Воспаление при хронической обструктивной болезни легких: молекулярные основы патогенеза

1. Дидковский Н.А., Дворецкий Л.И. Наследственные факторы и местная защита при неспецифических заболеваниях легких. М.: Медицина, 1990.
2. Шмелев Е.И. Хроническая обструктивная болезнь легких. В кн.: Респираторная медицина. Под ред. А.Г.Чучалина. М.: ГЭОТАР-Медиа, 2007; 1: 597–650.
3. Bosken CH, Hards J, Gatter K, Hogg JC. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992; 145: 911–7.
4. Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645–53.
5. van der Strate BW, Postma DS, Brandsma CA et al. Cigarette smoke-induced emphysema: a role for the В cell? Am J Respir Crit Care Med 2006; 173: 751–8.
6. Cotran RS. Tissue repair: cellular growth, fibrosis and wound healing. In: Robbins pathologic basis of disease. 6th ed. Ramzi S. Cotran, Vinay Kumar, Tucker Collins. W.B.Saunders Company. Philadelphia, 1999; 89–112.
7. Dentener MA, Vernooy JH, Hendriks S, Wouters EF. Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation. Thorax 2005; 60: 114–9.
8. Van der Geld YM, Van Straaten JFM, Postma DS, Timens W. Role of proteoglycans in development and pathogenesis of emphysema. In: Garg HG, Roughley PJ, Hales CA, eds, Proteoglycans in Lung Disease. New York: Marcel Dekker, 2002; 241–67.
9. Timens W, Coers W, Van Straaten JFM, Postma DS. Extracellular matrix and inflammation: a role for fibroblast-mediated tissue repair in the pathogenesis of emphysema? Eur Respir Rev 1997; 7: 119–23.
10. Repine JE, Bast A, Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. Am J Resp Crit Med 1997; 156: 341–57.
11. Cardoso WV, Sekhon HS, Hyde DM, Thurlbeck WM. Collagen and elastin in human pulmonary emphysema. Am Rev Respir Dis 1993; 147: 975–81.
12. Finlay GA, O'Donnell MD, O'Connor CM et al. Elastin and collagen remodelinginemphysema -a scanning electron microscopy study. Am J Pathol 1996; 149: 1405–15.
13. Lang MR, Fiaux GW, Gillooly M et al. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax 1994; 49: 319–26.
14. Konno K, Arai H, Motomiya M et al. A biochemical study on glycosaminoglycans (mucopolysaccharides) in emphysematous and in aged lungs. Am Rev Respir Dis 1982; 126: 797–801.
15. Shapiro SD, Ingenito EP. The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years. Am J Respir Cell Mol Biol 2005; 32: 367–72.
16. Finlay GA, Russell KJ, McMahon KJ et al. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997; 52: 502–6.
17. Beeh KM, Beier J, Kornmann O, Buhl R. Sputum matrix metalloproteinase-9, tissue inhibitor o metalloprotmease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects. Respir Med 2003; 97: 634–9.
18. Vignola AM, Riccobono L, Mirabella A et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 1998; 158: 1945–50.
19. Imai K, Dalai SS, Chen ES et al. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. Am J Respir Crit Care Med 2001; 163: 786–91.
20. Russell RE, Thorley A, Culpitt SV el al. Alveolar macrophage-mediated elastolysis: roles ofmatrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol 2002; 283: L867–73.
21. Lim S, Roche N, Oliver BG et al. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers: regulation by interleukin-10. Am J Respir Crit Care Med 2000; 162: 1355–60.
22. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997; 277: 2002–4.
23. Lanone S, Zheng T, Zhu Z et al. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest 2002; 110: 463–74.
24. Camoretti-Mercado B, Solway J. Transforming growth factor-p11 and disorders of the lung. Cell Biochem Biophys 2005; 43: 131–48.
25. Shapiro SD, Goldstein NM, Houghton AM et al. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 2003; 163: 2329–35.
26. Wang Z, Zheng T, Zhu Z et al. Interferon у induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000; 192: 1587–99.
27. Shiomi T, Okada Y, Foronjy R et al. Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp Lung Res 2003; 29: 1–15.
28. Bartalesi B, Cavarra E, Fineschi S et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 2005; 25: 15–22.
29. Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 2003; 28: 555–62.
30. Tuder RM, Zhen L, Cho CY et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003; 29: 88–97.
31. Tuder RM, Yoshida T, Arap W et al. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc 2006; 3: 503–11.
32. Taraseviciene-Stewart L, Scerbavicius R, Choe KH et al. An animal model of autoimmune emphysema. Am J Respir Crit Care Med 2005; 171: 734–42.
33. Sullivan AL, Simonian PL, Falta MT et al. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med 2005; 172: 590–6.
34. Gray T, Coakley R, Hirsh A et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-ip in human bronchial epithelia. Am J Physiol 2004; 286: L320–30.
35. Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-α-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol 2004; 287: 1420–7.
36. Deshmukh HS, Case LM, Wesselkamper SC et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med 2005; 171: 305–14.
37. Voynow JA, Fischer BM, Malarkey DE et al. Neutrophil elastase induces mucus cell metaplasia in mouse lung. Am J Physiol 2004; 287: L1293–302.
38. Kuhn C, Homer RJ, Zhu Z et al. Airway hyperresponsiveness and airway obstruction in transgenic mice: morphologic correlates in mice overexpressing interleukin (IL)-l 1 and IL-6 in the lung. Am J Respir Cell Mol Biol 2000; 22: 289–95.
39. Wang RD, Tai H, Xie C et al. Cigarette smoke produces airway wall remodeling in rat tracheal explants. Am J Respir Crit Care Med 2003; 168: 1232–6.
40. Копьева Т.Н., Бармина Г.В., Свищев А.В., Макарова О.В. Морфология и патогенез хронического бронхита. Арх. патол. 1989; 7: 83–7.
41. Massague J, Pandiella A. Membrane-anchored growth factors. Annu Rev Biochem 1993; 62: 515–41.
42. Puddicombe SM, Polosa R, Richter A et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000; 14: 1362–74.
43. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-a converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol 2004; 287: L420–27.
44. Takeyama K, Jung B, Shim JJ et al. Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol Lung Cell Mol Physiol 2001; 280: L165–72.
45. Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol 2002; 26: 447–52.
46. Kim JH, Lee SY, Bak SM et al. Effects of matrix metalloproteinase inhibitor on LPS-induced goblet cell metaplasia. Am J Physiol Lung Cell Mol Physiol 2004; 287: L127–33.
47. Takeyama K, Agusti C, Ueki I et al. Neutrophil-dependent goblet cell degranulation: Role of membrane-bound elastase and adhesion molecules. Am J Physiol 1998; 275: L294–302.
48. Sommerhoff CP, Nadel JA, Basbaum CB et al. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 1990; 85: 682–9.
49. Agusti C, Takeyama K, Cardell LO et al. Goblet cell degranulation after antigen challenge in sensitized guinea pigs: Role of neutrophils. Am J Respir Crit. Care Med 1998; 158: 1253–8.
50. Hermiston ML, Gordon JI. In vivo analysis of cadherin function in the mouse intestinal epithelium: Essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol 1995; 129: 489–506.
51. Tinkle CL, Lechler T, Pasolli HA et al. Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci USA 2004; 101: 552–7.
52. Marshall CJ. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80: 179–85.
53. Изаксон Э. О патолого-анатомических изменениях легочных сосудов при эмфизематозных процессах в легких. Дис. ... д-ра мед. СПб., 1870. (Пульмонология. 2005; 4: 41–52).
54. Wright JL, Levy RD, Churg A. Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 2005; 60: 605–9.
55. Wright JL, Kerstjens HAM, Timens W. What is new in chronic obstructive pulmonary disease? Eur Resp Mon 2007; 39: 153–69.
56. Wright JL, Tai H, Churg A. Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. J Appl Physiol 2006; 100: 672–6.
57. Beghe B, Bazzan E, Baraldo S et al. Eur Respir J 2006; 28: 556–62.

А.Л.Черняев, М.В.Самсонова