Клинический случай наблюдения пациента с ожирением и неалкогольной жировой болезнью печени
Клинический случай наблюдения пациента с ожирением и неалкогольной жировой болезнью печени
Комшилова К.А., Трошина Е.А. Клинический случай наблюдения пациента с ожирением и неалкогольной жировой болезнью печени. Consilium Medicum. 2015; 17 (4): 59–61.
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Komshilova K.A., Troshina E.A. Clinical observation of patient with obesity and non-alcoholic fatty liver disease case study. Consilium Medicum. 2015; 17 (4): 59–61.
Клинический случай наблюдения пациента с ожирением и неалкогольной жировой болезнью печени
Комшилова К.А., Трошина Е.А. Клинический случай наблюдения пациента с ожирением и неалкогольной жировой болезнью печени. Consilium Medicum. 2015; 17 (4): 59–61.
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Komshilova K.A., Troshina E.A. Clinical observation of patient with obesity and non-alcoholic fatty liver disease case study. Consilium Medicum. 2015; 17 (4): 59–61.
Неалкогольная жировая болезнь печени (НАЖБП) – заболевание, тесно ассоциированное с ожирением, особенно абдоминальным, и разными метаболическими маркерами риска развития сердечно-сосудистых заболеваний и сахарного диабета типа 2, что, естественно, отражается на заболеваемости, прогнозе и продолжительности жизни лиц с ожирением. В статье приведен клинический случай наблюдения и лечения пациента с ожирением и НАЖБП, ассоциированных с характерным комплексом метаболических нарушений. Показано, что комбинированная терапия, включающая модификацию образа жизни и прием метформина у лиц с ожирением и НАЖБП, является безопасной и эффективной в отношении коррекции обнаруженных метаболических нарушений.
Non-alcoholic fatty liver disease (NAFLD) is an obesity-related disease associated especially with abdominal obesity, and various metabolic markers of cardiovascular disease and diabetes mellitus type 2 risk and all these parameters can affect the incidence of disease, prognosis and longevity of people with obesity. The article deals with the case study of observation and treatment of the patient with obesity and NAFLD, associated with a characteristic complex of metabolic disorders. We have shown that combined therapy, including the modification of lifestyle and application of metformin in people with obesity and NAFLD, is safe and effective correction of metabolic disorders.
1. Targher G et al. Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease. N Engl J Med 2010.
2. Misra VL, Khashab M, Chalasani N. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk. Curr Gastroenterol Rep 2009; 11: 50–5.
3. Stefan N, Kantartzis K, Häring H. Causes and Metabolic Consequences of Fatty Liver. Endocr Rev 2008; 29 (7): 939–60.
4. Lazo M, Clark J. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008; 28 (4): 339–50.
5. Musso G, Gambino R, Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obesity Rev 2010; 11 (6): 430–45.
6. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM 2010; 103 (2): 71–83.
7. Festi D, Colecchia A, Sacco T et al. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev 2004; 5 (1): 27–42.
8. Adams L, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgraduate medical J 2006; 82: 315–22.
9. Marchesini G, Bianchi G, Tomassetti S et al. Metformin in non-alcoholic steatohepatitis. Lancet 2001; 358 (9285): 893–4.
10. Nair S, Diehl A, Wiseman M. Metformin in the triement of non- alcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther 2004; 20: 23–8.
11. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and nonalcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274–85.
12. Chalasani N, Younossi Z, Lavine JE et al. The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 2012;107: 811–26.
13. Kleiner DE, Brunt EM, Van Natta M et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41 (6): 1313–21.
________________________________________________
1. Targher G et al. Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease. N Engl J Med 2010.
2. Misra VL, Khashab M, Chalasani N. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk. Curr Gastroenterol Rep 2009; 11: 50–5.
3. Stefan N, Kantartzis K, Häring H. Causes and Metabolic Consequences of Fatty Liver. Endocr Rev 2008; 29 (7): 939–60.
4. Lazo M, Clark J. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008; 28 (4): 339–50.
5. Musso G, Gambino R, Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obesity Rev 2010; 11 (6): 430–45.
6. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM 2010; 103 (2): 71–83.
7. Festi D, Colecchia A, Sacco T et al. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev 2004; 5 (1): 27–42.
8. Adams L, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgraduate medical J 2006; 82: 315–22.
9. Marchesini G, Bianchi G, Tomassetti S et al. Metformin in non-alcoholic steatohepatitis. Lancet 2001; 358 (9285): 893–4.
10. Nair S, Diehl A, Wiseman M. Metformin in the triement of non- alcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther 2004; 20: 23–8.
11. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and nonalcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274–85.
12. Chalasani N, Younossi Z, Lavine JE et al. The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 2012;107: 811–26.
13. Kleiner DE, Brunt EM, Van Natta M et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41 (6): 1313–21.
Авторы
К.А.Комшилова*, Е.А.Трошина
ФГБУ Эндокринологический научный центр Минздрава России. 117036, Россия, Москва, ул. Дмитрия Ульянова, д. 11
*komshilovaksenia@rambler.ru
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K.A.Komshilova*, E.A.Troshina
Endocrinology Research Center of the Ministry of Health of the Russian Federation. 117036, Russian Federation, Moscow, ul. Dmitriia Ul'ianova, d. 11
*komshilovaksenia@rambler.ru