human losses. Many countries were forced to promptly reorganize their healthcare system in order to save patients with COVID-19. The pathogenesis and specifics of the disease are not completely understood, but one pattern is particularly clear: COVID-19 tends to be more severe in people with obesity. Fatty tissue is known to support chronic low‑grade inflammation and has its own endocrine activity. Over time, it became obvious that some patients still have consequences following the acute phase of COVID-19, which in some cases lead to irreversible changes in the body and reduced quality of life. This condition was called post-COVID syndrome. In this article, we review the long-term effects of COVID-19 on different body systems. We focused on pathogenic infection mechanisms and features of post-COVID syndrome in people with obesity.

Keywords: obesity, COVID-19, post-COVID syndrome, pathogenic mechanisms

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Авторы

Е.С. Фролова*¹, П.П. Веселовский², Г.А. Чумакова², Н.Г. Веселовская^1,2, А.В. Отт^1,2

¹Алтайский краевой кардиологический диспансер, Барнаул, Россия;
²Алтайский государственный медицинский университет, Барнаул, Россия
*frolovaec@mail.ru

________________________________________________

Ekaterina S. Frolova*¹, Pavel P. Veselovsky², Galina A. Chumakova², Nadezhda G. Veselovskaya^1,2, Anna V. Ott^1,2

¹Altai Regional Cardiology Dispensary, Barnaul, Russia;
²Altai State Medical University, Barnaul, Russia
*frolovaec@mail.ru

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