1. Синопальников А.И., Романовских А.Г. Инфекционное обострение хронической обструктивной болезни легких. Cons. Med. 2006; 8 (1).
2. Murphy TF, Sethi S. Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 146: 1067–83.
3. Sethi S, Murphy TF. Bacterial Infection in Chronic Obstructive Pulmonary Disease in 2000: a State-of-the-Art Review. Clin Microbiol Rev 2001; 14 (2): 336–63.
4. Murphy T, Sethi S, Niederman M. The role of bacteria in exacerbations of COPD: a constructive view. Chest 2000; 118: 204–9.
5. Monso E, Ruiz J, Rosell A et al. Bacterial infection in chronic obstructive pulmonary disease: a study of stable and exacerbated outpatients using the protected specimen brush. Am J Respir Crit Care Med 1995; 152: 1316–20.
6. Sethi S, Muscarella K, Evans N et al. Airway inflammation and etiology of acute exacerbations of chronic bronchitis. Chest 2000; 118: 1557–65.
7. Stockley RA, O’Brien C, Pye A, Hill SL. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest 2000; 117: 1638–45.
8. Sethi S, Wrona C, Grant BJB, Murphy TF. Strain specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004; 169: 448–53.
9. Eller J, Ede A, Schaberg T et al. Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. Chest 1998; 113: 1542–8.
10. Страчунский Л.С. Практическое руководство по антиинфекционной химиотерапии. М., 2007.
11. Anthonisen NR, Manfreda J, Warren CP et al Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987; 106: 196–204.
12. Elmes PC, King TK, Langlands JH et al Value of ampicillin in the hospital treatment of exacerbations of chronic bronchitis. BMJ 1965; 2: 904–8.
13. Jorgensen AF, Coolidge J, Pedersen PA et al. Amoxicillin in treatment of acute uncomplicated exacerbations of chronic bronchitis: a double-blind, placebo-controlled multicentre study in general practice. Scand J Prim Health Care 1992; 10; 7–11.
14. Nouira S, Marghli S, Belghith M et al Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomised placebo-controlled trial. Lancet 2001; 358: 2020–5.
15. Pines A, Raafat H, Plucinski K et al Antibiotic regimens in severe and acute purulent exacerbations of chronic bronchitis. BMJ 1968; 2: 735–8.
16. Allegra L, Grassi C, Grossi E, Pozzi E. Ruolo degli antidiotici nel trattamento delle riacutizza della bronchite cronica. Ital J Chest Dis 1991; 45; 138–48.
17. Saint S, Bent S, Vittinghof E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analisis. 
JAMA 1995; 273; 957–60.
18. Ram F, Rodriguez-Roisin R, Granados-Navarrete A et al. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006; 3.
19. Puhan M, Vollenweider D, Latshang T et al. Exacerbations of chronic obstructive pulmonary disease: when are antibiotics indicated? A systematic review. Respir Res 2007; 8: 30.
20. Nouria S, Marghli S, Belghith M et al. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomized placebo-controlled trial. Lancet 2001; 358: 2020–5.
21. GOLD Executive Summary. Eur Respir J 2007; 176: 532–55.
22. Miravitlles M. Exacerbations of chronic оbstructive pulmonary disease when are bacteria important? Eur Respir J 2002; 20 (Suppl. 36): 9–19.
23. Sethi S, Evans N, Grant BJB, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002; 347: 465–71.
24. Anthonisen NR. Bacteria and exacerbations of chronic obstructive pulmonary disease. New Engl J Med 2002; 347: 526–7.
25. Siempos II, Dimopoulos G, Korbila IP et al. Macrolides, quinolones, and amoxicillin/clavulanate for chronic bronchitis: a meta-analysis. Eur Respir J 2007; 29: 1127–37.
26. Chang КС, Leung СС. Meta-analysis may not be practicable for guiding antibiotic therapy. ERJ 2008; 31 (4): 906–7.
27. Дворецкий Л.И., Дубровская Н.В., Грудинина С.А. и др. Левофлоксацин и макролиды при обострении хронического бронхита. Результаты длительного мониторинга больных. Инфекции и антимикробная терапия. 2005; 1: 20–7.
28. Lode H, Eller J, Linnhoff M. Levofloxacin versus clarithromycin in COPD exacerbation focus on exacerbation-free interval. Eur Resp J 2004; 24: 947–53.
29. Wilson R, Allegra L, Huchon G et al. Short-term and long-term outcomes of moxifloxacin compared to standard antibioic treatment in acute exacerbations of chronic bronchitis. Chest 2004; 125: 953–64.
30. The Working Party on Trials of Chemotherapy in Early Chronic Bronchitis of The Medical Research Council. Value of chemoprophylaxis and chemotherapy in early chronic bronchitis. BMJ 1966; 5499: 317–22.
31. Davis AL, Grobow EJ, Kaminski T et al. Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. II. Chemoprophylaxis with daily chloramphenicol. Am Rev Respir Dis 1965; 92: 900–13.
32. Priedie RB, Datta N, Massey DG et al. A trial of continuous winter chemotherapy in chronic bronchitis. Lancet 1960; 2: 723–7.
33. Francis R, Spicer C. Chemotherapy in chronic bronchitis: Influence of daily penicillin and tetracycline on exacerbations and their cost. BMJ 1960; 1: 297–303.
34. Johnston RN, Lockart W, Smith DH et al. A trial of phenethicillin in chronic bronchitis. BMJ 1961; 2: 985–6.
35. Davis AL, Grobow EJ, Tompsett R et al. Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. I. Chemoprophylaxis with intermittent tetracycline. Am J Med 1961; 31: 365–81.
36. Buchanan J, Buchanan WW, Melrose AG et al. Long-term prophylactic administration of tetracycline to chronic bronchitis. Lancet 1958; 2: 719–22.
37. Pines A. Controlled trials of a sulphonamide given weekly to prevent exacerbations of chronic bronchitis. BMJ 1967; 3: 202–4.
38. Johnston RN, McNeill RS, Smith DH et al. Five-year winter chemoprophylaxis for chronic bronchitis. BMJ 1969; 4: 265–9.
39. Black P, Staykova T, Chacko E et al. Prophylactic antibiotic therapy for chronic bronchitis. Cochrane Database Syst Rev 2003; 1: CD004105.
40. Murphy TF, Sethi S. Bacterial infection in chronic obstructive pulmonary disease. Am Respir Dis 1992; 146: 1067–83.
41. Sethi S, Jones PW, Theron MS, Miravitlles M et al. Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Respiratory Res 2010; 11 (10).
42. Albert RK, Connett J, Bailey WC et al. Azithromycin for Prevention of Exacerbations of COPD. N Engl J Med 2011; 365: 689–98.

Л.И.Дворецкий 

ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава РФ