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Комбинированная терапия артериальной гипертензии: новая фиксированная комбинация блокатора рецептора ангиотензина II и диуретика (азилсартана медоксомила с хлорталидоном)
Комбинированная терапия артериальной гипертензии: новая фиксированная комбинация блокатора рецептора ангиотензина II и диуретика (азилсартана медоксомила с хлорталидоном)
Остроумова О.Д., Фомина В.М. Комбинированная терапия артериальной гипертензии: новая фиксированная комбинация блокатора рецептора ангиотензина II и диуретика (азилсартана медоксомила с хлорталидоном). Consilium Medicum. 2015; 17 (10): 13–18. DOI: 10.26442/2075-1753_2015.10.13-18
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Аннотация
В статье рассматриваются разные аспекты комбинированной терапии артериальной гипертонии. Обсуждаются взаимодополняющие эффекты и преимущества комбинации блокаторов рецепторов ангиотензина II (БРА) и диуретика, описаны клинические ситуации, где ее применение становится приоритетным. Подробно проанализированы имеющиеся литературные данные об эффективности, в том числе сравнительной, и безопасности комбинации азилсартана медоксомила с хлорталидоном. Подчеркиваются преимущества азилсартана среди представителей класса БРА и хлорталидона среди диуретиков.
Ключевые слова: артериальная гипертония, фиксированные комбинации, блокаторы рецепторов ангиотензина II, азилсартан, диуретики, хлорталидон.
Ключевые слова: артериальная гипертония, фиксированные комбинации, блокаторы рецепторов ангиотензина II, азилсартан, диуретики, хлорталидон.
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The article deals with the different aspects of the combined therapy in arterial hypertension. We discuss complementary effects and advantage of combination of angiotensin II receptor blockers (ARBs) and diuretic; describe clinical setting where the usage of that combination is preferred. We have been analyzing in detail, the available literature data concerning efficacy, including comparative efficacy, and safety of using combination of azilsartan and chlorthalidone. We underline the advantages of azilsartan among ARBs class and chlorthalidone among diuretics.
Key words: arterial hypertension, fixed-dose combinations, Angiotensin II Receptor Blockers, azilsartan, diuretics, chlorthalidone.
Key words: arterial hypertension, fixed-dose combinations, Angiotensin II Receptor Blockers, azilsartan, diuretics, chlorthalidone.
Полный текст
Список литературы
1. Диагностика и лечение артериальной гипертензии (Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов). Системные гипертензии. 2010; 3: 5–26. / Diagnosis and treatment of arterial hypertension (Recommendations for the management of arterial hypertension Russian Medical Society of Arterial Hypertension and Society of Cardiology of the Russian Federation. Systemic Hypertension. 2010; 3: 5–26. [in Russian]
2. Чазова И.Е., Ратова Л.Г. Комбинированная терапия артериальной гипертонии. М.: Медиа-Медика, 2007; с. 86–94. / Chazova I.E., Ratova L.G. Kombinirovannaia terapiia arterial'noi gipertonii. M.: Media-Medika, 2007; s. 86–94. [in Russian]
3. Ojima M, Igata H, Tanaka M et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther 2011; 336 (3): 801–8.
4. Sica D, White W, Weber M et al. Comparison of the Novel Angiotensin II Receptor Blocker Azilsartan Medoxomil vs Valsartan by Ambulatory Blood Pressure Monitoring. J Clin Hypertens (Greenwich) 2011; 13: 467–72.
5. Bakris GL, Sica D, Weber M et al. The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. J Clin Hypertens (Greenwich) 2011; 13 (2): 81–8.
6. White WB, Weber MA, Sica D et al. Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension 2011; 57 (3): 413–20.
7. Bönner G, Bakris G, Sica D et al. Antihypertensive efficacy of the angiotensin receptor blocker azilsartan medoxomil compared with the angiotensin-converting enzyme inhibitor ramipril. J Hum Hypertens 2013; 27 (8): 479–86.
8. The ALLHAT officers and coordinators for the ALLHAT collaborative research group. Major outcome in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blоcker vs diuretic. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981–97.
9. Systolic Hypertension in the Elderly Program Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program. JAMA 1991; 265: 3255–64.
10. Neaton JD, Grimm RH Jr, Prineas RJ et al. Treatment of mild hypertension study: Final results: Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713–24.
11. Kurtz TW. Chlorthalidone: don’t call it “thiazide-like” anymore. Hypertension 2010; 56: 335–7.
12. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43: 4–9.
13. Peterzan MA, Hardy R, Chaturvedi N, Hughes AD. Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Hypertension 2012; 59: 1104–9.
14. Sica D, Bakris GL, White WB et al. Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study. J Clin Hypertens (Greenwich) 2012; 14: 284–92.
15. Clinicaltrials.gov. Efficacy and safety of azilsartan medoxomil co-administered with chlorthalidone in participants with essential hypertension. Study NCT00591773. Available from: http://clinicaltrials.gov/ct2/show/NCT00591773?term=NCT00591773&rank=1. Accessed December 13, 2011.
16. Juhasz А, Collier D, Caulfield M, Agabiti-Rosei E et al. Achievement of blood pressure targets and safety of azilsartan medoxomil/chlortalidone fixed dose combination versus azilsartan medoxomil in hypertensive patients uncontrolled on monotherapy. J Hypertens 2015; 33: e-Supplement 2, e-8.
17. Bakris G, Sica D, White WB et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med 2012; 125: 1229e1–1229.e10.
18. Cushman WC, Bakris GL, White WB et al. Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension. Hypertension 2012; 60: 310–8.
19. Kupfer S, Neutel JM, Cushman WC et al. Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone versus olmesartan medoxomil/hydrochlorothiazide. J Hypertens 2012; 30: e-Supplement 1, e-162.
20. Sica DA, Zhao L, Oparil S et al. Long-term safety of fixed doses: azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in hypertensive patients with stage 3 chronic kidney disease. J Hypertens 2014; 32: e-Supplement 1, e-582.
2. Chazova I.E., Ratova L.G. Kombinirovannaia terapiia arterial'noi gipertonii. M.: Media-Medika, 2007; s. 86–94. [in Russian]
3. Ojima M, Igata H, Tanaka M et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther 2011; 336 (3): 801–8.
4. Sica D, White W, Weber M et al. Comparison of the Novel Angiotensin II Receptor Blocker Azilsartan Medoxomil vs Valsartan by Ambulatory Blood Pressure Monitoring. J Clin Hypertens (Greenwich) 2011; 13: 467–72.
5. Bakris GL, Sica D, Weber M et al. The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. J Clin Hypertens (Greenwich) 2011; 13 (2): 81–8.
6. White WB, Weber MA, Sica D et al. Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension 2011; 57 (3): 413–20.
7. Bönner G, Bakris G, Sica D et al. Antihypertensive efficacy of the angiotensin receptor blocker azilsartan medoxomil compared with the angiotensin-converting enzyme inhibitor ramipril. J Hum Hypertens 2013; 27 (8): 479–86.
8. The ALLHAT officers and coordinators for the ALLHAT collaborative research group. Major outcome in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blоcker vs diuretic. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981–97.
9. Systolic Hypertension in the Elderly Program Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program. JAMA 1991; 265: 3255–64.
10. Neaton JD, Grimm RH Jr, Prineas RJ et al. Treatment of mild hypertension study: Final results: Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713–24.
11. Kurtz TW. Chlorthalidone: don’t call it “thiazide-like” anymore. Hypertension 2010; 56: 335–7.
12. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43: 4–9.
13. Peterzan MA, Hardy R, Chaturvedi N, Hughes AD. Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Hypertension 2012; 59: 1104–9.
14. Sica D, Bakris GL, White WB et al. Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study. J Clin Hypertens (Greenwich) 2012; 14: 284–92.
15. Clinicaltrials.gov. Efficacy and safety of azilsartan medoxomil co-administered with chlorthalidone in participants with essential hypertension. Study NCT00591773. Available from: http://clinicaltrials.gov/ct2/show/NCT00591773?term=NCT00591773&rank=1. Accessed December 13, 2011.
16. Juhasz А, Collier D, Caulfield M, Agabiti-Rosei E et al. Achievement of blood pressure targets and safety of azilsartan medoxomil/chlortalidone fixed dose combination versus azilsartan medoxomil in hypertensive patients uncontrolled on monotherapy. J Hypertens 2015; 33: e-Supplement 2, e-8.
17. Bakris G, Sica D, White WB et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med 2012; 125: 1229e1–1229.e10.
18. Cushman WC, Bakris GL, White WB et al. Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension. Hypertension 2012; 60: 310–8.
19. Kupfer S, Neutel JM, Cushman WC et al. Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone versus olmesartan medoxomil/hydrochlorothiazide. J Hypertens 2012; 30: e-Supplement 1, e-162.
20. Sica DA, Zhao L, Oparil S et al. Long-term safety of fixed doses: azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in hypertensive patients with stage 3 chronic kidney disease. J Hypertens 2014; 32: e-Supplement 1, e-582.
2. Чазова И.Е., Ратова Л.Г. Комбинированная терапия артериальной гипертонии. М.: Медиа-Медика, 2007; с. 86–94. / Chazova I.E., Ratova L.G. Kombinirovannaia terapiia arterial'noi gipertonii. M.: Media-Medika, 2007; s. 86–94. [in Russian]
3. Ojima M, Igata H, Tanaka M et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther 2011; 336 (3): 801–8.
4. Sica D, White W, Weber M et al. Comparison of the Novel Angiotensin II Receptor Blocker Azilsartan Medoxomil vs Valsartan by Ambulatory Blood Pressure Monitoring. J Clin Hypertens (Greenwich) 2011; 13: 467–72.
5. Bakris GL, Sica D, Weber M et al. The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. J Clin Hypertens (Greenwich) 2011; 13 (2): 81–8.
6. White WB, Weber MA, Sica D et al. Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension 2011; 57 (3): 413–20.
7. Bönner G, Bakris G, Sica D et al. Antihypertensive efficacy of the angiotensin receptor blocker azilsartan medoxomil compared with the angiotensin-converting enzyme inhibitor ramipril. J Hum Hypertens 2013; 27 (8): 479–86.
8. The ALLHAT officers and coordinators for the ALLHAT collaborative research group. Major outcome in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blоcker vs diuretic. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981–97.
9. Systolic Hypertension in the Elderly Program Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program. JAMA 1991; 265: 3255–64.
10. Neaton JD, Grimm RH Jr, Prineas RJ et al. Treatment of mild hypertension study: Final results: Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713–24.
11. Kurtz TW. Chlorthalidone: don’t call it “thiazide-like” anymore. Hypertension 2010; 56: 335–7.
12. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43: 4–9.
13. Peterzan MA, Hardy R, Chaturvedi N, Hughes AD. Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Hypertension 2012; 59: 1104–9.
14. Sica D, Bakris GL, White WB et al. Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study. J Clin Hypertens (Greenwich) 2012; 14: 284–92.
15. Clinicaltrials.gov. Efficacy and safety of azilsartan medoxomil co-administered with chlorthalidone in participants with essential hypertension. Study NCT00591773. Available from: http://clinicaltrials.gov/ct2/show/NCT00591773?term=NCT00591773&rank=1. Accessed December 13, 2011.
16. Juhasz А, Collier D, Caulfield M, Agabiti-Rosei E et al. Achievement of blood pressure targets and safety of azilsartan medoxomil/chlortalidone fixed dose combination versus azilsartan medoxomil in hypertensive patients uncontrolled on monotherapy. J Hypertens 2015; 33: e-Supplement 2, e-8.
17. Bakris G, Sica D, White WB et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med 2012; 125: 1229e1–1229.e10.
18. Cushman WC, Bakris GL, White WB et al. Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension. Hypertension 2012; 60: 310–8.
19. Kupfer S, Neutel JM, Cushman WC et al. Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone versus olmesartan medoxomil/hydrochlorothiazide. J Hypertens 2012; 30: e-Supplement 1, e-162.
20. Sica DA, Zhao L, Oparil S et al. Long-term safety of fixed doses: azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in hypertensive patients with stage 3 chronic kidney disease. J Hypertens 2014; 32: e-Supplement 1, e-582.
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2. Chazova I.E., Ratova L.G. Kombinirovannaia terapiia arterial'noi gipertonii. M.: Media-Medika, 2007; s. 86–94. [in Russian]
3. Ojima M, Igata H, Tanaka M et al. In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J Pharmacol Exp Ther 2011; 336 (3): 801–8.
4. Sica D, White W, Weber M et al. Comparison of the Novel Angiotensin II Receptor Blocker Azilsartan Medoxomil vs Valsartan by Ambulatory Blood Pressure Monitoring. J Clin Hypertens (Greenwich) 2011; 13: 467–72.
5. Bakris GL, Sica D, Weber M et al. The comparative effects of azilsartan medoxomil and olmesartan on ambulatory and clinic blood pressure. J Clin Hypertens (Greenwich) 2011; 13 (2): 81–8.
6. White WB, Weber MA, Sica D et al. Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension 2011; 57 (3): 413–20.
7. Bönner G, Bakris G, Sica D et al. Antihypertensive efficacy of the angiotensin receptor blocker azilsartan medoxomil compared with the angiotensin-converting enzyme inhibitor ramipril. J Hum Hypertens 2013; 27 (8): 479–86.
8. The ALLHAT officers and coordinators for the ALLHAT collaborative research group. Major outcome in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blоcker vs diuretic. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981–97.
9. Systolic Hypertension in the Elderly Program Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program. JAMA 1991; 265: 3255–64.
10. Neaton JD, Grimm RH Jr, Prineas RJ et al. Treatment of mild hypertension study: Final results: Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713–24.
11. Kurtz TW. Chlorthalidone: don’t call it “thiazide-like” anymore. Hypertension 2010; 56: 335–7.
12. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004; 43: 4–9.
13. Peterzan MA, Hardy R, Chaturvedi N, Hughes AD. Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Hypertension 2012; 59: 1104–9.
14. Sica D, Bakris GL, White WB et al. Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study. J Clin Hypertens (Greenwich) 2012; 14: 284–92.
15. Clinicaltrials.gov. Efficacy and safety of azilsartan medoxomil co-administered with chlorthalidone in participants with essential hypertension. Study NCT00591773. Available from: http://clinicaltrials.gov/ct2/show/NCT00591773?term=NCT00591773&rank=1. Accessed December 13, 2011.
16. Juhasz А, Collier D, Caulfield M, Agabiti-Rosei E et al. Achievement of blood pressure targets and safety of azilsartan medoxomil/chlortalidone fixed dose combination versus azilsartan medoxomil in hypertensive patients uncontrolled on monotherapy. J Hypertens 2015; 33: e-Supplement 2, e-8.
17. Bakris G, Sica D, White WB et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med 2012; 125: 1229e1–1229.e10.
18. Cushman WC, Bakris GL, White WB et al. Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension. Hypertension 2012; 60: 310–8.
19. Kupfer S, Neutel JM, Cushman WC et al. Comparison of long-term safety of fixed-dose combinations azilsartan medoxomil/chlorthalidone versus olmesartan medoxomil/hydrochlorothiazide. J Hypertens 2012; 30: e-Supplement 1, e-162.
20. Sica DA, Zhao L, Oparil S et al. Long-term safety of fixed doses: azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in hypertensive patients with stage 3 chronic kidney disease. J Hypertens 2014; 32: e-Supplement 1, e-582.
Авторы
О.Д.Остроумова*1,2, В.М.Фомина1
1 ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1;
2 ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 1
*ostroumova.olga@mail.ru
1 ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1;
2 ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 1
*ostroumova.olga@mail.ru
________________________________________________
O.D.Ostroumova*1,2, V.M.Fomina1
1 A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1;
2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 1
*ostroumova.olga@mail.ru
1 A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1;
2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 1
*ostroumova.olga@mail.ru
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