Будесонид и формотерол: от эффективной комбинации к SMART-терапии

1. Воробьев П.А., Белевский А.С., Авксентьева М.В. и др. Клинико-экономическое исследование целесообразности применения препарата Симбикорт Турбухалер для лечения бронхиальной астмы средней степени тяжести. Пульмонология. 2007; 1: 54–9.
2. Цой А.Н., Архипов В.В. SMART: новая концепция применения Симбикорта для терапии больных бронхиальной астмой. Рус. мед. журн. 2006; 14 (7): 525–9.
3. Цой А.Н., Архипов В.В. GINA 2006: новые рекомендации по фармакотерапии бронхиальной астмы. Рус. мед. журн. 2007; 15 (4): 255–8.
4. Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J 2007; 29 (3): 587–95.
5. Bateman ED, Fairall L, Lombardi DM, English R. Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol. Respir Res 2006; 7 (1): 13.
6. Bisgaard H, Le Roux P, Bjamer D et al. Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma. Chest 2006; 130 (6): 1733–43.
7. Boulet LP, Drollmann A, Magyar P et al. Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma. Respir Med 2006; 100 (5): 785–94.
8. Buhl R, Vogelmeier C. Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma. Curr Med Res Opin 2007; 23 (8): 1867–78.
9. Busse WW, Pedersen S, Pauwels RA et al. START Investigators Group. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol 2008; 121 (5): 1167–74.
10. Busse WW, Shah SR, Somerville L et al. Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients. J Allergy Clin Immunol 2008; 121 (6): 1407–14.
11. Capraz F, Kunter E, Cermik H et al. The effect of inhaled budesonide and formoterol on bronchial remodeling and HRCT features in young asthmatics. Lung 2007; 185 (2): 89–96.
12. Ceylan E, Gencer M, Aksoy S. Addition of formoterol or montelukast to low-dose budesonide: an efficacy comparison in short- and long-term asthma control. Respiration 2004; 71 (6): 594–601.
13. Decramer M, Selroos O. Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide/formoterol in a single inhaler (Symbicort) in both diseases. Int J Clin Pract 2005; 59 (4): 385–98.
14. Dellamary LA, Tarara TE, Smith DJ et al. Hollow porous particles in metered dose inhalers. Pharm Res 2000; 17 (2): 168–74.
15. Duong M, Gauvreau G, Watson R et al. The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge. J Allergy Clin Immunol 2007; 119 (2): 322–7.
16. Dusser D, Vicaut E, Lefranois G, Formoterol HFA group. Double-blind, double-dummy, multinational, multicenter, parallel-group design clinical trial of clinical non-inferiority of formoterol 12 microg/unit dose in a b.i.d. regimen administered via an HFA-propellant-pMDI or a dry powder inhaler in a 12-week treatment period of moderate to severe stable persistent asthma in adult patients. Respiration 2005; 72 (Suppl. 1): 20–7.
17. Eklund A, Tronde A, Johannes-Hellberg I et al. Pharmacokinetics of budesonide and formoterol administered via a series of single-drug and combination inhalers: four open-label, randomized, crossover studies in healthy adults. Biopharm Drug Dispos 2008; Jul 11. [Epub ahead of print].
18. FitzGerald JM, Boulet LP, Follows RM. The CONCEPT trial: a 1-year, multicenter, randomized,double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma. Clin Ther 2005; 27 (4): 393–406.
19. Gawchik SM. Successful treatment of previously uncontrolled adult asthma with budesonide inhalation suspension: five-year case histories (October). Ann Pharmacother 2007; 41 (10): 1728–33.
20. Green RH, Brightling CE, McKenna S et al. Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Eur Respir J 2006; 27 (6): 1144–51.
21. Jenkins C, Kolarikova R, Kuna P et al. Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma. Respirology 2006; 11 (3): 276–86.
22. Johansson G, Andreasson EB, Larsson PE, Vogelmeier CF. Cost effectiveness of budesonide/formoterol for maintenance and reliever therapy versus salmeterol/fluticasone plus salbutamol in the treatment of asthma. Pharmacoeconomics 2006; 24 (7): 695–708.
23. Jonkers RE, Bantje TA, Aalbers R. Onset of relief of dyspnoea with budesonide/formoterol or salbutamol following methacholine-induced severe bronchoconstriction in adults with asthma: a double-blind, placebo-controlled study. Respir Res 2006; 7 (1): 141.
24. Holt S, Ryder-Lewis S, Masoli M et al. Fixed and adjustable dose asthma action plans based on combination therapy: A pilot study. Respirology 2005; 10 (4): 497–503.
25. Kuna P, Creemers JP, Vondra V et al. Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma. Respir Med 2006; 100 (12): 2151–9.
26. Kurashima K, Kanauchi T, Hoshi T et al. Effect of early versus late intervention with inhaled corticosteroids on airway wall thickness in patients with asthma. Respirology 2008; Aug 18. [Epub ahead of print].
27. Lotvall J. Combination therapy in asthma - fixed or variable dosing in different patients? Curr Med Res Opin 2004; 20 (11): 1711–27.
28. Lundborg M, Wille S, Bjermer L et al. Maintenance plus reliever budesonide/formoterol compared with a higher maintenance dose of budesonide/formoterol plus formoterol as reliever in asthma: an efficacy and cost-effectiveness study. Curr Med Res Opin 2006; 22 (5): 809–21.
29. Masoli M, Williams M, Weatherall M, Beasley R. The 24h duration of bronchodilator action of the budesonide/formoterol combination inhaler. Respir Med 2006; 100 (1): 20–5.
30. Menezes MB, Teixeira AL, Filho JT, Vianna EO. Inflammatory and functional effects of increasing asthma treatment with formoterol or double dose budesonide. Respir Med 2008; Jul 14. [Epub ahead of print].
31. Morice AH, Peterson S, Beckman O, Osmanliev D. Therapeutic comparison of a new budesonide/formoterol pMDI with budesonide pMDI and budesonide/formoterol DPI in asthma. Int J Clin Pract 2007; 61 (11): 1874–83.
32. Morice AH, Hochmuth L, Ekelund J et al. Comparable long-term safety and efficacy of a novel budesonide/formoterol pressurized metered-dose inhaler versus budesonide/formoterol Turbuhaler in adolescents and adults with asthma. Pulm Pharmacol Ther 2008; 21 (1): 32–9.
33. Noonan M, Rosenwasser LJ, Martin P et al. Efficacy and safety of budesonide and formoterol in one pressurised metered-dose inhaler in adults and adolescents with moderate to severe asthma: a randomized clinical trial. Drugs 2006; 66 (17): 2235–54.
34. O'Byrne PM, Bisgaard H, Godard PP et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005; 171 (2): 129–36.
35. O'Byrne PM, Pedersen S, Busse WW et al. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest 2006; 129: 1478–85.
36. O'Byrne PM. Acute asthma intervention: Insights from the STAY study. J Allergy Clin Immunol 2007; 119 (6): 1332–6.
37. Overbeek SE, Mulder PG, Baelemans SM et al. Formoterol added to low-dose budesonide has no additional anti-inflammatory effect in asthmatic patients. Chest 2005; 128 (3): 1121–7.
38. Palmqvist M, Arvidsson P, Beckman O et al. Onset of bronchodilation of budesonide/formoterol vs. salmeterol/fluticasone in single inhalers. Pulm Pharmacol Ther 2001; 14 (1): 29–34.
39. Pauwels RA, Busse WW, O'Byrne PM et al. The inhaled Steroid Treatment as Regular Therapy in early asthma (START) study: rationale and design. Control Clin Trials– 2001; 22 (4): 405–19.
40. Pohunek P, Kuna P, Jorup C, De Boeck K. Budesonide/formoterol improves lung function compared with budesonide alone in children with asthma. Pediatr Allergy Immunol 2006; 17 (6): 458–65.
41. Price D, Haughney J, Lloyd A et al. An economic evaluation of adjustable and fixed dosing with budesonide/formoterol via a single inhaler in asthma patients: the ASSURE study. Curr Med Res Opin 2004; 20 (10): 1671–89.
42. Rabe KF, Atienza T, Magyar P et al. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet 2006; 368 (9537): 744–53.
43. Rabe KF, Pizzichini E, Stallberg B et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Chest 2006; 129 (2): 246–56.
44. Reddel HK, Barnes DJ. Pharmacological strategies for self-management of asthma exacerbations. Eur Respir J 2006; 28 (1): 182–99.
45. Scicchitano R, Aalbers R, Ukena D et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin 2004; 20 (9): 1403–18.
46. Sears MR, Boulet LP, Laviolette M et al. Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma. Eur Respir J 2008; 31 (5): 982–9.
47. Sears MR, Ottosson A, Radner F, Suissa S. Long-acting {beta}-agonists: A review of formoterol safety data from asthma clinical trials. Eur Respir J 2008; Sep 3. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/18768573.
48. Sovani MP, Whale CI, Oborne J et al. Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help? Br J Gen Pract 2008; 58 (546): 37–43.
49. Tan WC, Lamm CJ, Chen YZ et al. Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study. Respirology 2006; 11 (6): 767–75.
50. Vogelmeier C, D'Urzo A, Pauwels Dagger R et al. Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option? Eur Respir J 2005; 26 (5): 819–28.
51. Zetterstrom O, Buhl R, Mellem H et al. Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone. Eur Respir J 2001; 18 (2): 262–8.

А.А.Визель, И.Ю.Визель